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    • 45. 发明申请
    • Decontamination of surfaces contaminated with prion-infected material with oxidizing agent-based formulations
    • 用基于氧化剂的配方对被朊病毒感染材料污染的表面进行去污
    • US20030073592A1
    • 2003-04-17
    • US10098767
    • 2002-03-14
    • STERIS INC.
    • Gerald E. McDonnellHerbert J. KaiserKathleen M. AntlogaJennifer A. Scocos
    • C02F005/08C11D001/00
    • A61L2/186A61K31/327A61L2/0082A61L2/0088A61L2/14A61L2/208A61L2/22A61L2202/24C11D3/3947C11D11/0023
    • A surface which carries a material which is infected with prions is cleaned with an alkaline cleaning solution to remove as much proteinaceous material as possible from the surface. The cleaning agent is an alkaline cleaning agent which attacks prions remaining on the surface and which attacks prions removed from the surface during the cleaning step. After the cleaning solution is drained, a solution of surfactants, buffers, and heavy metal free corrosion inhibitors is circulated over the surface at 50null-60null C. The surfactants disperse and unclump the prion-contaminated material. A strong oxidant, preferably peracetic acid, is added to the solution to bring the peracetic acid concentration to 1,000-2,500 ppm. The peracetic acid or other strong oxidant attacks the prions, particularly the unclumped prion strands, deactivating the prions. After rinsing and drying, the surface may be wrapped in a microbe impermeable barrier and subjected to terminal sterilization, such as steam autoclaving.
    • 携带被朊病毒感染的材料的表面用碱性清洁溶液清洗,以从表面去除尽可能多的蛋白质材料。 清洁剂是一种碱性清洁剂,其在清洁步骤中侵袭残留在表面上的朊病毒,并且其在表面上去除朊病毒。 清洁溶液排干后,表面活性剂,缓冲剂和无重金属的缓蚀剂溶液在50°-60°C的表面循环。表面活性剂分散并释放朊病毒污染物质。 向该溶液中加入强氧化剂,优选过乙酸,使过乙酸浓度达到1,000-2,500ppm。 过乙酸或其他强氧化剂会侵袭朊病毒,特别是未切开的朊病毒链,使朊病毒失活。 在漂洗和干燥之后,表面可以包裹在微生物不渗透屏障中并进行终端灭菌,例如蒸汽高压灭菌。