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41. 发明授权

US08956388B2 Integrated vascular device with puncture site closure component and sealant 有权
标题翻译：具有穿刺部位闭合部件和密封剂的集成血管装置
公开(公告)号：US08956388B2
公开(公告)日：2015-02-17
申请号：US12106928
申请日：2008-04-21
申请人： Richard S. Ginn , W. Martin Belef
发明人： Richard S. Ginn , W. Martin Belef
IPC分类号： A61B17/08 , A61B17/10 , A61B17/00 , A61B17/128 , A61B17/064 , A61M25/06
CPC分类号： A61B17/10 , A61B17/00491 , A61B17/0057 , A61B17/064 , A61B17/0643 , A61B17/083 , A61B17/128 , A61B17/1285 , A61B2017/00637 , A61B2017/00663 , A61B2017/00668 , A61B2017/00672 , A61B2017/00862 , A61B2017/0641 , A61M25/0662
摘要： Apparatus are provided for use in sealing a vascular puncture site. The invention comprises an integrated vascular device having a sheath with a closure component and puncture sealant. The closure component is disposed on and advanceable over the exterior of the sheath and may comprise any of a variety of apparatus suited for closing a vascular puncture. Once the closure component has been actuated to close the puncture, sealant is introduced to seal the puncture. The sheath and closure component are then removed from the patient.
摘要翻译：提供用于密封血管穿刺部位的装置。本发明包括具有护套的集成血管装置，其具有封闭部件和穿刺密封剂。闭合部件设置在护套的外部并可前进，并且可以包括适于闭合血管穿刺的各种装置中的任何一种。一旦闭合部件被致动以闭合穿刺，则引入密封剂以密封穿刺。然后从患者中取出护套和闭合部件。

42. 发明授权

US08905937B2 Methods and apparatus for locating a surface of a body lumen 有权
标题翻译：用于定位体腔表面的方法和装置
公开(公告)号：US08905937B2
公开(公告)日：2014-12-09
申请号：US12393877
申请日：2009-02-26
申请人： Brian A. Ellingwood , Arkady Kokish
发明人： Brian A. Ellingwood , Arkady Kokish
IPC分类号： A61B5/02 , A61B5/053 , A61B5/00 , A61B17/12 , A61B17/00 , A61B19/00
CPC分类号： A61B5/1076 , A61B5/053 , A61B5/0538 , A61B5/4836 , A61B5/6862 , A61B5/6876 , A61B5/6885 , A61B17/00234 , A61B17/0057 , A61B2017/00022 , A61B2017/0003 , A61B2017/00106 , A61B2017/00243 , A61B2017/00292 , A61B2017/00575 , A61B2017/00668 , A61B2017/00672 , A61B2017/12018 , A61B2090/065 , A61B2560/0266 , A61B2562/12
摘要： An embodiment of an apparatus for locating a surface of a body lumen is disclosed. The apparatus includes a locator assembly that has a distal end region configured to extend into an opening of the body lumen and to selectably engage at least a portion of the body lumen adjacent to the opening. The distal end region includes at least one surface engaging element that is configured to engage the surface of the body lumen. The apparatus includes a measuring device that is in electrical communication with the surface engaging element. The measuring device is configured to determine changes in measurable characteristics of the surface engaging element. Methods and apparatus for locating a surface of a body lumen are also disclosed.
摘要翻译：公开了一种用于定位体腔表面的装置的实施例。该装置包括定位器组件，该定位器组件具有构造成延伸到体腔的开口中的远端区域，并且可选地接合与开口相邻的体腔的至少一部分。远端区域包括至少一个表面接合元件，其构造成接合体腔的表面。该装置包括与表面接合元件电连通的测量装置。测量装置被配置为确定表面接合元件的可测量特性的变化。还公开了用于定位体腔表面的方法和装置。

43. 发明授权

US08808310B2 Resettable clip applier and reset tools 有权
标题翻译：可复位夹子施放器和复位工具
公开(公告)号：US08808310B2
公开(公告)日：2014-08-19
申请号：US11674930
申请日：2007-02-14
申请人： Andrew Jones , James Suffel
发明人： Andrew Jones , James Suffel
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/1227 , A61B17/128 , A61B2017/00672
摘要： An apparatus for closing a wall of a body lumen to deploy a closure element. The apparatus comprises a resettable triggering system which may be slideably moved within a housing to advance a carrier assembly and/or locating assembly, and which deploys the closure element. Upon deployment of a closure element, the carrier assembly may be positioned in a distal position and locked in place within a housing. The lock may be effected by a flexible snap fit interlocking feature which is selectively releasable. Release of the locking feature may be performed by externally insertable tools which engage the flexible snap fit and release the interlocking features. The triggering system may also include a catch which is released upon deployment of a closure element. The catch can be reset to allow the triggering system to be re-engaged into a pre-deployment condition and position.
摘要翻译：一种用于封闭体腔壁以展开闭合元件的装置。该装置包括可复位的触发系统，其可以在壳体内可滑动地移动以推进载体组件和/或定位组件，并且其展开闭合元件。在展开闭合元件时，托架组件可以定位在远侧位置并且锁定在壳体内的适当位置。锁可以通过可选择性地释放的柔性卡扣配合互锁特征来实现。锁定特征的释放可以通过外部可插入的工具来执行，这些工具接合柔性卡扣配合并释放互锁特征。触发系统还可以包括在展开闭合元件时释放的卡扣。可以重新设置捕获，以允许触发系统重新接合到预部署状态和位置。

44. 发明授权

US08758396B2 Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use 有权
标题翻译：血管鞘与生物可吸收性穿刺部位闭合装置及使用方法
公开(公告)号：US08758396B2
公开(公告)日：2014-06-24
申请号：US11411925
申请日：2006-04-27
申请人： Richard S. Ginn , William N. Aldrich
发明人： Richard S. Ginn , William N. Aldrich
IPC分类号： A61D1/00
CPC分类号： A61B17/0643 , A61B17/0057 , A61B17/064 , A61B17/083 , A61B17/1285 , A61B17/3415 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00862 , A61B2017/0641 , A61M25/0662
摘要： Apparatus and methods are provided for use in sealing a vascular puncture site. The invention comprises an introducer sheath with an integrated closure component. The closure component includes a fastener and an advanceable, deformable clip having a delivery configuration in which opposing sides do not contact one another, and a deployed configuration, in which the fastener causes opposing sides of the deformable clip to close towards one another. The clip is advanced along the sheath until it pierces opposing sides of a vessel wall at a puncture site. The clip is then deformed with the fastener to draw opposing sides of the puncture together, and the sheath is withdrawn to seal the wound. The clip and fastener preferably are bioabsorbable.
摘要翻译：提供了用于密封血管穿刺部位的装置和方法。本发明包括具有集成闭合部件的引导器护套。闭合部件包括紧固件和可推进的可变形夹具，其具有相对侧面不彼此接触的输送构造，以及展开构造，其中紧固件使可变形夹的相对侧面彼此靠近。夹子沿护套前进，直到穿刺部位穿过血管壁的相对侧。然后夹子用紧固件变形以将穿刺的相对侧拉在一起，并且将护套取出以密封伤口。夹和紧固件优选是生物可吸收的。

45. 发明授权

US08603136B2 Apparatus and methods for providing tactile feedback while delivering a closure device 有权
公开(公告)号：US08603136B2
公开(公告)日：2013-12-10
申请号：US11744089
申请日：2007-05-03
申请人： Richard S. Ginn
发明人： Richard S. Ginn
IPC分类号： A61B17/08 , A61B17/10 , A61D17/00
CPC分类号： A61B17/0057 , A61B17/064 , A61B34/76 , A61B2017/00367 , A61B2017/00637 , A61B2017/00654 , A61B2017/00663 , A61B2017/00668 , A61B2017/00672 , A61B2017/081
摘要： An apparatus for sealing a passage through tissue includes a tubular member, a plug, and a locator member. The plug is disposed on a distal end of the tubular member and includes an external thread. The locator member is inserted into a lumen of the tubular member until a distal portion is disposed beyond the plug. The distal portion includes a helically wound wire and a tether coupled to the wire that is movable for causing the wire to buckle. To seal a passage communicating with a blood vessel, the distal portion of the locator member is inserted into the passage, and the plug is threaded into the passage until the distal portion extends into the vessel. The tether is pulled to buckle the wire, and the plug is unthreaded until the buckled wire contacts a wall of the vessel, whereupon the plug is released to seal the passage.

46. 发明授权

US08486108B2 Closure device and methods for making and using them 有权
公开(公告)号：US08486108B2
公开(公告)日：2013-07-16
申请号：US11344891
申请日：2006-02-01
申请人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
发明人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
IPC分类号： A61B17/08
CPC分类号： A61B17/08 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00867 , A61B2017/0641 , A61B2017/081 , H03K3/356139 , H03K3/356156
摘要： A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

47. 发明申请

US20120255655A1 METHODS FOR MANUFACTURING A CLIP AND CLIP 有权
标题翻译：制作夹子和夹子的方法
公开(公告)号：US20120255655A1
公开(公告)日：2012-10-11
申请号：US13525839
申请日：2012-06-18
申请人： Michael T. Carley , Richard S. Ginn
发明人： Michael T. Carley , Richard S. Ginn
IPC分类号： C21D9/00 , C21D8/00
CPC分类号： A61B17/068 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00867 , C22C19/007 , C22F1/00 , C22F1/10 , C22F1/16
摘要： The present disclosure relates to a clip manufactured according to a method which can be used to engage body tissue for the purpose of closing wounds. Such clips are generally annular in shape and have radially inwardly extending tines. The present disclosure first forms a precursor which, in one embodiment, has the tines extending radially outwardly from the annular body and then forms the clip by inverting the precursor such that the tines extend radially inwardly. In an alternate embodiment, the precursor is formed with an over-sized lateral dimension and then compressed inwardly to bring the tines closer together and to reduce the lateral dimension of the precursor. Such clips may be manufactured from a superelastic alloy such as nickel-titanium, in which case the inverted or compressed precursor must be heated and quenched to heat set the clip in its final shape.
摘要翻译：本公开涉及一种根据可以用于接合身体组织以便关闭伤口的方法制造的夹子。这种夹子通常是环形的并且具有径向向内延伸的尖齿。本公开内容首先形成前体，在一个实施例中，前体具有从环形体径向向外延伸的齿，然后通过倒转前体形成夹子，使得尖齿径向向内延伸。在替代实施例中，前体形成为具有超大尺寸的侧向尺寸，然后被向内压缩以使尖齿更靠近在一起并减小前体的横向尺寸。这样的夹子可以由超弹性合金例如镍钛制造，在这种情况下，必须加热和淬火反转或压缩的前体以将夹子热定型成其最终形状。

48. 发明授权

US08202283B2 Methods for manufacturing a clip and clip 有权
标题翻译：制造夹子和夹子的方法
公开(公告)号：US08202283B2
公开(公告)日：2012-06-19
申请号：US12945646
申请日：2010-11-12
申请人： Michael T. Carley , Richard S. Ginn
发明人： Michael T. Carley , Richard S. Ginn
IPC分类号： A61B17/08 , C22F1/00
CPC分类号： A61B17/068 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00867 , C22C19/007 , C22F1/00 , C22F1/10 , C22F1/16
摘要： The present disclosure relates to a clip manufactured according to a method which can be used to engage body tissue for the purpose of closing wounds. Such clips are generally annular in shape and have radially inwardly extending tines. The present disclosure first forms a precursor which, in one embodiment, has the tines extending radially outwardly from the annular body and then forms the clip by inverting the precursor such that the tines extend radially inwardly. In an alternate embodiment, the precursor is formed with an over-sized lateral dimension and then compressed inwardly to bring the tines closer together and to reduce the lateral dimension of the precursor. Such clips may be manufactured from a superelastic alloy such as nickel-titanium, in which case the inverted or compressed precursor must be heated and quenched to heat set the clip in its final shape.
摘要翻译：本公开涉及一种根据可以用于接合身体组织以便关闭伤口的方法制造的夹子。这种夹子通常是环形的并且具有径向向内延伸的尖齿。本公开内容首先形成前体，在一个实施例中，前体具有从环形体径向向外延伸的齿，然后通过倒转前体形成夹子，使得尖齿径向向内延伸。在替代实施例中，前体形成为具有超大尺寸的侧向尺寸，然后被向内压缩以使尖齿更靠近在一起并减小前体的横向尺寸。这样的夹子可以由超弹性合金例如镍钛制造，在这种情况下，必须加热和淬火反转或压缩的前体以将夹子热定型成其最终形状。

49. 发明授权

US08128644B2 Closure device and methods for making and using them 有权
公开(公告)号：US08128644B2
公开(公告)日：2012-03-06
申请号：US10667144
申请日：2003-09-19
申请人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
发明人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
IPC分类号： A61B17/08
CPC分类号： A61B17/08 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00867 , A61B2017/0641 , A61B2017/081 , H03K3/356139 , H03K3/356156
摘要： A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

50. 发明申请

US20110313452A1 CLOSURE DEVICE AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：封闭装置及其制造和使用方法
公开(公告)号：US20110313452A1
公开(公告)日：2011-12-22
申请号：US13222899
申请日：2011-08-31
申请人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
发明人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
IPC分类号： A61B17/03
CPC分类号： A61B17/08 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00867 , A61B2017/0641 , A61B2017/081 , H03K3/356139 , H03K3/356156
摘要： A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.
摘要翻译：用于接合组织的夹具包括限定平面并围绕垂直于平面延伸的中心轴设置的大致环形的主体。主体包括交替的内部和外部弯曲区域，围绕夹子的周边限定Z字形图案。身体偏向平面构型，该平面构型位于平面内，并可朝向延伸出平面的横向构型偏转。齿从内部弯曲区域延伸，尖齿在平面构型中朝向中心轴线定向，并且在横向构型中平行于中心轴线。尖齿可以包括比主尖齿短的主要尖齿和次要尖齿。主尖齿可以设置在相对的内部弯曲区域上并且朝向彼此定向，使得它们在平面构造中重叠。

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