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41. 发明申请

US20150359839A1 METHODS FOR PREVENTING OR TREATING INSULIN RESISTANCE 审中-公开
公开(公告)号：US20150359839A1
公开(公告)日：2015-12-17
申请号：US14598095
申请日：2015-01-15
申请人： P. Darrell Neufer , Ethan J. Anderson , Hazel H. Szeto
发明人： P. Darrell Neufer , Ethan J. Anderson , Hazel H. Szeto
IPC分类号： A61K38/07
CPC分类号： A61K38/07 , A61K38/06 , C07K5/1019
摘要： The invention provides methods of preventing or treating insulin resistance in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.

42. 发明申请

US20140273247A1 METHODS FOR MONITORING CHANGES IN THE CORE OF LIPOPROTEIN PARTICLES IN METABOLISM AND DISEASE 有权
标题翻译：用于监测代谢和疾病中脂蛋白颗粒核心变化的方法
公开(公告)号：US20140273247A1
公开(公告)日：2014-09-18
申请号：US13839420
申请日：2013-03-15
申请人： EAST CAROLINA UNIVERSITY
发明人： David P. Cistola , Michelle Robinson
IPC分类号： G01N24/08
CPC分类号： G01R33/448 , A61B5/055 , A61B5/14546 , A61B5/150022 , A61B5/7275 , G01N24/08 , G01N33/49 , G06F19/00
摘要： A method is disclosed for measuring the properties of protein and lipoprotein elements in a sample. The method includes the of placing a small volume of a sample into a NMR instrument tuned to measure a particular nucleus, applying a series of radiofrequency pulses with intermittent delays in order to measure spin-spin and/or spin-lattice relaxation time constants from the time-domain decay of the signal, without the use of chemical shifts and without converting data into the frequency domain by Fourier transform or other means, at least partially suppressing the water signal prior to the beginning of a sequence used to record relaxation time constants in the time domain, optionally utilizing relaxation contrast agents or other chemical additives to perturb the solvent water or other elements of the sample, analyzing the exponentially decaying NMR signal in the time domain using multi-exponential analysis, and comparing differences in the relaxation time constants for lipoprotein- or protein-specific elements within a single human subject, or between subjects, to assess normal and abnormal metabolism reflective of increased disease risk or active disease.
摘要翻译：公开了一种用于测量样品中蛋白质和脂蛋白元件的性质的方法。该方法包括将小体积的样品放入被调谐以测量特定核的NMR仪器中，施加具有间歇延迟的一系列射频脉冲，以测量自旋 - 自旋和/或自旋 - 晶格弛豫时间常数信号的时域衰减，而不使用化学位移，并且通过傅里叶变换或其他方式将数据转换成频域，至少部分地抑制用于记录弛豫时间常数的序列开始之前的水信号时域，任选地使用松弛造影剂或其他化学添加剂来扰乱样品的溶剂水或其他元素，使用多指数分析分析时域中的指数衰减NMR信号，并比较单个人类受试者或受试者之间的脂蛋白或蛋白质特异性元件，以评估正常和ab 正常代谢反映出增加的疾病风险或活动性疾病。

43. 发明授权

US08634077B2 Methods and systems for optically characterizing a turbid material using a structured incident beam 有权
标题翻译：使用结构化入射光束光学表征混浊物质的方法和系统
公开(公告)号：US08634077B2
公开(公告)日：2014-01-21
申请号：US13122062
申请日：2009-10-01
申请人： Xin-Hua Hu , Cheng Chen
发明人： Xin-Hua Hu , Cheng Chen
IPC分类号： G01N21/55
CPC分类号： G01N21/4738 , G01N21/4785 , G01N2021/4709 , G01N2021/4735 , G01N2201/0635
摘要： Methods and systems for optically characterizing a turbid sample are provided. A structured light beam is impinged on the sample. The sample includes an embedded region. A reflected light image of the structured light beam is detected from the sample. A measured reflectance image of the structured light beam for the sample is determined based on the reflected light image and a reflectance standard. The following parameters are determined: absorption coefficients ÿa, scattering coefficient ÿs and anisotropy factor g of the sample from the reflectance image. A size parameter of the embedded region is estimated based on the absorption coefficients ÿa, scattering coefficient ÿs and/or anisotropy factor g of the sample from the measured reflectance image.
摘要翻译：提供了用于光学表征混浊样品的方法和系统。结构化光束撞击样品。样本包括一个嵌入区域。从样品中检测结构化光束的反射光图像。基于反射光图像和反射率标准确定样品的结构化光束的测量反射率图像。确定以下参数：来自反射图像的样品的吸收系数μa，散射系数μs和各向异性因子g。基于来自测量的反射率图像的样品的吸收系数μa，散射系数μs和/或各向异性因子g来估计嵌入区域的尺寸参数。

44. 发明授权

US08580739B2 Methods of reducing myocardial injury following myocardial infarction 有权
标题翻译：降低心肌梗死后心肌损伤的方法
公开(公告)号：US08580739B2
公开(公告)日：2013-11-12
申请号：US13299096
申请日：2011-11-17
申请人： Jitka A. I. Virag , Jessica L. Dries
发明人： Jitka A. I. Virag , Jessica L. Dries
IPC分类号： A61P9/10
CPC分类号： A61K38/177 , A61K9/0019 , A61K38/17 , A61K38/19 , A61K45/06 , C07K14/705 , C07K2319/30
摘要： The present invention discloses methods of reducing injury resulting from cardiovascular disease, such as myocardial infarction, and/or promoting myocardial repair. The methods include administering an ephrin and pharmaceutical compositions including ephrins to a subject. Kits useful for accomplishing the same are also provided.
摘要翻译：本发明公开了减少心血管疾病（例如心肌梗塞）和/或促进心肌修复引起的损伤的方法。所述方法包括将ephrin和药物组合物施用于受试者。还提供了用于实现它们的套件。

45. 发明申请

US20130245456A1 Methods, Systems and Computer Program Products for Non-Invasive Determination of Blood Flow Distribution Using Speckle Imaging Techniques and Hemodynamic Modeling 有权
标题翻译：使用斑点成像技术和血液动力学建模的无创测定血流分布的方法，系统和计算机程序产品
公开(公告)号：US20130245456A1
公开(公告)日：2013-09-19
申请号：US13833862
申请日：2013-03-15
申请人： EAST CAROLINA UNIVERSITY
发明人： Thomas Bruce Ferguson, JR. , Xin-Hua Hu , Cheng Chen
IPC分类号： A61B5/026
CPC分类号： A61B5/0261 , A61B5/0044 , A61B5/0059 , A61B5/0066 , A61B5/0077 , A61B5/02007 , A61B5/0402 , G02B27/48 , G06T7/0012
摘要： Non-invasive methods for determining blood flow distribution in a region of interest are provided. The method includes illuminating a region of interest of a subject with a coherent light source; sequentially acquiring at least two speckle images of the region of interest, wherein sequentially acquiring the at least two speckle images comprises acquiring the at least two speckle images in synchronization with motion of the heart of the subject; and electronically processing the at least two acquired speckle images based on the temporal variation of the pixel intensities in the at least two acquired speckle images to generate a laser speckle contrast imaging (LSCI) image, determine distribution of blood flow speed in principal vessels and quantify perfusion distribution in tissue in the region of interest from the LSCI image. The LSCI image enables detection of different blood flow speeds.
摘要翻译：提供了用于确定感兴趣区域中的血流分布的非侵入性方法。该方法包括用相干光源照射被摄体的感兴趣区域; 顺序地获取所述感兴趣区域的至少两个散斑图像，其中顺序地获取所述至少两个斑点图像包括与所述对象的心脏的运动同步地获取所述至少两个斑点图像; 并且基于所述至少两个获取的散斑图像中的像素强度的时间变化来电子处理所述至少两个获取的斑点图像，以产生激光散斑对比成像（LSCI）图像，确定主血管中血流速度的分布并量化灌注分布在LSCI图像感兴趣区域的组织中。 LSCI图像可以检测不同的血流速度。

46. 发明授权

US07828712B2 Frequency altered feedback for treating non-stuttering pathologies 有权
标题翻译：频率改变的反馈用于治疗非口吃病变
公开(公告)号：US07828712B2
公开(公告)日：2010-11-09
申请号：US10530669
申请日：2003-09-30
申请人： Michael P. Rastatter , Joseph S. Kalinowski , Andrew M. Stuart
发明人： Michael P. Rastatter , Joseph S. Kalinowski , Andrew M. Stuart
IPC分类号： A61F5/58 , A61B19/00
CPC分类号： A61F5/58 , G10L21/00 , G10L2021/0575 , H04R25/353 , H04R2225/43
摘要： Methods and devices treat treating non-stuttering pathologies having impaired or decreased communication skills by administering a frequency altered auditory feedback signal to a subject having a non-stuttering pathology while the subject is speaking or talking to thereby improve the subject's communication skills.Certain methods for treating subjects having non-stuttering pathologies or disorders presenting with an impairment or dysfunction in communication skills using frequency altered auditory feedback, comprise: (a) positioning a ear-supported device (devoid of external cabling during normal operation) for receiving auditory signals associated with a subject's speech in close proximity to at least one ear of an individual, the device being adapted to be in communication with at least one of the ear canals of the individual; (b) receiving in the device an audio signal associated with the subject's speech; (c) generating from the device a frequency altered auditory feedback signal having an associated frequency shift between about +/−2 octaves relative to the received audio signal; and (d) transmitting the frequency altered auditory feedback signal to at least one ear canal of the subject.
摘要翻译：方法和装置通过在受试者讲话或说话时向具有非口吃病理学的受试者施用频率改变的听觉反馈信号来治疗具有受损或减少的沟通技巧的非口吃病理学，从而改善受试者的沟通能力。用于治疗具有非口吃病变或症状的受试者的某些方法，其使用频率改变的听觉反馈在通信技能中出现损伤或功能障碍，包括：（a）定位耳朵支持的装置（在正常操作期间没有外部布线）用于接收听觉与个体的至少一个耳朵非常接近的与受试者的言语相关联的信号，该设备适于与个体的至少一个耳道通信; （b）在设备中接收与被摄体的语音相关联的音频信号; （c）从所述装置产生频率改变的听觉反馈信号，所述频率改变的听觉反馈信号相对于所接收的音频信号具有在大约+/- 2个八度之间的相关联的频移; 和（d）将频率改变的听觉反馈信号发送到被摄体的至少一个耳道。

47. 发明授权

US07507410B2 Monoclonal antibody DS6, tumor-associated antigen CA6, and methods of use thereof 有权
标题翻译：单克隆抗体DS6，肿瘤相关抗原CA6及其使用方法
公开(公告)号：US07507410B2
公开(公告)日：2009-03-24
申请号：US11680190
申请日：2007-02-28
申请人： Anne Elizabeth Kellogg , Diane A. Semer
发明人： Anne Elizabeth Kellogg , Diane A. Semer
IPC分类号： A61K39/395
CPC分类号： G01N33/57407 , A61K2039/505 , C07K16/30 , G01N2800/12
摘要： The present application describes a monoclonal antibody selected from the group consisting of monoclonal antibody DS6, monoclonal antibodies that specifically bind to the antigen or epitope bound by monoclonal antibody DS6, and fragments of the foregoing that specifically bind to the antigen or epitope bound by monoclonal antibody DS6. Methods of use of such antibodies and the isolated antigen bound by such antibodies are also described.
摘要翻译：本申请描述了选自单克隆抗体DS6，特异性结合由单克隆抗体DS6结合的抗原或表位的单克隆抗体的单克隆抗体，以及特异性结合由单克隆抗体结合的抗原或表位的前述片段 DS6。还描述了使用这种抗体的方法和由这种抗体结合的分离的抗原。

48. 发明授权

US07445906B2 Method of detecting cancer using delta-catenin 有权
标题翻译：使用δ-连环蛋白检测癌症的方法
公开(公告)号：US07445906B2
公开(公告)日：2008-11-04
申请号：US10872692
申请日：2004-06-21
申请人： Qun Lu , Yan-hua Chen
发明人： Qun Lu , Yan-hua Chen
IPC分类号： G01N33/574 , G01N33/53 , C12Q1/00
CPC分类号： G01N33/57415 , C12Q1/6886 , G01N33/574 , G01N33/57434
摘要： The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from said subject, and then determining the presence or absence of delta-catenin in said sample, or increased levels of delta-catenin in said sample as compared to a normal or control subject. The presence of delta-catentin in said sample, or increased levels of delta-catenin in said sample, indicating said subject is afflicted with or at least at risk of developing cancer.
摘要翻译：本发明提供了用于检测或筛选受试者中癌症存在的方法。该方法包括从所述受试者获得，提供或收集组织或流体样品（例如尿液样品），然后确定所述样品中δ-连环蛋白的存在或不存在，或所述样品中δ-连环蛋白的增加水平为与正常或对照对象相比。所述样品中δ-卡汀的存在或所述样品中δ-连环蛋白的水平升高，表明所述受试者患有或至少具有发生癌症的风险。

49. 发明授权

US07351805B2 Monoclonal antibody DS6, tumor-associated antigen CA6, and methods of use thereof 有权
公开(公告)号：US07351805B2
公开(公告)日：2008-04-01
申请号：US10465176
申请日：2003-06-19
申请人： Anne Elizabeth Kellogg , Diane A. Semer
发明人： Anne Elizabeth Kellogg , Diane A. Semer
IPC分类号： C07K16/00
CPC分类号： G01N33/57407 , A61K2039/505 , C07K16/30 , G01N2800/12
摘要： The present application describes a monoclonal antibody selected from the group consisting of monoclonal antibody DS6, monoclonal antibodies that specifically bind to the antigen or epitope bound by monoclonal antibody DS6, and fragments of the foregoing that specifically bind to the antigen or epitope bound by monoclonal antibody DS6. Methods of use of such antibodies and the isolated antigen bound by such antibodies are also described.

50. 发明授权

US07349523B2 Radiation isocenter measurement devices and methods and 3-D radiation isocenter visualization systems and related methods 失效
标题翻译：辐射等距中心测量装置和方法以及三维辐射等距中心可视化系统及相关方法
公开(公告)号：US07349523B2
公开(公告)日：2008-03-25
申请号：US11171729
申请日：2005-06-30
申请人： Todd Perrin Jenkins , Ron Russell Allison , Claudio Sibata
发明人： Todd Perrin Jenkins , Ron Russell Allison , Claudio Sibata
IPC分类号： A61N5/10
CPC分类号： A61N5/1048 , A61B6/583 , A61N2005/1076
摘要： A three-dimensional phantom assembly for use with a radiation treatment device includes a three-dimensional support member having at least two, spaced apart opposed surfaces configured to hold at least one generally planar radiation sensitive dosimeter sheet such that the dosimeter sheet generally conforms to a shape defined by the two opposed surfaces. During irradiation, a radiation beam trajectory passes through the two opposed surfaces. Related systems methods for determining a radiation isocenter and/or generating a 3-D visualization of the radiation isocenter using radiation patterns obtained using a phantom are also described.
摘要翻译：与放射治疗装置一起使用的三维幻影组件包括具有至少两个间隔开的相对表面的三维支撑构件，其构造成保持至少一个基本上平面的辐射敏感剂量计片，使得剂量计片材通常符合形状由两个相对的表面限定。在照射期间，辐射束轨迹穿过两个相对的表面。还描述了用于确定辐射等距中心和/或使用使用体模获得的辐射图形生成辐射等角点的3-D可视化的相关系统方法。

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