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31. 发明授权

US4033960A 2-Mercaptoquinoxaline-di-N-oxide products and a method for their preparation 失效
标题翻译： 2-巯基喹喔啉二-N-氧化物产物及其制备方法
公开(公告)号：US4033960A
公开(公告)日：1977-07-05
申请号：US639084
申请日：1975-12-09
申请人： Florin Seng , Kurt Ley
发明人： Florin Seng , Kurt Ley
IPC分类号： C07D241/52
CPC分类号： C07D241/52
摘要： Compounds of the formula ##STR1## and alkali metal or alkaline earth metal salts thereof, wherein R.sup.1 and R.sup.2 are the same or different and each is hydrogen, alkyl, alkoxy, haloalkyl, polyhaloalkyl, haloalkoxy, polyhaloalkoxy or halo; R.sup.3 is methyl, hydroxy or amino; are produced by treating the corresponding 3-cyanoquinoxaline-di-N-oxide of the formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as above defined, with hydrogen sulfide or an alkali metal or alkaline earth metal salt thereof. When a salt of hydrogen sulfide is used, the resulting mercaptide product may be converted to the corresponding mercaptan by treatment with an acid to produce the corresponding 2-mercaptoquinoxaline-di-N-oxide.
摘要翻译：式中的化合物及其碱金属或碱土金属盐，其中R 1和R 2相同或不同，各自为氢，烷基，烷氧基，卤代烷基，多卤代烷基，卤代烷氧基，多卤代烷氧基或卤素; R3是甲基，羟基或氨基; 通过用硫化氢或其碱金属或碱土金属盐处理相应的式为“IMAGE”的3-氰基喹喔啉二-N-氧化物，其中R 1，R 2和R 3如上所定义。当使用硫化氢的盐时，所得到的硫醇盐产物可以通过用酸处理转化成相应的硫醇，生成相应的2-巯基喹喔啉二-N-氧化物。

32. 发明授权

US4007184A Substituted alkyl esters of quinoxaline-di-N-oxide-2-carboxylic acid 失效
标题翻译：喹喔啉二-N-氧化物-2-羧酸的取代的烷基酯
公开(公告)号：US4007184A
公开(公告)日：1977-02-08
申请号：US621219
申请日：1975-10-09
申请人： Timothy H. Cronin , Kenneth Richardson
发明人： Timothy H. Cronin , Kenneth Richardson
IPC分类号： A23K1/16 , A23K1/18 , C07D263/14 , C07D241/52
CPC分类号： C07D263/14 , A23K20/137 , A23K50/30
摘要： Novel alkyl esters of quinoxaline-di-N-oxide-2-carboxylic acid substituted on the alkyl portion of the ester by hydroxy, acyloxy, N-alkyl carbamyloxy, dialkylaminoacyloxy, carboxyacyloxy, alkoxycarbonyloxy, haloacyloxy, amino and mono- and disubstituted amino, useful as antibacterial agents and in promoting growth and improving feed efficiency of animals in general.
摘要翻译：通过羟基，酰氧基，N-烷基氨基甲酰氧基，二烷基氨基酰氧基，羧基酰氧基，烷氧基羰基氧基，卤代酰氧基，氨基和一取代和二取代的氨基取代的酯的烷基部分上的喹喔啉二-N-氧化物-2-羧酸的新型烷基酯，通常用作抗菌剂和促进动物的生长和提高饲料效率。

33. 发明授权

US3984553A Veterinary feedstuffs 失效
标题翻译：兽用饲料
公开(公告)号：US3984553A
公开(公告)日：1976-10-05
申请号：US563084
申请日：1975-03-28
申请人： Florin Seng , Kurt Ley , Karl Georg Metzger
发明人： Florin Seng , Kurt Ley , Karl Georg Metzger
IPC分类号： C07D241/52 , C07D277/18 , C07D491/04 , A61K31/495
CPC分类号： C07D277/18 , C07D241/52 , C07D491/04
摘要： Imines of 2-formylquinoxaline-3-carboxylic acid-1,4-dioxides and their salts are obtained through treatment of the lactone or a salt of 2-hydroxymethylquinoxaline-N,N-dioxide-3-carboxylic acid with a reactant bearing a free primary amino group. Veterinary feedstuffs are produced by combining a nutritious material with an imine as above described.
摘要翻译：通过用含有游离的反应物的内酯或2-羟甲基喹喔啉-N，N-二甲基-3-羧酸的盐处理2-甲酰基喹喔啉-3-羧酸-1,4-二氧化物及其盐，伯氨基。通过将营养物质与如上所述的亚胺组合来生产兽药饲料。

34. 发明授权

US3984547A Veterinary feedstuffs 失效
公开(公告)号：US3984547A
公开(公告)日：1976-10-05
申请号：US562879
申请日：1975-03-28
申请人： Florin Seng , Kurt Ley , Karl Georg Metzger
发明人： Florin Seng , Kurt Ley , Karl Georg Metzger
IPC分类号： B01J21/00 , C07D241/52 , C07D277/18 , C07D491/04 , A61K31/495 , A61K31/535
CPC分类号： B01J21/005 , C07D241/52 , C07D277/18 , C07D491/04
摘要： Imines of 2-formylquinoxaline-3-carboxylic acid-1,4-dioxides and their salts are obtained through treatment of the lactone or a salt of 2-dihydroxymethylquinoxaline-N,N-dioxide-3-carboxylic acid with a reactant bearing a free primary amino group. Veterinary feedstuffs are produced by combining a nutritious material with an imine as above described.

35. 发明授权

US3983235A Veterinary feedstuffs 失效
公开(公告)号：US3983235A
公开(公告)日：1976-09-28
申请号：US562403
申请日：1975-03-27
申请人： Florin Seng , Kurt Ley , Karl Georg Metzger
发明人： Florin Seng , Kurt Ley , Karl Georg Metzger
IPC分类号： A23K1/16 , B01J21/00 , C07D241/52 , C07D277/18 , C07D491/04 , A61K31/495
CPC分类号： C07D241/52 , A23K20/116 , A23K20/137 , B01J21/005 , C07D277/18 , C07D491/04
摘要： Imines of 2-formylquinoxaline-3-carboxylic acid-1,4-dioxides and their salts are obtained through treatment of the lactone or a salt of 2-dihydroxymethylquinoxaline-N,N-dioxide-3-carboxylic acid with a reactant bearing a free primary amino group. Veterinary feedstuffs are produced by combining a nutritious material with an imine as above described.

36. 发明授权

US3966951A Esters of quinoxaline-1,4-dioxides 失效
标题翻译：喹喔啉-1,4-二氧化物的酯
公开(公告)号：US3966951A
公开(公告)日：1976-06-29
申请号：US564363
申请日：1975-04-02
申请人： Banavara L. Mylari
发明人： Banavara L. Mylari
IPC分类号： A23K20/195 , A61K31/495 , A61P3/00 , A61P31/04 , C07D241/52 , C07D241/36
CPC分类号： C07D241/52
摘要： Disclosed herein are novel esters of quinoxaline-1,4-dioxide of the structure ##SPC1##In whichX is selected from the group consisting of a single bond, lower n-alkylene and --(CH.sub.2).sub.p --CH=CH--(CH.sub.2).sub.q -- where p and q may have integral values from zero to four with the proviso that p+q is less than or equal to four;A is selected from the group consisting of hydrogen, hydroxyl, lower alkyl, lower alkoxy, fluorine, chlorine, bromine, iodine, cyano and trifluoromethyl;And R is selected from the group consisting of hydrogen, lower alkanoyl and .alpha.-hydroxy lower alkyl.When administered to animals, these compounds function as antibacterial agents, promote growth and improve feed efficiency. They are particularly useful in the prophylaxis and treatment of pasturellosis and salmonellosis and are notable for their extremely low toxicity in the test animal.
摘要翻译：本文公开了具有下列结构的喹喔啉-1,4-二氧化物的新型酯：其中X选自单键，低级正亚烷基和 - （CH 2）p -CH = CH-（CH 2）q - 其中p和q可以具有从零到四的整数值，条件是p + q小于或等于4; A选自氢，羟基，低级烷基，低级烷氧基，氟，氯，溴，碘，氰基和三氟甲基; AND R选自氢，低级烷酰基和α-羟基低级烷基。

37. 发明授权

US3870718A 2-imidazolidine substituted quinoxaline-1,4-dioxides and intermediates therefor 失效
标题翻译： 2-咪唑啉取代的喹啉-1,4-二氧化物及其中间体
公开(公告)号：US3870718A
公开(公告)日：1975-03-11
申请号：US40511473
申请日：1973-10-10
申请人： PFIZER
发明人： ABU EL-HAJ MARWAN J
IPC分类号： C07D241/52 , C07D277/10 , C07D51/78
CPC分类号： C07D241/52 , C07D277/10
摘要： WHEREIN X is a 6- or a 7-position substituent and is hydrogen, chloro, bromo, fluoro, methyl, methoxy and trifluoromethyl; Y is O, S and NR1 wherein R1 is hydrogen and lower alkyl; A is alkylene of from two to five carbon atoms which places at least two carbon atoms between the N and Y or Z atoms to which it is attached; R2 is lower alkyl; Z is chloro and bromo; THE NON-TOXIC ACID ADDITION SALTS OF THOSE COMPOUNDS WHEREIN Y is -NR1; and method for their preparation are described. All compounds of formulae I and II are useful as antibacterial agents. Compounds of formulae II are valuable intermediates for further synthesis.

The 2-heterocyclic- and 2-(N-( omega haloalkyl)carbamyl)substituted quinoxaline-1,4-dioxides having formulae I and II, respectively:
摘要翻译：分别具有式I和II的2-杂环 - 和2- [N-（ω-卤代烷基）氨基甲酰基]取代的喹喔啉-1,4-二氧化物：

38. 发明授权

US3846415A New imines, their preparation and their pharmaceutical use 失效
公开(公告)号：US3846415A
公开(公告)日：1974-11-05
申请号：US35940173
申请日：1973-05-11
申请人： BAYER AG
发明人： SENG F , LEY K , METZGER K
IPC分类号： A23K1/16 , C07D241/52 , C07D277/18 , C07D491/04 , C07D51/78
CPC分类号： C07D241/52 , A23K20/116 , A23K20/137 , C07D277/18 , C07D491/04
摘要： Imines of 2-formylquinoxaline-3-carboxylic acid-1,4-dioxides and their salts are obtained through treatment of the lactone or a salt of 2-dihydroxymethylquinoxaline-N,N-dioxide-3-carboxylic acid with a reactant bearing a free primary amino group. The resultant compounds and their non-toxic salts are antibacterial agents and can be incorporated in pharmaceutical compositions and feedstuffs for this use. A typical embodiment is 2(carbomethoxyhydrazonomethyl)-quinoxaline-3-carboxylic acid-1,4dioxide.

39. 发明授权

US3803145A Quinoxaline-di-n-oxides 失效
标题翻译：喹诺酮二氧化氮
公开(公告)号：US3803145A
公开(公告)日：1974-04-09
申请号：US907270
申请日：1970-02-05
申请人： PFIZER
发明人： ELIE ABUSHANAB
IPC分类号： C07D241/52 , C07D51/78
CPC分类号： C07D241/52
摘要： 2-SUBSTITUTED-3-SULFINYL- AND SULFONYL-QUINOXALINE-DI-NOXIDES, PREPARED FROM THE CORRESPONDING 3-THIOQUINOXALINE-DI-N-OXIDES, AND THEIR NOVEL CONVERSION TO 2-SUBSTITUTED-3-HALOQUINOXAKINE-DI-N-OXIDES USING AQUEOUS SOLUTIONS OF THE APPROPRIATE HYDROGEN HALIDE AT TEMPERATURES OF 25-110*C.

40. 发明授权

US3793323A Amino-substituted benzo(g)pteridine-di-n-oxides 失效
标题翻译：氨基取代的苄基（G）哌啶二氧化氮
公开(公告)号：US3793323A
公开(公告)日：1974-02-19
申请号：US3793323D
申请日：1971-07-07
申请人： BAYER AG
发明人： METZGER K , SENG F , LEY K
IPC分类号： C07D241/52 , C07D475/06 , C07D57/28
CPC分类号： C07D241/52 , C07D475/06
摘要： 4-AMINO - PYRIMIDO - (4,5,B) - QUINOXALINE - 5,10DIOXIDES OF THE FORMULA:

4-(R-NH-),5,10-DI(O=)BENZO(G)PTERIDINE

WHEREIN R IS HYDROGEN, A STRAIGHT OR BRANCHED CHAIN SATURATED OR PARTIALLY UNSATURATED SUBSTITUTED OR UNSUBSTITUTED ALIPHATIC MOIETY OR A SUBSTITUTED OR UNSUBSTITUTED CYCLOALIPHATIC MOIETY, ARE PRODUCED BY REACTING QUINOXALINE-DI-N-OXISE OF THE FORMULA:

1,4-DI(O=),2-((CH3-)2-N-CH=N-),3-(NC-)QUINOXALINE

WITH AN AMINE OF THE GENERAL FORMULA R-NH2, WHEREIN R IS AS DEFINED, ABOVE IN A DILUENT, AT A TEMPERATURE IN THE RANGE OF 20* TO 100* C. THESE COMPOUNDS ARE USEFUL FRO THEIR ANTIOMICROBIAL ACTIVITY. THEY EXHIBIT ACTIVITY AGAINST BOTH GRAM POSITIVE AND GRAM NEGATIVE BACTERIA.

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