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31. 发明申请

US20110247657A1 Rinse Aid, Comprising Fatty Acid Alkanolamide Polyalkylene Glycol Ethers 审中-公开
标题翻译：冲洗助剂，包括脂肪酸烷醇酰胺聚亚烷基二醇醚
公开(公告)号：US20110247657A1
公开(公告)日：2011-10-13
申请号：US13140265
申请日：2009-12-11
申请人： Frederic Bauer , Sabine Both , Teresa Alexandre , Melanie Nagel , Snsgar Behler , Frank Clasen
发明人： Frederic Bauer , Sabine Both , Teresa Alexandre , Melanie Nagel , Snsgar Behler , Frank Clasen
IPC分类号： A47L15/42 , C07C233/05 , C07C233/18 , C11D3/60
CPC分类号： C11D1/526 , C11D1/662 , C11D1/72 , C11D1/835 , C11D3/2086 , C11D3/3418
摘要： Provided for are rinse aids that exhibit improved drying properties during automatic dish washing and thus allow cleaning methods at lower temperatures than customer reference agents. The rinse aids comprise a) at least one surfactant according to the general formula (I), where R1 is a saturated or unsaturated, branched or linear alkyl or alkenyl radical having 6 to 22 carbon atoms, R2 is hydrogen or an alkyl group having 1 to 6 carbon atoms or a group R3, and R3 is a group A-(O—CH2CHR4—)m—OR5 and R4 and R5 independently from each other are a hydrogen atom or an alkyl group having 1 to 4 carbon atoms and A is a (CH2)n— group or a hydroxyl alkyl group having 2 to 6 carbon atoms and n is an integer from 1 to 6 and m is an integer or a fractional number from 1 to 10 and furthermore b) at least one hydrotrope, c) at least one organic hydroxycarboxylic acid and d) water.
摘要翻译：提供用于在自动洗碗过程中表现出改进的干燥性能的漂洗助剂，因此允许在低于客户参考试剂的温度下进行清洁方法。漂洗助剂包括a）至少一种根据通式（I）的表面活性剂，其中R 1是具有6-22个碳原子的饱和或不饱和的，支链或直链的烷基或链烯基，R2是氢或具有1 至6个碳原子或基团R 3，且R 3为A - （O-CH 2 CHR 4 - ）m-OR 5基团，R 4和R 5彼此独立地为氢原子或具有1至4个碳原子的烷基，A为（CH2）n-基或碳原子数2〜6的羟基烷基，n为1〜6的整数，m为1〜10的整数或分数，b）至少1个水溶助长剂c ）至少一种有机羟基羧酸和d）水。

32. 发明授权

US08017804B2 Lipids, lipid complexes and use thereof 有权
标题翻译：脂质，脂质复合物及其用途
公开(公告)号：US08017804B2
公开(公告)日：2011-09-13
申请号：US11579700
申请日：2005-05-06
申请人： Oliver Keil , Jörg Kaufmann
发明人： Oliver Keil , Jörg Kaufmann
IPC分类号： C07C233/05
CPC分类号： C07C209/50 , A61K9/1271 , A61K9/1272 , A61K31/713 , A61K47/183 , A61K47/186 , A61K47/24 , A61K47/543 , A61K47/544 , A61K47/6911 , C07C231/02 , C07C279/14 , C12N15/111 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12N2310/321 , C12N2320/32 , C12N2310/3521
摘要： The present invention is related to a compound according to formula (I), wherein R1 and R2 are each and independently selected from the group comprising alkyl; n is any integer between 1 and 4; R3 is an acyl selected from the group comprising lysyl, ornithyl, 2,4-diaminobutyryl, histidyl and an acyl moiety according to formula (II), wherein m is any integer from 1 to 3 and YÉ is a pharmaceutically acceptable anion.
摘要翻译：本发明涉及式（I）化合物，其中R 1和R 2各自独立地选自烷基; n是1到4之间的整数; R3是选自根据式（II）的赖氨酰，鸟氨酰基，2,4-二氨基丁酰基，组氨酰和酰基部分的酰基，其中m是1至3的任何整数，YÉ是药学上可接受的阴离子。

33. 发明申请

US20110200549A1 Organic Compounds Suitable For Modulating Fragrance Compositions 审中-公开
标题翻译：适用于调制香料组合物的有机化合物
公开(公告)号：US20110200549A1
公开(公告)日：2011-08-18
申请号：US13120941
申请日：2009-09-29
申请人： Thierry Granier , Boris Schilling
发明人： Thierry Granier , Boris Schilling
IPC分类号： A61L9/01 , C07C233/05 , C07C233/01 , C07C271/10 , C07D213/56 , C07D233/64 , C07C271/18 , A61K8/33 , A61Q13/00 , A24B15/10
CPC分类号： C07D213/40 , A61L9/01 , C07D233/61
摘要： Disclosed are compounds having the ability to modulate, namely to improve, enhance and/or modify fragrance compositions due to their ability to inhibit cytochrome P450 enzymes, e.g. CYP2A, e.g. 2A13 and 2A6, and CYP2B6.
摘要翻译：公开了具有调节，即改善，增强和/或改善香料组合物的能力的化合物，因为它们抑制细胞色素P450酶的能力，例如， CYP2A，例如 2A13和2A6，以及CYP2B6。

34. 发明授权

US07977510B2 Fluorine-containing polyether compound and process for producing the same 有权
标题翻译：含氟聚醚化合物及其制造方法
公开(公告)号：US07977510B2
公开(公告)日：2011-07-12
申请号：US12988665
申请日：2009-04-21
申请人： Satoru Saito
发明人： Satoru Saito
IPC分类号： C07C233/05 , C07C231/02
CPC分类号： C08G65/007 , C08G65/33313 , C08G65/33317
摘要： A fluorine-containing polyether compound having the following general formula: (where R1 is a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or a phenyl group; X is a bromine atom or an iodine atom; l and m each are independently an integer of 10 or more; and l+m is 30-200) can be produced by reaction of a fluorine-containing dicarboxylic acid fluoride compound having the following general formula: (where l and m each are independently an integer of 10 or more, and l+m is 30-200) with an aromatic amine compound having the following general formula: [where R1 is a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or a phenyl group, R2 is a hydrogen atom or a group represented by the general formula —SiR3R4R5 (where R3, R4 and R5 each are independently an alkyl group having 1 to 10 carbon atoms or a phenyl group); and X is a bromine atom or an iodine atom] preferably in the presence of pyridine or a tertiary amine compound such as triethylamine, etc.
摘要翻译：具有以下通式的含氟聚醚化合物：其中R1是氢原子，具有1至3个碳原子的烷基或苯基; X是溴原子或碘原子; l和m各自是独立地为10以上的整数，l + m为30〜200）可以通过具有以下通式的含氟二羧酸氟化物反应来制备：（其中l和m各自独立地为10的整数或更多和l + m为30-200）与芳族胺化合物具有以下通式：其中R 1是氢原子，具有1至3个碳原子的烷基或苯基，R 2是氢原子或由通式-SiR 3 R 4 R 5（其中R 3，R 4和R 5各自独立地为具有1〜10个碳原子的烷基或苯基）表示的基团; 和X是溴原子或碘原子]，优选在吡啶或叔胺化合物如三乙胺等的存在下。

35. 发明授权

US07960586B2 Purification of armodafinil 有权
标题翻译：甲状腺素的净化
公开(公告)号：US07960586B2
公开(公告)日：2011-06-14
申请号：US12229048
申请日：2008-08-18
申请人： Boaz Gome
发明人： Boaz Gome
IPC分类号： C07C233/05
CPC分类号： C07B63/00 , C07B57/00 , C07C315/06 , C07C317/44
摘要： The invention encompasses processes for obtaining pure armodafinil substantially free of disulfide impurities that is suitable for use on an industrial scale. In particular, a processes for purifying armodafinil from bis(diphenylmethyl)disulfide comprising: dissolving crude armodafinil in ethanol to form a solution; adding a solvent selected from the group consisting of linear or branched C5-C8 alkyl, linear or branched C5-C8 ether, and mixtures thereof to the solution to form a reaction mixture; cooling the reaction mixture; and isolating pure armodafinil from the reaction mixture.
摘要翻译：本发明包括用于获得基本上不含适于在工业规模上使用的二硫化物杂质的纯的甲状腺素的方法。特别是从二（二苯基甲基）二硫化物中净化犰狳的方法，其特征在于：将粗制的甲状腺素溶于乙醇中形成溶液; 向溶液中加入选自直链或支链C5-C8烷基，直链或支链C5-C8醚及其混合物的溶剂，形成反应混合物; 冷却反应混合物; 并从反应混合物中分离纯的armodafinil。

36. 发明授权

US07851642B2 δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compound 失效
标题翻译： δ-氨基-γ-羟基-ω-芳基 - 链烷酸酰胺化合物
公开(公告)号：US07851642B2
公开(公告)日：2010-12-14
申请号：US12483582
申请日：2009-06-12
申请人： Daniel Kaspar Baeschlin , Juergen Klaus Maibaum , Holger Sellner
发明人： Daniel Kaspar Baeschlin , Juergen Klaus Maibaum , Holger Sellner
IPC分类号： C07C233/05 , A61K31/65
CPC分类号： C07C237/20 , C07C237/24 , C07C255/60 , C07C271/22 , C07C271/24 , C07C323/41 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/42 , C07D207/09 , C07D295/027 , C07D307/79 , C07D313/08 , C07D319/18 , C07D333/08
摘要： Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and methods of administering them for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.
摘要翻译：公开了具有肾素抑制性质的式（I）的δ-氨基-γ-羟基-ω-芳基 - 链烷酰胺化合物及其盐。还公开了包含这些化合物的药物组合物及其用于治疗高血压，动脉粥样硬化，不稳定冠状动脉综合征，充血性心力衰竭，心脏肥大，心脏纤维化，心肌梗死后心肌梗塞，不稳定冠状动脉综合征，舒张功能障碍，慢性肾脏疾病，肝脏纤维化，糖尿病引起的并发症，如肾病，血管病变和神经病变，冠状动脉血管疾病，血管成形术后再狭窄，眼内压升高，青光眼，异常血管生长，醛固酮增多症，认知障碍，阿尔茨海默病，痴呆，焦虑状态和认知疾病

37. 发明申请

US20100227929A1 TRANSDERMAL COMPOSITIONS 有权
公开(公告)号：US20100227929A1
公开(公告)日：2010-09-09
申请号：US12630630
申请日：2009-12-03
申请人： Griscom Bettle, III
发明人： Griscom Bettle, III
IPC分类号： A61K31/16 , C07C233/05 , A61P31/02 , A61P17/02
CPC分类号： A61K47/186 , A01N25/00 , A61K8/42 , A61K9/0014 , A61K31/164 , A61K31/205 , A61K36/45 , A61K36/58 , A61K36/87 , A61K45/06 , A61K47/12 , A61K47/18 , A61L26/0066 , A61L2300/208 , A61L2300/22 , A61L2300/404 , A61L2300/802 , A61Q5/12 , A61Q17/00 , A61Q17/005 , A61Q19/00 , C07C233/05 , A61K2300/00
摘要： The present invention is directed to transdermal compositions and the uses thereof. These compositions include at least one of the following components: a C1-C6 dialkyl, C12-C30 dialkyl quaternary ammonium salt, a C12-C30 fatty acid, a nitrogenous organic base, C12-30 fatty alcohol, monoglyceride or the reaction products thereof.

38. 发明授权

US07786329B2 Process for preparing ester oxazolidine compounds and their conversion to Florfenicol 有权
标题翻译：制备酯恶唑烷化合物及其转化为氟苯尼考的方法
公开(公告)号：US07786329B2
公开(公告)日：2010-08-31
申请号：US11515135
申请日：2006-08-31
申请人： James C. Towson
发明人： James C. Towson
IPC分类号： C07C233/05
CPC分类号： C07C315/04 , C07D263/04 , C07D263/06 , C07C317/32
摘要： A process for preparing ester oxazolidine compounds is disclosed. These compounds are useful intermediates in processes for making Florfenicol.
摘要翻译：公开了制备酯恶唑烷化合物的方法。这些化合物在制备氟苯尼考的方法中是有用的中间体。

39. 发明授权

US07741521B2 Inhibition of bid-induced cell-death using small organic molecules 有权
标题翻译：使用小有机分子抑制招标诱导的细胞死亡
公开(公告)号：US07741521B2
公开(公告)日：2010-06-22
申请号：US11645239
申请日：2006-12-22
申请人： John C. Reed , Maurizio Pellecchia
发明人： John C. Reed , Maurizio Pellecchia
IPC分类号： C07C233/05 , C07C233/65 , A61K31/16
CPC分类号： C07C323/41 , G01N2500/04
摘要： Various phenylamine derivatives are described as well as the use of compounds to inhibit BID protein for controlling apoptotic cascade.
摘要翻译：描述了各种苯胺衍生物以及化合物用于抑制BID蛋白以控制凋亡级联的用途。

40. 发明授权

US07687665B2 2-methylprop anamides and their use as pharmaceuticals 失效
标题翻译： 2-甲基丙酰胺及其作为药物的用途
公开(公告)号：US07687665B2
公开(公告)日：2010-03-30
申请号：US11159865
申请日：2005-06-23
申请人： Wenqing Yao , Colin Zhang , Jincong Zhuo , Meizhong Xu , Konstantinos Agrios , Brian Metcalf
发明人： Wenqing Yao , Colin Zhang , Jincong Zhuo , Meizhong Xu , Konstantinos Agrios , Brian Metcalf
IPC分类号： C07C233/05 , A61K31/165
CPC分类号： C07C233/11 , C07C233/13 , C07C233/19 , C07C233/22 , C07C233/23 , C07C235/22 , C07C323/60 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/28 , C07C2602/42 , C07D209/14 , C07D209/16 , C07D307/22 , C07D319/20
摘要： The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
摘要翻译：本发明涉及11-和bgr的抑制剂。 1型羟基类固醇脱氢酶，盐皮质激素受体（MR）的拮抗剂及其药物组合物。本发明的化合物可用于治疗与11-bgr的表达或活性相关的各种疾病; 羟基类固醇脱氢酶1型和/或与醛固酮过量相关的疾病。

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