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31. 发明申请

US20020177987A1 Spatial profiling of proteins using hydrophobic moments 有权
标题翻译：使用疏水力矩的蛋白质的空间分析
公开(公告)号：US20020177987A1
公开(公告)日：2002-11-28
申请号：US09818461
申请日：2001-03-27
申请人： International Business Machines Corporation
发明人： Benjamin D. Silverman
IPC分类号： G01N033/53 , G06G007/48 , G06G007/58
CPC分类号： G06F19/16
摘要： Generally, the present invention provides a number of procedures to spatially profile proteins by using hydrophobic moments. In all procedures, a hydrophobicity distribution of a protein is shifted and normalized. In one procedure, a shape or profile of a curve of a second-order moment of hydrophobicity is determined. A second procedure involves determining one or more ratios, such as the ratio of a distance at which the second order moment of hydrophobicity vanishes to the distance at which a zero-order moment of hydrophobicity vanishes. The distance at which a peak occurs in a profile of the zero- or second-order moment of hydrophobicity can also be used for comparison. For many of these procedures, a surface or profiling contour can be chosen and used to accumulate hydrophobicities and to determine the moments. These procedures can be combined to provide a good mathematical determination of whether a protein belongs to a particular class of proteins.
摘要翻译：通常，本发明提供了通过使用疏水力矩空间分布蛋白质的多个程序。在所有程序中，蛋白质的疏水性分布被移动并归一化。在一个过程中，确定疏水性的二阶矩的曲线的形状或轮廓。第二个过程涉及确定一个或多个比率，例如二次疏水性时刻消失的距离与零阶矩的疏水性消失的距离之比。在疏水性的二次或二次矩的轮廓中发生峰的距离也可用于比较。对于许多这些程序，可以选择表面或轮廓轮廓并用于积累疏水性并确定力矩。这些程序可以组合以提供蛋白质是否属于特定类别的蛋白质的良好的数学确定。

32. 发明申请

US20020146441A1 Selection method for cosmetic auxiliaries 审中-公开
标题翻译：化妆品助剂的选择方法
公开(公告)号：US20020146441A1
公开(公告)日：2002-10-10
申请号：US10029725
申请日：2001-12-20
发明人： Steffen Sonnenberg , Anja Finke , Simone Peters , Andreas Klamt , John Lohrenz , Thorsten Burger , Svend Matthiesen
IPC分类号： G06G007/48 , G06G007/58 , G06F019/00 , G01N033/48 , G01N033/50 , A61K007/00
CPC分类号： A61K8/31 , A61Q17/04 , A61Q19/00
摘要： A mathematical determination model is used to select cosmetic auxiliaries for cosmetic products and for the manufacture.
摘要翻译：数学测定模型用于选择化妆品的化妆品助剂和制造。

33. 发明申请

US20020087297A1 Method, apparatus, and computer program for Monte Carlo ion implantation simulation, and semiconductor device manufacturing method based on the simulation 有权
标题翻译：蒙特卡罗离子注入仿真的方法，装置和计算机程序，以及基于模拟的半导体器件制造方法
公开(公告)号：US20020087297A1
公开(公告)日：2002-07-04
申请号：US09950278
申请日：2001-09-12
发明人： Takahisa Kanemura
IPC分类号： G06G007/58
CPC分类号： G06F17/5018 , G06F2217/06
摘要： A Monte Carlo ion implantation simulation method speedily calculates an implanted ion distribution in a semiconductor substrate. The method includes finding a unit cell in which an implanted trial particle is present, finding a basic cell in which the trial particle is present among basic cells that form the unit cell, finding a directional range in which the trial particle travels, obtaining collision candidate atoms with their locations from a database according to the found basic cell and directional range, setting a thermal vibration displacement for each of the collision candidate atoms that has not set thermal vibration displacement, calculating a collision parameter and free-flight distance for each of the collision candidate atoms, selecting, as a collision atom, one of the collision candidate atoms that has a collision parameter smaller than a predetermined maximum collision parameter and a smallest positive free-flight distance, and calculating a collision between the trial particle and the collision atom to find the after-collision location and momentum of the trial particle. This method reduces the number of collision candidate atoms obtained from the database.
摘要翻译：蒙特卡罗离子注入模拟方法快速计算半导体衬底中的注入离子分布。该方法包括找到其中存在植入的试验颗粒的单元电池，找到在形成单位电池的基本电池中存在试验颗粒的基本电池，找到试验颗粒行进的方向范围，获得碰撞候选原子与其数据库的位置根据所找到的基本单元和方向范围，为未设置热振动位移的每个碰撞候选原子设定热振动位移，计算每个的冲击参数和自由飞行距离碰撞候选原子，作为碰撞原子选择具有小于预定最大碰撞参数和最小正自由飞行距离的碰撞参数的碰撞候选原子之一，并计算试验颗粒与碰撞原子之间的碰撞找到碰撞后的位置和试验粒子的动量。该方法减少了从数据库获得的碰撞候选原子数。

34. 发明申请

US20020042701A1 System and method to simulate hemodynamics 失效
标题翻译：用于模拟血液动力学的系统和方法
公开(公告)号：US20020042701A1
公开(公告)日：2002-04-11
申请号：US09973433
申请日：2001-10-09
发明人： Michael B. Dancu , John M. Tarbell
IPC分类号： G06G007/50 , G06G007/58
CPC分类号： G09B23/28 , Y10S623/916 , Y10S623/917 , Y10S623/921
摘要： A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.
摘要翻译：用于血液动力学模拟的系统包括具有血管属性的容器，包含一定量的流体的储存器，连接容器和储存器的管道，以及用于使系统内的流体循环的至少一个泵。流体可以是组织培养基或血液类似物流体，并且血管可以包括附着在其内部的哺乳动物细胞。驱动系统包括由凸轮联接的两个往复运动的驱动轴，使得脉动流和脉动压力的解耦能够提供对壁剪切应力和周向应变的独立控制。轴驱动两个相位相差180度的泵，并连接在容器的上游和下游，并实现这种解耦。

35. 发明申请

US20040162712A1 Method for screening compounds using consensus selection 审中-公开
标题翻译：使用共识选择筛选化合物的方法
公开(公告)号：US20040162712A1
公开(公告)日：2004-08-19
申请号：US10754484
申请日：2004-01-09
申请人： ICAGEN, Inc.
发明人： Albert M. Van Rhee
IPC分类号： G06G007/48 , G06G007/58
CPC分类号： G16C20/60 , G16B35/00
摘要： A method for screening compounds for biological activity is disclosed. In one embodiment, a test library of compounds is selected. Then, a first analytical model is formed using a first recursive partitioning process using a digital computer. The first recursive partitioning process is performed on at least some of the compounds in the test library of compounds. Subsequent analytical models are formed using subsequent recursive partitioning processes using the digital computer. The subsequent recursive partitioning processes are performed on at least some of the compounds in the test library of compounds. Then, a consensus compound set is determined using the first analytical model and one or more of the subsequent analytical models.
摘要翻译：公开了用于筛选生物活性化合物的方法。在一个实施方案中，选择化合物的测试文库。然后，使用使用数字计算机的第一递归分割处理形成第一分析模型。对化合物的测试文库中的至少一些化合物进行第一递归分配过程。使用数字计算机的后续递归分割过程形成后续分析模型。随后的递归分割过程在化合物的测试文库中的至少一些化合物上进行。然后，使用第一分析模型和一个或多个后续分析模型确定共有化合物集合。

36. 发明申请

US20040091500A1 Recombinant allergens 审中-公开
标题翻译：重组过敏原
公开(公告)号：US20040091500A1
公开(公告)日：2004-05-13
申请号：US10719553
申请日：2003-11-20
申请人： ALK-Abello A/S
发明人： Hans Henrik Ipsen , Michael Dho Spangfort , Jorgen Nedergaard Larsen
IPC分类号： A61K039/00 , G06G007/48 , G06G007/58
CPC分类号： C07K14/415 , A61K38/00 , A61K39/00
摘要： Novel recombinant allergens are disclosed. The allergens are non-naturally occurring mutants derived from naturally-occurring allergens. The overall null-carbon backbone tertiary structure of the allergens is essentially preserved. Also disclosed are methods for preparing the recombinant allergens as well as the use of the recombinant allergens for the treatment of allergic reactions.
摘要翻译：公开了新型重组变应原。过敏原是衍生自天然存在的变应原的非天然存在的突变体。过敏原的总体α-碳骨架三级结构基本保持不变。还公开了制备重组变应原的方法以及重组变应原用于治疗过敏反应的方法。

37. 发明申请

US20040088116A1 Methods and systems for creating and using comprehensive and data-driven simulations of biological systems for pharmacological and industrial applications 审中-公开
标题翻译：用于创建和使用用于药理学和工业应用的生物系统的综合和数据驱动模拟的方法和系统
公开(公告)号：US20040088116A1
公开(公告)日：2004-05-06
申请号：US10439288
申请日：2003-05-14
申请人： Gene Network Sciences, Inc.
发明人： Iya Khalil , Colin Hill
IPC分类号： G06G007/48 , G06G007/58 , G06F019/00 , G01N033/48 , G01N033/50
CPC分类号： G16B5/00 , G16B20/00 , G16B40/00 , G16B50/00 , Y02A90/24 , Y02A90/26
摘要： Presented herein are techniques and methodologies for creating large-scale data-driven models of biological systems and exemplary applications thereof including drug discovery and industrial applications. Exemplary embodiments include creating a core skeletal simulation (scaleable to any size) from known biological information, collecting quantitative and qualitative experimental data to constrain the simulation, creating a probable reactions database, integrating the core skeletal simulation, the database of probable reactions, and static and dynamical time course measurements to generate an ensemble of biological network structures and their corresponding molecular concentration profiles and phenotypic outcomes that approximate output of the original biological network used for prediction, and finally experimentally validating and iteratively refining the model. The invention further describes methods of taking conventional small-scale models and extending them to comprehensive large-scale models of biological systems. The methods presented further describe ways to create models of arbitrary size and complexity and various ways to incorporate data to account for missing biological information.
摘要翻译：本文提出了用于创建生物系统的大规模数据驱动模型及其示例性应用的技术和方法，包括药物发现和工业应用。示例性实施例包括从已知生物信息创建核心骨架模拟（可扩展到任何大小），收集定量和定性实验数据以约束模拟，创建可能的反应数据库，整合核心骨架模拟，可能反应的数据库和静态和动态时程测量，以生成生物网络结构的整体及其相应的分子浓度分布和近似预测原始生物网络输出的表型结果，最后实验验证并迭代地提炼模型。本发明还描述了采用常规小规模模型并将其扩展到综合大规模生物系统模型的方法。所提出的方法进一步描述了创建任意大小和复杂性的模型的方法，以及将数据合并以考虑缺失的生物信息的各种方法。

38. 发明申请

US20040083085A1 Integrated virtual slide and live microscope system 审中-公开
标题翻译：集成虚拟幻灯片和实时显微镜系统
公开(公告)号：US20040083085A1
公开(公告)日：2004-04-29
申请号：US10620016
申请日：2003-07-14
发明人： Jack A. Zeineh , Usman Rashid , Rui-Tao Dong
IPC分类号： G06G007/48 , G06G007/58 , H04N007/16
CPC分类号： G02B21/367 , G06T9/007
摘要： A method for creating a virtual slide is provided. A virtual slide is a digital representation of an area of interest of a microscopic slide. One method is to use a motorized microscope that can move a specimen with respect to a microscopic objective. With such a system, one can capture one or more images through a microscopic objective, such that a region of interest is imaged. Each image is then joined together to form a composite or nullvirtual image.null In one embodiment, after a virtual slide is created, a user may fully utilize the full capabilities of the remote microscope. Among these capabilities is a set of nulloptical objectivesnull and :virtual objectives.null Optical objectives are images created by digitizing an image through a microscopic objective in real time. Virtual objectives are digitally created magnifications created by utilizing the existing virtual slide data to digitally create a field of view.
摘要翻译：提供了一种创建虚拟幻灯片的方法。虚拟幻灯片是微观幻灯片的感兴趣区域的数字表示。一种方法是使用可以相对于微观物镜移动样本的电动显微镜。利用这样的系统，可以通过微观物镜捕获一个或多个图像，使得感兴趣的区域成像。然后将每个图像连接在一起以形成复合或“虚拟图像”。在一个实施例中，在创建虚拟幻灯片之后，用户可以充分利用远程显微镜的全部功能。这些功能包括一组“光学目标”和“虚拟目标”。光学目标是通过实时微观目标对图像进行数字化创建的图像。虚拟目标是通过利用现有的虚拟幻灯片数据数字化创建的放大倍数创建一个视野。

39. 发明申请

US20040049014A1 Humanized immunoglobulins 审中-公开
标题翻译：人源化免疫球蛋白
公开(公告)号：US20040049014A1
公开(公告)日：2004-03-11
申请号：US10389417
申请日：2003-03-13
申请人： Protein Design Labs, Inc.
发明人： Cary L. Queen , Man Sung Co , William P. Schneider , Nicholas F. Landolfi , Kathleen L. Coelingh , Harold E. Selick
IPC分类号： C07K016/44 , G06G007/48 , G06G007/58
CPC分类号： C07K16/087 , A61K38/00 , A61K2039/505 , C07K16/00 , C07K16/088 , C07K16/249 , C07K16/2803 , C07K16/2866 , C07K16/2896 , C07K16/465 , C07K2317/24 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2319/00 , C07K2319/02 , C07K2319/30
摘要： Novel methods for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobulin and a framework region from an accepting human immunoglobulin are provided. Each humanized immunoglobulin chain will usually comprise, in addition to the CDR's, amino acids from the donor immunoglobulin framework that are, e.g., capable of interacting with the CDR's to effect binding affinity, such as one or more amino acids which are immediately adjacent to a CDR in the donor immunoglobulin or those within about about 3 null as predicted by molecular modeling. The heavy and light chains may each be designed by using any one or all of various position criteria. When combined into an intact antibody, the humanized immunoglobulins of the present invention will be substantially non-immunogenic in humans and retain substantially the same affinity as the donor immunoglobulin to the antigen, such as a protein or other compound containing an epitope.
摘要翻译：提供了具有一个或多个互补决定区（CDR）和来自供体免疫球蛋白的可能的附加氨基酸和来自接受人免疫球蛋白的框架区的人源化免疫球蛋白的生产和组合物的新方法。除了CDR之外，每个人源化免疫球蛋白链通常还包含来自供体免疫球蛋白框架的氨基酸，例如能够与CDR相互作用以产生结合亲和力，例如一个或多个氨基酸，其紧邻于供体免疫球蛋白中的CDR或大约约3A内的CDR通过分子模拟预测。重链和轻链各自可以通过使用各种位置标准中的任何一个或全部来设计。当组合成完整的抗体时，本发明的人源化免疫球蛋白在人体中将基本上是非免疫原性的，并且保留与抗原例如含有表位的蛋白质或其它化合物基本上与供体免疫球蛋白相同的亲和力。

40. 发明申请

US20040033527A1 Methods of using a three-dimensional model of a Fc epsilon receptor alpha chain 审中-公开
标题翻译：使用Fcε受体α链的三维模型的方法
公开(公告)号：US20040033527A1
公开(公告)日：2004-02-19
申请号：US10293992
申请日：2002-11-13
发明人： Theodore S. Jardetzky , Scott Clayton Garman , Jean-Pierre Kinet
IPC分类号： G01N033/53 , G06G007/48 , G06G007/58
CPC分类号： C07K14/70535 , A61K38/00
摘要： The present invention includes three-dimensional models of antibody receptor proteins, such as FcnullRInull proteins, and methods to produce such models. The present invention also includes muteins having increased stability and/or antibody binding activity, as well as methods to produce such muteins, preferably using information derived from three-dimensional models of the present invention. Also included are nucleic acid sequences encoding muteins of the present invention and use of those sequences to produce such muteins. Also included is the use of the model to identify compounds that inhibit the binding of an antibody receptor protein to an antibody. The present invention also includes uses of such muteins and inhibitory compounds, for example, in methods to diagnose and protect animals from allergy and other abnormal immune responses.
摘要翻译：本发明包括抗体受体蛋白质如FcepsilonRIα蛋白质的三维模型，以及产生这种模型的方法。本发明还包括具有增加的稳定性和/或抗体结合活性的突变蛋白，以及优选使用从本发明的三维模型得到的信息来产生这种突变蛋白的方法。还包括编码本发明的突变蛋白的核酸序列和这些序列的用途来产生这种突变蛋白。还包括使用该模型来鉴定抑制抗体受体蛋白与抗体结合的化合物。本发明还包括这样的突变蛋白和抑制性化合物的用途，例如在诊断和保护动物免于过敏和其他异常免疫应答的方法中。

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