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31. 发明申请

US20210130803A1 SUBTILASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 有权
公开(公告)号：US20210130803A1
公开(公告)日：2021-05-06
申请号：US17143313
申请日：2021-01-07
申请人： NOVOZYMES A/S
发明人： Frank Winther Rasmussen , Peter Kamp Hansen , Lars Lehman Hylling Christensen
IPC分类号： C12N9/54 , C11D3/386 , C12N9/52
摘要： The present invention relates to novel subtilase variants exhibiting increased stability and preferably on par or improved wash performance. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.

32. 发明申请

US20210130734A1 PROCESS OF EXTRACTING OIL FROM THIN STILLAGE 有权
公开(公告)号：US20210130734A1
公开(公告)日：2021-05-06
申请号：US17147623
申请日：2021-01-13
申请人： NOVOZYMES A/S
发明人： Nathaniel Kreel , Joseph Jump
IPC分类号： C11B13/00 , C12P7/64 , C12N9/28 , C12N9/52 , C12N9/58 , C12N9/50 , C11B3/00 , C12N9/34 , C12P7/10
摘要： The present invention relates to processes of recovering oil after liquefaction and/or from thin stillage and/or syrup/evaporated centrate from a fermentation product production process by adding a thermostable protease to the whole stillage, thin stillage and/or syrup.

33. 发明授权

US10961523B2 Multilayer nano-cell 有权
公开(公告)号：US10961523B2
公开(公告)日：2021-03-30
申请号：US16996457
申请日：2020-08-18
申请人： Boke Zhang
发明人： Boke Zhang
IPC分类号： C12N9/52 , A61K9/51 , A61K31/728 , A61K38/00
摘要： A multilayer nano-cell includes an innermost water phase core including biomolecules in an aqueous solution; a first layer, including an oil phase layer encapsulating the innermost water phase core, thereby forming a water-in-oil structure, the oil phase layer including caprylic/capric triglyceride and macrogol-35-glycerol-rizinoleat; a second layer, including a water phase layer encapsulating the first layer, the water phase layer including hyaluronic acid, Cu-GHK tripeptide, palmitoyl-KTTKS pentapeptide, and hexapeptide argireline; a third layer, including another oil phase layer encapsulating the second layer; a fourth layer, including another water phase layer encapsulating the third layer; a fifth layer, including another oil phase layer encapsulating the fourth layer; and a sixth layer, including an outmost cream layer encapsulating the fifth layer.

34. 发明申请

US20210079370A1 ANIMAL PRODUCT FREE SYSTEM AND PROCESS FOR PURIFYING A BOTULINUM TOXIN 有权
公开(公告)号：US20210079370A1
公开(公告)日：2021-03-18
申请号：US17064548
申请日：2020-10-06
申请人： Allergan, Inc.
发明人： Hui Xiang
IPC分类号： C12N9/52 , C07K14/33 , C12N1/20 , C12N9/64 , C12P21/02
摘要： Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.

35. 发明授权

US10920172B2 Process of recovering oil 有权
公开(公告)号：US10920172B2
公开(公告)日：2021-02-16
申请号：US16449703
申请日：2019-06-24
申请人： NOVOZYMES A/S
发明人： Nathaniel Kreel , Joseph Jump
IPC分类号： C11B13/00 , C11B3/00 , C12N9/52 , C12N9/58 , C12N9/50 , C12P7/64 , C12N9/28 , C12N9/34 , C12P7/10 , B01D3/00
摘要： The present invention relates to processes of recovering oil after liquefaction and/or from thin stillage and/or syrup/evaporated centrate from a fermentation product production process by adding a thermostable protease to the whole stillage, thin stillage and/or syrup.

36. 发明申请

US20210040468A1 COMPOSITIONS AND METHODS FOR PRODUCING CLOSTRIDIAL COLLAGENASES 有权
公开(公告)号：US20210040468A1
公开(公告)日：2021-02-11
申请号：US17004857
申请日：2020-08-27
申请人： BioSpecifics Technologies Corp.
发明人： Thomas L. WEGMAN , Bo YU
IPC分类号： C12N9/52 , A61K38/48 , C12N1/20
摘要： The present invention provides a method for producing a drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum. The method utilizes an improved medium for the cultivation of Clostridium histolyticum which includes a non-meat-derived (i.e., non-mammalian) peptone or vegetable peptone. The method includes one or more of: (1) reducing glucose content in the meat-free or vegetable-derived media; and (2) increasing the salt concentration in the meat-free or vegetable-derived media. Also provided is a drug product which includes collagenase I and collagenase II at an optimized fixed mass ratio, and which has a purity of greater than at least 95%.

37. 发明申请

US20210024912A1 Cell-Free Expression System Having Novel Inorganic Polyphosphate-Based Energy Regeneration 有权
公开(公告)号：US20210024912A1
公开(公告)日：2021-01-28
申请号：US17039575
申请日：2020-09-30
申请人： NTxBio, LLC
发明人： Alexander Koglin , Michael Humbert
IPC分类号： C12N9/52 , C12N9/12 , C12N9/04
摘要： The invention relates to an in vitro cell-free expression system incorporating a novel inorganic polyphosphate-based energy regeneration system. In certain embodiments, the invention includes a cell-free expression system where the cellular energy source, ATP, is regenerated from inorganic polyphosphate using a dual enzyme system. In this embodiment, this dual enzyme system may include thermostable Adenosyl Kinase, and/or Polyphosphate Kinase enzymes.

38. 发明授权

US10851363B1 Multilayer nano-cell containing biomolecules 有权
公开(公告)号：US10851363B1
公开(公告)日：2020-12-01
申请号：US16419508
申请日：2019-05-22
申请人： Boke Zhang
发明人： Boke Zhang
IPC分类号： C12N9/52 , A61K9/51 , A61K31/728 , B01D15/36 , B01D61/24 , A61K38/00
摘要： Method for preparing botulinum neurotoxin and nanoparticle thereof are provided. The method includes fermenting bacteria Clostridium botulinum in a fermentation media free of animal-derived ingredients and contacting the fermentation media with an anion exchange media slurry and obtaining a supernatant including the botulinum neurotoxin by centrifugation. The method further includes dialyzing the supernatant and collecting a dialyzed solution including the botulinum neurotoxin, contacting the dialyzed solution with an anion exchange chromatography column, contacting an elute collected from the anion exchange chromatography column with a cation exchange chromatography column, and collecting an elute. The nanoparticle includes multi-layer including an innermost water phase core including biomolecules encapsulated by an oil phase layer, thereby forming a water-in-oil structure, water phase layers; oil phase layers; and an outmost cream layer. The water phase layers and the oil phase layers alternatively encapsulate the water-in-oil structure. The biomolecules include botulinum neurotoxin and/or hyaluronic acid.

39. 发明授权

US10793846B2 Compositions and methods for treating celiac sprue disease 有权
公开(公告)号：US10793846B2
公开(公告)日：2020-10-06
申请号：US15575159
申请日：2016-06-08
申请人： UNIVERSITY OF WASHINGTON , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Ingrid Swanson Pultz , Clancey Wolf , Justin Bloomfield Siegel , Christine Elaine Tinberg , Lance Stewart , David Baker
IPC分类号： C12N9/52 , A61K38/00 , A61P1/14 , C12N9/50
摘要： Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO: 1, are provided, wherein (a) the polypeptide degrades a PFQPQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.

40. 发明授权

US10787684B2 Large gene excision and insertion 有权
公开(公告)号：US10787684B2
公开(公告)日：2020-09-29
申请号：US14319693
申请日：2014-06-30
申请人： President and Fellows of Harvard College
发明人： Susan M. Byrne , George M. Church
IPC分类号： C12Q1/68 , C12N9/14 , C12N9/22 , C12N9/52 , C12N15/00 , C07H21/02 , C07H21/04 , A61K38/43 , C12N15/90 , C12N15/10
摘要： Methods of simultaneously excising large nucleic acid sequences from a target nucleic acid and inserting large foreign nucleic sequences into the target nucleic acid sequence using DNA binding protein nucleases are described.

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