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31. 发明申请

US20040191893A1 Cell or drug encapsulation device having a wet seal 审中-公开
标题翻译：具有湿密封的细胞或药物包封装置
公开(公告)号：US20040191893A1
公开(公告)日：2004-09-30
申请号：US10462915
申请日：2003-06-16
发明人： Steven C. Newman , Brian H. Kram , Terry A. Hubbard
IPC分类号： C12M001/12 , C12M003/06
CPC分类号： A61K9/0024 , A61F2/022
摘要： A biologically implantable containment device having a wet seal, the device being adaptable for drug formulations or cell suspensions. A porous membrane, in a tubular configuration, is formed and can be configured as part of a closed cell-tight system for loading. During loading, the containment device membrane is wet, while the loading system remains cell-tight. The containment device is wet-sealed through a combination of heat and pressure, while the system remains cell-tight. Sealing the containment device substantially or completely eliminates metabolic functioning of any organisms in the vicinity of the closure. The wet-seal is formed by melting a thermoplastic material that is in contact with the membrane. The containment device is separated from the cell-tight loading system, which remains closed after separation.
摘要翻译：具有湿密封的生物可植入的容纳装置，该装置适用于药物制剂或细胞悬液。形成管状构造的多孔膜，并且可以构造成用于装载的密闭密闭系统的一部分。在装载过程中，容纳装置膜是湿的，而装载系统保持细胞密封。密封装置通过热和压力的组合进行湿式密封，同时系统保持细胞密封。封闭容器基本上或完全消除封闭物附近任何生物体的代谢功能。通过熔化与膜接触的热塑性材料形成湿密封。密封装置与牢固的装载系统分开，分离后保持关闭。

32. 发明申请

US20040132177A1 Thermoformed container for cell culture 审中-公开
标题翻译：用于细胞培养的热成型容器
公开(公告)号：US20040132177A1
公开(公告)日：2004-07-08
申请号：US10742658
申请日：2003-12-19
发明人： Antoine Heron
IPC分类号： C12M001/12
CPC分类号： B29C51/14 , B01L3/505 , B29K2025/00 , B29K2067/00 , B29K2069/00 , B29K2995/0065 , B29L2031/712 , C12M23/10 , C12M23/20 , C12M23/24 , C12M25/06
摘要： The invention relates to a container intended for use in cell culture. The container includes a first and a second sheet that are secured to one another in the vicinity of their periphery so as to form an interior volume intended to receive cells and at least one access route designed to allow the introduction and/or the recovery of cells. Each of the sheets includes at least one layer made of a polymer material that allows the cells to adhere. Moreover, at least one of the two sheets is thermoformed. The invention also relates to a system including at least two elements connected together as a closed circuit by a tube. One of the elements is a container of the invention. The invention also includes the use of such containers and systems for culturing adherent cells and/or cells that are suspended in the medium.
摘要翻译：本发明涉及一种旨在用于细胞培养的容器。容器包括在其周边附近彼此固定的第一和第二片，以便形成用于接纳细胞的内部容积和设计成允许细胞的引入和/或回收的至少一个进入途径。每个片材包括至少一层由聚合物材料制成的层，其允许细胞粘附。此外，两片中的至少一个被热成型。本发明还涉及一种包括由管连接在一起作为闭路的至少两个元件的系统。元件之一是本发明的容器。本发明还包括使用这种容器和系统来培养悬浮在培养基中的贴壁细胞和/或细胞。

33. 发明申请

US20040132176A1 Oligosaccharide synthesizer 失效
标题翻译：寡糖合成仪
公开(公告)号：US20040132176A1
公开(公告)日：2004-07-08
申请号：US10715385
申请日：2003-11-19
发明人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
IPC分类号： C12M001/12
CPC分类号： C12P19/30
摘要： After various sugar nucleotide solutions and glycosyltransferases (or primers) have been mixed, they are introduced into a reaction tank (column) with primers (or glycosyltransferases) immobilized thereon. Then solutions coming out of the reaction tank are led to an ultrafiltration column. The oligosaccharide synthesizer according to the present invention is equipped with a flow path for ensuring that glycosyltransferases or primers separated by the ultrafiltration column are returned into a container for storing each solution in a sample injector.
摘要翻译：在各种糖核苷酸溶液和糖基转移酶（或引物）已被混合之后，将它们引入固定在其上的引物（或糖基转移酶）的反应罐（柱）中。然后将从反应槽出来的溶液引入超滤柱。根据本发明的寡糖合成仪配备有用于确保由超滤塔分离的糖基转移酶或引物返回到用于将每种溶液存储在样品注射器中的容器中的流动路径。

34. 发明申请

US20040132175A1 Cell culture chamber and bioreactor for extracorporeal culture of animal cells 审中-公开
标题翻译：细胞培养室和动物细胞体外培养的生物反应器
公开(公告)号：US20040132175A1
公开(公告)日：2004-07-08
申请号：US10333377
申请日：2003-12-19
发明人： Jerome Vetillard , Francis Herodin , Richard Caterini
IPC分类号： C12M001/12
CPC分类号： C12M35/08 , C12M25/16 , C12M29/04
摘要： The invention concerns a cell culture chamber having at least two planar filtering membranes with different cut-off, delimited by an envelope with axis of symmetry formed by an outer lateral wall, two end walls and inlet ports and outlet ports for dynamic liquid media, and a bioreactor containing the culture chamber for extracorporeal culture of animal cells.
摘要翻译：本发明涉及具有至少两个具有不同截止面的平面过滤膜的细胞培养室，其由具有由外侧壁，两个端壁和用于动态液体介质的入口端口和出口形成的对称轴线的包络限定，以及含有用于动物细胞体外培养的培养室的生物反应器。

35. 发明申请

US20040121456A1 Rapid cell block embedding method and apparatus 有权
标题翻译：快速细胞嵌入方法和装置
公开(公告)号：US20040121456A1
公开(公告)日：2004-06-24
申请号：US10697993
申请日：2003-10-30
发明人： Andrew H. Fischer
IPC分类号： C12M001/12
CPC分类号： B01L3/502 , B01L2300/0681 , B01L2300/0877 , B01L2400/0487 , G01N1/36 , G01N2001/315
摘要： A method and apparatus for embedding cells that utilizes a flow-through embedding technique maximizes the efficiency of extractions and decreases time for embedding the cell fragments, minimizes cell loss, and automatically positions cell samples at the position in which a microtome blade will section them. The apparatus includes a cell flow pathway defined by an inflow tube for delivering cell fragments from a cell sample to a sample port. The sample port is in fluid communication with a tissue cassette having attached thereto a filter. The cell flow pathway is in communication with a reagent flow pathway for delivering the reagents through the sample port to the cassette. The apparatus is configured such that the application of pressure directs the cell fragments from the cell sample through the cell flow pathway, and effects delivery of the reagents through the reagent flow pathway. The apparatus produces an embedded cell block having concentrated cells near the plane of the block to be sectioned in a quick and efficient manner.
摘要翻译：用于嵌入细胞的方法和装置利用流通嵌入技术使提取的效率最大化，并且减少嵌入细胞片段的时间，使细胞损失最小化，并且将细胞样品自动定位在切片机刀片将切片的位置。该装置包括由流入管限定的细胞流动通道，用于将细胞片段从细胞样品递送到样品端口。样品端口与附着有过滤器的组织盒流体连通。细胞流动路径与用于将试剂通过样品端口输送到盒的试剂流动通路连通。该装置被配置为使得压力的施加将细胞样品的细胞碎片引导通过细胞流动途径，并且通过试剂流动途径实现试剂的递送。该装置产生一个具有集中的细胞的嵌入式细胞块，该细胞块以块状物的平面附近以快速和有效的方式分割。

36. 发明申请

US20040067546A1 Apparatus and method for purification and assay of neurites 审中-公开
标题翻译：用于神经突的纯化和测定的装置和方法
公开(公告)号：US20040067546A1
公开(公告)日：2004-04-08
申请号：US10389619
申请日：2003-03-14
申请人： Innovative Cell Systems, LLC
发明人： Jay Leng , Russell Curry
IPC分类号： C12M001/12 , C12N005/00
CPC分类号： B01L3/50255 , B01L2300/0829 , C12M25/04 , C12N5/0068 , C12N5/0619 , C12N2533/52
摘要： An apparatus and method for purification and assay of neurites is useful for separation and analyses of extension organelles and/or protrusion of cells for purification, production, observation, and quantification of neurites in the neurobiology field. The present invention provides a pore-sized controlled porous filter membrane which outspace side surface is coated with a cell adhesion layer to form an adhesion surface, and combines the neuronal cells with the porous filter membrane in an aqueous environment under conditions in which outgrown neurites from cell bodies of the neuronal cells are attracted to and grow on the adhesion surface, wherein the outgrown neurites of the neuronal cells pass through pores provided in the porous filter membrane to the adhesion surface while each of the pores has a size smaller than the cell bodies of the neuronal cells so as to prevent the cell bodies of the neuronal cells passing through the pores and remaining on an opposing side surface of the porous filter membrane.
摘要翻译：用于神经突的纯化和测定的装置和方法可用于分离和分析用于神经生物学领域中神经突的纯化，产生，观察和定量的细胞的延伸细胞器和/或突起。本发明提供一种孔隙尺寸的受控多孔过滤膜，其外侧侧表面涂覆有细胞粘附层以形成粘附表面，并且在水溶液环境中将神经元细胞与多孔过滤膜结合，其中外来的神经突从神经细胞的细胞体被吸引并粘附在粘附表面上，其中神经元细胞的外生神经突穿过多孔过滤膜中提供的孔到粘附表面，而每个孔的尺寸小于细胞体的神经细胞，以防止神经元细胞的细胞体通过孔并保留在多孔滤膜的相对的侧表面上。

37. 发明申请

US20040029265A1 Cell culture case 审中-公开
标题翻译：细胞培养情况
公开(公告)号：US20040029265A1
公开(公告)日：2004-02-12
申请号：US10398713
申请日：2003-08-19
发明人： Nobutoshi Doi , Syushi Sano , Tsuyoshi Tsukioka , Koichi Nobori
IPC分类号： C12M001/12
CPC分类号： C12M25/10 , C12M29/16
摘要： A cell culture vessel which has, sealed therein, hollow fibers having the function of a semipermeable membrane and a fibrous cell substrate being susceptible to attachment of cells, and has connecting parts communicating with the inner portion of the hollow fiber which opens at both ends of the hollow fiber and connecting parts communicating with the space between the hollow fiber and the vessel, wherein both ends of the hollow fibers are fixed to both end portions of the vessel by partitions so that the inner portion of the hollow fiber communicates with the exterior of the vessel, and wherein the cell substrate is housed in the space between the hollow fiber and the vessel; and a method for cell culture using the cell culture vessel. The cell culture vessel allows a high density culture of an animal cell, in particular, a cell prone to attach to a support.
摘要翻译：一种细胞培养容器，其中密封有具有半透膜功能的中空纤维和易于附着细胞的纤维细胞基底，并且具有连通部分与中空纤维的内部连通，该内部部分在两端开口中空纤维和连接部分与中空纤维和容器之间的空间连通，其中中空纤维的两端通过隔板固定在容器的两端部，使得中空纤维的内部与容器，并且其中所述电池基板容纳在所述中空纤维和所述容器之间的空间中; 以及使用细胞培养容器的细胞培养方法。细胞培养容器允许动物细胞的高密度培养，特别是易于附着于支持物的细胞。

38. 发明申请

US20030228685A1 Bioartificial liver system 有权
标题翻译：生物人工肝系统
公开(公告)号：US20030228685A1
公开(公告)日：2003-12-11
申请号：US10164817
申请日：2002-06-07
发明人： Scott L. Nyberg
IPC分类号： C12M001/12
CPC分类号： C12N5/067 , A61M1/3472 , A61M1/3489 , B01D63/02 , B01D2313/50
摘要： A bioartificial liver system is described that incorporates a cell reservoir and hepatocyte spheroids to both increase the number of and longevity of cells in the system. Additional methods are also described for forming spheroid aggregates from isolated hepatocytes.
摘要翻译：描述了一种生物人造肝系统，其包含细胞储存器和肝细胞球体，以增加系统中细胞的数量和寿命。还描述了用于从分离的肝细胞形成球形聚集体的另外的方法。

39. 发明申请

US20030170610A1 System and method for optimizing tissue barrier transfer of compounds 失效
公开(公告)号：US20030170610A1
公开(公告)日：2003-09-11
申请号：US10371372
申请日：2003-02-20
发明人： Michael J. Cima , Hongming Chen , J. Richard Gyory
IPC分类号： C12M001/34 , C12M001/00 , C12M001/12
CPC分类号： G01N33/5088 , G01N13/00
摘要： The present invention relates to high-throughput systems and methods to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrier transfer, such as transdermal transfer, of components in each combination. The methods of the present invention allow determination of the effects of inactive components, such as solvents, excipients, enhancers, adhesives and additives, on tissue barrier transfer of active components, such as pharmaceuticals. The invention thus encompasses the high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for improved tissue transport, such as transdermal transport.

40. 发明申请

US20030022360A1 Biofilter equipped with a stirrer and injector of solid feed and method for removing odor and volatile organic compounds from waste gases suing the same 失效
标题翻译：配有搅拌器和固体进料器的生物过滤器，以及从废气中除去气味和挥发性有机化合物的方法
公开(公告)号：US20030022360A1
公开(公告)日：2003-01-30
申请号：US10182682
申请日：2002-07-31
发明人： Hee Wook Ryu , Kyung Suk Cho , Tae-Ho Lee
IPC分类号： A61L009/01 , C12M001/12
CPC分类号： B01D53/84 , Y02A50/2358
摘要： The present invention relates to an apparatus and a method removing contaminated gas by a biofilter resolving malodorous substance and volatile organic compounds, included in the waste gas generated from industrial and environmental facilities, into innoxious substances such as water, microorganism and carbon dioxide by means of microorganism The agitator of microorganism carrier of the present invention prevents the clog induced from the growth of microorganism, the increase of pressure loss thereby and the decrease of removing capacity of malodorous substance and volatile organic compounds by desorbing the biofilm.
摘要翻译：本发明涉及通过生物过滤器去除被污染气体的装置和方法，其将由工业和环境设施产生的废气中包含的恶臭物质和挥发性有机化合物分解成无害物质如水，微生物和二氧化碳，借助于微生物本发明的微生物载体的搅拌器通过解吸生物膜来防止由微生物生长引起的堵塞，由此引起的压力损失的增加和恶臭物质和挥发性有机化合物的去除能力的降低。

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