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31. 发明申请

US20070203169A1 Isomers and 42-epimers of rapamycin ester analogs, methods of making and using the same 审中-公开
标题翻译：雷帕霉素酯类似物的异构体和42-差向异构体，制备和使用它们的方法
公开(公告)号：US20070203169A1
公开(公告)日：2007-08-30
申请号：US11364313
申请日：2006-02-28
申请人： Jonathon Zhao
发明人： Jonathon Zhao
IPC分类号： A61K31/4745 , C07D491/14
CPC分类号： C07D498/18
摘要： Isomers and 42-epimers of rapamycin ester analogs and pharmaceutically acceptable salts or prodrugs thereof, are immunomodulatory agents and are useful in the treatment of restenosis and immune and autoimmune diseases. Also disclosed are cancer-, fungal growth-, restenosis-, post-transplant tissue rejection- and immune- and autoimmune disease-inhibiting compositions and a method of inhibiting cancer, fungal growth, restenosis, post-transplant tissue rejection, and immune and autoimmune disease in a mammal. One particular preferred application of such isomers and 42-epimers of rapamycin ester analogs is in medicated devices and local vascular delivery wherein the stability and lipid solubility and subsequently diffusion through tissue and cell membranes are essential to the success of rapamycin containing combination devices.
摘要翻译：雷帕霉素酯类似物和其药学上可接受的盐或前药的异构体和42-差向异构体是免疫调节剂，可用于治疗再狭窄和免疫和自身免疫性疾病。还公开了癌症，真菌生长，再狭窄，移植后组织排斥和免疫和自身免疫疾病抑制组合物以及抑制癌症，真菌生长，再狭窄，移植后组织排斥和免疫和自身免疫的方法哺乳动物的疾病雷帕霉素酯类似物的这种异构体和42-差向异构体的一个特别优选的应用是在药物装置和局部血管输送中，其中稳定性和脂质溶解度以及随后通过组织和细胞膜的扩散对于含雷帕霉素的组合装置的成功是必需的。

32. 发明申请

US20070197518A1 Antibacterial agents 失效
标题翻译：抗菌剂
公开(公告)号：US20070197518A1
公开(公告)日：2007-08-23
申请号：US11641215
申请日：2006-12-19
申请人： Timothy Johnson , Dennis McNamara , Debra Sherry , Peter Toogood
发明人： Timothy Johnson , Dennis McNamara , Debra Sherry , Peter Toogood
IPC分类号： A61K31/5383 , C07D491/14
CPC分类号： C07D498/22
摘要： Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical composition.
摘要翻译：本文描述的是抗菌化合物，制备化合物的方法，含有这些化合物的药物组合物和利用该化合物和药物组合物治疗细菌感染的方法。

33. 发明申请

US20070173642A1 Process for the purification of macrolides 有权
标题翻译：大环内酯类的纯化方法
公开(公告)号：US20070173642A1
公开(公告)日：2007-07-26
申请号：US10596227
申请日：2003-12-05
申请人： Nitin Patil , Rakesh Mendhe , Anand Khedkar , Ramakrishnan Melarkode , Ramavana Gururaja
发明人： Nitin Patil , Rakesh Mendhe , Anand Khedkar , Ramakrishnan Melarkode , Ramavana Gururaja
IPC分类号： C07H17/08 , C07D491/14
CPC分类号： C07D498/18
摘要： Process for the recovery of a macrolide in substantially pure form comprising: a) treatment of an impure or crude macrolide with water immiscible solvent, b) optional concentration of the mixture, c) treatment with ammonia gas to phase out impurities, d) separation of impurities, d) optional concentration of the phase containing the macrolide, f) loading on silica gel chromatography, optionally reversed phase or pretreated with silver, and elution of the macrolide, g) affording the macrolide in substantially pure form, h) optional repetition of step f) and g) to afford the macrolide in substantially pure form. The macrolide is preferably tacrolimus, immunomycin or sirolimus.
摘要翻译：用于以基本上纯的形式回收大环内酯的方法，其包括：a）用与水不混溶的溶剂处理不纯或粗大环内酯，b）任选浓缩混合物，c）用氨气处理以逐步除去杂质，d）杂质，d）含有大环内酯的相的任选浓度，f）在硅胶色谱法上任选反相或用银预处理，并用大环内酯洗脱，g）提供基本上纯的形式的大环内酯; h）任选的重复步骤f）和g）以大致纯的形式提供大环内酯。大环内酯优选为他克莫司，免疫霉素或西罗莫司。

34. 发明申请

US20070142423A1 Rapamycin analogues and the uses thereof in the treatment of neurological, proliferative, and inflammatory disorders 失效
标题翻译：雷帕霉素类似物及其在治疗神经，增殖和炎性疾病中的用途
公开(公告)号：US20070142423A1
公开(公告)日：2007-06-21
申请号：US11698504
申请日：2007-01-26
申请人： Edmund Graziani , Kevin Pong , Jerauld Skotnicki
发明人： Edmund Graziani , Kevin Pong , Jerauld Skotnicki
IPC分类号： A61K31/4745 , C07D267/22 , C07D491/14
CPC分类号： C07D498/18 , C07D491/14 , C07D498/22
摘要： The present invention provides compounds of the following structure, wherein R1, R2, R4, R4′, R6, R7, and R15 are defined above: These compounds are useful in treating neurological disorders or complications due to stroke or head injury; benign or malignant neoplastic disease, carcinomas and adenocarcinomas; proliferative disorders; and inflammatory disorders. The compounds are therefore useful as neuroprotective and neuroregenerative, anti-proliferative, and anti-inflammatory agents.
摘要翻译：本发明提供下列结构的化合物，其中R 1，R 2，R 4，R 4'，或 >，R 6，R 7和R 15定义如上：这些化合物可用于治疗由于中风或神经系统疾病引起的神经障碍或并发症头部受伤; 良性或恶性肿瘤性疾病，癌和腺癌; 增生性疾病; 和炎症性疾病。因此，这些化合物可用作神经保护和神经再生，抗增殖和抗炎剂。

35. 发明申请

US20070142331A1 LIPOPHILIC ANTICANCER DRUG COMPOUNDS, COMPOSITIONS AND RELATED METHODS 失效
标题翻译： LIPOPHILIC ANTICANCER DRUG化合物，组合物和相关方法
公开(公告)号：US20070142331A1
公开(公告)日：2007-06-21
申请号：US11611457
申请日：2006-12-15
申请人： Yuehua Zhang , Lynn Gold
发明人： Yuehua Zhang , Lynn Gold
IPC分类号： A61K31/4745 , C07D491/14 , A61K31/675
CPC分类号： C07D491/22 , C07D498/18
摘要： Lipophilic anticancer drug compounds, compositions that include the compounds, and methods for treating a cell proliferative disease using the compounds.
摘要翻译：亲脂性抗癌药物化合物，包括该化合物的组合物，以及使用该化合物治疗细胞增殖性疾病的方法。

36. 发明申请

US20070122746A1 BENZOPYRAN COLORANTS, METHOD OF MANUFACTURE, AND METHOD OF USE 有权
标题翻译： BENZOPYRAN COLORANTS，METHOD OF MANUFACTURE，AND METHOD OF USE
公开(公告)号：US20070122746A1
公开(公告)日：2007-05-31
申请号：US11289159
申请日：2005-11-28
申请人： Yogendrasinh Chauhan , Adil Dhalla , Rahul Khanwelkar , Sivakumar Krishnamoorthy , Kiran Puthamane
发明人： Yogendrasinh Chauhan , Adil Dhalla , Rahul Khanwelkar , Sivakumar Krishnamoorthy , Kiran Puthamane
IPC分类号： G11B7/24 , C07D491/14
CPC分类号： G11B7/2534 , C07D491/14 , C08K5/0041 , C08K5/45 , C09B57/00
摘要： A compound of Formula (I) wherein X is hydrogen or a radical of Formula (II), R1 independently at each occurrence is a C1-C20 aliphatic radical, a C3-C10 cycloaliphatic radical, or a C3-C10 aromatic radical; R2, R3, R4 and R5 are independently at each occurrence a halogen, a nitro group, a cyano group, a hydroxy group, a C1-C20 aliphatic radical, a C3-C20 cycloaliphatic radical, or a C6-C20 aromatic radical; and “n”, “q”, and “p” are each independently integers having a value of 0 to 3, and “m” is an integer having a value of 0 to 4.
摘要翻译：式（I）的化合物，其中X为氢或式（II）的基团，R 1在每次出现时独立地为C 1 -C 20 脂族基团，C 3 -C 10脂环族基团或C 3 -C 10亚烷基基团芳香族; R 2，R 3，R 4和R 5在每次出现时独立地为卤素，硝基，氰基，羟基，C 1 -C 20脂族基，C 3 -C 20烷基， SUB>脂环族基团或C 6 -C 20 -C 20芳族基团; 和“n”，“q”和“p”各自独立地为0〜3的整数，“m”为0〜4的整数。

37. 发明申请

US20070099948A1 Camptothecin derivatives and improved synthetic methods 失效
标题翻译：喜树碱衍生物和改进的合成方法
公开(公告)号：US20070099948A1
公开(公告)日：2007-05-03
申请号：US11588021
申请日：2006-10-26
申请人： Brian Shull
发明人： Brian Shull
IPC分类号： A61K31/4745 , C07D491/14
CPC分类号： C07D491/22
摘要： The present invention relates to compositions and methods for preparing pharmaceutical compositions. In some embodiments, the invention includes compounds and methods of resolving chiral compounds. In some embodiments, the invention includes chiral and crystalline compositions and hydrates. In some embodiments, the invention contemplates compositions comprising camptothecin derivatives and synthetic intermediates thereof. In some embodiments, the invention includes methods of protecting, inserting, modifying, separating isomers, and removing chemical groups.
摘要翻译：本发明涉及制备药物组合物的组合物和方法。在一些实施方案中，本发明包括拆分手性化合物的化合物和方法。在一些实施方案中，本发明包括手性和结晶组合物和水合物。在一些实施方案中，本发明涉及包含喜树碱衍生物及其合成中间体的组合物。在一些实施方案中，本发明包括保护，插入，修饰，分离异构体和除去化学基团的方法。

38. 发明申请

US20070088029A1 Tricycloundecane compounds useful as modulators of nuclear hormone receptor function 有权
标题翻译：三环十二烷化合物可用作核激素受体功能的调节剂
公开(公告)号：US20070088029A1
公开(公告)日：2007-04-19
申请号：US11581873
申请日：2006-10-17
申请人： James Balog , David Fairfax , Gregory Martin , Mark Salvati , Hai-Yun Xiao
发明人： James Balog , David Fairfax , Gregory Martin , Mark Salvati , Hai-Yun Xiao
IPC分类号： A61K31/5383 , A61K31/4745 , C07D491/14 , C07D471/14
CPC分类号： C07D498/18 , C07D471/18
摘要： Tricycloundecanes compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds are disclosed.
摘要翻译：公开了三环十四烷化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。

39. 发明申请

US20060293523A1 Novel rhodamine dyes 审中-公开
标题翻译：新型罗丹明染料
公开(公告)号：US20060293523A1
公开(公告)日：2006-12-28
申请号：US11433810
申请日：2006-05-12
申请人： Michael Filosa , John Marshall , Richard Allen
发明人： Michael Filosa , John Marshall , Richard Allen
IPC分类号： C07D491/14 , C07D311/88
CPC分类号： B41M5/3275 , B41M5/3335 , B41M5/3375 , B41M5/38235 , B41M5/385 , C07D493/10 , C07D493/20 , C09B11/24 , C09B67/0025
摘要： There are described novel rhodamine color-forming compounds. The rhodamine color-forming compounds exhibit a first color when in a crystalline form and a second color, different from the first color, when in an amorphous form.
摘要翻译：描述了新颖的罗丹明成色化合物。当以无定形形式时，形成结晶形式的罗丹明成色化合物呈现出第一种颜色，第二种颜色与第一种颜色不同。

40. 发明申请

US20060264456A1 Phosphorus-containing compounds & uses thereof 有权
标题翻译：含磷化合物及其用途
公开(公告)号：US20060264456A1
公开(公告)日：2006-11-23
申请号：US11494418
申请日：2006-07-27
申请人： Chester Metcalf , Leonard Rozamus , Yihan Wang , David Berstein
发明人： Chester Metcalf , Leonard Rozamus , Yihan Wang , David Berstein
IPC分类号： A61K31/4745 , C07D491/14
CPC分类号： A61K45/06 , A61K31/675 , C07F9/6561
摘要： This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is —O—, —S— or —NR2—; Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA; K is O or S; each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5 moiety to P; each occurrence of R2 and R5 is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; and each occurrence of R6 is independently —PK(YR5)(YR5), —SO2(YR5) or —(O)(YR5); so long as any R2, or R5 moiety linked directly to P is not H; wherein two R2, R5 and/or R6 moieties may be chemically linked to one another to form a ring; each occurrence of G is independently —O—, —S—, —NR2— or (M)x; each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M′ moiety may be saturated or unsaturated; each occurrence of x is independently an integer from 1-6; and the other variables are as defined herein.
摘要翻译：本发明涉及含有部分JQA-的新的含磷化合物族，其中：A不存在或为-O - ， - S-或-NR 2 - 。 Q不存在或（如果A是-O-，-S-或-NR 2 - ）Q可以是-V-，-OV-，-SV-或-NR 2 V-，其中V是脂族，杂脂族，芳基或杂芳基部分，使得J通过A或通过VA，OVA，SVA或NR 2 O直接与环己基环连接 > VA; K为O或S; 每次出现的Y独立地是-O - ， - S - ， - NR 2 - 或 - 连接R 5部分与P的键; 每个出现的R 2和R 5独立地是脂族，杂脂族，芳基或杂芳基部分，或H; 且每次出现的R 6独立地为-PK（YR 5），（YR 5）， - SO 2 - （YR 5）或 - （O）（YR 5）; 只要与P直接连接的任何R“或R 5”部分不是H; 其中两个R 2，R 5和/或R 6 O 6部分可以彼此化学连接以形成环; 每次出现的G独立地是-O - ， - S - ， - NR 2 - 或（M）x。每次出现的M独立地是取代或未取代的亚甲基部分，任何M-M'部分可以是饱和或不饱和的; 每次出现的x独立为1-6的整数; 其他变量如本文所定义。

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