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31. 发明授权

US3852460A Acid salts of 2-benzimidazolecarbamic acid, alkyl esters as fungicides 失效
标题翻译：作为杀真菌剂的2-苯甲酰氨基苯甲酸的酸钠
公开(公告)号：US3852460A
公开(公告)日：1974-12-03
申请号：US30320972
申请日：1972-11-02
申请人： LITTLER C , RICHARDS B
发明人： LITTLER C , RICHARDS B
IPC分类号： A01N47/18 , C07D235/32 , A01N9/22
CPC分类号： C07D235/32 , A01N47/18
摘要： Useful fungicidal compositions are composed of a fungicidal amount of a compound of the formula:

WHEREIN R is methyl or ethyl and A is an acid having an ionization constant greater than 1 X 10 6. The compounds of this formula can be combined with additional acid having an ionization constant greater than 1 X 10 6. The invention also includes the compositions described above combined with certain dispersants or crystallization inhibitors and then neutralized.
摘要翻译：有用的杀真菌组合物由杀真菌剂量的下式化合物组成：

32. 发明授权

US3711503A Substituted carbonyl-carbamidyl-benzimidazole-2-yl-carbamic acid esters 失效
标题翻译：取代的碳 - 碳酰胺基苯并咪唑-2-酰氯酸酯
公开(公告)号：US3711503A
公开(公告)日：1973-01-16
申请号：US3711503D
申请日：1970-06-30
申请人： BAYER AG
发明人： WIDDIG A , SASSE K , GREWE F , KASPERS H , SCHEINPFLUG H , FROHBERGER P
IPC分类号： A01N47/38 , C07D235/32 , C07D49/38
CPC分类号： C07D235/32 , A01N47/38
摘要： 1-(N-(ALKYL, CYCLOALKYL, PHENYL OR SUBSTITUTED PHENYL)-SOR -O-CARBONYL-CARBAMIDYL)-BENZIMIDAZOLE-2-YL-CARBAMIC ACID ALKYL ESTERS, WHICH POSSESS FUNGICIDAL PROPERTIES AND WHICH MAY BE PRODUCED BY CONVENTIONAL METHODS.

33. 发明授权

US3705939A Fungicidal compositions and methods utilizing metal complexes 失效
标题翻译：使用金属复合物的杀真菌成分和方法
公开(公告)号：US3705939A
公开(公告)日：1972-12-12
申请号：US3705939D
申请日：1969-10-21
申请人： DU PONT
发明人： KLOPPING HEIN L
IPC分类号： C07D235/32
CPC分类号： C07D235/32
摘要： METAL COMPLEXES PREPARED BY REACTING (1) ORGANIC COMPOUNDS HAVING THE FORMULA

2-(R-OOC-NH-)BENZIMIDAZOLE

WHEREIN R IS LOWER ALKYL, AND (2) METAL SALTS, SUCH AS ZINC CHLORIDE OR COPPER ACETATE, ARE USEFUL AS FUNGICIDES.

34. 发明授权

US3694454A 1-{8 1{40 -carboxylic acylamino-2{40 ,2{40 ,2{40 -trichloro)-ethyl{9 -2-(hydrocarbyloxycarbonyl-amino)-benzimidazoles 失效
标题翻译： 1- {8 1 {40-羧酰基氨基亚胺-2 {40,2（40,2 {40-三氯乙基） - 乙基{9 -2-（氢氯氰基 - 氨基） - 苯并咪唑
公开(公告)号：US3694454A
公开(公告)日：1972-09-26
申请号：US3694454D
申请日：1970-07-17
申请人： BOEHRINGER SOHN INGELHEIM
发明人： OST WALTER , THOMAS KLAUS , JERCHEL DIETRICH
IPC分类号： C07D235/32 , C07D49/38
CPC分类号： C07D235/32
摘要： WHEREIN R1 and R2 are each hydrogen, chlorine, bromine, ALKYL OF ONE TO FOUR CARBON ATOMS OR ALKOXY OF ONE TO FOUR CARBON ATOMS, R3 is alkyl of one to three carbon atoms or allyl, and R4 is hydrogen, alkyl of one to 17 carbon atoms which may have from one to three halogen substituents or one 2,4dichlorophenoxy substituent attached thereto, phenyl, alkenyl of two to 17 carbon atoms and 1 to 3 double bonds, or alkoxy of one to 12 carbon atoms; THE COMPOUNDS ARE USEFUL AS PROPHYLACTIC AS WELL AS CURATIVE BIOCIDAL AGENTS, ESPECIALLY AS FUNGICIDAL AGENTS AGAINST ALL TYPES OF Levow; Tobias E. fungi, such as mildew, plant rust, Fusaria and the like.
Compounds of the formula
摘要翻译：式WHEREIN R 1和R 2的化合物各自为氢，氯，溴，一个至四个碳原子的烷基或一个至四个碳原子的烷基，R 3为一至三个碳原子的烷基或烯丙基，且R 4为氢，烷基可以具有一至三个卤素取代基或一个连接到其上的2,4-二氯苯氧基取代基的具有1至17个碳原子的苯基，2至17个碳原子的烯基和1至3个双键，或1至12个碳原子的烷氧基 ; 该化合物有利于作为生物化学试剂，特别是作为杀真菌剂的所有类型的Levow; Tobias E.真菌，如霉菌，植物锈病，Fusaria等。

35. 发明授权

US3662069A Alkyl 1-(n-substituted thiocarbamoyl)-2-benzimidazolecarbamates as fungicides and mite ovicides 失效
标题翻译：烷基1-（N-取代的甲硫氨基）-2-苯并咪唑类化合物作为杀真菌剂和螨剂
公开(公告)号：US3662069A
公开(公告)日：1972-05-09
申请号：US3662069D
申请日：1969-05-16
申请人： DU PONT
发明人： DITTMAR BRUCE IVOR
IPC分类号： A23K1/16 , A23K3/00 , A23L3/3463 , A23L3/3544 , C07D235/32 , A01N9/22
CPC分类号： C07D235/32 , A23K20/137 , A23K30/00 , A23L3/3463 , A23L3/3544
摘要： THE NOVEL COMPOUNDS OF THE FOLLOWING STRUCTURE ARE USEFUL AS FUNGICIDES AND MITE OVICIDES:

1-(A-NH-C(=S)-),2-(R1-OOC-NH-),X-BENZIMIDAZOLE

WHEREIN R1 IS METHYL, ETHYL, ISOPROPYL OR SEC-BUTYL; X IS HYDROGEN, HALOGEN, METHYL, METHOXY OR NITRO; AND A IS VARIOUS ACYL, ALKOXYCARBONYL OR ALKYL SULFONYL GROUPS. THESE COMPOUNDS ARE MADE BY THE REACTION OF AN ALKYL 2-BENZIMIDAZOLECARBAMATE WITH A N-SUBSTITUTED ISOTHIOCYANATE. AN EXEMPLARY SPECIE OF THIS CLASS IS 1-((METHOXYCARBONYL)-THIOCARBAMOYL)-2-BENZIMIDAZOLECARBAMATE.

36. 发明授权

US3641048A Alkyl 1 - (substituted alkylideneaminooxycarbonyl) - 2 -benzimidazolecarbamates 失效
标题翻译：烷基1 - （取代的烷基氨基甲酰氧羰基）-2-苯基咪唑并[
公开(公告)号：US3641048A
公开(公告)日：1972-02-08
申请号：US3641048D
申请日：1969-07-29
申请人： DU PONT
发明人： DITTMAR BRUCE I
IPC分类号： C07D235/32 , C07D49/38
CPC分类号： C07D235/32
摘要： A GROUP OF ALKYL 1 - (SUBSTITUTED ALKYLDENEAMINOOXYCARBONYL) - 2 - BENZIMIDAZOLECARBAMATES ARE USEFUL AS FUNGICIDES AND MITE OVICIDES. THESE COMPOUNDS CAN BE PREPARED BY REACTING ALKYL 2-BENZIMIDAZOLECARBAMATES WITH A CHLOROFORMATE DERIVED FROM AN OXIME AND PHOSGENE IN THE PRESENCE OF AN ACID ACCEPTOR, E.G. TRIETHYLAMINE. A COMPOUND EXEMPLARY OF THE GROUP IS METHYL 1-(1METHYLTHIO)ETHYLENEAMINOOXYCARBONYL) -2-BENZIMIDAZOLECARBAMATE.

37. 发明授权

US3574845A Anthelmintic compositions and methods employing esters of benzimidazolyl carbamic acids and their thio analogs 失效
标题翻译：使用苯并咪唑碳水化合物及其硫代氨基甲酸酯的安全性组合物和方法
公开(公告)号：US3574845A
公开(公告)日：1971-04-13
申请号：US3574845D
申请日：1966-07-01
申请人： SMITH KLINE FRENCH LAB
发明人： ACTOR PHILIP PAUL , PAGANO JOSEPH FRANK
IPC分类号： A61K31/00 , C07D235/32 , A61K27/00
CPC分类号： A61K31/00 , C07D235/32
摘要： ANTHELMINITIC COMPOSITIONS COMPRISING ESTERS OF BENZIMIDAZOLYL CARBAMIC ACIDS, AND THEIR THIO ANALOGS, BOTH OF WHICH MAY BE OPTIONALLY SUBSTITUTED ON THE BENZENE RING, ARE DISCLOSED. A PROCESS FOR THEIR PREPARATION INVOLVES REACTING CYANAMIDE IN A SUITABLE ORGANIC SOLVENT WITH THE APPROPRIAW ALKYL SUBSTITUTED HALOFORMATE TO FORM A CYANOCARBAMATE, FOLLOWED BY THE ADDITION OF AN O-PHENYLENEDIAMINE TO YIELD THE DESCIRBED ANTHELMINTIC AGENTS.

38. 发明申请

US20190016686A1 SALTS OF COMPOUNDS HAVING A BENZIMIDAZOLIC STRUCTURE, USES AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
公开(公告)号：US20190016686A1
公开(公告)日：2019-01-17
申请号：US15750479
申请日：2016-08-04
申请人： ISTITUTO SUPERIORE DI SANITÀ , UNIVERSITÀ DEGLI STUDI "G.D'ANNUNZIO" CHIETI-PESCARA , UNIVERSITÀ DEGLI STUDI DI ROMA"LA SAPIENZA"
发明人： Roberto CIRILLI , Simone CARRADORI , Adriano CASULLI , Celeste DE MONTE
IPC分类号： C07D235/32 , C07D235/28 , C07D417/04 , C07D409/06 , C07B57/00 , A61P33/10 , A61P35/02
摘要： The present invention relates to salts of anthelmintic compounds with a benzimidazolic structure, such as albendazole (ABZ), fenbendazole (FBZ), triclabendazole (TRBZ), or sulphoxides thereof, flubendazole (FLZ), mebendazole (MBZ), oxibendazole (OBZ), thiabendazole (TBZ), cambendazole (CBZ), parbendazole (PBZ), nocodazole (NCZ), the use thereof and a process for preparation thereof.

39. 发明授权

US09556170B2 Substituted-1H-benzo[d]imidazole series compounds as lysine-specific demethylase 1 (LSD1) inhibitors 有权
标题翻译：取代的1H-苯并[d]咪唑系列化合物作为赖氨酸特异性脱甲基酶1（LSD1）抑制剂
公开(公告)号：US09556170B2
公开(公告)日：2017-01-31
申请号：US14471134
申请日：2014-08-28
申请人： University of Utah
发明人： Hariprasad Vankayalapati , Sunil Sharma , Venkataswamy Sorna
IPC分类号： C07D471/04 , C07D401/12 , C07D235/32
CPC分类号： C07D471/04 , C07D235/32 , C07D401/12
摘要： The present invention provides compounds which are useful as inhibitors of lysine-specific demethylase 1 (“LSD1”). The present invention also relates to pharmaceutical compositions containing these compounds. The present invention also relates to a method for preparing these compounds. The present invention also relates to a method of treating a mammalian disorder in which LSD1 levels are elevated by administering these compounds and compositions to a patient in need thereof. The present invention also relates to a method for decreasing histone demethylase activity in a mammal comprising administering to the mammal an effective amount of these compounds and compositions.
摘要翻译：本发明提供可用作赖氨酸特异性脱甲基酶1（“LSD1”）抑制剂的化合物。本发明还涉及含有这些化合物的药物组合物。本发明还涉及一种制备这些化合物的方法。本发明还涉及通过向有需要的患者施用这些化合物和组合物来治疗哺乳动物疾病的方法，其中LSD1水平升高。本发明还涉及一种用于降低哺乳动物组蛋白去甲基化酶活性的方法，包括向哺乳动物施用有效量的这些化合物和组合物。

40. 发明申请

US20130041002A1 DENIBULIN DI-HYDROCHLORIDE 有权
标题翻译：丹尼林二氢氯化物
公开(公告)号：US20130041002A1
公开(公告)日：2013-02-14
申请号：US13560785
申请日：2012-07-27
申请人： Kale RUBY
发明人： Kale RUBY
IPC分类号： C07D235/32 , A61P35/00 , A61P9/10 , A61P19/02 , A61P17/06 , A61P27/02 , A61K31/4184 , A61P29/00
CPC分类号： C07D235/32 , A61K31/4184 , A61K45/06
摘要： MN-029 di-hydrochloride (MN-029.2HCl, Formula 2) is a potent vascular targeting agent. The present invention focuses on the synthesis and characterization of the di-hydrochloride salt MN-029 and the preparation of pharmaceutically acceptable formulations thereof. Methods are disclosed of using the compound and formulations thereof in the treatment of diseases that rely on the generation of neovasculature by angiogenesis for disease progression.
摘要翻译： MN-029二盐酸盐（MN-029.2HCl，式2）是有效的血管靶向剂。本发明着重于二盐酸盐MN-029的合成和表征及其药学上可接受的制剂的制备。公开了使用该化合物及其制剂治疗依赖于通过血管发生用于疾病进展的新血管生成的疾病的方法。

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