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31. 发明授权

US4131620A Sulfamic acid halides and their manufacture 失效
标题翻译：氨基磺酰卤及其制造
公开(公告)号：US4131620A
公开(公告)日：1978-12-26
申请号：US807064
申请日：1977-06-16
申请人： Gerhard Hamprecht
发明人： Gerhard Hamprecht
IPC分类号： C07C307/00 , A01N41/08 , C07C67/00 , C07C301/00 , C07C303/22 , C07C307/02 , C07D285/16 , C07C155/00 , C07C51/58 , C07C161/00
CPC分类号： C07D285/16 , A01N41/08
摘要： New sulfamic acid halides and a process for their manufacture by reacting N-(.alpha.-haloalkyl)-sulfamic acid halides with alcohols. The products are starting materials for the manufacture of crop protection agents, dyes and pharmaceuticals.
摘要翻译：新的氨基磺酰卤和通过使N-（α-卤代烷基） - 氨基磺酰卤与醇反应而制备的方法。这些产品是用于制造作物保护剂，染料和药物的起始材料。

32. 发明授权

US09249091B2 Post-treated sulfurized salt of an alkyl-substituted hydroxyaromatic composition 有权
标题翻译：经后处理的烷基取代的羟基芳族组合物的硫化盐
公开(公告)号：US09249091B2
公开(公告)日：2016-02-02
申请号：US13727892
申请日：2012-12-27
申请人： Andrew R. Gibbs , Curtis Campbell
发明人： Andrew R. Gibbs , Curtis Campbell
IPC分类号： C07C307/00 , C10M159/16 , C07G99/00
CPC分类号： C07C307/00 , C07G17/00 , C10M159/16 , C10M2217/043 , C10N2230/64 , C10N2240/04 , C10N2240/08 , C10N2240/10 , C10N2240/102 , C10N2240/30 , C10N2250/10 , C10N2260/10 , C10N2210/02
摘要： Disclosed herein is a post-treated salt of a sulfurized alkyl-substituted hydroxyaromatic composition which is a reaction product of (a) a salt of a sulfurized alkyl-substituted hydroxyaromatic composition, wherein the alkyl-substituted hydroxyaromatic compound is derived from alkylation of a hydroxyaromatic compound with one or more olefins comprising C9 to C18 oligomers of monomers selected from propylene, butylene or mixtures thereof, (b) a source of an aldehyde and (c) a primary and/or secondary monoamine compound having at least one active hydrogen. The post-treated salt of a sulfurized alkylhydroxyaromatic composition disclosed herein has a reduced content of unsulfurized alkyl-substituted hydroxyaromatic compound and its unsulfurized metal salt as compared to the content, by combined mass, of the unsulfurized alkyl-substituted hydroxyaromatic compound and its unsulfurized metal salt present in the non-post-treated salt of a sulfurized alkyl-substituted hydroxyaromatic composition.
摘要翻译：本文公开了硫化烷基取代的羟基芳族组合物的后处理盐，其是（a）硫化烷基取代的羟基芳族组合物的盐的反应产物，其中烷基取代的羟基芳族化合物衍生自羟基芳族化合物的烷基化包含选自丙烯，丁烯或其混合物的单体的C 9至C 18低聚物的一种或多种烯烃的化合物，（b）醛源和（c）具有至少一个活性氢的伯和/或仲单胺化合物。本文公开的硫化烷基羟基芳族化合物的后处理盐与未硫化的烷基取代的羟基芳族化合物及其未硫化金属的组合质量相比，未硫化的烷基取代的羟基芳族化合物及其未硫化金属盐的含量降低存在于硫化烷基取代的羟基芳族组合物的非后处理盐中的盐。

33. 发明授权

US08859814B2 Alpha-substituted N-sulfonyl gylcine amides antagonists of CCR10, compositions containing the same and methods for using them 有权
标题翻译： CCR10的α-取代的N-磺酰基Gylcine酰胺拮抗剂，含有它们的组合物和使用它们的方法
公开(公告)号：US08859814B2
公开(公告)日：2014-10-14
申请号：US12992766
申请日：2009-05-14
申请人： Derek Cogan , Alexander Heim-Riether , Wang Mao , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Jiang-Ping Wu , Yu Yang
发明人： Derek Cogan , Alexander Heim-Riether , Wang Mao , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Jiang-Ping Wu , Yu Yang
IPC分类号： C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00 , C07C241/00 , C07C241/02 , C07D211/00 , C07D211/68 , C07D211/80 , C07D213/02 , C07D217/00 , C07D209/04 , C07D231/00 , C07D277/60 , C07D277/62 , C07D211/22 , C07D403/12 , C07D217/06 , C07D295/185 , C07D513/04 , C07D487/04 , C07D211/70 , C07D401/14 , C07D209/08 , C07D211/62 , C07C311/19 , C07D211/16 , C07D409/12 , C07D413/12 , C07C311/44 , C07D407/12 , C07D401/12
CPC分类号： C07C311/19 , C07C311/44 , C07D209/08 , C07D211/16 , C07D211/22 , C07D211/62 , C07D211/70 , C07D217/06 , C07D295/185 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D487/04 , C07D513/04
摘要： Disclosed is a compound of formula (I). Wherein R1, R2Ar and Cy are as defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions of the compound of formula (I), methods of making the compounds of formula I, and methods of using the compounds of formula (I) to treat a disorder associated with activation of CCR10.
摘要翻译：公开了式（I）的化合物。其中R1，R2Ar和Cy如本文所定义，或其药学上可接受的盐。还公开了式（I）化合物的药物组合物，制备式I化合物的方法和使用式（I）化合物治疗与CCR10活化相关的病症的方法。

34. 发明授权

US08552050B2 Activators of pyruvate kinase M2 and methods of treating disease 有权
标题翻译：丙酮酸激酶M2的活化剂和治疗疾病的方法
公开(公告)号：US08552050B2
公开(公告)日：2013-10-08
申请号：US12672827
申请日：2008-08-18
申请人： Lewis C. Cantley , Matthew G. Vander Heiden , Heather R. Christofk
发明人： Lewis C. Cantley , Matthew G. Vander Heiden , Heather R. Christofk
IPC分类号： A01N43/56 , A01N43/08 , A01N37/10 , A01N41/06 , A61K31/415 , A61K31/34 , A61K31/19 , A61K31/18 , C07D231/00 , C07D307/02 , C07C63/04 , C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00
CPC分类号： A61K45/06
摘要： The invention described herein features methods, compositions, and kits for the use of activators of PKM2 for the treatment, prevention, or amelioration of diseases related to PKM2 function, including, e.g., cancer, diabetes, atherosclerosis, restenosis, obesity, autoimmune disorders, and proliferative disorders.
摘要翻译：本文描述的发明特征在于使用PKM2激活剂用于治疗，预防或改善与PKM2功能有关的疾病的方法，组合物和试剂盒，包括例如癌症，糖尿病，动脉粥样硬化，再狭窄，肥胖症，自身免疫性疾病，和增殖性疾病。

35. 发明授权

US08329757B2 Curcumin analog compositions and related methods 有权
标题翻译：姜黄素类似物组合物及相关方法
公开(公告)号：US08329757B2
公开(公告)日：2012-12-11
申请号：US12579361
申请日：2009-10-14
申请人： Danyang Chen
发明人： Danyang Chen
IPC分类号： A01N35/00 , A61K31/12 , C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00
CPC分类号： A61K31/415 , A61K31/18 , C07C311/29 , C07D231/12
摘要： Novel curcumin-analog compounds are disclosed that are antioxidants useful in inhibition of pro-inflammation, angiogenic, and vascular permeability factors and elimination of reactive oxygen species. The curcumin compounds specifically inhibit VEGF and are useful in treating various diseases that are mediated through the oxidative stress pathway, including those that are characterized by inflammation, angiogenesis, or vascular leakage.
摘要翻译：公开了新型的姜黄素类似物，其是可用于抑制促炎症，血管生成和血管通透性因子和消除活性氧的抗氧化剂。姜黄素化合物特异性地抑制VEGF，并且可用于治疗通过氧化应激途径介导的各种疾病，包括以炎症，血管生成或血管渗漏为特征的那些疾病。

36. 发明申请

US20120225782A1 PESTICIDES 有权
标题翻译：农药
公开(公告)号：US20120225782A1
公开(公告)日：2012-09-06
申请号：US13444286
申请日：2012-04-11
申请人： Nneka T. Breaux , Michael R. Loso , Timothy C. Johnson , Jonathan M. Babcock , Benjamin M. Nugent , Timothy P. Martin , Annette V. Brown , Ronald Ross, JR. , William C. Lo , Matthias S. Ober
发明人： Nneka T. Breaux , Michael R. Loso , Timothy C. Johnson , Jonathan M. Babcock , Benjamin M. Nugent , Timothy P. Martin , Annette V. Brown , Ronald Ross, JR. , William C. Lo , Matthias S. Ober
IPC分类号： C07D401/10 , A01N47/34 , A01N43/40 , A01P7/04 , A01N43/84 , C07D413/12 , A01P3/00 , A01P13/00 , C07C307/00 , C07D211/70
CPC分类号： C07C381/10 , A01N43/40 , A01N47/34 , A01N47/36 , A01N47/44 , C07C2601/02 , C07C2601/14 , C07C2603/18 , C07D213/32 , C07D401/12 , C07D405/12 , C07D413/12
摘要： Compounds having the following generic formula are disclosed.
摘要翻译：公开了具有以下通式的化合物。

37. 发明授权

US08257868B2 Molten salt composition and use thereof 有权
标题翻译：熔盐组成及其用途
公开(公告)号：US08257868B2
公开(公告)日：2012-09-04
申请号：US11886781
申请日：2006-03-22
申请人： Rika Hagiwara , Kazuhiko Matsumoto , Kenichiro Tamaki , Toshiyuki Nohira , Takuya Goto
发明人： Rika Hagiwara , Kazuhiko Matsumoto , Kenichiro Tamaki , Toshiyuki Nohira , Takuya Goto
IPC分类号： H01M4/13 , H01M6/18 , H01M10/0562 , C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00 , H01M6/14
CPC分类号： C25D3/66 , C07C311/48 , H01B1/06 , H01M10/0568
摘要： A molten salt composition is disclosed containing two or more types of molten salt MTFSI whose anion is an imide anion TFSI and whose cation is an alkali metal M exhibits a lower electrolyte melting point and a wider operating temperature range than a simple salt does. This brings about various advantages such as a wider range of materials that are chosen for use in batteries and the like.
摘要翻译：公开了含有阴离子为酰亚胺阴离子TFSI并且其阳离子为碱金属M的两种或更多种熔融盐MTFSI的熔融盐组合物，其表现出比简单盐更低的电解质熔点和更宽的工作温度范围。这带来了各种优点，例如选择用于电池等的更宽范围的材料。

38. 发明授权

US08138218B2 Growth hormone secretagogues 有权
标题翻译：生长激素促分泌素
公开(公告)号：US08138218B2
公开(公告)日：2012-03-20
申请号：US11989181
申请日：2006-07-24
申请人： Zheng Xin Dong , John S. Eynon , Yeelana Shen
发明人： Zheng Xin Dong , John S. Eynon , Yeelana Shen
IPC分类号： A01N43/38 , A01N43/12 , A01N41/06 , A01N37/18 , A61K31/405 , A61K31/38 , A61K31/18 , A61K31/16 , C07D333/56 , C07D333/72 , C07D409/02 , C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00 , C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00
CPC分类号： C07K14/72 , C07K5/06026 , C07K5/06086
摘要： A family of peptides and peptidomimetic compounds useful as GHS analogs according to either formula (I) or (II) as depicted below: or a pharmaceutically acceptable salts thereof, wherein the variables are as defined in the specification.
摘要翻译：可用作如下所述的式（I）或（II）的GHS类似物的肽和拟肽化合物家族：或其药学上可接受的盐，其中变量如说明书中所定义。

39. 发明授权

US07816560B1 Long chain n-alkyl compounds and oxa-derivatives thereof 有权
标题翻译：长链正烷基化合物及其氧杂衍生物
公开(公告)号：US07816560B1
公开(公告)日：2010-10-19
申请号：US10031145
申请日：2000-08-10
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： C07C211/00 , C07C303/00 , C07C307/00 , C07C309/00
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译：描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。长链N-烷基是C8-C16烷基。长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。

40. 发明申请

US20100105894A1 Cyclopropane compounds and pharmaceutical use thereof 审中-公开
标题翻译：环丙烷化合物及其药物用途
公开(公告)号：US20100105894A1
公开(公告)日：2010-04-29
申请号：US12457391
申请日：2009-06-09
申请人： Takashi Inaba , Julia Haas , Makoto Shiozaki , Nicole M. Littmann , Katsutaka Yasue , Steven W. Andrews , Atushi Sakai , Andrew M. Fryer , Takafuml Matsuo , Ellen R. Laird , Akira Suma , Yuichi Shinozaki , Yoshikazu Hori , Hiroto Imai , Tamotsu Negoro
发明人： Takashi Inaba , Julia Haas , Makoto Shiozaki , Nicole M. Littmann , Katsutaka Yasue , Steven W. Andrews , Atushi Sakai , Andrew M. Fryer , Takafuml Matsuo , Ellen R. Laird , Akira Suma , Yuichi Shinozaki , Yoshikazu Hori , Hiroto Imai , Tamotsu Negoro
IPC分类号： C07D243/08 , C07C229/02 , C07C307/00 , C07D409/02 , C07D231/10 , C07D401/02 , C07D261/06 , C07D333/34 , C07D241/04 , C07D271/06 , C07D257/04 , C07D295/00 , C07D215/14 , C07D205/04 , C07D413/02 , C07D241/36 , C07D413/14 , C07D223/14
CPC分类号： C07C311/29 , C07C311/13 , C07C311/20 , C07C311/22 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07C2603/08 , C07C2603/18 , C07C2603/30 , C07D205/04 , C07D207/48 , C07D209/44 , C07D211/58 , C07D211/96 , C07D213/18 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/81 , C07D213/82 , C07D217/08 , C07D231/12 , C07D233/64 , C07D237/12 , C07D239/22 , C07D243/08 , C07D257/04 , C07D261/08 , C07D271/06 , C07D271/107 , C07D277/26 , C07D277/36 , C07D277/82 , C07D295/26 , C07D307/79 , C07D307/91 , C07D333/18 , C07D333/34 , C07D333/36 , C07D333/38 , C07D333/62 , C07D401/04 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1—(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30, etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有聚集蛋白聚糖蛋白聚糖酶抑制活性和MMP-13抑制活性的化合物，可用作骨关节炎，类风湿性关节炎等的治疗剂，更具体而言，可以使用式（1）所示的环丙烷化合物：其中，R 1为 - （CH 2 ）m-X-（CH 2）n -Al等，其中m和n相同或不同，各自为0〜6，X为单键等，而A1为取代的C3-14烃环基，等等。; R2和R3相同或不同，各自为氢原子， - （CH2）p-X1-（CH2）q-A2等，其中p和q相同或不同，各自为0至6，X1 是单键等，A2是任选取代的C 3-14烃环基等; R4是-CO 2 R 9等，其中R9是氢原子等; 和R 20和R 21相同或不同，各自为氢原子， - （CH 2）m 12 -X 12 - （CH 2）m 12 -R 30等，其中m12和m12相同或不同，各自为0至6， X12为单键等，R30为氢原子等; 或其前药或其药学上可接受的盐。

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