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    • 37. 发明申请
    • PROCESS FOR PRODUCING A NANO RESVERATROL MICROEMULSION SYSTEM
    • US20190336922A1
    • 2019-11-07
    • US16505692
    • 2019-07-08
    • Hong Ngoc Thi Dang
    • Hong Ngoc Thi DangNam Hai Lai
    • B01F3/08B01F3/22B01F3/20A61K9/107A61K9/51
    • The present invention relates to a process of producing a nano resveratrol microemulsion system includes: (i) preparing a dispersal phase by dissolving resveratrol in an ethanol solvent; (ii) preparing a carrier by heating a liquid PEG (polyethylene glycol) accounted from 40 to 60% by mass of the mixture of PEG and water to a temperature ranging from 60 to 80° C., then adding zeolite catalyst (0.1-0.4% by mass of mixture of PEG and water), stirring evenly; (iii) adding the carrier to the dispersal phase (in a ratio by mass of 40:60), continuing heating the said dispersal phase to 100° C., stirring at a speed of 400 to 800 rpm; (iv) elmusifying as follows: when the temperature arrives at 100° C., adding Tween to the mixture of the carrier and dispersal phase in step (iii) in a ratio by mass of 40:60, continuing to stir at a speed of 500 to 700 rpm, at a temperature of 100° C. to 130° C. perform emulsification at speed of 2500 to 3500 rpm, combining stirring at a speed of 400 and 600 rpm, in vacuum, the reaction temperature is maintained at 150° C. for 3 to 5 hours, the reation is quenched, the temperature is decreased slowly until it is in the range of 40 to 60° C.; (v) filtrating the product by injecting through nanofilter system before filling-packaging.