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31. 发明申请

US20220175009A1 NUTRITIONAL COMPOSITION AND INFANT FORMULA FOR PROMOTING DE NOVO MYELINATION 有权
公开(公告)号：US20220175009A1
公开(公告)日：2022-06-09
申请号：US17678672
申请日：2022-02-23
申请人： SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
发明人： Nora Schneider , Jonas Hauser , Sean Deoni , Tamas Bartfai , Jonathan O'Regan
IPC分类号： A23L33/00 , A23L33/12 , A23L33/15 , A23L33/16 , A61K45/06 , A24B15/38 , A61P25/28 , A61K9/00 , A61K31/14 , A61K31/202 , A61K31/519 , A61K31/661 , A61K31/70 , A61K31/714 , A61K33/00 , A61K33/06 , A61K33/26 , A61K33/30 , A61K33/42
摘要： A synthetic nutritional composition comprising a phospholipid and/or a metabolic precursor and/or metabolite thereof for use to promote, support or optimise de novo myelination, in particular the de novo myelination trajectory, and/or brain structure, and/or brain connectivity, and/or intellectual potential and/or cognitive potential, and/or learning potential and/or cognitive functioning in a subject, in particular a formula fed subject.

32. 发明授权

US11344575B2 Vascular calcification prevention and treatment 有权
公开(公告)号：US11344575B2
公开(公告)日：2022-05-31
申请号：US15649084
申请日：2017-07-13
申请人： Summit Innovation Labs, LLC
发明人： Satyanarayana Majeti , Haile Mehansho , Ghebre Egziabher Tzeghai
IPC分类号： A61K33/42 , A61K31/355 , A61K31/12 , A61K31/07 , A61K31/122 , A61K31/353 , A61K9/08 , A61K31/593 , A61K33/06 , A61K45/06 , A61K9/00 , A61K33/14
摘要： The invention encompasses compositions and methods for effectively interfering, reducing and preventing conversion of vascular smooth muscle cells (VSMCs) and circulating stem cells to osteoblastic bone-like cells, thereby reducing and/or preventing vascular calcification (VC) or calcium mineral (hydroxyapatite) deposition in the vasculature. The severity and extent of calcification in the major arteries reflect atherosclerotic plaque burden and strongly predict cardiovascular morbidity and mortality. The present inventive compositions used for administration to human and other mammalian subjects comprise select actives that inhibit, interfere or regulate the biochemical processes leading to such calcification and include (1) at least one agent that modulates expression and/or activity of peroxisome activated protein receptor gamma (PPAR-γ); (2) at least one agent that inhibits expression and/or suppresses activity of one or more of the osteogenic transcription factors (Cbfα1/Runx2, Osterix, Msx2) and β-catenin signaling; (3) at least one agent that inhibits expression and/or suppresses activity of one or more of bone morphogenetic proteins (BMPs: BMP 2 and 4), alkaline phosphatase (ALP), and osteocalcin; (4) at least one agent that inhibits the activity of Reactive Oxygen Species (ROS); and (5) at least one agent that suppresses one or more of inflammatory mediators including interleukins IL-1α, IL-1β, IL-6, NF-κB, TNF-α, matrix metalloproteinases (MMPs) and prostaglandin E2 (PGE2). The compositions may further comprise at least one agent that promotes expression and/or carboxylation of matrix Gla protein (MGP). Advantageously, these select actives include materials such as phytonutrients, vitamins and minerals that have been broadly used in food and drink products and are safe for human and pet/animal consumption. Compositions with such combinations have the ability to prevent, treat and reverse VC not only in coronary arteries but also in other tissues capable of undergoing undesirable calcification. In addition the present compositions are effective against associated conditions or contributory factors/inducers to VC, including diabetes, obesity, hypertension, inflammation, oxidative stress, osteoporosis and arthritis.

33. 发明授权

US11331361B2 Hybrid herbal and drug composition and method of formulation 有权
公开(公告)号：US11331361B2
公开(公告)日：2022-05-17
申请号：US16858352
申请日：2020-04-24
申请人： Shui Yin Lo
发明人： Shui Yin Lo
IPC分类号： A61K36/00 , A61K36/481 , A61K35/32 , A61K33/42 , A61K31/203 , A61K36/18 , A61K36/232 , A61K31/59 , A61K31/51 , A61K31/4418 , A61K33/22 , A61K35/64 , A61K33/30 , A61K35/644 , A61K35/586 , A61K33/06
摘要： A hybrid herbal and drug composition includes an amount of Chinese herb about 0.01 to 5% by weight of the composition; an amount of animal-based matter about 0.01 to 5% by weight of the composition; an amount of vitamin about 0.01 to 5% by weight of the composition; an amount of mineral about 0.01 to 5% by weight of the composition; an amount of hormone about 0.01 to 5% by weight of the composition; an amount of factory produced product about 0.01 to 5% by weight of the composition; and an amount of the purified water about 70% to 99.94% by weight of the composition.

34. 发明申请

US20220110969A1 Ready-To-Use Potassium Phosphates In Sodium Chloride Solutions 有权
公开(公告)号：US20220110969A1
公开(公告)日：2022-04-14
申请号：US17499001
申请日：2021-10-12
申请人： Nivagen Pharmaceuticals, Inc.
发明人： Brijeshkumar B. Pandya , Govind R. Jagadale , Dasaradhi Lakkaraju , Bala Tripura Sundari Chodavarapu , Anand Shukla , Jwalant Shukla
IPC分类号： A61K33/42 , A61K9/08 , A61M39/02 , A61M5/168
摘要： A ready-to-use (RTU) potassium phosphates in sodium chloride solution for phosphorus replacement therapy includes potassium phosphate and sodium chloride at a fixed volume with 15 mmol/100 mL phosphorus and 22 mEq/100 mL potassium and less than 50 mcg/L aluminum.

35. 发明授权

US11297872B2 Nutritional composition and infant formula for promoting de novo myelination 有权
公开(公告)号：US11297872B2
公开(公告)日：2022-04-12
申请号：US16061121
申请日：2016-12-13
申请人： NESTEC S.A.
发明人： Nora Schneider , Jonas Hauser , Sean Deoni , Tamas Bartfai , Jonathan O'Regan
IPC分类号： A23L33/00 , A23L33/12 , A23L33/15 , A23L33/16 , A61K45/06 , A24B15/38 , A61P25/28 , A61K9/00 , A61K31/14 , A61K31/202 , A61K31/519 , A61K31/661 , A61K31/70 , A61K31/714 , A61K33/00 , A61K33/06 , A61K33/26 , A61K33/30 , A61K33/42
摘要： A synthetic nutritional composition comprising a phospholipid and/or a metabolic precursor and/or metabolite thereof for use to promote, support or optimise de novo myelination, in particular the de novo myelination trajectory, and/or brain structure, and/or brain connectivity, and/or intellectual potential and/or cognitive potential, and/or learning potential and/or cognitive functioning in a subject, in particular a formula fed subject.

36. 发明申请

US20220062329A1 METHOD OF ADMINISTRATION AND TREATMENT 有权
公开(公告)号：US20220062329A1
公开(公告)日：2022-03-03
申请号：US17497794
申请日：2021-10-08
申请人： Dyve Biosciences, Inc.
发明人： Ryan BEAL
IPC分类号： A61K33/00 , A61K9/00 , A61K47/22 , A61K9/16 , A61K31/704 , A61K39/395 , A61K47/14 , A61K9/06 , A61K31/198 , A61K35/00 , A61K47/10 , A61K47/18 , A61K47/24 , A61K31/685 , A61K33/42 , C07K16/28 , A61P35/04 , A61K31/133 , A61K33/30 , A61K47/02 , A61K47/12 , A61K31/045 , A61K31/661 , A61K9/70 , A61K31/4172
摘要： Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.

37. 发明授权

US11241384B1 Compositions and methods for improving gastrointestinal absorption of electrolytes 有权
公开(公告)号：US11241384B1
公开(公告)日：2022-02-08
申请号：US16941385
申请日：2020-07-28
申请人： IGH NATURALS, INC.
发明人： Sourabh Kharait
IPC分类号： A61K9/08 , A61K31/702 , A61K33/06 , A61K47/42 , A61K47/14 , A61K33/42 , A61K9/00
摘要： The present disclosure relates generally to compositions and methods for improving gastrointestinal absorption function and correct deficiencies by preserving intestinal epithelial absorptive function. In particular, the compositions and methods for useful for improving gastrointestinal absorption of electrolytes.

38. 发明申请

US20220000777A1 LIPOSOMAL ENHANCED INTRA-PERITONEAL CHEMOTHERAPY 有权
公开(公告)号：US20220000777A1
公开(公告)日：2022-01-06
申请号：US17290329
申请日：2019-11-04
申请人： TESORX PHARMA, LLC
发明人： Michael G. OEFELEIN , Natarajan VENKATESAN , Nitin K. SWARNAKAR , Teresa B. HONG , Guru V. BETAGERI , Ramachandran THIRUCOTE , Lining Zhu HUTCHINSON
IPC分类号： A61K9/127 , A61P35/00 , A61K31/337 , A61K33/42 , A61K47/24
摘要： The invention described herein is directed to treating neoplasms by intraperitoneal administration of liposomal formulations of chemotherapeutic drugs. Methods of instilling liposomal formulations of taxane and platin chemotherapeutic agents into the peritoneal cavity of a subject to treat ovarian cancer or a primary peritoneal cancer are disclosed.

39. 发明申请

US20210379142A1 AGONISTS OF GUANYLATE CYCLASE AND THEIR USES 有权
公开(公告)号：US20210379142A1
公开(公告)日：2021-12-09
申请号：US17184256
申请日：2021-02-24
申请人： Bausch Health Ireland Limited
发明人： Dennis RIFF , Gary S. JACOB , Kunwar SHAILUBHAI , Patrick H. GRIFFIN
IPC分类号： A61K38/10 , A61K38/12 , A61K45/06 , A61K38/04 , A61K31/53 , A61K31/192 , A61K31/352 , A61K31/4468 , A61K31/501 , A61K31/519 , A61K31/7004 , A61K9/28 , A61K31/194 , A61K33/42
摘要： This invention provides a method of colonic cleansing.

40. 发明授权

US11155647B2 Water-soluble polysaccharide derivatives, process for their preparation, and their uses 有权
公开(公告)号：US11155647B2
公开(公告)日：2021-10-26
申请号：US16616731
申请日：2018-05-29
申请人： JOINTHERAPEUTICS S.R.L.
发明人： Giulio Bianchini , Lanfranco Callegaro
IPC分类号： C08B37/08 , A61K31/722 , A61K31/734 , A61K31/737 , A61K31/765 , A61K33/42 , A61K38/39
摘要： A neutral salt consisting of a polyaminosaccharide cation and an anion, as well as a procedure for the preparation of the neutral salt and uses thereof as a biomaterial and as an ingredient in pharmaceutical compositions are disclosed. Indeed, said neutral salt has surprisingly exhibited high water-solubility and high purity, the preparation procedure having minimised the content of high-risk contaminants in the final product and reduced reaction and purification times.

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