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31. 发明授权

US06313179B1 Treatment of hyperproliferative skin disorders with C18 to C20 aliphatic alcohols 失效
标题翻译：用C18〜C20脂肪醇治疗过度增生性皮肤病
公开(公告)号：US06313179B1
公开(公告)日：2001-11-06
申请号：US09210005
申请日：1998-12-11
申请人： Laura E. Pope , Mohammed H. Khalil , John F. Marcelletti , Lee R. Katz , David H. Katz
发明人： Laura E. Pope , Mohammed H. Khalil , John F. Marcelletti , Lee R. Katz , David H. Katz
IPC分类号： A61K31045
CPC分类号： A61K31/045 , Y10S514/863
摘要： A method is disclosed for treating a benign or malignant hyperproliferative skin lesion, comprising topically administering a C18 to C20 aliphatic alcohol to the skin lesion in a pharmaceutically acceptable carrier.
摘要翻译：公开了一种治疗良性或恶性过度增生性皮肤病变的方法，包括向药学上可接受的载体中的皮肤病变局部施用C18至C20脂族醇。

32. 发明授权

US06288128B1 &bgr;,&ggr;-dihydropolyprenyl alcohol derivatives and pharmaceutical composition containing a polyprenyl compound 失效
标题翻译： β，γ-二氢聚丙烯醇衍生物和含有聚异戊二烯基化合物的药物组合物
公开(公告)号：US06288128B1
公开(公告)日：2001-09-11
申请号：US08601489
申请日：1996-02-14
申请人： Masaichi Yamamoto , Seiichi Araki , Hiroshi Yamamoto , Isao Yamatsu , Takeshi Suzuki , Akiharu Kajiwara , Yoshikazu Suzuki , Haruyoshi Arai
发明人： Masaichi Yamamoto , Seiichi Araki , Hiroshi Yamamoto , Isao Yamatsu , Takeshi Suzuki , Akiharu Kajiwara , Yoshikazu Suzuki , Haruyoshi Arai
IPC分类号： A61K31045
CPC分类号： C07C255/00 , A61K31/045 , A61K31/765 , C07C29/147 , C07C33/02 , C07C43/15 , C07C49/04 , C07C49/203 , C07C51/08 , C07C51/38 , C07C57/03 , C07C69/007 , C07C69/145 , C07C69/78 , C12C11/02 , C07C57/13
摘要： A &bgr;,&ggr;-dihydropolyprenyl alcohol derivative having the formula: wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group, is new and useful as a prophylactic therapeutic agent for human and animal immuno-deficiency deseases and phylactic agent against human and animal infectious deseases. Another disclosed polyprenyl compound is also useful as the same agent.
摘要翻译：具有下式的β，γ-二氢聚芴醇衍生物：其中n为5-7的整数，R为氢，低级烷基或脂族或芳族酰基，是新的并且可用作人和人的预防治疗剂动物免疫缺陷病和针对人类和动物感染性疾病的门诊药物。另一种公开的聚异戊二烯基化合物也可用作相同的试剂。

33. 发明授权

US06225354B1 High molecular weight primary aliphatic alcohols obtained from beeswax and pharmaceutical use thereof 有权
标题翻译：从蜂蜡获得的高分子量伯脂肪醇及其药物用途
公开(公告)号：US06225354B1
公开(公告)日：2001-05-01
申请号：US09337339
申请日：1999-06-21
申请人： Pedro P. Perez
发明人： Pedro P. Perez
IPC分类号： A61K31045
CPC分类号： C07C29/76 , C07C31/02
摘要： The present invention relates to a naturally obtained mixture of higher molecular weight primary aliphatic alcohols which contain 24 to 34 carbon atoms. This invention also relates to the process for obtaining the alcohol mixture by extraction and purification with organic solvents from beeswax without saponification ofthe beeswax. The alcohol mixture obtained from beeswax has enhanced purity and contains a mixture of alcohols having 24, 26, 27, 28, 29, 30, 32 and 34 carbon atoms. The alcohol mixture is useful in pharmaceutical compositions, foodstuffs and dietary supplements and is effective for lowering cholesterol in LDL-C levels so that it is effective in treating hypercholesterolemia. Consequently the composition may be used to reduce the risk of coronary heart disease, the atherosclerotic process (platelet hyperaggregability, ischemia and thrombosis) and also acts as an anti-inflammatory and anti-thrombotic agent. The composition also possesses neurotrophic properties and is useful for improving male sexual activity.
摘要翻译：本发明涉及天然得到的含有24至34个碳原子的较高分子量伯脂肪醇的混合物。本发明还涉及通过蜂蜡中的有机溶剂提取和纯化而获得醇混合物的方法，而不需要将蜂蜡皂化。从蜂蜡获得的醇混合物具有提高的纯度，并且含有具有24,26,27,28,29,30,32和34个碳原子的醇的混合物。醇混合物可用于药物组合物，食品和膳食补充剂中，并且可有效降低LDL-C水平的胆固醇，从而有效治疗高胆固醇血症。因此，该组合物可用于降低冠心病，动脉粥样硬化过程（血小板超聚集，局部缺血和血栓形成）的风险，并且还用作抗炎和抗血栓形成剂。该组合物还具有神经营养性质，可用于改善男性的性活动。

34. 发明授权

US06218436B1 Pharmaceutically active carotenoids 失效
标题翻译：药物活性类胡萝卜素
公开(公告)号：US06218436B1
公开(公告)日：2001-04-17
申请号：US08774052
申请日：1996-12-23
申请人： Alan N Howard , John T Landrum , Richard A Bone
发明人： Alan N Howard , John T Landrum , Richard A Bone
IPC分类号： A61K31045
CPC分类号： A61K31/045 , A23L33/155 , A23V2002/00 , A61K31/047 , A61K31/07 , A61K33/34 , Y10S514/912 , A61K33/32 , A61K33/30 , A61K33/24 , A61K31/375 , A61K31/355 , A61K31/015 , A61K31/01 , A61K2300/00 , A23V2250/211
摘要： The carotenoids lutein and zeaxanthin are disclosed for pharmaceutical use in the treatment of advanced macular degeneration. High dosages are deployed to produce the high serum carotenoid levels needed to cause take-up by the macula.
摘要翻译：公开了类胡萝卜素叶黄素和玉米黄质用于药物用于治疗晚期黄斑变性。部署高剂量以产生引起黄斑引起所需的高血清类胡萝卜素水平。

35. 发明授权

US06214888B1 Dermatological compounds 失效
标题翻译：皮肤病化合物
公开(公告)号：US06214888B1
公开(公告)日：2001-04-10
申请号：US09086547
申请日：1998-05-28
申请人： Wu Yun Ren , David A. Brown
发明人： Wu Yun Ren , David A. Brown
IPC分类号： A61K31045
CPC分类号： C07C35/29 , A61K31/045 , A61K31/047 , C07C2602/42
摘要： The present invention relates to novel monocyclic and bicyclic monoterpene diols that stimulate melanogenesis in mammalian skin, hair, wool or fur, and, are useful for treating or preventing various skin and proliferative disorders, neurodegenerative diseases, and diseases regulated by the nitric oxide/cyclic GMP/protein kinase G pathway.
摘要翻译：本发明涉及刺激哺乳动物皮肤，毛发，羊毛或毛皮中黑素生成的新颖单环和双环单萜二醇，并且可用于治疗或预防各种皮肤和增殖性疾病，神经退行性疾病和由一氧化氮/环状 GMP /蛋白激酶G途径。

36. 发明授权

US06194468B1 Hair growth stimulants 失效
标题翻译：头发生长兴奋剂
公开(公告)号：US06194468B1
公开(公告)日：2001-02-27
申请号：US09211053
申请日：1998-12-15
申请人： Renzo Hattori , Tadashi Fukuma
发明人： Renzo Hattori , Tadashi Fukuma
IPC分类号： A61K31045
CPC分类号： A61Q7/00 , A61K8/34 , A61K8/345 , A61K8/347 , A61K8/41 , A61K8/416 , A61K8/42 , A61K8/4973 , A61K8/63 , A61K8/675 , A61K8/678 , A61K2800/70 , A61K2800/782 , Y10S514/88
摘要： A hair growth stimulant comprising p-menthane-3,8-diol and at least one substance from the group of a blood circulation promoter, a 5&agr;-reductase inhibitor, an antihistaminic, a cell activator, an antiphlogistic and an antimicrobial is disclosed. The hair growth stimulant is free from hormonal action, does not cause side effects and has excellent hair growth promoting effects.
摘要翻译：公开了一种包含对薄荷烷-3,8-二醇和至少一种来自血液循环促进剂，5α-还原酶抑制剂，抗组胺剂，细胞活化剂，消炎药和抗微生物剂的物质的毛发生长刺激剂。头发生长兴奋剂没有激素作用，不会引起副作用，具有优异的头发生长促进作用。

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