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31. 发明授权

US07818065B2 Conducting polymer nanowire brain-machine interface systems and methods 有权
公开(公告)号：US07818065B2
公开(公告)日：2010-10-19
申请号：US11396340
申请日：2006-03-31
申请人： Rodolfo R. Llinas , Ian W. Hunter , Bryan P. Ruddy
发明人： Rodolfo R. Llinas , Ian W. Hunter , Bryan P. Ruddy
IPC分类号： A61N1/00
CPC分类号： A61B5/04001 , A61B5/4041 , B82Y10/00 , Y10S977/762 , Y10S977/925
摘要： The present invention relates to conducting polymer nanowires and their use in a brain-machine interface which is secure, robust and minimally invasive. In accordance with a first aspect of the present invention, a vascular-based brain-machine interface comprising conducting polymer nanowires is disclosed.

32. 发明授权

US07227056B2 Coleopteran-resistant transgenic plants and methods of their production 有权
标题翻译：鞘翅目抗性转基因植物及其生产方法
公开(公告)号：US07227056B2
公开(公告)日：2007-06-05
申请号：US10614076
申请日：2003-07-03
申请人： Leigh H. English , Susan M. Brussock , Thomas M. Malvar , James W. Bryson , Caroline A. Kulesza , Frederick S. Walters , Stephen L. Slatin , Michael A. Von Tersch , Charles Romano
发明人： Leigh H. English , Susan M. Brussock , Thomas M. Malvar , James W. Bryson , Caroline A. Kulesza , Frederick S. Walters , Stephen L. Slatin , Michael A. Von Tersch , Charles Romano
IPC分类号： C12N15/82 , A01H5/00 , A01H5/10
CPC分类号： C07K14/325 , Y10S977/925
摘要： Disclosed are nucleic acid segments comprising synthetically-modified genes encoding Coleopteran-toxic B. thuringiensis δ-endotoxins. Also disclosed are methods of using these genes for the recombinant expression of polypeptides, the preparation of vectors containing the genes, and methods for transforming suitable host cells.
摘要翻译：公开了包含编码鞘翅目昆虫毒素苏云金芽孢杆菌δ-内毒素的合成修饰基因的核酸片段。还公开了使用这些基因重组表达多肽的方法，含有该基因的载体的制备以及用于转化合适的宿主细胞的方法。

33. 发明授权

US06951922B2 Antibodies immunologically reactive with broad-spectrum delta endotoxins 失效
标题翻译：与广谱δ内毒素免疫反应的抗体
公开(公告)号：US06951922B2
公开(公告)日：2005-10-04
申请号：US10817182
申请日：2004-04-02
申请人： Thomas Malvar , Amy Jelen Gilmer
发明人： Thomas Malvar , Amy Jelen Gilmer
IPC分类号： A01H5/00 , A01N63/00 , C07K14/325 , C07K16/12 , C12N1/21 , C12N5/02 , C12N5/10 , C12N15/09 , C12N15/82 , C12P21/02 , C12R1/07 , G01N33/53 , C07K16/00 , C12P21/08
CPC分类号： C12N15/8286 , C07K14/325 , C07K2319/00 , Y02A40/162 , Y10S435/975 , Y10S977/914 , Y10S977/924 , Y10S977/925
摘要： Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity against coleopteran, dipteran and lepidopteran insects. Also disclosed are the nucleic acid segments encoding these novel peptides. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention.
摘要翻译：公开了具有改进的对鞘翅目，二ter和鳞翅目昆虫的杀虫活性的新型合成修饰的苏云金芽孢杆菌嵌合晶体蛋白。还公开了编码这些新肽的核酸片段。公开了制备和使用这些基因和蛋白质的方法以及重组表达和合适宿主细胞转化的方法。转化的宿主细胞和表达修饰的内毒素的转基因植物也是本发明的方面。

34. 发明申请

US20050203604A1 Medical devices incorporating carbon nanotube material and methods of fabricating same 有权
标题翻译：纳入碳纳米管材料的医疗器械及其制造方法
公开(公告)号：US20050203604A1
公开(公告)日：2005-09-15
申请号：US11038731
申请日：2005-01-20
申请人： Scott Brabec , Kenneth Gardeski
发明人： Scott Brabec , Kenneth Gardeski
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0565 , Y10S977/905 , Y10S977/925 , Y10S977/931
摘要： The present invention relates generally to medical devices; in particular and without limitation, to unique electrodes and/or electrical lead assemblies for stimulating cardiac tissue, muscle tissue, neurological tissue, brain tissue and/or organ tissue; to electrophysiology mapping and ablation catheters for monitoring and selectively altering physiologic conduction pathways; and, wherein said electrodes, lead assemblies and catheters optionally include fluid irrigation conduit(s) for providing therapeutic and/or performance enhancing materials to adjacent biological tissue, and wherein each said device is coupled to or incorporates nanostructure or materials therein. The present invention also provides methods for fabricating, deploying, and operating such medical devices.
摘要翻译：本发明一般涉及医疗器械; 特别是但不限于用于刺激心脏组织，肌肉组织，神经组织，脑组织和/或器官组织的独特电极和/或电引线组件; 用于电生理测绘和消融导管，用于监测和选择性地改变生理传导途径; 并且其中所述电极，引线组件和导管可选地包括用于向相邻生物组织提供治疗和/或性能增强材料的流体冲洗导管，并且其中每个所述装置与其中的纳米结构或材料耦合或结合。本发明还提供了制造，部署和操作这种医疗装置的方法。

35. 发明授权

US06871092B2 APPARATUS DESIGNED TO MODULATE THE NEUROVEGETATIVE SYSTEM AND INTEGRATE ITS ACTION WITH THAT OF THE CENTRAL NERVOUS SYSTEM; APPLICATIONS IN THE TREATMENT OF THE VASCULAR SYSTEM AND ORTHOPAEDIC DISORDERS 有权
标题翻译：设计用于调节神经移植系统并与中央神经系统整合其作用的装置; 应用于治疗血管系统和对症治疗
公开(公告)号：US06871092B2
公开(公告)日：2005-03-22
申请号：US10070949
申请日：2001-07-27
申请人： Lorenzo Piccone
发明人： Lorenzo Piccone
IPC分类号： A61N1/32 , A61N1/36 , A61N1/18
CPC分类号： A61N1/326 , A61N1/025 , A61N1/36021 , Y10S977/904 , Y10S977/925
摘要： This invention relates to a new type of apparatus designed to modulate the neurovegetative system and integrate the neurovegetative action with that of the central nervous system. The method is not invasive, because it uses pulses transmitted through the skin; the intensity of the stimulus is controlled directly by the patient in order to achieve better integration with the central nervous system. This invention effectively treats vascular disorders resulting from obstruction of the arteries of the legs, heart and brain because it induces vasodilatation and increases blood flow and the production of new blood vessels. The method also improves lesions of the spinal column, especially those affecting the back and neck, and other orthopaedic disorders.
摘要翻译：本发明涉及一种设计用于调节神经递质系统并将神经递质作用与中枢神经系统整合的新型装置。该方法不侵入，因为它使用透过皮肤的脉冲; 刺激的强度由患者直接控制，以便与中枢神经系统更好的整合。本发明有效地治疗由于阻塞腿，心脏和脑的动脉而导致的血管疾病，因为它引起血管扩张并增加血流量和新血管的产生。该方法还改善了脊柱的损伤，特别是影响后颈部和其他整形外科疾病的损伤。

36. 发明申请

US20030182682A1 Antibodies immunologically reactive with broad-spectrum delta endotoxins 有权
标题翻译：与广谱δ内毒素免疫反应的抗体
公开(公告)号：US20030182682A1
公开(公告)日：2003-09-25
申请号：US10365645
申请日：2003-02-12
申请人： Monsanto Technology LLC
发明人： Thomas Malvar , Amy Jelen Gilmer
IPC分类号： A01H001/00 , C12N015/82 , G01N033/53 , G01N033/567 , C07H021/04 , C12P021/02 , C12N001/21 , C07K014/325
CPC分类号： C12N15/8286 , C07K14/325 , C07K2319/00 , Y02A40/162 , Y10S435/975 , Y10S977/914 , Y10S977/924 , Y10S977/925
摘要： Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity against coleopteran, dipteran and lepidopteran insects. Also disclosed are the nucleic acid segments encoding these novel peptides. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention.
摘要翻译：公开了具有改进的对鞘翅目，二ter和鳞翅目昆虫的杀虫活性的新型合成修饰的苏云金芽孢杆菌嵌合晶体蛋白。还公开了编码这些新肽的核酸片段。公开了制备和使用这些基因和蛋白质的方法以及重组表达和合适宿主细胞转化的方法。转化的宿主细胞和表达修饰的内毒素的转基因植物也是本发明的方面。

37. 发明申请

US20030039997A1 Pentopyranosyl nucleic acid arrays, and uses thereof 有权
标题翻译：戊吡喃糖基核酸阵列及其用途
公开(公告)号：US20030039997A1
公开(公告)日：2003-02-27
申请号：US10150402
申请日：2002-05-16
申请人： Aventis Research and Technologies GmbH & Co. KG
发明人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Gerhard Burdinski
IPC分类号： C12Q001/68 , G01N033/53 , G01N033/542 , C12M001/34 , G01F001/64 , G01N027/26 , G01N033/50
CPC分类号： C07H21/00 , A61K47/549 , A61K49/0013 , C07H19/04 , C07H21/02 , C07H21/04 , G01N33/532 , Y10S977/728 , Y10S977/80 , Y10S977/836 , Y10S977/894 , Y10S977/896 , Y10S977/904 , Y10S977/914 , Y10S977/915 , Y10S977/924 , Y10S977/925
摘要： The invention relates to a pentopyranosylnucleoside of the formula (I) or of the formula (II) 1 their preparation and use for the production of a therapeutic, diagnostic and/or electronic component.
摘要翻译：本发明涉及式（I）或式（II）的戊吡喃糖基核苷及其制备和用于制备治疗，诊断和/或电子成分的方法。

38. 发明授权

US06492125B2 Method to assess library X library interactions 失效
标题翻译：评估库X库相互作用的方法
公开(公告)号：US06492125B2
公开(公告)日：2002-12-10
申请号：US09332613
申请日：1999-06-14
申请人： Lawrence M. Kauvar , John Sedat
发明人： Lawrence M. Kauvar , John Sedat
IPC分类号： G01N3353
CPC分类号： G01N33/54313 , G01N33/585 , G01N33/68 , Y10S977/918 , Y10S977/924 , Y10S977/925
摘要： Particulate labels that can be individually identified comprise particulate supports to which are bound at least two distinguishable signal-generating moieties, such as fluorophores emitting at different wavelengths, which signals are detectable and measurable in situ. By varying the ratio and/or amounts of the signal-generating moieties, a multiplicity of different and distinguishable labels is obtained. Each different label can then be coupled to a different reagent and the individual interactions of each reagent with a target observed in parallel.
摘要翻译：可以单独鉴定的颗粒状标签包括结合至少两个可区分的信号产生部分的颗粒载体，例如以不同波长发射的荧光团，该信号可原位检测和可测量。通过改变信号产生部分的比例和/或量来获得多个不同且可区别的标签。然后可以将每个不同的标记偶联到不同的试剂上，并且每个试剂与平行观察到的目标的各个相互作用。

39. 发明申请

US20020064865A1 Polynucleotide compositions encoding broad spectrum delta-endotoxins 有权
标题翻译：编码广谱δ-内毒素的多核苷酸组合物
公开(公告)号：US20020064865A1
公开(公告)日：2002-05-30
申请号：US09873873
申请日：2001-06-04
发明人： Thomas Malvar , Amy Jelen Gilmer
IPC分类号： G01N033/554 , G01N033/569 , C12N009/99 , A01H005/00 , C12N001/21
CPC分类号： C12N15/8286 , C07K14/325 , C07K2319/00 , Y02A40/162 , Y10S435/975 , Y10S977/914 , Y10S977/924 , Y10S977/925
摘要： Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity against coleopteran, dipteran and lepidopteran insects. Also disclosed are the nucleic acid segments encoding these novel peptides. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention.
摘要翻译：公开了具有改进的对鞘翅目，二ter和鳞翅目昆虫的杀虫活性的新型合成修饰的苏云金芽孢杆菌嵌合晶体蛋白。还公开了编码这些新肽的核酸片段。公开了制备和使用这些基因和蛋白质的方法以及重组表达和合适宿主细胞转化的方法。转化的宿主细胞和表达修饰的内毒素的转基因植物也是本发明的方面。

40. 发明申请

US20010044116A1 MULTIHUED LABELS 失效
标题翻译：多媒体标签
公开(公告)号：US20010044116A1
公开(公告)日：2001-11-22
申请号：US09332613
申请日：1999-06-14
发明人： LAWRENCE M. KAUVAR , JOHN SEDAT
IPC分类号： G01N033/53 , G01N033/542 , G01N033/537 , G01N033/543 , C07K016/00 , G01N033/566 , G01N033/531
CPC分类号： G01N33/54313 , G01N33/585 , G01N33/68 , Y10S977/918 , Y10S977/924 , Y10S977/925
摘要： Particulate labels that can be individually identified comprise particulate supports to which are bound at least two distinguishable signal-generating moieties, such as fluorophores emitting at different wavelengths, which signals are detectable and measurable in situ. By varying the ratio and/or amounts of the signal-generating moieties, a multiplicity of different and distinguishable labels is obtained. Each different label can then be coupled to a different reagent and the individual interactions of each reagent with a target observed in parallel.
摘要翻译：可以单独鉴定的颗粒状标签包括结合至少两个可区分的信号产生部分的颗粒载体，例如以不同波长发射的荧光团，该信号可原位检测和可测量。通过改变信号产生部分的比例和/或量来获得多个不同且可区别的标签。然后可以将每个不同的标记偶联到不同的试剂上，并且每个试剂与平行观察到的目标的各个相互作用。

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