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    • 35. 发明申请
    • Method and System for Determination of Molecular Interaction Parameters
    • 测定分子相互作用参数的方法和系统
    • US20160223566A1
    • 2016-08-04
    • US15097839
    • 2016-04-13
    • GE Healthcare Bio-Sciences AB
    • Robert KarlssonKarl AnderssonChristina Wass
    • G01N33/68
    • G01N33/53B01L3/5027G01N33/543G01N33/6854G01N35/08G01N2333/912G01N2333/936G01N2333/974G01N2333/988G01N2500/04G01N2500/20Y10S707/99943
    • A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface. An analytical system for carrying out the method, a computer program, a computer program product and a computer system for performing the method are also disclosed.
    • 确定固定在固体支持物表面的配体与溶液中配体的结合配偶体之间的可逆分子相互作用的动力学参数的方法包括顺序地,不经过固定配体的中间再生或更新,流过多个含有 在固体支持物表面上结合配偶体的不同已知浓度,监测与固体支持物表面结合的结合配偶体的瞬时量与结合配偶体的时间和溶液浓度相关并收集结合数据,以及通过全局拟合来确定动力学参数 用于结合配偶体和固定的配体与收集的结合数据之间相互作用的预定动力学模型,该模型允许在固体支持物表面的质量传递限制。 还公开了用于执行该方法的分析系统,计算机程序,计算机程序产品和用于执行该方法的计算机系统。
    • 38. 发明申请
    • METHODS, SYSTEMS, AND COMPUTER PROGRAM PRODUCTS FOR IMPLEMENTING INTELLIGENT AGENT SERVICES
    • 用于实施智能代理服务的方法,系统和计算机程序产品
    • US20160162589A1
    • 2016-06-09
    • US15041042
    • 2016-02-11
    • AT&T Intellectual Property I, LP
    • Steven N. Tischer
    • G06F17/30H04L29/08
    • G06F17/30867G06F17/30312G06F17/30377G06F17/30604H04L67/22Y10S707/99933Y10S707/99943
    • An aspect includes generating an ontological domain based upon information elements, which elements represent aspects of detectable behaviors of an individual. A portion of the behaviors are captured via input of the individual, and another portion is received from a source that is independent of the computer and absent any user input. The generating includes creating subdomains of contextually organized collections of the information elements by topic, comparing the information elements across the subdomains, determining relationships of the information elements across topics based on common features, and determining relevance of the relationships across the subdomains based on measurable aspects of the information elements, whereby the relationships determined to be relevant are identified as an interest of the individual. The services also include searching sources of information using the information elements having the relationships determined to be relevant, and transmitting a solution to a device associated with the individual.
    • 一方面包括基于信息元素生成本体论领域,哪些元素表示个体可检测行为的方面。 行为的一部分通过个体的输入来捕获,另一部分从独立于计算机的源接收并且不存在任何用户输入。 生成包括通过主题创建信息元素的上下文组织的集合的子域,比较子域中的信息元素,基于共同特征确定各个主题之间的信息元素的关系,以及基于可测量的方面来确定子域之间的关系的相关性 的信息要素,将确定为相关的关系确定为个人的利益。 服务还包括使用具有确定为相关的关系的信息元素来搜索信息源,并将解决方案发送到与个人相关联的设备。