专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US06914051B1 Penetrating antibiotic gel for soft tissue diseases 有权
标题翻译：穿透抗生素凝胶软组织疾病
公开(公告)号：US06914051B1
公开(公告)日：2005-07-05
申请号：US09896368
申请日：2001-06-28
申请人： David M Allen
发明人： David M Allen
IPC分类号： A61K31/7048 , A61K47/10 , A61K47/24 , A61K9/00 , A61K9/06 , A61K9/10 , A61K9/127
CPC分类号： A61K31/7048 , A61K9/0014 , A61K47/10 , A61K47/24 , Y10S514/825 , Y10S514/886 , Y10S514/887 , Y10S514/937 , Y10S514/944 , Y10S514/946
摘要： A penetrating antibiotic gel for treating pain, inflammation and other pathological conditions affecting musculoskeletal tissues and other soft tissues of the body. The composition includes an antibiotic compound and a mobilizing agent in an amount sufficient to enable the antimicrobial compound to penetrate into the sub-dermal soft tissues. The antimicrobial compound may be a macrolide antibiotic compound such as azithromycin, erythromycin or roxithromycin, for example, and the mobilizing agent may be an organogel compound, such as pluronic lecithin liposomal organogel (PLO). The composition may further include a penetration enhancing adjuvant, such as d-limonene, for example. The composition may be applied topically so as to penetrate into the sub-dermal soft tissues, or may injected so as to be absorbed into the soft tissues locally.
摘要翻译：用于治疗影响肌肉骨骼组织和身体其他软组织的疼痛，炎症和其他病理状况的穿透性抗生素凝胶。组合物包含足以使抗微生物化合物渗透到皮下软组织中的量的抗生素化合物和动员剂。抗微生物化合物可以是大环内酯类抗生素化合物，例如阿奇霉素，红霉素或罗红霉素，并且动员剂可以是有机凝胶化合物，例如普流尼克磷脂脂质体有机凝胶（PLO）。组合物可以进一步包括渗透促进佐剂，例如d-柠檬烯。组合物可以局部施用以渗透到皮下软组织中，或者可以注射以局部吸收到软组织中。

32. 发明申请

US20050123632A1 Anti-inflammatory activity of a specific turmeric extract 有权
标题翻译：特定姜黄提取物的抗炎活性
公开(公告)号：US20050123632A1
公开(公告)日：2005-06-09
申请号：US10989874
申请日：2004-11-15
申请人： Guan Chen , Robert Lantz , Aniko Solyom , Barbara Timmermann , Shivanand Jolad
发明人： Guan Chen , Robert Lantz , Aniko Solyom , Barbara Timmermann , Shivanand Jolad
IPC分类号： A61K36/00 , A61K36/9066 , A61K35/78
CPC分类号： A61K36/9066 , Y10S514/825 , Y10S514/885 , Y10S514/886
摘要： Disclosed herein are mixtures of turmeric extract oils. One mixture of turmeric oils is the hexane soluble fraction obtained by dissolving turmeric powder in hexane to form a hexane mixture, filtering the hexane mixture and evaporating the hexane from the turmeric oil mixture. A more refined turmeric oil combination is the oil left after the turmeric oil mixture is dissolved in hexane, placed on a silica gel/hexane chromatography column, and eluted with hexane into fractions that were then evaporated, thereby leaving the refined turmeric oil combination. Also disclosed are methods for treating inflammation, arthritis and rheumatoid arthritis and a pharmaceutical dosage form of the refined turmeric oil combination.
摘要翻译：本文公开了姜黄提取物油的混合物。姜黄油的一种混合物是通过将姜黄粉溶于己烷中形成己烷混合物，过滤己烷混合物并从姜黄油混合物中蒸发己烷而获得的己烷可溶级分。更精炼的姜黄油组合是将姜黄油混合物溶解在己烷中后留下的油，置于硅胶/己烷层析柱上，用己烷洗脱，然后蒸发，从而留下精制的姜黄油组合。还公开了治疗炎症，关节炎和类风湿性关节炎的方法以及精制姜黄油组合的药物剂型。

33. 发明申请

US20050048148A1 Compositions comprising thylakoids useful in the modulation of inflammation process 有权
标题翻译：包含可用于调节炎症过程的类囊体的组合物
公开(公告)号：US20050048148A1
公开(公告)日：2005-03-03
申请号：US10482797
申请日：2002-07-02
申请人： Alain Anderson , Elyse Bissonnette , Rejean Drouin , Marc Purcell
发明人： Alain Anderson , Elyse Bissonnette , Rejean Drouin , Marc Purcell
IPC分类号： A61K45/00 , A61K31/573 , A61K31/60 , A61K36/00 , A61K36/18 , A61K36/21 , A61P29/00 , A61P43/00 , A61K35/78
CPC分类号： A61K36/00 , A61K36/21 , Y10S514/886 , Y10S514/887 , A61K2300/00
摘要： This invention relates to the use of a thylakoid extract that is preferably stabilized and activable for treating inflammation. Different types of cell or tissue targets and inflammatory stimuli have been used to evaluate the performance of the extract, which, in all cases successfully modulate inflammation through a balance of pro/anti-inflammatory cytokines. Compositions comprising the extract and other anti-inflammatory agents, namely glucocorticoids or NSAIDs are further disclosed and claimed.
摘要翻译：本发明涉及优选稳定和可激活用于治疗炎症的类囊体提取物的用途。已经使用不同类型的细胞或组织靶标和炎症刺激来评价提取物的性能，其在所有情况下通过促炎症/抗炎细胞因子的平衡成功地调节炎症。包含提取物和其它消炎剂的组合物，即糖皮质激素或NSAIDs进一步公开和要求保护。

34. 发明授权

US06833353B1 Use of immunosuppressants for MMP mediated diseases 失效
标题翻译：免疫抑制剂用于MMP介导的疾病
公开(公告)号：US06833353B1
公开(公告)日：2004-12-21
申请号：US09786359
申请日：2001-03-14
申请人： Nobuchika Yamamoto , Harumi Yamazaki , Takeshi Ishikawa , Shigeru Johki , Fumihiko Sakai
发明人： Nobuchika Yamamoto , Harumi Yamazaki , Takeshi Ishikawa , Shigeru Johki , Fumihiko Sakai
IPC分类号： A61K3800
CPC分类号： A61K38/13 , A61K31/00 , A61K31/436 , Y10S514/886
摘要： A new use of immunosuppressant for treating or preventing MMp-medicated diseases is provided. The preferred immunosuppresants are tacrolimus, cyclosporing A or 33-epi-chloro-33-desoxyascomycin (pimecrolimus). Particularly, preferable MMP-mediated diseases are the diseases or conditions caused by gelatinase and/or collagenase, and/or inflammatory diseases concerned with gelatinase; such as arthritis (e.g., osteoarthritis, rheumatoid arthritis, etc.) cerebral diseases (e.g., stroke, etc.), tissue ulceration (e.g., corneal, epidermal and gastriculceration, etc.), abnormal wound healing, periodontal diseases, bone diseases (e.g., Paget's diseases, osteoporosis. etc.), tumor growth, tumor metastasis or invasion, HIV-infection, decubitus, decubitis ulcer, restenosis, epidermolysis bullosa, sepsis, septic shock, neoplasm, psoriasis, neovascularization and multiple sclerosis.
摘要翻译：提供了一种新的免疫抑制剂用于治疗或预防MMP药物疾病的新用途。优选的免疫抑制剂是他克莫司，环孢菌素A或33-表氯-3-脱氧菌丝霉素（吡美莫司）。特别地，优选的MMP介导的疾病是由明胶酶和/或胶原酶引起的疾病或病症，和/或与明胶酶相关的炎性疾病; 例如关节炎（例如骨关节炎，类风湿性关节炎等）脑疾病（例如中风等），组织溃疡（例如角膜，表皮和胃溃疡等），异常伤口愈合，牙周病，骨病（例如佩吉特氏病，骨质疏松症等），肿瘤生长，肿瘤转移或侵袭，HIV感染，褥疮，褥疮性溃疡，再狭窄，大疱性表皮松解，败血症，败血性休克，肿瘤，牛皮癣，新生血管形成和多发性硬化。

35. 发明申请

US20040235811A1 Fatty acid modified forms of glucocorticoids 审中-公开
标题翻译：脂肪酸修饰形式的糖皮质激素
公开(公告)号：US20040235811A1
公开(公告)日：2004-11-25
申请号：US10681614
申请日：2003-10-08
申请人： Sepracor Inc.
发明人： Mark G. Currie , Steven Jones , Charles M. Zepp
IPC分类号： A61K031/56 , C07J005/00
CPC分类号： C07J5/00 , C07J5/0076 , C07J5/0092 , C07J71/0031 , Y10S514/826 , Y10S514/886
摘要： Compounds are disclosed of the formula 1 in which R3 is C8 to C24 hydrocarbon or the residue of misoprostol. The compounds are useful for treating rhinitis and asthma, particularly by inhalation, and for treating inflammation, particularly by local or topical administration.
摘要翻译：公开了下式的化合物，其中R 3为C 8至C 24烃或米索前列醇的残基。该化合物可用于治疗鼻炎和哮喘，特别是通过吸入治疗和治疗炎症，特别是通过局部或局部给药治疗炎症。

36. 发明申请

US20040228905A1 Anti-inflammatory and antimicrobial uses for bioactive glass compositions 审中-公开
公开(公告)号：US20040228905A1
公开(公告)日：2004-11-18
申请号：US10865636
申请日：2004-06-10
发明人： David C. Greenspan , Jon K. West , Sean Lee , James L. Meyers , Mason Diamond
IPC分类号： A61K033/24 , A61K009/14 , A61K031/65
CPC分类号： A61Q1/02 , A61K8/25 , A61K45/06 , A61L15/18 , A61L15/44 , A61L15/46 , A61Q5/00 , A61Q17/005 , A61Q19/00 , C03C4/0007 , Y10S424/13 , Y10S514/829 , Y10S514/83 , Y10S514/831 , Y10S514/859 , Y10S514/861 , Y10S514/862 , Y10S514/863 , Y10S514/864 , Y10S514/886 , Y10S514/887 , Y10S514/951 , Y10S514/965
摘要： Compositions and methods for treating wounds to significantly reduce the healing time, reduce the incidence of scar formation, improve the success of skin grafts, reduce the inflammatory response and providing anti-bacterial treatments to a patient in need thereof, that include small non-interlinked particles of bioactive glass or highly porous bioactive glass, are disclosed. Anti-bacterial solutions derived from bioactive glass, and methods of preparation and use thereof, are also disclosed. The compositions include non-interlinked particles of bioactive glass, alone or in combination with anti-bacterial agents and/or anti-inflammatory agents. The compositions can include an appropriate carrier for topical administration. Anti-bacterial properties can be imparted to implanted materials, such as prosthetic implants, sutures, stents, screws, plates, tubes, and the like, by incorporating small bioactive glass particles or porous bioactive glass into or onto the implanted materials. Anti-bacterial properties can also be imparted to devices used for in vitro and ex vivo cell culture by incorporating non-interlinked particles of bioactive glass into the devices. Anti-bacterial compositions derived from aqueous extracts of bioactive glass are also disclosed. These compositions can be used, for example, in food preparation, solutions used for cell culture, and buffer solutions, such as i.v. solutions.

37. 发明申请

US20040180009A1 Methods for preventing photodamaged skin by administering selegiline or desmethylselegiline 失效
标题翻译：通过施用司来吉兰或去甲司来吉兰来防止光损伤皮肤的方法
公开(公告)号：US20040180009A1
公开(公告)日：2004-09-16
申请号：US10806494
申请日：2004-03-23
发明人： Mark G. Resnick
IPC分类号： A61K007/42 , A61K009/00 , A61K031/137
CPC分类号： A61K31/137 , Y10S514/87 , Y10S514/871 , Y10S514/886 , Y10S514/887 , Y10S514/944
摘要： The present invention is directed to methods that can be used in the treatment of wounds, burns, and photodamaged skin. Methods can be used for both humans and animals and involve the administration of compositions containing selegiline and/or desmethylselegiline.
摘要翻译：本发明涉及可用于治疗伤口，烧伤和光损伤皮肤的方法。方法可以用于人和动物，并涉及施用含有司来吉兰和/或去甲司来吉兰的组合物。

38. 发明申请

US20040131606A1 Product and process for liquefaction of mucus for sputum 有权
标题翻译：用于痰粘液液化的产品和方法
公开(公告)号：US20040131606A1
公开(公告)日：2004-07-08
申请号：US10660118
申请日：2003-09-10
发明人： Carl W. White
IPC分类号： A61K038/48
CPC分类号： A61K38/44 , A61K9/0053 , A61K31/385 , A61K31/7084 , C12N9/0051 , C12Y108/01009 , C12Y108/0401 , Y10S514/824 , Y10S514/826 , Y10S514/886 , A61K2300/00
摘要： Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The composition contains a protein or peptide containing a thioredoxin active-site in reduced state and optionally further contains a reducing system.
摘要翻译：公开了用于降低过度或异常粘稠或粘性粘液或痰液的粘度和/或内聚力和/或增加液化的组合物和方法。组合物含有含有还原状态的硫氧还蛋白活性位点的蛋白质或肽，并且任选地还含有还原体系。

39. 发明授权

US06753320B1 LIF for use in modulating inflammation and pain 有权
标题翻译： LIF用于调节炎症和疼痛
公开(公告)号：US06753320B1
公开(公告)日：2004-06-22
申请号：US09712028
申请日：2000-11-13
申请人： Paul H. Patterson , Clifford J. Woolf
发明人： Paul H. Patterson , Clifford J. Woolf
IPC分类号： A61K4800
CPC分类号： A61K38/1709 , Y10S514/886 , Y10S514/887
摘要： A method for inhibiting and/or reducing inflammation and/or pain in an individual is provided, as well as edema and macrophage infiltration associated with inflammation. The method comprises administration of leukemia inhibitory factor (LIF) to a cell or an individual in an amount effective to inhibit and/or reduce inflammation and/or pain.
摘要翻译：提供了抑制和/或减少个体炎症和/或疼痛的方法，以及与炎症相关的水肿和巨噬细胞浸润。该方法包括以有效抑制和/或减少炎症和/或疼痛的量向细胞或个体施用白血病抑制因子（LIF）。

40. 发明申请

US20040105840A1 Protein conjugates with a water-soluble biocompatible, biodegradable polymer 有权
标题翻译：蛋白质与水溶性生物相容的生物可降解聚合物结合
公开(公告)号：US20040105840A1
公开(公告)日：2004-06-03
申请号：US10622998
申请日：2003-07-18
发明人： Olaf B. Kinstler , David L. Ladd , Mikahil I. Papisov
IPC分类号： A61K031/765 , C08G016/02
CPC分类号： C12N9/6421 , A61K38/00 , A61K47/59 , A61K47/62 , C07K14/54 , C07K14/5759 , C08L59/00 , Y10S514/886 , Y10S514/909
摘要： The present invention broadly relates to the field of protein modification, and, more specifically, to conjugates of proteins or analogs thereof to a water-soluble biocompatible polymer and methods of making and using the same.
摘要翻译：本发明广泛涉及蛋白质修饰领域，更具体地说，涉及蛋白质或其类似物与水溶性生物相容性聚合物的结合物及其制备和使用方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式