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31. 发明申请

US20070287198A1 Directed-flow assay device 有权
标题翻译：定向流量测定装置
公开(公告)号：US20070287198A1
公开(公告)日：2007-12-13
申请号：US11452725
申请日：2006-06-13
申请人： Ronald T. LaBorde , Herbert S. Chow
发明人： Ronald T. LaBorde , Herbert S. Chow
IPC分类号： G01N33/551 , C12M3/00
CPC分类号： G01N33/558 , B01L3/5023 , B01L9/52 , B01L2200/026 , B01L2300/0825 , G01N33/54326 , G01N33/54386 , Y10S435/805 , Y10S435/81 , Y10S436/807 , Y10S436/808 , Y10S436/81
摘要： A diagnostic assay device that directs an applied sample to the analytical membrane of a directed flow device. The device has a sample receiving port defined by layers of built-up material on one end of the test strip. The port contains the sample and specifically directs it to the membrane in a controlled fashion. Additional features include configuration of the housing in a general C-shape with the test strip spanning the opening of the C-shape to allow access by a reader device. A preferred method employs superparamagnetic particles to label the target analytes for detection and measurement by means of an electromagnetic reader device.
摘要翻译：将应用的样品引导到定向流动装置的分析膜的诊断测定装置。该装置具有在测试条的一端上由积累材料层限定的样品接收端口。港口包含样品，并以受控的方式将其特异性地引导到膜上。另外的特征包括壳体的一般C形结构，测试条跨过C形开口以允许读取器装置进入。优选的方法使用超顺磁性颗粒来标记目标分析物，以便通过电磁读取器装置进行检测和测量。

32. 发明申请

US20070243630A1 Quantitative lateral flow assays and devices 有权
标题翻译：定量侧流测定和装置
公开(公告)号：US20070243630A1
公开(公告)日：2007-10-18
申请号：US11595777
申请日：2006-11-08
申请人： Hans Boehringer , Gerald Rowley , Allan Pronovost
发明人： Hans Boehringer , Gerald Rowley , Allan Pronovost
IPC分类号： G01N33/566
CPC分类号： G01N33/689 , G01N33/558 , G01N33/76 , Y10S435/805 , Y10S435/81 , Y10S435/969 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/805 , Y10S436/808 , Y10S436/81
摘要： This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention employ labelled reagents which are either analyte analogs or complementary specific binding pair members for the analyte and a novel arrangement of capture zones comprising immobilized specific binding substances for either the analyte or the labelled reagent to effect bound from unbound labelled reagent as a function of analyte concentration. The capture zones are disposed on a non-bibulous matrix defining a flow path from a sample receiving zone to the capture zone. The devices of this invention also include multilane flow paths and multiple capture zones to quantitate analyte.
摘要翻译：本发明提供固相特异性结合侧流测定方法，用于定量高分子量和低分子量分析物的装置和试剂盒。本发明的方法和装置使用标记试剂，其为分析物的分析物类似物或互补特异性结合对成员，以及包含用于分析物或标记试剂的固定化特异性结合物质的俘获区的新布置，以实现未结合的标记试剂作为分析物浓度的函数。捕获区域设置在非吸收性矩阵上，其限定从样品接收区到捕获区的流动路径。本发明的装置还包括多通道流动路径和多个捕获区域以定量分析物。

33. 发明申请

US20070111299A1 Device and method for multiple analyte detection 审中-公开
公开(公告)号：US20070111299A1
公开(公告)日：2007-05-17
申请号：US11651318
申请日：2007-01-09
申请人： Timothy Woudenberg , Michael Albin , Reid Kowallis , Yefim Raysberg , Robert Ragusa , Emily Winn-Deen
发明人： Timothy Woudenberg , Michael Albin , Reid Kowallis , Yefim Raysberg , Robert Ragusa , Emily Winn-Deen
IPC分类号： C12M1/34
CPC分类号： C12Q1/6816 , B01J2219/00317 , B01J2219/00599 , B01J2219/00722 , B01L3/5027 , B01L3/502715 , B01L3/50851 , B01L7/52 , B01L2200/027 , B01L2200/0642 , B01L2300/0816 , B01L2300/0864 , B01L2300/1827 , B01L2400/049 , C12Q1/08 , C40B40/06 , C40B50/08 , C40B60/14 , G01N21/6452 , G01N2035/00148 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , C12Q2565/631
摘要： The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. The device includes a substrate which defines a sample-distribution network having (i) a sample inlet, (ii) one or more detection chambers, and (iii) channel means providing a dead-end fluid connection between each of the chambers and the inlet. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.

34. 发明授权

US07195922B1 Allergen detection 失效
标题翻译：过敏原检测
公开(公告)号：US07195922B1
公开(公告)日：2007-03-27
申请号：US10009109
申请日：2000-06-09
申请人： Ramin Pirzad
发明人： Ramin Pirzad
IPC分类号： G01N33/00 , G01N21/78
CPC分类号： G01N33/52 , G01N31/22 , G01N33/6809 , Y10S436/805 , Y10S436/808
摘要： A method of determining allergen activity in dust comprises: providing a dust sample; extracting from the dust sample at least one breakdown component or proteins or peptides; reacting the extracted at least one breakdown component with a colorimetric amine detection reagent such as TNBSA; and quantitatively measuring the intensity of any resulting coloration. The allergen activity may be gauged by the intensity of coloration.
摘要翻译：确定粉尘中过敏原活性的方法包括：提供粉尘样品; 从灰尘样品中提取至少一种分解成分或蛋白质或肽; 将所提取的至少一种击穿组分与比色胺检测试剂如TNBSA反应; 并定量测量任何所得着色的强度。过敏原活性可以通过着色强度来测定。

35. 发明申请

US20070042499A1 Device and method for simultaneously carrying out blood group determination, serum cross-check and antibody detection test 有权
标题翻译：同时进行血型测定，血清交叉检验和抗体检测试验的装置和方法
公开(公告)号：US20070042499A1
公开(公告)日：2007-02-22
申请号：US10563681
申请日：2004-07-08
申请人： Peter Schwind , Klemens Loster
发明人： Peter Schwind , Klemens Loster
IPC分类号： G01N21/00
CPC分类号： G01N33/80 , G01N33/558 , Y10S435/97 , Y10S436/808 , Y10S436/81
摘要： This invention relates to a device for the simultaneous qualitative or quantitative determination of several analytes in a liquid sample, comprising a membrane (2) with a charging zone (5), for the application of the liquid sample, at least two indicator zones which can interact with the analyte(s) and at least one absorption region (3), which accepts the fluid after passing through the indicator zones, whereby the indicator zones lie between the charging zone (5) and an absorption region (3), characterized in that the flow directions (flow tracks) are essentially parallel from the application zone (5) through each indicator zone to an absorption region (3) and at least two different flow tracks are present. The invention further relates to a method for the determination of several analytes or derivatives thereof in a liquid sample, comprising: application of the sample to the charging zone (5) of a membrane of the device as given in claims 1 to 8, whereby said sample is present in sufficient amounts to permit the sample fluid to flow in the direction of the absorption region (3) through the indicator zones and to permit the analytes or derivatives thereof in the liquid sample to form a complex in the indicator zone.
摘要翻译：本发明涉及用于同时定量或定量测定液体样品中几种分析物的装置，其包括具有用于施用液体样品的带电区（5）的膜（2），至少两个指示区，其可以与分析物和至少一个吸收区域（3）相互作用，其在通过指示区域之后接受流体，由此指示区域位于充电区域（5）和吸收区域（3）之间，其特征在于流动方向（流动轨迹）从施加区域（5）基本上平行通过每个指示器区域到吸收区域（3），并且存在至少两个不同的流动轨迹。本发明还涉及一种用于确定液体样品中几种分析物或其衍生物的方法，包括：将样品施加到如权利要求1至8所述的装置的膜的装料区（5）中，由此所述样品以足够的量存在以允许样品流体沿吸收区域（3）的方向通过指示器区域流动，并允许液体样品中的分析物或衍生物在指示器区域中形成复合物。

36. 发明申请

US20070042414A1 Retentate chromatography and protein chip arrays with applications in biology and medicine 审中-公开
标题翻译：保留色谱和蛋白质芯片阵列在生物学和医学应用
公开(公告)号：US20070042414A1
公开(公告)日：2007-02-22
申请号：US11509278
申请日：2006-08-23
申请人： T. Hutchens , Tai-Tung Yip
发明人： T. Hutchens , Tai-Tung Yip
IPC分类号： C40B30/06 , C40B40/08 , C40B50/06
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
摘要翻译：本发明提供了用于分析样品中分析物的滞留层析方法。所述方法包括在多种不同的选择性条件下将分析物吸附到底物上，并通过解吸光谱法检测保留在底物上的分析物。这些方法在生物学和医学中是有用的，包括临床诊断和药物发现。

37. 发明申请

US20070037233A1 Detection of Preharvest Sprouting in Cereal Grains 失效
标题翻译：检测谷物中的收获前发芽
公开(公告)号：US20070037233A1
公开(公告)日：2007-02-15
申请号：US11421712
申请日：2006-06-01
申请人： John Skerritt
发明人： John Skerritt
IPC分类号： G01N33/53 , C07K16/40
CPC分类号： G01N33/573 , Y10S436/808 , Y10S530/866
摘要： A two-site immunoassay for the qualitative or quantitative detection of alpha-amylase in a test sample, said immunoassay comprising; (i) exposing said test sample to a first (“capture”) antibody or fragment thereof which specifically or preferentially binds to a first epitope on said alpha-amylase, under conditions permitting binding of said first antibody or fragment thereof to alpha-amylase if present, (ii) subsequently exposing bound alpha-amylase, if any, to a second (“detection”) antibody or fragment thereof which specifically or preferentially binds to a second epitope on said alpha-amylase that is distinct from said first epitope, under conditions permitting binding of said second antibody or fragment thereof to said bound alpha-amylase, and (iii) detecting any binding of said second antibody or fragment thereof to said bound alpha-amylase, wherein either of said first or second epitopes is an epitope comprising one or more of the amino acid sequences; IDRLVSIRTRGQIHS (SEQ ID NO: 1), CRDDRPYADG (SEQ ID NO: 2), VNWVNKVGGS (SEQ ID NO: 3) and variants thereof showing ≧80%, more preferably ≧90%, sequence identity. The immunoassay is useful for detecting weather damage (i.e. pre-harvest sprouting) in cereal grain.
摘要翻译：用于定量或定量检测测试样品中α-淀粉酶的双位点免疫测定法，所述免疫测定法包括：（i）在允许所述第一抗体或其片段与α-淀粉酶结合的条件下，将所述测试样品暴露于第一（“捕获”）抗体或其片段，其特异性或优先地结合所述α-淀粉酶上的第一表位，如果存在，（ii）随后将结合的α-淀粉酶（如果有的话）暴露于与所述第一表位不同的所述α-淀粉酶上特异性或优先结合至第二表位的第二（“检测”）抗体或其片段，允许所述第二抗体或其片段与所述结合的α-淀粉酶结合的条件，和（iii）检测所述第二抗体或其片段与所述结合的α-淀粉酶的任何结合，其中所述第一或第二表位中的任一个是包含一个或多个氨基酸序列; IDRLVSIRTRGQIHS（SEQ ID NO：1），CRDDRPYADG（SEQ ID NO：2），VNWVNKVGGS（SEQ ID NO：3）及其变体显示≥80％，更优选≥90％的序列同一性。免疫测定可用于检测谷物中的天气损伤（即收获前发芽）。

38. 发明授权

US07172873B2 Methods of detecting early renal disease in animals 有权
标题翻译：检测动物早期肾病的方法
公开(公告)号：US07172873B2
公开(公告)日：2007-02-06
申请号：US10112648
申请日：2002-03-28
申请人： Thomas McDonald , Wayne Arthur Jensen , Annika Weber , Janet S. Andrews
发明人： Thomas McDonald , Wayne Arthur Jensen , Annika Weber , Janet S. Andrews
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , C07K16/18 , G01N33/6893 , G01N2800/347 , Y10S436/808 , Y10S436/815
摘要： The present invention provides a method for the detection of early renal disease in animals. The method includes the steps of (a) obtaining a sample from an animal to be tested and (b) determining the amount of albumin in the sample. An amount of albumin in the range of from 10 μg/ml to about 300 μg/ml indicates the presence of early renal disease. The present invention also provides antibodies to canine, feline and equine albumin which can be used to detect the presence of early renal disease.
摘要翻译：本发明提供一种检测动物早期肾病的方法。该方法包括以下步骤：（a）从待测试的动物获得样品，和（b）测定样品中白蛋白的量。 10μg/ ml至约300μg/ ml范围内的白蛋白量表明存在早期肾脏疾病。本发明还提供了可用于检测早期肾病的存在的犬，猫和马白蛋白的抗体。

39. 发明授权

US07172728B2 Test strip containers and methods of using the same 有权
标题翻译：测试条容器及其使用方法
公开(公告)号：US07172728B2
公开(公告)日：2007-02-06
申请号：US10116086
申请日：2002-04-02
申请人： Gary Otake
发明人： Gary Otake
IPC分类号： G01N31/22 , G01N21/00
CPC分类号： G01N33/48778 , A61B10/0045 , G01N33/48757 , Y10S436/808 , Y10T436/25
摘要： Devices for dispensing test strips and methods of using the same are provided. The subject devices are characterized by having a base and a cover, where the cover includes a test strip selecting element. The subject devices may also be characterized by having a test strip holding means, which may include a cover with resiliently deformable walls and/or a gravity controlled test strip holding mechanism. In the subject methods, a test strip container with at least one test strip is provided and placed into a position that causes at least one test strip contained in the base to move into the cover so that a single test strip is selected for use. The subject methods may also include positioning the device in a particular orientation that causes a selected test strip to be held in a fixed position. The subject invention also includes kits which include the subject devices.
摘要翻译：提供用于分配测试条的装置及其使用方法。主题装置的特征在于具有底座和盖，其中盖包括测试条选择元件。主题装置的特征还在于具有测试条保持装置，其可以包括具有可弹性变形的壁和/或重力控制的测试条保持机构的盖。在主题方法中，提供具有至少一个测试条的测试条容器并将其放置在使得包含在基座中的至少一个测试条移动到盖中的位置，使得选择单个测试条使用。主题方法还可以包括将设备定位在使得所选择的测试条被保持在固定位置的特定取向上。本发明还包括包括本发明装置的试剂盒。

40. 发明授权

US07160734B2 Retentate chromatography and protein chip arrays with applications in biology 有权
标题翻译：保留色谱和蛋白质芯片阵列与生物学应用
公开(公告)号：US07160734B2
公开(公告)日：2007-01-09
申请号：US10150587
申请日：2002-05-17
申请人： T. William Hutchens , Tai-Tung Yip
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： G01N33/543
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
摘要翻译：本发明提供了用于分析样品中分析物的滞留层析方法。所述方法包括在多种不同的选择性条件下将分析物吸附到底物上，并通过解吸光谱法检测保留在底物上的分析物。这些方法在生物学和医学中是有用的，包括临床诊断和药物发现。

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