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    • 34. 发明申请
    • Self Assembling Beta-Barrel Proteins Position Nanotubes
    • 自组装β-桶蛋白位置纳米管
    • US20160016801A1
    • 2016-01-21
    • US14772665
    • 2014-03-05
    • PROLUME, LTD.
    • Bruce Bryan
    • C01B31/02C07K14/005C08J9/12C12N9/02
    • C01B31/0226B82Y30/00B82Y40/00C01B32/158C01B32/16C07K14/005C08H1/00C08J9/122C08J2383/00C12N9/0069C12N2770/00051
    • The present invention relates to the extraordinary properties of recently discovered nanotubes. This disclosure teaches a method for using barrel proteins acting as scaffolds to guide assembly of nanotubes, and using nano-molecular molding jigs to format the nanotubes into stable arrays with the precise geometric architecture desired. This disclosure teaches nanotube technology with principles of protein folding and aggregated self-assembly. In certain embodiments, the disclosure teaches using highly modified barrel proteins to form hydrophobic and hydrophilic channels that guide the nanotubes into their centers, or other geometric patterns utilizing silicone aerogel to form nano-molecular molds, jigs, and surfaces to position nanotubes in precise geometric arrangements and arrays. This disclosure teaches new uses of barrel proteins as self-assembling molding tools to develop new nanometer scaled devices and their uses herein.
    • 本发明涉及最近发现的纳米管的非凡性质。 本公开教导了一种使用用作支架的桶蛋白引导纳米管的组装的方法,并且使用纳米分子模制夹具将纳米管形成具有所需精确几何结构的稳定阵列。 本公开教导了具有蛋白质折叠和聚合自组装原理的纳米管技术。 在某些实施方案中,本公开教导使用高度修饰的桶蛋白以形成引导纳米管进入其中心的疏水和亲水的通道,或利用硅氧烷气凝胶形成纳米分子模具,夹具和表面以定位精确几何的纳米管的其它几何图案 安排和阵列。 本公开教导了桶蛋白质的新用途作为自组装模制工具来开发新的纳米级装置及其在这里的用途。