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31. 发明申请

US20070293418A1 Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis 有权
标题翻译：具有降低的酶水解趋势的药理学活性肽缀合物
公开(公告)号：US20070293418A1
公开(公告)日：2007-12-20
申请号：US11807159
申请日：2007-05-25
申请人： Bjarne Larsen
发明人： Bjarne Larsen
IPC分类号： A61K38/16 , C07K1/06 , C07K14/00 , C12P21/04
CPC分类号： C07K14/665 , A61K38/00 , A61K47/64 , A61K47/65 , A61K47/67 , B82Y5/00 , C07K1/1075 , C07K14/575 , C07K14/57545 , C07K14/675 , C07K14/68 , C07K14/685 , C07K14/695 , C07K2319/31
摘要： The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage comprising a pharmacologically active peptide sequence (X) and a stabilising peptide sequence (Z) of 4-20 amino acid residues covalently bound to X.
摘要翻译：本发明涉及具有减少的酶切割趋势的药理学活性肽缀合物，其包含与X共价结合的4-20个氨基酸残基的药理学活性肽序列（X）和稳定肽序列（Z）。

32. 发明申请

US20070290173A1 HIGHLY HOMOGENOEOUS MOLECULAR MARKERS FOR ELECTROPHORESIS 审中-公开
标题翻译：高均质分子标记用于电泳
公开(公告)号：US20070290173A1
公开(公告)日：2007-12-20
申请号：US11840164
申请日：2007-08-16
申请人： Mitra Tadayoni-Rebek , Joseph Amshey , Regina Rooney
发明人： Mitra Tadayoni-Rebek , Joseph Amshey , Regina Rooney
IPC分类号： C09K11/06 , C07K14/00
CPC分类号： C07K7/08 , C07K1/1075 , C07K1/1077 , C07K1/26 , C07K14/00 , G01N27/44726
摘要： The invention relates to marker molecules for identifying physical properties of molecular species separated by the use of electrophoretic systems. The invention further relates to methods for preparing and using marker molecules.
摘要翻译：本发明涉及用于鉴定通过使用电泳系统分离的分子物质的物理性质的标记分子。本发明还涉及制备和使用标记分子的方法。

33. 发明申请

US20060063699A1 Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis 失效
标题翻译：具有降低的酶水解趋势的药理学活性肽缀合物
公开(公告)号：US20060063699A1
公开(公告)日：2006-03-23
申请号：US11007772
申请日：2004-12-07
申请人： Bjarne Larsen
发明人： Bjarne Larsen
IPC分类号： C07K14/47 , A61K38/10
CPC分类号： C07K14/665 , A61K38/00 , A61K47/64 , A61K47/65 , A61K47/67 , B82Y5/00 , C07K1/1075 , C07K14/575 , C07K14/57545 , C07K14/675 , C07K14/68 , C07K14/685 , C07K14/695 , C07K2319/31
摘要： The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage comprising a pharmacologically active peptide sequence (X) and a stabilising petide sequence (Z) of 4-20 amino acid residues covalently bound to X.
摘要翻译：本发明涉及具有降低的酶切性趋势的药理学活性肽缀合物，其包含与X共价结合的4-20个氨基酸残基的药理学活性肽序列（X）和稳定化合物（Z）序列。

34. 发明申请

US20040254347A1 Method of cross-linking peptides 审中-公开
标题翻译：交联肽的方法
公开(公告)号：US20040254347A1
公开(公告)日：2004-12-16
申请号：US10307562
申请日：2002-11-25
申请人： Academia Sinica
发明人： Han-Jia Lin , Yee-Hsiung Chen
IPC分类号： C12P021/06 , C07K014/00
CPC分类号： C12N9/104 , C07K1/1075 , C12P21/00
摘要： A method of cross-linking a peptide to form a homopolymer of the peptide, to immobilize the peptide on a solid phase and to enhance antigenicity of the peptide is disclosed. The method comprises the steps of preparing a fusion peptide by incorporating a cross-linking segment including a tetrapeptide sequence QXK(S/T) into the peptide and cross-linking the peptide by a glutaminase.
摘要翻译：公开了将肽交联以形成肽的均聚物的方法，以将肽固定在固相上并增强肽的抗原性。该方法包括以下步骤：通过将包含四肽序列QXK（S / T）的交联链段并入肽中并通过谷氨酰胺酶交联而制备融合肽。

35. 发明申请

US20040101939A1 Method for reducing or preventing modification of a polypeptide in solution 审中-公开
公开(公告)号：US20040101939A1
公开(公告)日：2004-05-27
申请号：US10302592
申请日：2002-11-22
发明人： Ling C. Santora , Krista H. Stanley
IPC分类号： C07K016/24 , C12N009/00 , C07K001/06
CPC分类号： C07K1/1077 , A23C2230/05 , C07K1/1075 , C07K1/36 , C07K16/241 , C07K2317/12 , C07K2317/21 , C12N9/96
摘要： The present invention encompasses a novel approach to reduce or to prevent modification of polypeptides in solution and to polypeptides obtained by such methods. Specifically, the invention relates to a method for reducing or preventing modification of polypeptides in milk, particularly milk obtained from a transgenic animal, and to polypeptides isolated using such methods.

36. 发明授权

US06703480B1 Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use 失效
标题翻译：肽二聚体作为红细胞生成素（EPO）受体的激动剂，以及相关的合成和使用方法
公开(公告)号：US06703480B1
公开(公告)日：2004-03-09
申请号：US09449064
申请日：1999-11-24
申请人： Palani Balu
发明人： Palani Balu
IPC分类号： C07K700
CPC分类号： C07K1/1072 , A61K38/00 , C07K1/1075 , C07K14/505
摘要： Novel peptide dimers are provided that bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist. The novel compounds have a first peptide chain R1 and a second peptide chain R2, wherein R1 and R2 may be the same or different, and are linked through a linking moiety. R1 is approximately 10 to 40 amino acid residues in length and comprises the sequence X3X4X5GPX6TX7X8X9 (SEQ ID NO: 1) wherein X3 is C or Hoc, X4 is R, H, L or W, X5 is M, F, I or nor-leucine (J), X6 is any one of the 20 genetically coded L-amino acids or J, X7 is W, 1-naphthylalanine (B) or 2-naphthylalanine (U), X8 is D, E, 1, L or V, and X9 is C or Hoc. Similarly, R2 comprises the sequence X′3X′4X′5GPX′6TX′7X′8X′9 (SEQ ID NO: 2) wherein X′3 is C or Hoc, X′4 is R, H, L or W, X′5 is M, F, I or J, X′6 is any one of the 20 genetically coded L-amino acids or J, X′7 is W, B or U, X8′ is D, E, I, L or V, and X′9 is C or Hoc. Methods for synthesizing the compounds are provided as well, as are pharmaceutical compositions and methods of use.
摘要翻译：提供结合并激活促红细胞生成素受体（EPO-R）或以其它方式作为EPO激动剂的新型肽二聚体。新化合物具有第一肽链R 1和第二肽链R 2，其中R 1和R 2可以相同或不同，并且通过连接部分连接。 R 1的长度为约10至40个氨基酸残基，并且包含其中X 3为C或Hoc，X 4为R，H，L或W的X 3 X 4 X 5 GPX 6 TX 7 X 8 X 9（SEQ ID NO：1），X 5为M，F，I 或不是亮氨酸（J），X6是20个遗传编码的L-氨基酸中的任一个，或者J，X7是W，1-萘基丙氨酸（B）或2-萘基丙氨酸（U），X8是D，E， L或V，X 9为C或Hoc。类似地，R 2包含序列X'3X'4X'5GPX'6TX'7X'8X'9（SEQ ID NO：2），其中X'3是C或Hoc，X'4是R，H，L或 W，X'5是M，F，I或J，X'6是20个遗传编码的L-氨基酸中的任一个或者J，X'7是W，B或U，X8'是D，E，I ，L或V，X'9为C或Hoc。还提供了合成化合物的方法，以及药物组合物和使用方法。

37. 发明申请

US20020045189A1 Polypeptide and process for measuring living body components using the same 失效
标题翻译：多肽和使用其测量活体成分的方法
公开(公告)号：US20020045189A1
公开(公告)日：2002-04-18
申请号：US09883394
申请日：2001-06-19
申请人： Wako Pure Chemical Industries, LTD.
发明人： Nobuko Imajo , Yukari Yamagata , Hideo Katoh , Shinji Satomura , Kenji Nakamura
IPC分类号： G01N033/53 , C07K007/00 , C07K014/00
CPC分类号： C07K7/06 , C07K1/1075 , C07K7/02 , C07K7/08 , Y02P20/55 , Y10S436/824
摘要： A living body component in a sample derived from a living body can be rapidly and accurately measured by reacting the sample with a reagent comprising a combined product of an affinity substance and a polypeptide having at least three acid residues derived from a strong acid, separating the resulting complex by a method applying negative change such as using an anion-exchanger, and determining the amount of the analyte to be measured, on the basis of the amount of the complex or free combined product.
摘要翻译：通过使样品与包含亲和物质和具有至少3个来源于强酸的酸残基的多肽的组合产物的试剂反应来快速准确地测定来自活体的样品中的活体成分，通过使用阴离子交换剂的负变化的方法得到的复合物，以及基于复合物或游离组合产物的量确定待测量的分析物的量。

38. 发明授权

US06258550B1 Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site 失效
标题翻译：多肽包括构象约束组，其侧翼于蛋白质 - 蛋白质相互作用位点
公开(公告)号：US06258550B1
公开(公告)日：2001-07-10
申请号：US09413492
申请日：1999-10-06
申请人： Herbert J. Evans , R. Manjunatha Kini
发明人： Herbert J. Evans , R. Manjunatha Kini
IPC分类号： G01N3353
CPC分类号： C07K1/1075 , A61K38/00 , C07K1/00 , C07K14/75
摘要： Among other things, methods of obtaining putative protein-protein interaction sites of biologically-active polypeptides are provided. The methods include searching the polypeptides for a regions that are flanked on each termini by at least one proline residue; and isolating or producing the flanked regions.
摘要翻译：提供了获得生物活性多肽的推定蛋白质 - 蛋白质相互作用位点的方法。所述方法包括：通过至少一个脯氨酸残基搜索在每个末端侧翼的区域的多肽; 并分离或产生侧翼区。

39. 发明授权

US6084066A Polypetides that include conformation-constraining groups which flank a protein-protein interaction site 失效
标题翻译： Polypetides包括侧翼于蛋白质 - 蛋白质相互作用位点的构象约束基团
公开(公告)号：US6084066A
公开(公告)日：2000-07-04
申请号：US231797
申请日：1999-01-15
申请人： Herbert J. Evans , R. Manjunatha Kini
发明人： Herbert J. Evans , R. Manjunatha Kini
IPC分类号： A61K38/00 , C07K1/00 , C07K1/107 , C07K14/75 , C07K7/06 , A61K38/04 , A61K37/02 , C07K3/08
CPC分类号： C07K14/75 , C07K1/00 , C07K1/1075 , A61K38/00
摘要： Homologs and analogs of naturally-occurring stem cell factor polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.
摘要翻译：天然存在的干细胞因子多肽的同源物和类似物含有天然对应物的一个或多个相互作用位点。相互作用位点侧面是构象约束部分，如脯氨酸或半胱氨酸。

40. 发明授权

US6017879A Template associated NPY Y2-receptor agonists 失效
标题翻译：模板相关NPY Y2受体激动剂
公开(公告)号：US6017879A
公开(公告)日：2000-01-25
申请号：US54393
申请日：1998-04-03
申请人： Manfred Mutter , Jean-Silvain Lacroix , Eric Grouzmann
发明人： Manfred Mutter , Jean-Silvain Lacroix , Eric Grouzmann
IPC分类号： A61K38/00 , A61P3/04 , A61P7/10 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P11/16 , A61P25/08 , A61P25/22 , A61P25/28 , A61P29/00 , A61P37/04 , A61P43/00 , C07K1/107 , C07K7/02 , C07K14/575 , A61K38/12 , A61K38/16
CPC分类号： C07K1/1075 , C07K14/57545 , C07K7/02 , A61K38/00
摘要： The present invention is directed to agonists of neuropeptide Y (NPY) or PYY that are formed by combining these peptides or a portion of these peptides with a template that promotes biologically active folds. Typically, templates consist of cyclized peptides containing one or more naphthyl ring structures. The agonists may be used in the treatment of diseases and conditions known to be responsive to NPY or PYY and, particularly in the treatment of asthma, rhinitis, and bronchitis.
摘要翻译：本发明涉及通过将这些肽或这些肽的一部分与促进生物活性折叠的模板组合而形成的神经肽Y（NPY）或PYY的激动剂。通常，模板由含有一个或多个萘环结构的环化肽组成。激动剂可用于治疗已知对NPY或PYY有反应的疾病和病症，特别是用于治疗哮喘，鼻炎和支气管炎。

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