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31. 发明申请

US20080132600A1 N-Substituted Imides As Polymerization Initiators 有权
公开(公告)号：US20080132600A1
公开(公告)日：2008-06-05
申请号：US11666887
申请日：2005-10-31
申请人： Peter Nesvadba , Johannes Benkhoff , Lucienne Bugnon , Karin Powell , Tunja Jung
发明人： Peter Nesvadba , Johannes Benkhoff , Lucienne Bugnon , Karin Powell , Tunja Jung
IPC分类号： C08L79/08 , C07D209/48 , C07D221/06 , C07D207/46 , C07D209/56
CPC分类号： C07D207/404 , B33Y70/00 , C07D207/46 , C07D209/48 , C07D221/14 , C08F4/00
摘要： The invention relates to novel N-substituted imides and polymerizable compositions comprising these N-substituted imides. The invention further relates to the use of N-substituted imides as polymerization initiators. The imides are compounds of the formula (I) and (II) wherein n is 1 or 2; m is 1 or 2; R1 and R2 are each, independently of one another, hydrogen, C1-C18alkyl, C1-C18alkenyl C6-C14aryl, aralkyl, C5-C12cycloalkyl, each of which may be substituted by halogen, C1-C4-alkyl, hydroxy, C1-C6alkoxy, carbonyl, C1-C6alkoxycarbonyl; or R1 and R2 together with the adjacent —CO—N—CO— group may form a monocyclic, bicyclic or polycyclic ring, said ring having up to 50 non hydrogen atoms and wherein said ring may contain the structural element (formula III) more than once; R3 if n is 1, is C1-C18alkyl, C6-C14aryl, aralkyl, C5-C12cycloalkyl, OR10 or SR11, NR12R13; wherein R3 if n is 2, is C2-C12alkylene, C6-C14arylene, xylylene R4 and R5, correspond to R1 and R2; R6 if n is 1, is hydrogen, C1-C18alkyl, C6-C14aryl, aralkyl, C5-C12cycloalkyl, NR14R15; wherein R6 if n is 2, is C2-C12alkylene, C6-C14arylene, xylylene; R7 is hydrogen, C1-C18alkyl, C6-C14aryl, aralkyl, C5-C12cycloalkyl, each of which may be substituted by halogen, C1-C4-alkyl, hydroxy, C1-C6alkoxy, carbonyl, C1-C6alkoxy-carbonyl; or R7 and R14 or R7 and R15 form together with the N-atom attached to R7 a 5-6 membered ring, optionally interrupted by —NH—, —N(C1-C8alkyl)-, —O- and/or S-atoms.

32. 发明申请

US20080081902A1 PURIFICATION OF SYNTHETIC OLIGOMERS 有权
标题翻译：合成低聚物的纯化
公开(公告)号：US20080081902A1
公开(公告)日：2008-04-03
申请号：US11865499
申请日：2007-10-01
申请人： Shiyue Fang
发明人： Shiyue Fang
IPC分类号： C07K1/14 , C07D209/56 , C07D403/02 , C07D491/02 , C07F9/06 , C07H1/06
CPC分类号： C07H1/06 , C07D207/404 , C07D491/16 , C07F9/146 , C07F9/2408 , C07F9/2412 , C07F9/572 , C07F9/5728 , C07F9/6561 , C07K1/02 , C07K1/04 , C07K1/14
摘要： This invention provides a novel method for purifying synthetic oligomers comprising capping, polymerizing and separating any failure sequences produced during oligomer synthesis. Either the failure sequence or the full-length oligomer may be polymerized. Optionally, small molecule impurities may also be incorporated into the polymerized material. The invention provides novel capping agents having a polymerizable functional group. The invention also provides kits comprising at least one composition of the present invention.
摘要翻译：本发明提供了一种用于纯化合成低聚物的新方法，其包括封端，聚合和分离低聚物合成期间产生的任何破坏序列。故障序列或全长低聚物可以聚合。任选地，也可以将小分子杂质掺入到聚合材料中。本发明提供具有可聚合官能团的新型封端剂。本发明还提供包含至少一种本发明组合物的试剂盒。

33. 发明授权

US07294649B2 Methamphetamine derivatives and conjugates for immunoassay 有权
标题翻译：甲基苯丙胺衍生物和结合物用于免疫测定
公开(公告)号：US07294649B2
公开(公告)日：2007-11-13
申请号：US11016619
申请日：2004-12-17
申请人： Raymond A. Hui , Stephen S. Vitone
发明人： Raymond A. Hui , Stephen S. Vitone
IPC分类号： A61K31/4015 , A61K31/135 , C07D207/40 , C07D233/30
CPC分类号： C07C331/28 , C07C233/18 , C07C271/16 , C07D207/404 , C07K16/44 , Y02P20/55 , Y10S436/815 , Y10S436/901 , Y10T436/13 , Y10T436/173845
摘要： Compounds of methamphetamine derivatives having a meta-substituted alkyl linker on the benzene ring and a protective group on the nitrogen of the methamphetamine hapten. Such compounds have the structure wherein R1 is an alkyl linker comprising 2-15 carbon atoms and 0-6 heteroatoms, R2 is a leaving group, and R3 is a protecting group.
摘要翻译：在苯环上具有间位取代的烷基接头的甲基苯丙胺衍生物和甲基苯丙胺半抗原氮的保护基的化合物。这样的化合物具有其中R 1是含有2-15个碳原子和0-6个杂原子的烷基接头的结构，R 2是离去基团， 3 是保护基。

34. 发明申请

US20070197455A1 Processes for the convergent synthesis of calicheamicin derivatives 审中-公开
标题翻译：加利车霉素衍生物的会聚合成方法
公开(公告)号：US20070197455A1
公开(公告)日：2007-08-23
申请号：US11708849
申请日：2007-02-20
申请人： Justin Keith Moran , Jianxin Gu
发明人： Justin Keith Moran , Jianxin Gu
IPC分类号： C07C69/74
CPC分类号： C07C323/60 , C07C319/20 , C07D207/404 , C07D207/46 , C07D309/14 , C07D405/14 , C07H15/203 , C07H15/26
摘要： This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates.
摘要翻译：本发明描述了加利车霉素衍生物的收敛合成方法，以及使用双功能和三官能连接物中间体的类似类似物。

35. 发明申请

US20070173643A1 Process for Producing Cyclic Compounds 有权
标题翻译：生产环状化合物的方法
公开(公告)号：US20070173643A1
公开(公告)日：2007-07-26
申请号：US11688022
申请日：2007-03-19
申请人： Todd Werpy , John Frye , James White , Johnathan Holladay , Alan Zacher
发明人： Todd Werpy , John Frye , James White , Johnathan Holladay , Alan Zacher
IPC分类号： C07D207/267 , C07D223/10 , C07D205/02
CPC分类号： C07D207/404
摘要： The invention includes methods of processing an initial di-carbonyl compound by conversion to a cyclic compound. The cyclic compound is reacted with an alkylating agent to form a derivative having an alkylated ring nitrogen. The invention encompasses a method of producing an N-alkyl product. Ammonia content of a solution is adjusted to produce a ratio of ammonia to di-carboxylate compound of from about 1:1 to about 1.5:1. An alkylating agent is added and the initial compound is alkylated and cyclized. The invention includes methods of making N-methyl pyrrolidinone (NMP). Aqueous ammonia and succinate is introduced into a vessel and ammonia is adjusted to provide a ratio of ammonia to succinate of less than 2:1. A methylating agent is reacted with succinate at a temperature of from greater than 100° C. to about 400° C. to produce N-methyl succinimide which is purified and hydrogenated to form NMP.
摘要翻译：本发明包括通过转化为环状化合物来处理初始二羰基化合物的方法。环状化合物与烷基化剂反应形成具有烷基化环氮的衍生物。本发明包括生产N-烷基产物的方法。调节溶液的氨含量以产生约1：1至约1.5：1的氨与二羧酸酯化合物的比例。加入烷基化剂并将该初始化合物烷基化并环化。本发明包括制备N-甲基吡咯烷酮（NMP）的方法。将氨水和琥珀酸钠引入容器中，并调节氨以提供小于2:1的氨与琥珀酸的比例。甲基化剂与琥珀酸酯在大于100℃至约400℃的温度下反应，生成N-甲基琥珀酰亚胺，将其纯化并氢化形成NMP。

36. 发明申请

US20070166276A1 Releasable polymeric conjugates based on aliphatic biodegradable linkers 审中-公开
标题翻译：基于脂肪族可生物降解接头的可释放聚合物共轭物
公开(公告)号：US20070166276A1
公开(公告)日：2007-07-19
申请号：US10557522
申请日：2003-08-13
申请人： Hong Zhao , Richard Greenwald , Susan Adler
发明人： Hong Zhao , Richard Greenwald , Susan Adler
IPC分类号： A61K38/17 , C08G63/91
CPC分类号： C07D277/16 , A61K47/60 , C07D207/404
摘要： Activated polymeric bicine derivatives such as Formula (I), as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
摘要翻译：公开了式（I）的活性聚合物二元衍生物以及由其制得的共轭物。还公开了制备和使用双金属衍生物的方法。

37. 发明申请

US20070148652A1 Reagent for detecting an analyte 有权
标题翻译：用于检测分析物的试剂
公开(公告)号：US20070148652A1
公开(公告)日：2007-06-28
申请号：US10582794
申请日：2004-12-14
申请人： Jens Norrild , Bo Laursen
发明人： Jens Norrild , Bo Laursen
IPC分类号： C12Q1/68 , G01N33/53 , C09B11/04
CPC分类号： G01N21/6428 , C07C309/14 , C07D207/404 , C07D401/12 , C09B11/10 , G01N33/533 , G01N33/542 , G01N33/582
摘要： A reagent for use in detecting an analyte comprises a fluorescent energy donor and an energy acceptor, wherein the energy acceptor is of the general formula: and wherein the distance between the energy donor and the energy acceptor of the reagent is capable of modulation by a suitable analyte to be detected.
摘要翻译：用于检测分析物的试剂包括荧光能量供体和能量受体，其中能量受体具有以下通式：并且其中能量给体和试剂的能量受体之间的距离能够通过合适的待检测的分析物。

38. 发明授权

US07211394B2 Detection of markers in nascent proteins 失效
标题翻译：新生蛋白中标记物的检测
公开(公告)号：US07211394B2
公开(公告)日：2007-05-01
申请号：US11145781
申请日：2005-06-06
申请人： Kenneth J. Rothschild , Jerzy Olejnik , Sanjay M. Sonar
发明人： Kenneth J. Rothschild , Jerzy Olejnik , Sanjay M. Sonar
IPC分类号： C12Q1/68
CPC分类号： C07D207/404 , A61K38/00 , A61K41/0042 , C07C205/45 , C07C205/57 , C07D311/16 , C07D405/12 , C07D495/04 , C07H19/04 , C07H21/00 , C07K1/1077 , C07K1/13 , C12P21/00 , C12Q1/68 , G01N33/532 , G01N33/582
摘要： The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives, or substances recognized by the protein synthesizing machinery. Markers may comprise cleavable moieties, detectable labels, reporter properties wherein markers incorporated into protein can be distinguished from unincorporated markers, or coupling agents which facilitate the detection and isolation of nascent protein from other components of the translation system. The invention also comprises proteins prepared using misaminoacylated tRNAs which can be utilized in pharmaceutical compositions for the treatment of diseases and disorders in humans and other mammals, and kits which may be used for the detection of diseases and disorders.
摘要翻译：本发明涉及用于在细胞或无细胞翻译系统中翻译的新生蛋白的非放射性标记，检测，定量和分离的方法。 tRNA分子被非放射性标记物错氨基酰化，其可以是非天然氨基酸，氨基酸类似物或衍生物，或由蛋白质合成机理识别的物质。标记可以包含可切割部分，可检测标记，报告基因特性，其中掺入蛋白质的标记可以与非组合标记物或促进从翻译系统的其他组分检测和分离新生蛋白质的偶联剂区别。本发明还包括使用可用于治疗人类和其他哺乳动物疾病和病症的药物组合物中的使用错氨基酰化tRNA制备的蛋白质，以及可用于检测疾病和病症的试剂盒。

39. 发明授权

US07169558B2 Detection of disease related genes 有权
标题翻译：检测疾病相关基因
公开(公告)号：US07169558B2
公开(公告)日：2007-01-30
申请号：US10401251
申请日：2003-03-27
申请人： Kenneth J. Rothschild , Sanjay M. Sonar , Jerzy Olejnik
发明人： Kenneth J. Rothschild , Sanjay M. Sonar , Jerzy Olejnik
IPC分类号： C12Q1/68
CPC分类号： A61K41/0042 , A61K38/00 , C07C205/45 , C07C205/57 , C07D207/404 , C07D311/16 , C07D405/12 , C07D495/04 , C07H19/04 , C07H21/00 , C07K1/1077 , C07K1/13 , C12P21/00 , C12Q1/6883 , G01N33/58
摘要： The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives, or substances recognized by the protein synthesizing machinery. Markers may comprise cleavable moieties, detectable labels, reporter properties wherein markers incorporated into protein can be distinguished from unincorporated markers, or coupling agents which facilitate the detection and isolation of nascent protein from other components of the translation system. The invention also comprises proteins prepared using misaminoacylated tRNAs which can be utflized in pharmaceutical compositions for the treatment of diseases and disorders in humans and other maninials, and kits which may be used for the detection of diseases and disorders.
摘要翻译：本发明涉及用于在细胞或无细胞翻译系统中翻译的新生蛋白的非放射性标记，检测，定量和分离的方法。 tRNA分子被非放射性标记物错氨基酰化，其可以是非天然氨基酸，氨基酸类似物或衍生物，或由蛋白质合成机理识别的物质。标记可以包含可切割部分，可检测标记，报告基因特性，其中掺入蛋白质的标记可以与非组合标记物或促进从翻译系统的其他组分检测和分离新生蛋白质的偶联剂区别。本发明还包括使用错氨基酰化tRNA制备的蛋白质，其可以在药物组合物中被用于治疗人类和其他肌肉疾病和病症，以及可用于检测疾病和病症的试剂盒。

40. 发明授权

US07087229B2 Releasable polymeric conjugates based on aliphatic biodegradable linkers 有权
标题翻译：基于脂肪族可生物降解接头的可释放聚合物共轭物
公开(公告)号：US07087229B2
公开(公告)日：2006-08-08
申请号：US10449849
申请日：2003-05-30
申请人： Hong Zhao , Richard B. Greenwald
发明人： Hong Zhao , Richard B. Greenwald
IPC分类号： A61K39/385 , A61K39/44 , A01N33/08 , A01N31/06
CPC分类号： C07D277/16 , A61K47/60 , C07D207/404
摘要： Activated polymeric bicine derivatives such as, as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
摘要翻译：公开了活性聚合物二元醇衍生物，以及由其制备的缀合物。还公开了制备和使用双金属衍生物的方法。

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