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31. 发明授权

US08476082B2 Device for detection of target molecules and uses thereof 有权
标题翻译：用于检测靶分子的装置及其用途
公开(公告)号：US08476082B2
公开(公告)日：2013-07-02
申请号：US13445233
申请日：2012-04-12
申请人： Nicholas A. Siciliano , Martin Joseph Bouliane
发明人： Nicholas A. Siciliano , Martin Joseph Bouliane
IPC分类号： G01N33/558
CPC分类号： G01N33/5302 , B01L3/5023 , B01L2200/026 , B01L2200/04 , B01L2200/10 , B01L2300/041 , B01L2300/049 , B01L2300/0636 , B01L2300/069 , B01L2300/0809 , B01L2300/087 , G01N33/56911 , G01N33/56916 , G01N33/56922 , Y10S435/81 , Y10S435/97 , Y10S436/804 , Y10S436/805 , Y10S436/807
摘要： Devices and methods for the detection of target molecules are disclosed. Devices and methods for detecting food-borne target molecules are also disclosed.
摘要翻译：公开了用于检测靶分子的装置和方法。还公开了用于检测食源性靶分子的装置和方法。

32. 发明申请

US20130027686A1 Analysis Device and Method 审中-公开
标题翻译：分析装置和方法
公开(公告)号：US20130027686A1
公开(公告)日：2013-01-31
申请号：US13500708
申请日：2010-10-07
申请人： Bruno BALLUCH , Walter Smetana , Ibrahim Atassi , Gottfried Koehler , Michael Edetsberger
发明人： Bruno BALLUCH , Walter Smetana , Ibrahim Atassi , Gottfried Koehler , Michael Edetsberger
IPC分类号： G01J3/28
CPC分类号： G01N15/1456 , B01F15/0205 , B01F15/0212 , B01L3/502 , B01L3/502715 , B01L2200/027 , B01L2300/042 , B01L2300/045 , B01L2300/047 , B01L2300/048 , B01L2300/049 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2400/0478 , B01L2400/0683 , G01N15/1463 , G01N15/1468 , G01N15/1475 , G01N35/0098 , G01N2015/0693 , G01N2015/1472 , G01N2035/00564 , G01N2035/00574
摘要： An analysis device, having a sample container unit (1) comprising: a sample container (2) for receiving a substantially liquid sample and marking the particles contained in the sample, having a cap (3) for fluid-tight closure of the sample container (2); a measuring cell unit (4), which is in fluidic communication with the sample container (2) via an outlet (43), which measuring cell unit has a liquid-conducting channel (49), at least one wall of which channel is embodied as at least partially transparent; a carrier unit (10), which has means for contactlessly transporting and/or concentrating marked particles contained in the sample fluid; and an optical unit (20) for spectroscopic and/or microscopic detection of the marked particles, having at least one light source (19, 21) for excitation of the marked particles in the sample.
摘要翻译：一种分析装置，具有样本容器单元（1），包括：样品容器（2），用于接收基本上液体的样品并标记包含在样品中的颗粒，具有用于样品容器的流体密封的盖（3）（2）; 测量单元单元（4），其经由出口（43）与样品容器（2）流体连通，该测量单元具有导液通道（49），至少一个壁的通道被实施至少部分透明; 载体单元（10），其具有用于非接触地输送和/或浓缩包含在样品流体中的标记颗粒的装置; 以及用于对标记的颗粒进行光谱和/或显微检测的光学单元（20），其具有用于激发样品中标记的颗粒的至少一个光源（19,21）。

33. 发明授权

US08312781B2 Sample frame for preparation of a plurality of sample vessels, in particular NMR sample tubes 有权
标题翻译：用于制备多个样品容器的样品框架，特别是NMR样品管
公开(公告)号：US08312781B2
公开(公告)日：2012-11-20
申请号：US12379210
申请日：2009-02-17
申请人： Kurt Himmelsbach , Beat Grossniklaus
发明人： Kurt Himmelsbach , Beat Grossniklaus
IPC分类号： B01L9/06
CPC分类号： G01N35/04 , B01L3/50825 , B01L3/50853 , B01L9/06 , B01L2200/0689 , B01L2200/141 , B01L2200/142 , B01L2300/049 , B01L2300/0832 , G01N35/0099 , G01N35/028 , G01N2035/0405 , G01R33/30
摘要： A sample frame (30; 81) for preparing a plurality of sample vessels (41, 42), in particular sample tubes, having a plurality of retainers, in each of which a sample vessel (41, 42) is situated, is characterized in that the sample vessels (41, 42) each have a cap (43, 44), which is put over the open end of the sample vessel (41, 42), the cap (41, 42) having a drilled hole (53, 54), through which the interior of the sample vessel (41, 42) is accessible, the sample frame (30; 81) has a removable cover plate (8), whose bottom side faces toward the caps (43, 44) of the sample vessels (41, 42) in the put-on state of the cover plate (8), and the cover plate (8) has an approximately funnel-shaped depression (11, 71) on the top side for each retainer, in whose center a through opening (57) through the cover plate (8) is provided, the through opening (57) aligning with the drilled hole (53, 54) of a cap (43, 44) of a sample vessel (41, 42) retained underneath when the cover plate (8) is put on. The sample frame according to the invention eases the closure of sample vessels, which have a cap with hole, in the context of an automated sample preparation.
摘要翻译：其特征在于，用于制备多个样品容器（41,42）的样品架（41,42），特别是具有多个保持器的样品管（41,42），其中每个样品容器（41,42）样品容器（41,42）各自具有盖（43,44），其盖在样品容器（41,42）的开口端上，所述盖（41,42）具有钻孔（53,44） 54），样品容器（41,42）的内部可通过其进行，样品框架（30; 81）具有可移除的盖板（8），其底侧朝向所述盖板（43,44）在盖板（8）的放置状态下的样品容器（41,42）和盖板（8）在每个保持器的顶侧上具有大致漏斗状的凹部（11,71），其中设置有穿过盖板（8）的通孔（57）的中心，通孔（57）与样品容器（41,42）的盖（43,44）的钻孔对齐，当盖板（8）被放置时保留在下面。根据本发明的样品框架在自动化样品制备的情况下简化了带有孔的样品容器的封闭。

34. 发明授权

US08304186B2 Reactor for performing biochemical processes 失效
标题翻译：用于进行生化过程的反应器
公开(公告)号：US08304186B2
公开(公告)日：2012-11-06
申请号：US12516228
申请日：2007-11-16
申请人： Sergio Stibelli , Niccolo Di Pietro
发明人： Sergio Stibelli , Niccolo Di Pietro
IPC分类号： C12Q1/68 , C12M1/00 , C07H21/00
CPC分类号： B04B5/0414 , B01L3/502 , B01L3/5021 , B01L3/50825 , B01L3/565 , B01L2200/026 , B01L2300/047 , B01L2300/049 , B01L2300/0832 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , G01N2035/00495
摘要： A reactor (1) for performing biochemical processes, particularly for extraction, purification, enrichment, sedimentation, comprising a container which is provided with at least one mouth (2) which is associated with closure means (3) of the removable type, the container having internally at least one process compartment (4), adapted to accommodate a sample of biochemical material to be processed, at least one containment chamber (5) for a process agent, and at least first means for transferring the process agent from the containment chamber to the process compartment.
摘要翻译：一种用于进行生物化学过程的反应器（1），特别是用于萃取，净化，富集，沉降的反应器（1），其包括容器，所述容器设置有至少一个与所述可移除类型的封闭装置（3）相关联的口（2）具有内部至少一个处理室（4），其适于容纳要处理的生物化学材料的样品，至少一个用于加工剂的容纳室（5）和至少第一装置，用于将加工剂从容纳室到加工隔室。

35. 发明申请

US20120260996A1 METHOD AND ARRANGEMENT FOR GENERATING OR DEPOSITING A STREAM OF FLUID SEGMENTS AND USE THEREOF 失效
标题翻译：用于产生或沉积流体流段的方法和装置及其使用
公开(公告)号：US20120260996A1
公开(公告)日：2012-10-18
申请号：US13252066
申请日：2011-10-03
申请人： Bastian Rapp , André Schumacher
发明人： Bastian Rapp , André Schumacher
IPC分类号： F17D3/00 , F04B19/00
CPC分类号： B01L3/502715 , B01L3/0293 , B01L3/502784 , B01L3/563 , B01L2200/027 , B01L2200/0642 , B01L2200/0673 , B01L2300/046 , B01L2300/049 , B01L2300/0829 , B01L2300/0864 , B01L2300/0867 , B01L2400/0457 , B01L2400/0469 , B01L2400/0633 , B33Y80/00 , Y10T137/0324 , Y10T137/3124 , Y10T137/4857 , Y10T436/118339 , Y10T436/2575
摘要： An arrangement and method for generating or depositing a stream of m>1 fluid segments, respectively separated by an intermediary medium which does not mix with the fluid segments. The arrangement includes a molded body having a channel for conducting the fluid stream, from which n≧m first access lines and n second access lines branch off. The first and second access lines are configured so to be inserted into n wells. The lengths of the first access lines differ from the lengths of the second access lines, and respectively one first valve is arranged in the channel, between the branching location for each second access line and the branching location for each associated first access line, and wherein respectively a second valve is arranged in each second access line.
摘要翻译：用于产生或沉积m 1流体段的装置和方法，分别由不与流体段混合的介质介质分离。该装置包括具有用于传导流体流的通道的模制体，n≥m个第一接入线和n个第二接入线从该流体流分支。第一和第二存取线被配置成插入n个孔中。第一接入线的长度与第二接入线的长度不同，并且一个第一阀被布置在通道中，每个第二接入线的分支位置和每个相关的第一接入线的分支位置之间，并且其中分别在每个第二进入管线中布置第二阀。

36. 发明申请

US20120193274A1 Apparatus and method for separating and isolating components of a biological fluid 有权
公开(公告)号：US20120193274A1
公开(公告)日：2012-08-02
申请号：US13506145
申请日：2012-03-30
申请人： John R. Chapman , Vijay Kumar , Brian K. Cinquini , Phillip D. Kingsley
发明人： John R. Chapman , Vijay Kumar , Brian K. Cinquini , Phillip D. Kingsley
IPC分类号： B01D21/26
CPC分类号： B01D21/26 , A61M1/029 , A61M2202/0413 , A61M2202/0464 , A61M2202/10 , B01D21/262 , B01D21/307 , B01D21/34 , B01D2221/10 , B01L3/50215 , B01L2300/048 , B01L2300/049 , B01L2300/0681 , B01L2400/0605 , B01L2400/0611 , G01N2035/00495
摘要： A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.

37. 发明申请

US20120172260A1 System and methods for localizing and analyzing samples on a Bio-Sensor chip 审中-公开
标题翻译：用于在Bio-Sensor芯片上定位和分析样品的系统和方法
公开(公告)号：US20120172260A1
公开(公告)日：2012-07-05
申请号：US13136978
申请日：2011-08-15
申请人： Robert Otillar , David Storek , Christer Johansson
发明人： Robert Otillar , David Storek , Christer Johansson
IPC分类号： C40B60/12
CPC分类号： G11C7/1066 , B01J19/0046 , B01J2219/00317 , B01J2219/0034 , B01J2219/00439 , B01J2219/00459 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502738 , B01L3/502761 , B01L2300/049 , B01L2400/0633 , C40B40/06 , C40B60/14 , G01N27/745 , G01N35/0098 , G01N2035/00247 , G01N2035/00574 , G06F7/723 , Y10T436/25
摘要： Chips that include one or more particle manipulation mechanisms, or force transduction elements, provided at specific locations to manipulate and localize particles proximal the substrate surface. In one embodiment, individually addressable magnetic control mechanisms such as electric coils are provided at specific locations to create a magnetic field to attract magnetic particles, such a magnetic or magnetizable beads, to those specific locations. In another embodiment, electrostatic control mechanisms such as electrodes are provided to attract and manipulate electrically charged micro-particles. A location may include a crater or well formed in the substrate, or it may include an element on the surface of the substrate. In some embodiments, one or more sensors are located proximal specific locations, e.g., specific craters, so as to analyze specific conditions at each location. In other embodiments, multiple locations share one or more sensors.
摘要翻译：芯片包括一个或多个颗粒操纵机构，或力传递元件，设置在特定位置以操纵和定位基板表面附近的颗粒。在一个实施例中，在特定位置处提供单独可寻址的磁控制机构，例如电线圈，以产生磁场，以吸引磁性粒子，例如磁性或可磁化的珠粒到这些特定位置。在另一个实施例中，提供诸如电极的静电控制机构以吸引和操纵带电的微粒。位置可以包括在基底中形成的火山口或井，或者其可以在基底的表面上包括元件。在一些实施例中，一个或多个传感器位于近端特定位置，例如特定的凹坑处，以便分析每个位置处的特定状况。在其他实施例中，多个位置共享一个或多个传感器。

38. 发明授权

US08191398B1 Vapor generator safety release device 有权
标题翻译：蒸汽发生器安全释放装置
公开(公告)号：US08191398B1
公开(公告)日：2012-06-05
申请号：US12559603
申请日：2009-09-15
申请人： Robin L. Matthews
发明人： Robin L. Matthews
IPC分类号： G01N21/00
CPC分类号： G01N33/0006 , B01L5/04 , B01L2200/141 , B01L2300/049 , B01L2400/0605
摘要： A vapor generator safety relief device for use in a surety system includes a conical flask, manifold, bubbler, and relief valve. The manifold includes a first chamber for inlet gas and a second chamber for outlet gas. The first chamber comprises an inlet port, an inlet tube, and a relief valve housing. The second chamber comprises an outlet tube and an outlet port. The bubbler is confluent with the inlet tube and disposed within the flask.
摘要翻译：在保证系统中使用的蒸汽发生器安全释放装置包括锥形瓶，歧管，起泡器和溢流阀。歧管包括用于入口气体的第一室和用于出口气体的第二室。第一室包括入口端口，入口管和安全阀壳体。第二室包括出口管和出口。起泡器与入口管汇合并置于烧瓶内。

39. 发明申请

US20120122649A1 Apparatus and method for separating and isolating components of a biological fluid 有权
公开(公告)号：US20120122649A1
公开(公告)日：2012-05-17
申请号：US13374983
申请日：2012-01-26
申请人： John R. Chapman , Vijay Kumar , Brian K. Cinquini , Phillip D. Kingsley
发明人： John R. Chapman , Vijay Kumar , Brian K. Cinquini , Phillip D. Kingsley
IPC分类号： B01D43/00
CPC分类号： B01D21/26 , A61M1/029 , A61M2202/0413 , A61M2202/0464 , A61M2202/10 , B01D21/262 , B01D21/307 , B01D21/34 , B01D2221/10 , B01L3/50215 , B01L2300/048 , B01L2300/049 , B01L2300/0681 , B01L2400/0605 , B01L2400/0611 , G01N2035/00495
摘要： A device for separating and isolating components of a biological fluid comprising a container for containing the fluid to be processed, a tube cap assembly for closing the container while providing filling and extraction communication therewith, a float assembly disposed within the container for funneling and controlling biological fluid flow into an inverted domed shaped isolation chamber within the float and controlling the biological fluid flow out of the isolation chamber for effecting an encapsulation or a sealed isolation of at least one component or fraction of the biological fluid flow within the isolation chamber during a centrifugation process. The device further comprising a flexible tube for connecting an extraction passageway disposed within the float assembly and an extraction valve of the tube cap assembly for allowing extraction of at least the one component or fraction encapsulated or isolated within the chamber.

40. 发明申请

US20110263461A1 METHODS AND DEVICES FOR COLLECTING SAMPLES IN A HIGH THROUGHPUT FORMAT 审中-公开
标题翻译：用于在高通量格式中收集样品的方法和装置
公开(公告)号：US20110263461A1
公开(公告)日：2011-10-27
申请号：US13092337
申请日：2011-04-22
申请人： Kumar KASTURY , Aparna PALAPARTHI
发明人： Kumar KASTURY , Aparna PALAPARTHI
IPC分类号： C40B50/00 , C40B60/14
CPC分类号： B01L3/50853 , B01L3/50851 , B01L9/523 , B01L2200/141 , B01L2300/044 , B01L2300/049 , B01L2300/0829 , G01N35/028 , G01N2035/00782
摘要： The present invention is directed methods for collecting and storing samples compatible for high throughput automation. The present invention is also directed to a device comprising: (a) a plate containing multiple wells, and (b) multiple rubber covers; wherein each rubber cover is (i) an integral part of the device, (ii) is on top of each well and individually seal each well, and (iii) has a pierceable area in the center of the cover. The device is suitable for collecting, storing, transporting, and tracking samples compatible for high throughput downstream automated processing.
摘要翻译：本发明是用于收集和存储兼容高通量自动化的样品的方法。本发明还涉及一种装置，包括：（a）含有多个孔的板，和（b）多个橡胶盖; 其中每个橡胶盖是（i）装置的整体部分，（ii）在每个井的顶部并且单独地密封每个井，以及（iii）在盖的中心具有可刺穿的区域。该设备适用于与高吞吐量下游自动化处理兼容的采集，存储，传输和跟踪样品。

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