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31. 发明申请

US20040215248A1 Self-adapting defibrillator induction feature 有权
标题翻译：自适应除颤器感应功能
公开(公告)号：US20040215248A1
公开(公告)日：2004-10-28
申请号：US10423073
申请日：2003-04-25
申请人： Medtronic, Inc.
发明人： Michael F. Hess
IPC分类号： A61N001/39
CPC分类号： A61N1/3712 , A61N1/385 , A61N1/3943
摘要： A system that includes a programming device and a defibrillator provides a self-adapting defibrillator induction feature to test the effectiveness of the defibrillator in detecting and terminating fibrillation of a heart, such as ventricular fibrillation. A fibrillation induction protocol and values for parameters of the protocol are selected. The defibrillator attempts to induce fibrillation according to the selected protocol and parameter values. Parameter values are modified and new protocols are selected until fibrillation is successfully induced, detected and terminated.
摘要翻译：包括编程设备和去纤颤器的系统提供自适应去纤颤器诱导特征，以测试除颤器在检测和终止心脏纤颤的有效性，例如心室颤动。选择原纤维诱导方案和参数参数值。除颤器试图根据选定的方案和参数值诱发颤动。参数值被修改，并且选择新的协议，直到成功诱发，检测和终止颤动。

32. 发明申请

US20040199209A1 Method and system for delivery of vasoactive drugs to the heart prior to and during a medical procedure 审中-公开
标题翻译：在医疗过程之前和期间将血管活性药物递送到心脏的方法和系统
公开(公告)号：US20040199209A1
公开(公告)日：2004-10-07
申请号：US10657353
申请日：2003-09-08
发明人： Michael R.S. Hill , Scott E. Jahns , James R. Keogh
IPC分类号： A61N001/36
CPC分类号： A61N1/36114 , A61N1/385
摘要： A method of performing a medical procedure, such as surgery, is provided. A first vasoactive substance is delivered to the site of a medical procedure. The procedure is then performed. A second vasoactive substance is then delivered to the site of the procedure.
摘要翻译：提供了一种执行诸如手术的医疗程序的方法。第一种血管活性物质被运送到医疗程序的现场。然后执行该过程。然后将第二血管活性物质递送至手术部位。

33. 发明申请

US20040186531A1 Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure 有权
标题翻译：在医疗过程之前和期间神经刺激和心脏感知的方法和系统
公开(公告)号：US20040186531A1
公开(公告)日：2004-09-23
申请号：US10724978
申请日：2003-12-01
发明人： Scott E. Jahns , Michael R.S. Hill , James R. Keogh
IPC分类号： A61N001/18
CPC分类号： A61N1/36017 , A61N1/36114 , A61N1/385
摘要： A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped in order to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued in order to allow the medical procedure to be continued. A sensor to sense a characteristic of a fluid or tissue, such as an impending contraction, may be also used during the medical procedure. Systems and devices for performing the medical procedure are also provided.
摘要翻译：提供了一种执行诸如手术的医疗程序的方法。刺激神经以将心脏的跳动调节到第一状态，例如停止或减缓的状态。医疗程序在心脏或另一个器官上进行。停止对神经的刺激，以便将心脏的跳动调节到第二状态，例如打浆状态。心脏本身也可能被刺激到跳动状态，例如通过起搏。可以继续刺激神经以允许继续医疗程序。也可以在医疗过程中使用用于感测流体或组织的特征的传感器，例如即将收缩的收缩。还提供用于执行医疗程序的系统和设备。

34. 发明申请

US20040172075A1 Method and system for vagal nerve stimulation with multi-site cardiac pacing 失效
标题翻译：多节点心脏起搏迷走神经刺激方法与系统
公开(公告)号：US20040172075A1
公开(公告)日：2004-09-02
申请号：US10737493
申请日：2003-12-16
发明人： Lisa L. Shafer , Steve R. LaPorte , James R. Keogh , Michael R.S. Hill , Matthew D. Bonner
IPC分类号： A61N001/362
CPC分类号： A61N1/39 , A61N1/36114 , A61N1/362 , A61N1/3627 , A61N1/36514 , A61N1/3684 , A61N1/385 , A61N1/3956
摘要： A method of performing a medical procedure is provided. The medical procedure includes stimulation of a patient's heart while stimulating a nerve of the patient in order to modulate the patient's inflammatory process. More particularly, the medical procedure includes pacing the ventricles of the patient's heart while stimulating the vagal nerve of the patient. Systems and devices for performing the medical procedure are also provided.
摘要翻译：提供了一种执行医疗程序的方法。医疗过程包括刺激患者的心脏同时刺激患者的神经以调节患者的炎症过程。更具体地，医疗过程包括在刺激患者的迷走神经的同时起搏患者心脏的心室。还提供用于执行医疗程序的系统和设备。

35. 发明授权

US06628987B1 Method and system for sensing cardiac contractions during vagal stimulation-induced cardiopalegia 有权
标题翻译：迷走神经刺激引起的心脏收缩期心脏收缩的方法和系统
公开(公告)号：US06628987B1
公开(公告)日：2003-09-30
申请号：US09669355
申请日：2000-09-26
申请人： Michael R. S. Hill , Scott E. Jahns , James R. Keogh
发明人： Michael R. S. Hill , Scott E. Jahns , James R. Keogh
IPC分类号： A61N136
CPC分类号： A61N1/36114 , A61N1/385
摘要： A system of performing a medical procedure, such as surgery, is provided. The system comprises a sensor to sense a state of cardiac tissue, such as an impending contraction and an indicator to indicate the state of the cardiac tissue. Methods and devices for performing the medical procedure are also provided.
摘要翻译：提供了一种执行诸如手术的医疗程序的系统。该系统包括用于感测心脏组织的状态的传感器，例如即将到来的收缩和用于指示心脏组织的状态的指示器。还提供了用于执行医疗程序的方法和装置。

36. 发明申请

US20020188325A1 Method and system for nerve stimulation prior to and during a medical procedure 有权
公开(公告)号：US20020188325A1
公开(公告)日：2002-12-12
申请号：US10207725
申请日：2002-07-29
发明人： Michael R.S. Hill , Scott E. Jahns , James R. Keogh
IPC分类号： A61N001/362
CPC分类号： A61N1/36114 , A61N1/056 , A61N1/362 , A61N1/36514 , A61N1/37288 , A61N1/385 , A61N1/39
摘要： A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ. The stimulation of the nerve is stopped in order to adjust the beating of the heart to a second condition, such as a beating condition. The heart itself may also be stimulated to a beating condition, such as by pacing. The stimulation of the nerve may be continued in order to allow the medical procedure to be continued. Systems and devices for performing the medical procedure are also provided.

37. 发明申请

US20020007197A1 Method for testing a technique intended to predict onset of heart arrhythmia using an animal test subject 失效
标题翻译：使用动物试验对象测试旨在预测心律失常发作的技术的方法
公开(公告)号：US20020007197A1
公开(公告)日：2002-01-17
申请号：US09884520
申请日：2001-06-18
发明人： Peng-Sheng Chen
IPC分类号： A61N001/00
CPC分类号： A61N1/385 , A61N1/36114 , A61N1/3956
摘要： A method is described for increasing the likelihood of the occurrence of an arrhythmia in a heart, particularly a ventricular arrhythmia of the type leading to Sudden Cardiac Death. The method includes the steps of creating an atrioventricular block in the heart of an animal test subject, inducing a myocardial infarction in the heart of the test subject, and then stimulating myocardial hyperinnervation the test subject. In a specific example described herein, the atrioventricular block is created by ablating the atrioventricular node of the heart using an ablation catheter. The myocardial infarction is induced by ligating the left anterior descending portion of the coronary artery. Myocardial hyperinnervation is stimulated by application of Nerve Growth Factor or other neurotrophic vectors to the left stellate ganglion. The test subject is an adult canine. By creating an atrioventricular block and a myocardial infarction within the heart of an adult canine test subject, then stimulating nerve growth within the left stellate ganglion of the subject using Nerve Growth Factor, it has been found that there is a significant increase in the likelihood of Sudden Cardiac Death arising from ventricular arrhythmias. It is believed that the Sudden Cardiac Death of the test subject arises in a manner very similar to circumstances wherein Sudden Cardiac Death occurs in human patients subject to a previous myocardial infarction. Thus, the method facilitates the collection of data pertinent to conditions within the heart arising prior to Sudden Cardiac Death and for developing and testing therapies intended to prevent Sudden Cardiac Death.
摘要翻译：描述了一种用于增加心脏中发生心律失常的可能性的方法，特别是导致突发性心脏死亡的类型的室性心律失常。该方法包括以下步骤：在动物测试对象的心脏中产生房室传导阻滞，在测试对象的心脏中诱发心肌梗死，然后刺激心脏超嗜化的测试对象。在本文所述的具体示例中，通过使用消融导管消融心脏房室结而产生房室传导阻滞。通过结扎冠状动脉的左前降支部分诱导心肌梗塞。通过将神经生长因子或其他神经营养载体应用于左星状神经节来刺激心肌过度增生。测试对象是成年犬。通过在成年犬试验对象的心脏内产生房室传导阻滞和心肌梗塞，然后使用神经生长因子刺激受试者的左星状神经节内的神经生长，已经发现，可能性显着增加心室心跳骤停引起心室心律失常。相信测试对象的突发性心脏死亡的发生方式非常类似于患有先前心肌梗死的人类患者中发生心脏骤停的情况。因此，该方法有助于收集与突发心脏死亡之前产生的心脏内的情况有关的数据，并且用于开发和测试旨在防止突发性心脏死亡的治疗。

38. 发明授权

US06266564B1 Method and device for electronically controlling the beating of a heart 有权
标题翻译：用于电子控制心脏跳动的方法和装置
公开(公告)号：US06266564B1
公开(公告)日：2001-07-24
申请号：US09433323
申请日：1999-11-03
申请人： Michael R. S. Hill , Kenneth R. Jonkman
发明人： Michael R. S. Hill , Kenneth R. Jonkman
IPC分类号： A61N136
CPC分类号： A61N1/36114 , A61B17/3417 , A61B2017/00243 , A61B2017/00969 , A61B2017/0243 , A61B2017/3445 , A61B2017/3449 , A61N1/056 , A61N1/362 , A61N1/385 , A61N1/3962
摘要： An electro-stimulation device includes a pair of electrodes for connection to at least one location in the body that affects or regulates the heartbeat. The electro-stimulation device both electrically arrests the heartbeat and stimulates the heartbeat. A pair of electrodes are provided for connection to at least one location in the body that affects or regulates the heartbeat. The pair of electrodes may be connected to an intravenous catheter for transvenous stimulation of the appropriate nerve. A first switch is connected between a power supply and the electrodes for selectively supplying current from the power supply to the electrodes to augment any natural stimuli to the heart and thereby stop the heart from beating. A second switch is connected between the power supply and the electrodes for selectively supplying current from the power supply to the electrodes to provide an artificial stimulus to initiate heartbeating. In another aspect, the invention is directed to a method for arresting the beat of a heart in a living body comprising the steps of connecting the pair of electrodes to at least one location in the body that affects or regulates the heartbeat and supplying an electrical current to the electrodes of sufficient amplitude and duration to arrest the heartbeat. The device may also serve to still the lungs by input to a respirator or by stimulation of the phrenic nerve during surgical procedures.
摘要翻译：电刺激装置包括一对电极，用于连接到体内至少一个影响或调节心跳的位置。电刺激装置既电气阻止心跳并刺激心跳。提供一对电极用于连接到体内至少一个影响或调节心跳的位置。该对电极可以连接到静脉导管，用于适当神经的经静脉刺激。第一开关连接在电源和电极之间，用于选择性地从电源向电极提供电流，以增加对心脏的任何自然刺激，从而阻止心脏跳动。第二开关连接在电源和电极之间，用于选择性地从电源向电极提供电流以提供人造刺激以启动心跳。另一方面，本发明涉及一种用于在生物体中阻止心脏的搏动的方法，包括以下步骤：将一对电极连接到体内至少一个位置，其影响或调节心跳并提供电流到足够的幅度和持续时间的电极以阻止心跳。该装置还可以通过输入呼吸器或在外科手术期间刺激膈神经而服用于肺。

39. 发明授权

US06263241B1 Method and apparatus for treatment of cardiac electromechanical dissociation 有权
标题翻译：用于治疗心脏机电解离的方法和装置
公开(公告)号：US06263241B1
公开(公告)日：2001-07-17
申请号：US09303380
申请日：1999-04-30
申请人： John P. Rosborough , D. Curtis Deno
发明人： John P. Rosborough , D. Curtis Deno
IPC分类号： A61N139
CPC分类号： A61N1/3962 , A61N1/385
摘要： An apparatus and method for treating post-defibrillation electromechanical dissociation (“EMD”). A first embodiment comprises an implantable defibrillator, which may include cardioversion and pacemaker capabilities, which has the capability of detecting and treating post defibrillation EMD. The stimulator/defibrillator has one or more leads with electrodes. At least one electrode for defibrillation may be an endocardial or epicardial electrode or other suitable defibrillation electrode. A sense circuit senses the electrical condition of the heart of the patient. A hemodynamic sensor senses a parameter correlated to the state of blood flow. The cardiac stimulator/defibrillator detects ventricular tachyarrhythmia including fibrillation and terminates ventricular tachyarrhythmia. After termination of the ventricular tachyarrhythmia, the stimulator/defibrillator can detect the presence of electrical rhythm in the heart correlated, however, with inadequate blood flow to sustain life. Under such conditions, the device provides an output to stimulate the heart to overcome electromechanical dissociation and restore adequate blood flow. The device may also be an external therapy device, as part of, or in conjunction with an external defibrillator. The method for treating the heart to restore blood flow where electromechanical dissociation occurs after termination of a ventricular tachyarrhythmia or ventricular fibrillation comprises identifying electromechanical disassociation after termination of a ventricular tachyarrhythmia or a fibrillation and providing electrical therapy, the therapy comprising a series of packets of electrical pulses.
摘要翻译：一种用于治疗除颤后机电解离的装置和方法（“EMD”）。第一实施例包括可植入除颤器，其可以包括心脏复律和起搏器能力，其具有检测和治疗除颤后EMD的能力。刺激器/除颤器具有一个或多个具有电极的引线。用于除颤的至少一个电极可以是心内膜或心外膜电极或其它合适的除颤电极。感测电路感测患者心脏的电气状况。血液动力学传感器检测与血流状态相关的参数。心脏刺激器/除颤器检测心律失常包括原纤维性颤动并终止室性快速性心律失常。在室性快速性心律失常终止后，刺激器/除颤器可以检测到心脏中电气节律的存在相关，然而血液流量不足以维持生命。在这种条件下，该装置提供一个输出来刺激心脏以克服机电解离并恢复足够的血流量。该装置也可以是外部治疗装置，作为外部去纤颤器的一部分或与其结合使用。用于治疗心脏以恢复血流的方法，其中机电解离发生在心室性快速性心律失常或心室颤动终止之后发生，包括在终止室性快速性心律失常或原纤维化并提供电疗法之后鉴定机电解离，该治疗包括一系列电气脉冲。

40. 发明授权

US6021345A Methods for detecting propensity for fibrillation using an electrical restitution curve 失效
标题翻译：使用电恢复曲线检测原纤维倾向的方法
公开(公告)号：US6021345A
公开(公告)日：2000-02-01
申请号：US705877
申请日：1996-08-28
申请人： Hrayr S. Karagueuzian , Timothy A. Denton
发明人： Hrayr S. Karagueuzian , Timothy A. Denton
IPC分类号： A61B5/0452 , A61B5/046 , A61N1/08 , A61N1/38 , A61N1/39 , G06F17/00 , G06F19/00 , G06Q50/00
CPC分类号： A61B5/046 , A61N1/08 , A61N1/385 , A61N1/3925 , A61B5/7253 , A61B5/7257
摘要： A method for detecting a heart disorder comprises examination of a phase-plane plot (PPP) of a patient electrocardiogram (EKG). The PPP's degree of deterministic chaos may be measured by a processor. Analysis of the PPP may indicate a propensity for fibrillation, that is, indicate both the risk of fibrillation and its actual onset (cases where risk is 100 percent). A second method for detecting a heart disorder comprises examination of a frequency-domain transform (such as an FFT) of a patient EKG. An automatic defibrillating device may comprise means for delivering a variable shock, the size of which is determined at least in part by the FFT's peak energy. A method for detecting drug toxicity comprises examination of a parameter time constant for an action-potential duration (APD) restitution curve which is constructed for the patient.
摘要翻译：用于检测心脏病的方法包括检查患者心电图（EKG）的相位图（PPP）。 PPP的确定性混沌程度可以由处理器测量。 PPP的分析可能表明纤维性颤动的倾向，也就是表明纤维性颤动的风险及其实际发作（风险为100％的情况）。用于检测心脏病的第二种方法包括检查患者EKG的频域变换（例如FFT）。自动除颤装置可以包括用于递送可变冲击的装置，其可以至少部分地由FFT的峰值能量来确定其大小。用于检测药物毒性的方法包括检查为患者构建的动作电位持续时间（APD）恢复曲线的参数时间常数。

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