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31. 发明授权

US6033917A Method for the preparation of free radical pharmaceuticals, diagnostics and devices using selenium conjugates 失效
标题翻译：用于制备自由基药物的方法，诊断和使用硒共轭物的装置
公开(公告)号：US6033917A
公开(公告)日：2000-03-07
申请号：US12146
申请日：1998-01-22
申请人： Julian E. Spallholz , Ted W. Reid
发明人： Julian E. Spallholz , Ted W. Reid
IPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48 , H04M1/03 , H04M1/19 , G01N33/553
CPC分类号： A61K31/095 , A61K31/13 , A61K33/04 , A61K47/48023 , A61K47/48123 , A61K47/48992
摘要： The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue containing at least one reactive group selected from the group consisting of aldehyde, amino, alcoholic, carboxylic, phosphate, sulfate, halogen or phenolic reactive groups and combinations thereof, to (ii) a carrier having a constituent capable of forming a covalent bond with said reactive groups of said selenium compound to produce a selenium-carrier conjugate which is capable of specific attachment to a target site. The carrier may be a protein, such as an antibody specific to a bacteria, virus, protozoa, or cell antigen, including without limitation, cell surface antigens, a peptide, carbohydrate, lipid, vitamin, drug, lectin, plasmid, liposome, nucleic acid or a non-metallic implantable device, such as an intraocular implant or a vascular shunt. The attachment of selenium compounds of the configurations described above to carriers when presented to either endogenous thiols, such as glutathione which occurs in all aerobic living cells, or exogenous thiols, such as glutathione or cysteine, produces superoxide (O.sub.2..sup.-), hydrogen peroxide, the hydroxyl radical (.OH) and other cytotoxic reactive oxygen species so as to collectively form a localized free radical pharmacology based upon the catalytic selenium anion, RSe.sup.31.
摘要翻译：本发明提供了通过共价连接（i）选自RSeH，RSeR，RSeR'，RSeSeR和RSeSeR'的有机硒化合物来制备硒 - 载体缀合物的方法，其中R和R'各自为脂族残基含有至少一个选自醛，氨基，醇，羧酸，磷酸酯，硫酸酯，卤素或酚反应性基团的反应性基团及其组合，（ii）具有能与所述化合物形成共价键的成分的载体所述硒化合物的反应性基团产生能够特异性附着于靶位点的硒 - 载体缀合物。载体可以是蛋白质，例如细菌，病毒，原生动物或细胞抗原特异的抗体，包括但不限于细胞表面抗原，肽，碳水化合物，脂质，维生素，药物，凝集素，质粒，脂质体，核酸酸或非金属可植入装置，例如眼内植入物或血管分流装置。当呈现给所有需氧活细胞中发生的内源性硫醇，如谷胱甘肽或外源硫醇，如谷胱甘肽或半胱氨酸时，上述构型的硒化合物与载体的连接产生超氧化物（O2-），过氧化氢，羟基自由基（.OH）和其他细胞毒活性氧，以共同形成基于催化硒阴离子RSe的局部自由基药理学。

32. 发明授权

US6015564A Cytotoxic T lymphocyte-inducing lipopeptides and use as vaccines 失效
标题翻译：细胞毒性T淋巴细胞诱导脂肽，用作疫苗
公开(公告)号：US6015564A
公开(公告)日：2000-01-18
申请号：US248082
申请日：1999-02-10
申请人： Christophe Boutillon , Frederic Martinon , Christian Sergheraert , Remy Magne , Helene Gras-Masse , Elisabeth Gomard , Andre Tartar , Jean-Paul Levy
发明人： Christophe Boutillon , Frederic Martinon , Christian Sergheraert , Remy Magne , Helene Gras-Masse , Elisabeth Gomard , Andre Tartar , Jean-Paul Levy
IPC分类号： A61K39/00 , A61K47/48 , A61P31/00 , A61P37/04 , C07K14/16 , A61K39/21 , A61K39/12 , C07K1/00
CPC分类号： C07K14/005 , A61K47/48023 , A61K47/48038 , A61K47/48053 , A61K47/48123 , A61K39/00 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
摘要： Cytotoxic lymphocyte-inducing lipopeptides comprising a peptide part having between 10 and 40 amino acids approximately and comprising at least one tigenic determinant. The lipopeptides also comprise one or more chains derived from fatty acids and one or more modified steroid groups. Said lipopeptides may be used for immunizing the human or animal body against pathogenic agents such as viruses or parasites. The peptide part may, in particular, be a fragment of the protein encoded by the ENV gene, by the NEF gene or by the GAG gene of HIV viruses.
摘要翻译：细胞毒性淋巴细胞诱导脂肽包含约10至40个氨基酸的肽部分，并且包含至少一个抗原决定簇。脂肽还包含一种或多种衍生自脂肪酸和一种或多种修饰类固醇基团的链。所述脂肽可以用于免疫人体或动物体内的病原体如病毒或寄生虫。肽部分尤其可以是由ENV基因，NEF基因或HIV病毒的GAG基因编码的蛋白质的片段。

33. 发明授权

US5910487A Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules 失效
标题翻译：阳离子两亲物和质粒用于细胞内递送治疗分子
公开(公告)号：US5910487A
公开(公告)日：1999-06-08
申请号：US546205
申请日：1995-10-20
申请人： Nelson S. Yew , Seng H. Cheng , Simon J. Eastman , John Marshall , Ronald K. Scheule , David J. Harris , Edward R. Lee , Craig S. Siegel
发明人： Nelson S. Yew , Seng H. Cheng , Simon J. Eastman , John Marshall , Ronald K. Scheule , David J. Harris , Edward R. Lee , Craig S. Siegel
IPC分类号： A61K9/127 , A61K47/48 , A61K48/00 , C07J41/00 , C07J43/00 , C12N15/88 , A61K37/00
CPC分类号： A61K9/1272 , A61K47/48023 , A61K47/48038 , A61K47/48046 , A61K47/48123 , A61K48/00 , C07J41/0005 , C07J41/0055 , C07J41/0061 , C07J43/003 , C12N15/88
摘要： Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from alkyl or acyl groups; and cationic groups, protonatable at physiological pH, derived from amines, alkylamines or polyalkylamines. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile. Novel and highly effective plasmid constructs are also disclosed, including those that are particularly effective at providing gene therapy for clinical conditions complicated by inflammation. Additionally, targeting of organs for gene therapy by intravenous administration of therapeutic compositions is described.
摘要翻译：提供了新的阳离子两亲物，其促进生物活性（治疗性）分子进入细胞。两亲物含有衍生自类固醇的单亲或二烷基胺或烷基或酰基的亲脂基团; 和在生理pH下可质子化的阳离子基团，衍生自胺，烷基胺或多烷基胺。还提供了通常通过使一种或多种阳离子两亲物的分散体与治疗分子接触而制备的治疗组合物。根据本发明的实践可以递送到细胞中的治疗分子包括DNA，RNA和多肽。本发明治疗组合物的代表性用途包括提供基因治疗以及向细胞递送反义多核苷酸或生物活性多肽。关于基因治疗的治疗组合物，通常以与阳离子两亲物络合的质粒的形式提供DNA。还公开了新型和高效的质粒构建体，包括在为炎症复杂的临床病症提供基因治疗方面特别有效的质粒构建体。另外，描述了通过静脉内施用治疗组合物靶向用于基因治疗的器官。

34. 发明授权

US5840710A Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules 失效
标题翻译：含有酯或醚连接的亲脂基团的阳离子两亲物用于治疗分子的细胞内递送
公开(公告)号：US5840710A
公开(公告)日：1998-11-24
申请号：US546087
申请日：1995-10-20
申请人： Edward R. Lee , David J. Harris , Craig S. Siegel , Mathieu B. Lane , Shirley C. Hubbard , Seng H. Cheng , Simon J. Eastman , John Marshall , Ronald K. Scheule
发明人： Edward R. Lee , David J. Harris , Craig S. Siegel , Mathieu B. Lane , Shirley C. Hubbard , Seng H. Cheng , Simon J. Eastman , John Marshall , Ronald K. Scheule
IPC分类号： A61K9/127 , A61K47/48 , A61K48/00 , C07J41/00 , C07J43/00 , C12N15/88 , A61K38/00 , C07C53/00 , C07C69/74
CPC分类号： B82Y5/00 , A61K47/48023 , A61K47/48038 , A61K47/48046 , A61K47/48123 , A61K48/00 , A61K9/1272 , C07J41/0005 , C07J41/0055 , C07J41/0061 , C07J43/003 , C12N15/88 , Y10S516/07
摘要： Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from alkyl or acyl groups; and cationic groups, protonatable at physiological pH, derived from amines, alkylamines or polyalkylamines. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile. Novel and highly effective plasmid constructs are also disclosed, including those that are particularly effective at providing gene therapy for clinical conditions complicated by inflammation. Additionally, targeting of organs for gene therapy by intravenous administration of therapeutic compositions is described.
摘要翻译：提供了新的阳离子两亲物，其促进生物活性（治疗性）分子进入细胞。两亲物含有衍生自类固醇的单亲或二烷基胺或烷基或酰基的亲脂基团; 和在生理pH下可质子化的阳离子基团，衍生自胺，烷基胺或多烷基胺。还提供了通常通过使一种或多种阳离子两亲物的分散体与治疗分子接触而制备的治疗组合物。根据本发明的实践可以递送到细胞中的治疗分子包括DNA，RNA和多肽。本发明治疗组合物的代表性用途包括提供基因治疗以及向细胞递送反义多核苷酸或生物活性多肽。关于基因治疗的治疗组合物，通常以与阳离子两亲物络合的质粒的形式提供DNA。还公开了新型和高效的质粒构建体，包括在为炎症复杂的临床病症提供基因治疗方面特别有效的质粒构建体。另外，描述了通过静脉内施用治疗组合物靶向用于基因治疗的器官。

35. 发明授权

US5837533A Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent 失效
标题翻译：包含与具有内体破坏剂的阳离子多胺结合的核酸的复合物
公开(公告)号：US5837533A
公开(公告)日：1998-11-17
申请号：US314060
申请日：1994-09-28
申请人： Raymond H. Boutin
发明人： Raymond H. Boutin
IPC分类号： C12N15/09 , A61K47/48 , A61K48/00 , C07C211/14 , C07C233/35 , C07C271/22 , C07K7/08 , C07K14/005 , C07K14/11 , C12N15/64 , C12N15/86 , C12N15/87 , C12N15/88 , C12N5/00 , C12N150/00
CPC分类号： C07K14/005 , A61K47/48046 , A61K47/48123 , C12N15/64 , C12N15/87 , A61K48/00 , C12N2760/16022
摘要： A multifunctional molecular complex for the transfer of a nucleic acid composition to a target cell is provided which comprises in any functional combination: A) said nucleic acid composition; and B) a transfer moiety comprising 1) one or more cationic polyamine components bound to said nucleic acid composition, each comprising from three to twelve nitrogen atoms; 2) one or more endosome membrane disruption promoting components attached to at least one nitrogen atom of at least one of said polyamine components, through an alkyl, carboxamide, carbamate, thiocarbamate, or carbamoyl bridging group, comprising a) at least one lipophilic long chain alkyl group, b) a fusogenic peptide comprising spike glycoproteins of enveloped animal viruses, or c) cholic acid or cholesteryl or derivatives; and optionally 3) one or more receptor specific binding components which are ligands for natural receptors of said target cell, attached through an alkyl, carboxamide, carbamate, thiocarbamate, or carbamoyl bridging group to either i) a further nitrogen atom of at least one of said polyamine components to which said one or more endosome membrane disruption promoting components is attached, or ii) a nitrogen atom of at least one further polyamine component which does not have attached thereto any endosome membrane disruption promoting component. Also provided are the transfer moiety alone, or in combination with the nucleic acid composition as a self-assembling combination, and the use of these compositions in methods for transfering nucleic acid compositions to cells or to cells of individuals, for immunizing individuals against a pathogen or disease, and for treating an individual with a disease.
摘要翻译：提供了用于将核酸组合物转移到靶细胞的多功能分子复合物，其包含任何功能组合：A）所述核酸组合物; 和B）转移部分，其包含1）与所述核酸组合物结合的一种或多种阳离子多胺组分，每个包含3至12个氮原子; 2）通过烷基，羧酰胺，氨基甲酸酯，硫代氨基甲酸酯或氨基甲酰基桥连连接到至少一个所述多胺组分的至少一个氮原子上的一种或多种内体膜破坏促进组分，其包含a）至少一种亲脂性长链烷基，b）包含包膜动物病毒的尖峰糖蛋白的融合肽，或c）胆酸或胆固醇或衍生物; 和任选地3）一种或多种受体特异性结合组分，其是所述靶细胞的天然受体的配体，通过烷基，羧酰胺，氨基甲酸酯，硫代氨基甲酸酯或氨基甲酰基桥连基团连接到i）至少一个的另外的氮原子所述一种或多种内体膜破坏促进组分所连接的所述多胺组分，或ii）至少一种不附着任何内体膜破坏促进组分的多胺组分的氮原子。还提供了转移部分单独或与作为自组装组合的核酸组合物组合，以及这些组合物在用于将核酸组合物转移至个体细胞或细胞的方法中的用途，用于免疫个体抵抗病原体或疾病，并用于治疗患有疾病的个体。

36. 发明授权

US5827703A Methods and composition for in vivo gene therapy 失效
标题翻译：体内基因治疗的方法和组成
公开(公告)号：US5827703A
公开(公告)日：1998-10-27
申请号：US246376
申请日：1994-05-19
申请人： Robert James Debs , Ning Zhu
发明人： Robert James Debs , Ning Zhu
IPC分类号： A01K67/027 , A61K9/127 , A61K31/711 , A61K38/00 , A61K39/00 , A61K47/18 , A61K47/28 , A61K47/48 , A61K48/00 , A61P31/12 , A61P35/00 , C07H21/04 , C07K14/00 , C07K14/47 , C07K14/55 , C12N15/09 , C12N15/88 , C12N15/64 , C12Q1/68
CPC分类号： C12N15/88 , A61K47/48023 , A61K47/48046 , A61K47/48053 , A61K47/48076 , A61K47/48123 , A61K47/48815 , A61K48/00 , A61K9/1272 , C07K14/00 , C07K14/4712 , C07K14/55 , A01K2217/05 , A61K38/00 , A61K39/00
摘要： Novel methods and compositions are provided for introducing a gene capable of modulating the genotype and phenotype into two or more tissues following systemic administration. The gene can be introduced into a mammalian host by way of an expression vector either as naked DNA or complexed to lipid carriers, particularly cationic lipid carriers. Multiple individual tissues can be transfected using naked DNA. Using a DNA: lipid carrier complex, multiple tissues and cell types can be transfected. The techniques and compositions find use in the palliation or treatment of any of a variety of genetic-based disorders.
摘要翻译：提供了新的方法和组合物，用于在全身给药后将能够调节基因型和表型的基因导入两个或更多个组织。该基因可以通过表达载体作为裸DNA引入哺乳动物宿主，或与脂质载体，特别是阳离子脂质载体复合。可以使用裸DNA转染多个单个组织。使用DNA：脂质载体复合物，可以转染多种组织和细胞类型。这些技术和组合物可用于缓解或治疗各种遗传性疾病中的任何一种。

37. 发明授权

US5747471A Cationic amphiphiles containing steroid lipophilic groups for intracellular delivery of therapeutic molecules 失效
标题翻译：含有类固醇亲脂基团的阳离子两亲物用于细胞内递送治疗分子
公开(公告)号：US5747471A
公开(公告)日：1998-05-05
申请号：US540867
申请日：1995-10-11
申请人： Craig S. Siegel , David J. Harris , Edward R. Lee , Shirley C. Hubbard , Seng H. Cheng , Simon J. Eastman , John Marshall , Ronald K. Scheule , Mathieu B. Lane , Eric A. Rowe
发明人： Craig S. Siegel , David J. Harris , Edward R. Lee , Shirley C. Hubbard , Seng H. Cheng , Simon J. Eastman , John Marshall , Ronald K. Scheule , Mathieu B. Lane , Eric A. Rowe
IPC分类号： A61K9/127 , A61K47/48 , A61K48/00 , C07J41/00 , C07J43/00 , C12N15/88 , A61K31/56 , A61K31/70 , B01F17/28
CPC分类号： C12N15/88 , A61K47/48023 , A61K47/48038 , A61K47/48046 , A61K47/48123 , A61K48/00 , A61K9/1272 , C07J41/0005 , C07J41/0055 , C07J41/0061 , C07J43/003
摘要： Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from ether or ester-linked alkyl groups, and cationic groups, protonatable at physiological pH, derived from amines, alkylamines or polyalkylamines. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile. Novel and highly effective plasmid constructs are also disclosed, including those that are particularly effective at providing gene therapy for clinical conditions complicated by inflammation.
摘要翻译：提供了新的阳离子两亲物，其促进生物活性（治疗性）分子进入细胞。两亲物含有衍生自单胺或二烷基胺类的类固醇，或由醚或酯连接的烷基衍生的亲脂基团，以及在生理pH下可质子化，衍生自胺，烷基胺或多烷基胺的阳离子基团。还提供了通常通过使一种或多种阳离子两亲物的分散体与治疗分子接触而制备的治疗组合物。根据本发明的实践可以递送到细胞中的治疗分子包括DNA，RNA和多肽。本发明治疗组合物的代表性用途包括提供基因治疗以及向细胞递送反义多核苷酸或生物活性多肽。关于基因治疗的治疗组合物，通常以与阳离子两亲物络合的质粒的形式提供DNA。还公开了新型和高效的质粒构建体，包括在为炎症复杂的临床病症提供基因治疗方面特别有效的质粒构建体。

38. 发明授权

US5719131A Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules 失效
标题翻译：含有二烷基胺亲脂基团的阳离子两亲物用于细胞内递送治疗分子
公开(公告)号：US5719131A
公开(公告)日：1998-02-17
申请号：US546110
申请日：1995-10-20
申请人： David J. Harris , Edward R. Lee , Craig S. Siegel , Seng H. Cheng , Simon J. Eastman , John Marshall , Ronald K. Scheule
发明人： David J. Harris , Edward R. Lee , Craig S. Siegel , Seng H. Cheng , Simon J. Eastman , John Marshall , Ronald K. Scheule
IPC分类号： A61K9/127 , A61K47/48 , A61K48/00 , C07J41/00 , C07J43/00 , C12N15/88 , A61K38/00
CPC分类号： A61K9/1272 , A61K47/48023 , A61K47/48038 , A61K47/48046 , A61K47/48123 , A61K48/00 , C07J41/0005 , C07J41/0055 , C07J41/0061 , C07J43/003 , C12N15/88 , Y10S516/07
摘要： Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from alkyl or acyl groups; and cationic groups, protonatable at physiological pH, derived from amines, alkylamines or polyalkylamines. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile. Novel and highly effective plasmid constructs are also disclosed, including those that are particularly effective at providing gene therapy for clinical conditions complicated by inflammation. Additionally, targeting of organs for gene therapy by intravenous administration of therapeutic compositions is described.
摘要翻译：提供了新的阳离子两亲物，其促进生物活性（治疗性）分子进入细胞。两亲物含有衍生自类固醇的单亲或二烷基胺或烷基或酰基的亲脂基团; 和在生理pH下可质子化的阳离子基团，衍生自胺，烷基胺或多烷基胺。还提供了通常通过使一种或多种阳离子两亲物的分散体与治疗分子接触而制备的治疗组合物。根据本发明的实践可以递送到细胞中的治疗分子包括DNA，RNA和多肽。本发明治疗组合物的代表性用途包括提供基因治疗以及向细胞递送反义多核苷酸或生物活性多肽。关于基因治疗的治疗组合物，通常以与阳离子两亲物络合的质粒的形式提供DNA。还公开了新型和高效的质粒构建体，包括在为炎症复杂的临床病症提供基因治疗方面特别有效的质粒构建体。另外，描述了通过静脉内施用治疗组合物靶向用于基因治疗的器官。

39. 发明授权

US5679644A Methods of treating diseases using triterpenoid acid derivatives 失效
标题翻译：使用三萜酸衍生物治疗疾病的方法
公开(公告)号：US5679644A
公开(公告)日：1997-10-21
申请号：US469137
申请日：1995-06-06
申请人： Narasinga Rao , Mark Brian Anderson , John Henry Musser
发明人： Narasinga Rao , Mark Brian Anderson , John Henry Musser
IPC分类号： C07D335/02 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/382 , A61K31/44 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61K31/7052 , A61K47/48 , A61K51/04 , A61P29/00 , A61P35/00 , A61P37/06 , C07D211/06 , C07D211/68 , C07D211/80 , C07D309/10 , C07H17/00 , C07H17/02 , C07H17/04 , C07J63/00 , A61K31/705
CPC分类号： A61K51/0491 , A61K47/48023 , A61K47/48123 , C07D309/10 , C07J63/008 , A61K2121/00 , A61K2123/00 , Y10S514/885 , Y10S514/889
摘要： Triterpenoid acid derivatives are described that exhibit dual pharmacophobic activities, specifically selectin ligand and leukotriene biosynthetic inhibitory activities, and that thus have significant applications for the treatment or prevention of certain diseases including cancer and diseases associated with the inflammatory process as well as applications for the diagnosis of disease.
摘要翻译：描述了三萜酸衍生物，其表现出双重排斥性活性，特别是选择蛋白配体和白细胞三烯生物合成抑制活性，因此具有治疗或预防某些疾病（包括癌症和与炎症过程相关的疾病）以及诊断应用的显着应用的疾病

40. 发明授权

US5627158A Antisense oligonucleotides of human regulatory subunit RI-.sub..alpha. of camp dependent protein kinases for the treatment of cancer 失效
标题翻译： cAMP依赖性蛋白激酶的人调节亚单位RI-α的反义寡核苷酸用于治疗癌症
公开(公告)号：US5627158A
公开(公告)日：1997-05-06
申请号：US60984
申请日：1993-05-14
申请人： Yoon S. Cho-Chung
发明人： Yoon S. Cho-Chung
IPC分类号： C07K14/655 , A61K31/7088 , A61K38/00 , A61K47/48 , A61K48/00 , A61P35/00 , C12N15/113 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C12N15/1137 , A61K47/48023 , A61K47/48123 , A61K38/00 , C12N2310/315
摘要： Antisense oligonucleotides of human regulatory subunit RI-alpha of cAMP-dependent protein kinases are disclosed along with pharmaceutical compositions containing these oligonucleotides as the active ingredients. These antisense oligonucleotides are useful for inhibiting the growth of cancer.
摘要翻译：公开了cAMP依赖性蛋白激酶的人调节亚基RI-α的反义寡核苷酸以及含有这些寡核苷酸作为活性成分的药物组合物。这些反义寡核苷酸可用于抑制癌症的生长。

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