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31. 发明申请

US20170020900A1 METHODS FOR SCREENING ANTIMICROBIAL AND ANTIVIRAL COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：用于筛选抗微生物和抗病毒化合物的方法及其用途
公开(公告)号：US20170020900A1
公开(公告)日：2017-01-26
申请号：US15051076
申请日：2016-02-23
申请人： The General Hospital Corporation , Northeastern University
发明人： Frederick M. AUSUBEL , Kim LEWIS , Terence I. MOY , Suresh GOPALAN
IPC分类号： A61K31/655 , A61K31/198 , A61K31/426 , A61K31/10 , A61K31/17 , A61K31/427 , A61K31/37 , A61K31/4184 , A61K31/122 , A61K31/517 , A61K31/44 , A61K31/496 , A61K31/27 , A61K31/5377 , A61K31/166
CPC分类号： A61K31/655 , A61K31/10 , A61K31/122 , A61K31/166 , A61K31/17 , A61K31/198 , A61K31/221 , A61K31/27 , A61K31/37 , A61K31/4184 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/496 , A61K31/517 , A61K31/5377 , C12Q1/18 , Y02A50/481
摘要： The invention features compounds that have antibacterial activity, their use for the treatment of bacterial infections, screening methods that use whole animals or plant seedlings to identify compounds that inhibit a pathogen in the animal or plant, and screening methods to identify compounds that increase the lifespan of an organism.
摘要翻译：本发明的特征在于具有抗菌活性的化合物，其用于治疗细菌感染的用途，使用全部动物或植物幼苗的筛选方法来鉴别抑制动物或植物中的病原体的化合物，以及筛选方法来鉴定增加寿命的化合物的生物体。

32. 发明申请

US20160331731A1 USE OF PSORALEN DERIVATIVES AND COMBINATION THERAPY FOR TREATMENT OF CELL PROLIFERATION DISORDERS 审中-公开
公开(公告)号：US20160331731A1
公开(公告)日：2016-11-17
申请号：US15220596
申请日：2016-07-27
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Wenle XIA , David Gooden , Erik J. Soderblom , Eric J. Toone , Neil L. Spector , Wayne F. Beyer, JR. , Harold Walder
IPC分类号： A61K31/436 , A61K31/4709 , A61K41/00 , A61K45/06
CPC分类号： A61K31/436 , A61K31/37 , A61K31/4709 , A61K31/517 , A61K41/0066 , A61K45/06 , A61K2300/00
摘要： Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.

33. 发明授权

US09457064B2 Method for treatment of vitiligo 有权
标题翻译：治疗白癜风的方法
公开(公告)号：US09457064B2
公开(公告)日：2016-10-04
申请号：US11193165
申请日：2005-07-29
申请人： Abburi Ramaiah
发明人： Abburi Ramaiah
IPC分类号： A61K31/37 , A61K31/366 , A61K8/64 , A61K38/04 , A61K38/18 , A61Q19/02 , C07K14/50
CPC分类号： A61K38/1825 , A61K31/366 , A61K31/37 , A61K2300/00
摘要： Synergistic therapies for the treatment of vitiligo are provided, in which basic fibroblast growth factor peptide(s) lotion was developed as a new mode of therapy for the treatment of vitiligo. It went through various phases of successful clinical trials in India and is marketed by the drug controller general (India). It is effective in 80% of stable and segmental vitiligo. Data are provided which demonstrate that combinatorial treatment of vitiligo by local application of bFGF peptide(s) lotions in association with psoralens and UV-A, or steroids or surgical procedures, produce a synergistic response in which the rate of repigmentation increases synergistically and more efficacious results are obtained than with any one of them alone. Any combinatorial therapy comprising the local application of bFGF peptide(s) lotion on the vitiligo patch in combination with any other therapies for the treatment of vitiligo also may act synergistically.
摘要翻译：提供了用于治疗白癜风的协同疗法，其中碱性成纤维细胞生长因子肽洗剂被开发为用于治疗白癜风的新的治疗方式。它经历了印度成功临床试验的各个阶段，由药物管制总局（印度）出售。在80％的稳定和节段性白癜风中有效。提供数据，其证明通过局部施用bFGF肽洗剂与补骨脂素和UV-A或类固醇或外科手术相结合的白癜风的组合治疗产生协同作用，其中色素沉降速率协同增加并且更有效得到的结果比其中任何一个单独获得。包括在白癜风贴片上局部应用bFGF肽洗剂的任何组合疗法与用于治疗白癜风的任何其它疗法组合也可以起协同作用。

34. 发明授权

US09439897B2 Use of psoralen derivatives and combination therapy for treatment of cell proliferation disorders 有权
标题翻译：补骨脂素衍生物和联合疗法用于治疗细胞增殖障碍的应用
公开(公告)号：US09439897B2
公开(公告)日：2016-09-13
申请号：US14603539
申请日：2015-01-23
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Wenle Xia , David Gooden , Erik J. Soderblom , Eric J. Toone , Neil L. Spector , Wayne F. Beyer, Jr. , Harold Walder
IPC分类号： A61K31/517 , A61K31/4709 , A61K31/436 , A61K31/37 , A61K41/00
CPC分类号： A61K31/436 , A61K31/37 , A61K31/4709 , A61K31/517 , A61K41/0066 , A61K45/06 , A61K2300/00
摘要： Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.
摘要翻译：用于治疗受试者细胞增殖疾病或病症的方法，包括将缺乏DNA交联基序的补骨脂素衍生物施用于癌细胞，施用补骨脂素或其衍生物和拉帕替尼，或施用补骨脂素或其衍生物和神经胶质细胞，并且进一步施加起始辐射能量形成能量源。

35. 发明授权

US09416121B2 Compounds for the treatment of mycobacterial infections 有权
标题翻译：用于治疗分枝杆菌感染的化合物
公开(公告)号：US09416121B2
公开(公告)日：2016-08-16
申请号：US14227372
申请日：2014-03-27
申请人： The Broad Institute, Inc. , Massachusetts General Hospital
发明人： Deborah Hung , Sarah Stanley , Tomohiko Kawate , Noriakie Iwase , Motohisa Shimizu
IPC分类号： C07D213/79 , C07D311/16 , C07D311/18 , C07D405/04
CPC分类号： C07D311/16 , A61K31/37 , A61K31/453 , A61K31/496 , A61K31/5377 , C07D311/18 , C07D405/04
摘要： The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，酯或前药：

36. 发明申请

US20160213644A1 Regulation of Body Weight Gain By Using Dibenzo-Alpha-Pyrones 有权
标题翻译：通过使用二苯并吡喃酮对体重增加的调节
公开(公告)号：US20160213644A1
公开(公告)日：2016-07-28
申请号：US14917721
申请日：2014-09-09
申请人： NATREON, INC.
发明人： Chandan K. Sen
IPC分类号： A61K31/37
CPC分类号： A61K35/04 , A61K31/37 , A61K35/66 , A61K36/09 , A61K2300/00
摘要： A method of using dibenzo-alpha-pyrones (DBPs) is provided wherein a subject is administered one or more of the aforementioned resulting in decreased body weight gain. In an embodiment, a 3-OH-DBP, 3,8-(OH)2-DBP, or a combination thereof is administered to an individual to control body weight gain.
摘要翻译：提供了使用二苯并吡喃酮（DBPs）的方法，其中给予受试者一种或多种以上导致体重增加减少。在一个实施方案中，向个体施用3-OH-DBP，3,8-（OH）2-DBP或其组合以控制体重增加。

37. 发明授权

US09393226B2 Use of osthole for treating focal segmental glomerulosclerosis 有权
标题翻译：使用osthole治疗局灶性节段性肾小球硬化症
公开(公告)号：US09393226B2
公开(公告)日：2016-07-19
申请号：US14693570
申请日：2015-04-22
申请人： National Defense Medical Center
发明人： Shuk-Man Ka , Ann Chen , Kuo-Feng Hua , Kuo-Ping Chao , Shun-Min Yang
IPC分类号： A61K31/37 , A61K45/06
CPC分类号： A61K31/37 , A61K45/06
摘要： The present invention relates to use of osthole for manufacturing a composition for treating focal segmental glomerulosclerosis (FSGS). Particularly, the present invention discloses that osthole is effective in treating focal segmental glomerulosclerosis (FSGS), which can alleviate various symptoms and signs of FSGS, including proteinuria, renal fibrosis, glomerular epithelial hyperplasia lesion (EPHL), and macrophage/lymphocyte infiltration in the kidney, etc.
摘要翻译：本发明涉及用于制造用于治疗局灶性节段性肾小球硬化症（FSGS）的组合物的孔的用途。特别地，本发明公开了一种治疗局灶性节段性肾小球硬化（FSGS）的方法，其可以缓解FSGS的各种症状和体征，包括蛋白尿，肾纤维化，肾小球上皮增生病变（EPHL）和巨噬细胞/淋巴细胞浸润肾等

38. 发明授权

US09381187B2 Radiation countermeasure agents 有权
标题翻译：辐射对策剂
公开(公告)号：US09381187B2
公开(公告)日：2016-07-05
申请号：US13985866
申请日：2012-02-16
申请人： David I. Sherris
发明人： David I. Sherris
IPC分类号： A61K31/35 , A61K31/366 , A61K31/37 , A61K31/4433 , A61K31/47 , A61K31/517 , A61K45/06
CPC分类号： A61K31/366 , A61K31/37 , A61K31/4433 , A61K31/47 , A61K31/517 , A61K45/06
摘要： Methods and compositions for reducing radiation damage in a subject with analog or derivative of benzo[c]chromen-6-one.
摘要翻译：用苯并[c]色烯-6-酮的类似物或衍生物减少受试者的辐射损伤的方法和组合物。

39. 发明授权

US09352040B2 Methods and systems for treating cell proliferation disorders 有权
标题翻译：治疗细胞增殖障碍的方法和系统
公开(公告)号：US09352040B2
公开(公告)日：2016-05-31
申请号：US14245668
申请日：2014-04-04
申请人： IMMUNOLIGHT, LLC.
发明人： Frederic Avery Bourke, Jr.
IPC分类号： A61K31/37 , A61K41/00 , A61K31/35 , A61K45/06 , A61K31/714 , A61K47/02 , A61F7/00 , A61H23/00 , A61K31/366 , A61N2/02 , A61N5/06 , A61N5/10
CPC分类号： A61K41/0071 , A61F7/00 , A61H23/00 , A61K31/35 , A61K31/366 , A61K31/37 , A61K31/714 , A61K41/00 , A61K41/0066 , A61K41/008 , A61K45/06 , A61K47/02 , A61N2/02 , A61N5/062 , A61N5/10 , A61N2005/0656 , A61N2005/1089 , A61N2005/1098 , A61K2300/00
摘要： Methods for the treatment of a cell proliferation disorder in a subject, involving: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of effecting a predetermined cellular change when activated, either alone or in combination with at least one energy modulation agent; and (2) applying an initiation energy from an initiation energy source to the subject, wherein the applying activates the activatable agent in situ, thus causing the predetermined cellular change to occur, wherein the predetermined cellular change treats the cell proliferation disorder, preferably by causing an increase or decrease in rate of cell proliferation, and a kit for performing the method, a computer implemented system for performing the method, a pharmaceutical composition useful in the method and a method for causing an autovaccine effect in a subject using the method.
摘要翻译：用于治疗受试者的细胞增殖病症的方法，涉及：（1）向受试者施用至少一种可活化的药剂，其能够在活化时实现预定的细胞变化，单独或与至少一种能量组合调制剂; 并且（2）将来自起始能量源的引发能量施加到受试者，其中所述施用在原位激活可活化试剂，从而引起预定的细胞变化，其中预定细胞变化治疗细胞增殖紊乱，优选通过引起细胞增殖速率的增加或减少，用于实施该方法的试剂盒，用于实施该方法的计算机实施系统，用于该方法的药物组合物和使用该方法在受试者中引起自身疫苗效应的方法。

40. 发明申请

US20160136129A1 CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY 审中-公开
公开(公告)号：US20160136129A1
公开(公告)日：2016-05-19
申请号：US14922472
申请日：2015-10-26
申请人： MEI Pharma, Inc.
发明人： Andrew Heaton , Alan Husband
IPC分类号： A61K31/353 , A61K31/337 , A61N5/10 , A61K31/4745 , A61K31/704 , A61K31/655 , A61K33/24 , A61K31/7068
CPC分类号： A61K31/353 , A23L33/105 , A61K31/282 , A61K31/337 , A61K31/37 , A61K31/4745 , A61K31/655 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K41/0038 , A61N5/10 , A61N2005/1098 , C07D311/38 , C07D311/58 , C07D311/62
摘要： Novel chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.

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