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31. 发明授权

US09700515B2 Compositions and methods for reducing overdose 有权
公开(公告)号：US09700515B2
公开(公告)日：2017-07-11
申请号：US15271469
申请日：2016-09-21
申请人： Isa Odidi
发明人： Isa Odidi
IPC分类号： A61K9/28 , A61K9/48 , A61K31/485 , A61K9/20 , A61K31/167 , A61K31/616 , A61K9/50 , A61K31/5513 , A61K31/515 , A61K31/37 , A61K31/4458 , A61K31/135 , A61K31/192 , A61K31/197 , A61K31/4439
CPC分类号： A61K47/02 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2059 , A61K9/28 , A61K9/2813 , A61K9/282 , A61K9/2846 , A61K9/2853 , A61K9/2886 , A61K9/4808 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/4891 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5031 , A61K31/00 , A61K31/135 , A61K31/167 , A61K31/192 , A61K31/197 , A61K31/366 , A61K31/37 , A61K31/4439 , A61K31/4458 , A61K31/485 , A61K31/515 , A61K31/5513 , A61K31/616 , A61K47/12 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38
摘要： Drug delivery formulations, uses thereof and methods of making same are provided in order to reduce the potential for abuse, misuse or improper administration of an addictive substance or any active substance and to prevent, reduce, inhibit, or delay purposeful or accidental overdose of an active substance by ingesting too many dosage forms at once, for example.

32. 发明授权

US09682064B2 Compounds for the treatment of mycobacterial infections 有权
公开(公告)号：US09682064B2
公开(公告)日：2017-06-20
申请号：US15215895
申请日：2016-07-21
申请人： The Broad Institute, Inc. , Massachusetts General Hospital
发明人： Deborah Hung , Sarah Stanley , Tomohiko Kawate , Noriakie Iwase , Motohisa Shimizu
IPC分类号： A61K31/35 , A61K31/37 , A61K31/5377 , A61K31/453 , A61K31/496
CPC分类号： C07D311/16 , A61K31/37 , A61K31/453 , A61K31/496 , A61K31/5377 , C07D311/18 , C07D405/04
摘要： The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:

33. 发明授权

US09662388B2 Methods and systems for treating cell proliferation disorders using plasmonics enhanced photospectral therapy (PEPST) and exciton-plasmon enhanced phototherapy (EPEP) 有权
公开(公告)号：US09662388B2
公开(公告)日：2017-05-30
申请号：US14947255
申请日：2015-11-20
申请人： Duke University , Immunolight, LLC
发明人： Tuan Vo-Dinh , Frederic A. Bourke, Jr.
IPC分类号： A61K41/00 , A61K39/00 , A61K31/37 , A61N5/06 , A61K9/14 , A61K47/48
CPC分类号： A61K41/0061 , A61K9/14 , A61K9/143 , A61K31/37 , A61K39/00 , A61K41/0028 , A61K41/0066 , A61K47/52 , A61K2039/57 , A61N5/06 , A61N5/062
摘要： The use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes used therein.

34. 发明申请

US20170065555A1 USE OF COUMARIN DERIVATIVES FOR THE PREPARATION OF DRUGS FOR TREATING SKIN DISEASES 有权
标题翻译：用于制备用于治疗皮肤疾病的药物的欧马林衍生物的使用
公开(公告)号：US20170065555A1
公开(公告)日：2017-03-09
申请号：US15356853
申请日：2016-11-21
申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , UNIVERSITE DE LIEGE
发明人： Michele REBOUD-RAVAUX , Chahrazade YERROUM-EL AMRI , Xiao TAN , Lixian QIN , Maurice PAGANO , Alain HOVNANIAN , Laetitia FURIO , Bernard PIROTTE
IPC分类号： A61K31/37
CPC分类号： A61K31/37 , A61K31/4433 , A61K31/4725 , C07D311/12 , C07D311/14 , C07D405/12
摘要： A compound of formula (I-1) wherein n equals 0 or 1, Z represents O or S, R1 represents one group chosen among the group consisting of hydrogen, C1-C7 alkyl, substituted, or not, by a halogen, a hydroxyl or a —O—R12 group, wherein R12 is a C1-C7 alkyl, a group —CH2—O—CO—R5 wherein R5 is chosen among a hydrogen atom and a C1-C7 alkyl, substituted or not by at least one halogen, a group —O—R13, wherein R13 is chosen among hydrogen and a C1-C7 alkyl, an amine or a —CH2-amine, R′1 represents a group chosen among hydrogen and —O—R14, wherein R14 is chosen among hydrogen and a C1-C7 alkyl, and R2 is chosen among the group consisting of a C1-C7 alkyl, a C3-C6 cycloalkyl, an aryl group, and an heteroaryl group for the treatment of pathologies involving excess activity of at least one member of the kallikrein family.
摘要翻译：其中n等于0或1，Z表示O或S，R1表示选自由卤素，羟基或-O-R12基团取代或未被取代的氢，C1-C7烷基的一个基团，其中 R 12是C 1 -C 7烷基，基团-CH 2 -O-CO-R 5，其中R 5选自氢原子和被至少一个卤素取代的C 1 -C 7烷基，-O-R 13基团，其中 R 13选自氢和C 1 -C 7烷基，胺或-CH 2 - 胺，R 1表示选自氢和-O-R 14中的基团，其中R 14选自氢和C 1 -C 7烷基，和 R2选自由C1-C7烷基，C3-C6环烷基，芳基和杂芳基组成的组，用于治疗涉及激肽释放酶家族的至少一个成员过量活性的病理学。

35. 发明申请

US20170056371A1 PHARMACEUTICAL COMPOSITIONS AND METHODS 审中-公开
标题翻译：药物组合物和方法
公开(公告)号：US20170056371A1
公开(公告)日：2017-03-02
申请号：US15351966
申请日：2016-11-15
申请人： Tyme, Inc.
发明人： Steven Hoffman
IPC分类号： A61K31/404 , A61K38/12 , A61K31/436 , A61K31/198 , A61K31/4166
CPC分类号： A61K31/404 , A61K9/0019 , A61K9/48 , A61K31/19 , A61K31/198 , A61K31/20 , A61K31/37 , A61K31/4166 , A61K31/436 , A61K31/55 , A61K31/787 , A61K38/12 , A61K38/31 , A61K2300/00
摘要： Pharmaceutical compositions and kits including a tyrosine hydroxylase inhibitor; melanin, a melanin promoter, or a combination thereof a p450 3A4 promoter; and a leucine aminopeptidase inhibitor are provided. Also provided are methods of treating cancer in a subject, comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3A4 promoter, and a leucine aminopeptidase inhibitor to the subject in need thereof. Also provided are methods of reducing cell proliferation in a subject comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3A4 promoter, and a leucine aminopeptidase inhibitor to the subject in need thereof.
摘要翻译：药物组合物和试剂盒，包括酪氨酸羟化酶抑制剂; 黑色素，黑色素启动子或其组合，p450 3A4启动子; 并提供亮氨酸氨基肽酶抑制剂。还提供了治疗受试者的癌症的方法，包括向有需要的受试者施用有效量的酪氨酸羟化酶抑制剂，黑色素启动子，p450 3A4启动子和亮氨酸氨基肽酶抑制剂。还提供了减少受试者细胞增殖的方法，包括向有需要的受试者施用有效量的酪氨酸羟化酶抑制剂，黑素启动子，p450 3A4启动子和亮氨酸氨基肽酶抑制剂。

36. 发明授权

US09572792B2 Coumarin compounds as receptor modulators with therapeutic utility 有权
标题翻译：香豆素化合物作为具有治疗效用的受体调节剂
公开(公告)号：US09572792B2
公开(公告)日：2017-02-21
申请号：US14729969
申请日：2015-06-03
申请人： Allergan, Inc.
发明人： Todd M. Heidelbaugh , John R. Cappiello , Phong X. Nguyen , Dario G. Gomez
IPC分类号： A61K31/365 , A61K31/366 , A61K31/37 , C07D311/16 , C07D311/18 , C07D405/12 , A61K31/4025 , A61K31/4433 , A61K31/453 , A61K31/501
CPC分类号： A61K31/37 , A61K31/365 , A61K31/366 , A61K31/4025 , A61K31/4433 , A61K31/453 , A61K31/501 , C07D311/16 , C07D311/18 , C07D405/12
摘要： The present invention relates to novel 2-oxo-2H-chromene-3-carboxamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
摘要翻译：本发明涉及新的2-氧代-2H-色烯-3-甲酰胺衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。

37. 发明授权

US09556138B2 Method of treatment for acne and an anti-acne formulation 有权
标题翻译：治疗痤疮和抗痤疮制剂的方法
公开(公告)号：US09556138B2
公开(公告)日：2017-01-31
申请号：US14384599
申请日：2013-03-12
申请人： PIRAMAL ENTERPRISES LIMITED
发明人： Somesh Sharma , Ashish Suthar , Kavita Salkar , Sandip Kedar
IPC分类号： C07D311/16 , A61K8/97 , A61K31/37 , A61K9/00 , A61Q19/00 , A61K8/49 , A61K36/73
CPC分类号： C07D311/16 , A61K8/498 , A61K8/97 , A61K9/0014 , A61K31/37 , A61K36/73 , A61Q19/008
摘要： The present disclosure relates to an anti-acne formulation comprising at least one active ingredient selected from the group consisting of coumarin based compounds of Formula I and Formula II; or pharmaceutically acceptable salts, polymorphs and derivatives thereof, and at least one pharmaceutically acceptable excipient. The present disclosure also relates to its application for preventing/curing/treating various acne conditions.
摘要翻译：本公开内容涉及包含至少一种选自由式I和式II的基于香豆素的化合物组成的组的活性成分的抗痤疮制剂; 或其药学上可接受的盐，多晶型物及其衍生物，和至少一种药学上可接受的赋形剂。本公开还涉及其用于预防/治疗/治疗各种痤疮病症的应用。

38. 发明申请

US20170020900A1 METHODS FOR SCREENING ANTIMICROBIAL AND ANTIVIRAL COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：用于筛选抗微生物和抗病毒化合物的方法及其用途
公开(公告)号：US20170020900A1
公开(公告)日：2017-01-26
申请号：US15051076
申请日：2016-02-23
申请人： The General Hospital Corporation , Northeastern University
发明人： Frederick M. AUSUBEL , Kim LEWIS , Terence I. MOY , Suresh GOPALAN
IPC分类号： A61K31/655 , A61K31/198 , A61K31/426 , A61K31/10 , A61K31/17 , A61K31/427 , A61K31/37 , A61K31/4184 , A61K31/122 , A61K31/517 , A61K31/44 , A61K31/496 , A61K31/27 , A61K31/5377 , A61K31/166
CPC分类号： A61K31/655 , A61K31/10 , A61K31/122 , A61K31/166 , A61K31/17 , A61K31/198 , A61K31/221 , A61K31/27 , A61K31/37 , A61K31/4184 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/496 , A61K31/517 , A61K31/5377 , C12Q1/18 , Y02A50/481
摘要： The invention features compounds that have antibacterial activity, their use for the treatment of bacterial infections, screening methods that use whole animals or plant seedlings to identify compounds that inhibit a pathogen in the animal or plant, and screening methods to identify compounds that increase the lifespan of an organism.
摘要翻译：本发明的特征在于具有抗菌活性的化合物，其用于治疗细菌感染的用途，使用全部动物或植物幼苗的筛选方法来鉴别抑制动物或植物中的病原体的化合物，以及筛选方法来鉴定增加寿命的化合物的生物体。

39. 发明申请

US20160331731A1 USE OF PSORALEN DERIVATIVES AND COMBINATION THERAPY FOR TREATMENT OF CELL PROLIFERATION DISORDERS 审中-公开
公开(公告)号：US20160331731A1
公开(公告)日：2016-11-17
申请号：US15220596
申请日：2016-07-27
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Wenle XIA , David Gooden , Erik J. Soderblom , Eric J. Toone , Neil L. Spector , Wayne F. Beyer, JR. , Harold Walder
IPC分类号： A61K31/436 , A61K31/4709 , A61K41/00 , A61K45/06
CPC分类号： A61K31/436 , A61K31/37 , A61K31/4709 , A61K31/517 , A61K41/0066 , A61K45/06 , A61K2300/00
摘要： Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.

40. 发明授权

US09457064B2 Method for treatment of vitiligo 有权
标题翻译：治疗白癜风的方法
公开(公告)号：US09457064B2
公开(公告)日：2016-10-04
申请号：US11193165
申请日：2005-07-29
申请人： Abburi Ramaiah
发明人： Abburi Ramaiah
IPC分类号： A61K31/37 , A61K31/366 , A61K8/64 , A61K38/04 , A61K38/18 , A61Q19/02 , C07K14/50
CPC分类号： A61K38/1825 , A61K31/366 , A61K31/37 , A61K2300/00
摘要： Synergistic therapies for the treatment of vitiligo are provided, in which basic fibroblast growth factor peptide(s) lotion was developed as a new mode of therapy for the treatment of vitiligo. It went through various phases of successful clinical trials in India and is marketed by the drug controller general (India). It is effective in 80% of stable and segmental vitiligo. Data are provided which demonstrate that combinatorial treatment of vitiligo by local application of bFGF peptide(s) lotions in association with psoralens and UV-A, or steroids or surgical procedures, produce a synergistic response in which the rate of repigmentation increases synergistically and more efficacious results are obtained than with any one of them alone. Any combinatorial therapy comprising the local application of bFGF peptide(s) lotion on the vitiligo patch in combination with any other therapies for the treatment of vitiligo also may act synergistically.
摘要翻译：提供了用于治疗白癜风的协同疗法，其中碱性成纤维细胞生长因子肽洗剂被开发为用于治疗白癜风的新的治疗方式。它经历了印度成功临床试验的各个阶段，由药物管制总局（印度）出售。在80％的稳定和节段性白癜风中有效。提供数据，其证明通过局部施用bFGF肽洗剂与补骨脂素和UV-A或类固醇或外科手术相结合的白癜风的组合治疗产生协同作用，其中色素沉降速率协同增加并且更有效得到的结果比其中任何一个单独获得。包括在白癜风贴片上局部应用bFGF肽洗剂的任何组合疗法与用于治疗白癜风的任何其它疗法组合也可以起协同作用。

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