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    • 38. 发明授权
    • Thiol-containing compounds for the removal of elements from tissues and formulations therefor
    • 用于从组织中除去元素的硫醇化合物及其制剂
    • US08575218B2
    • 2013-11-05
    • US13041798
    • 2011-03-07
    • Boyd E. HaleyDavid A. AtwoodNiladri Gupta
    • Boyd E. HaleyDavid A. AtwoodNiladri Gupta
    • A01N37/12A01N37/10A01N43/00
    • A61K31/198A61K31/216A61K31/695A61K31/795B01D53/64B01D2253/106B01D2253/25B01D2257/602B01D2258/0283B01D2258/0291C07F7/1804
    • Methods and pharmaceutical formulations for ameliorating heavy metal toxicity and/or oxidative stress are disclosed, comprising administering pharmaceutically effective amounts of ligands according to the present disclosure. The ligands are of the general structure: where R1 comprises benzene, pyridine, pyridin-4-one, naphthalene, anthracene, phenanthrene or alkyl groups, R2 comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, R3 comprises alkyls, aryls, a carboxyl group, carboxylate esters, organic groups or biological groups, X comprises hydrogen, lithium, sodium, potassium, rubidium, cesium, francium, alkyls, aryls, a carboxyl group, carboxylate esters, thiophosphate, N-acetyl cysteine, mercaptoacetic acid, mercaptopropionic acid, thiolsalicylate, organic groups or biological groups, n independently equals 1-10, m=1-6, Y comprises hydrogen, polymers, silicas or silica supported substrates, and Z comprises hydrogen, alkyls, aryls, a carboxyl group, carboxylate esters, a hydroxyl group, NH2, HSO3, halogens, a carbonyl group, organic groups, biological groups, polymers, silicas or silica supported substrates.
    • 公开了用于改善重金属毒性和/或氧化应激的方法和药物制剂,其包括施用根据本公开的药学有效量的配体。 配体具有以下通式:其中R1包括苯,吡啶,吡啶-4-酮,萘,蒽,菲或烷基,R2包括氢,烷基,芳基,羧基,羧酸酯,有机基团或生物基团 R 3包括烷基,芳基,羧基,羧酸酯,有机基团或生物基团,X包括氢,锂,钠,钾,铷,铯,ium,烷基,芳基,羧基,羧酸酯,硫代磷酸酯,N 乙酰半胱氨酸,巯基乙酸,巯基丙酸,硫代水杨酸,有机基团或生物基团,n独立地等于1-10,m = 1-6,Y包括氢,聚合物,二氧化硅或二氧化硅负载的底物,Z包括氢,烷基, 芳基,羧基,羧酸酯,羟基,NH 2,HSO 3,卤素,羰基,有机基团,生物基团,聚合物,二氧化硅或二氧化硅负载的基质。