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31. 发明授权

US07476743B2 Compounds, compositions, and methods 失效
标题翻译：化合物，组合物和方法
公开(公告)号：US07476743B2
公开(公告)日：2009-01-13
申请号：US10529634
申请日：2003-10-02
申请人： Xiangping Qian , Gustave Bergnes , David J. Morgans, Jr. , Steven David Knight , Dashyant Dhanak
发明人： Xiangping Qian , Gustave Bergnes , David J. Morgans, Jr. , Steven David Knight , Dashyant Dhanak
IPC分类号： C07D249/12 , A01N43/64
CPC分类号： C07D249/12 , C07D403/04
摘要： 1,2,4-Tiazole-5-ones useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译：公开了通过调节KSP的活性来治疗细胞增殖性疾病和病症的1,2,4-噻唑-5-酮。

32. 发明授权

US07465807B2 Process for preparing benzimidazole thiophenes 失效
标题翻译：制备苯并咪唑噻吩的方法
公开(公告)号：US07465807B2
公开(公告)日：2008-12-16
申请号：US10575210
申请日：2004-10-12
申请人： Mui Cheung , Kyle Allen Emmitte
发明人： Mui Cheung , Kyle Allen Emmitte
IPC分类号： C07D409/04
CPC分类号： C07D491/04 , C07D409/04 , C07D409/14
摘要： The present invention provides a process for preparing benzimidazole thiophene compounds.
摘要翻译：本发明提供一种制备苯并咪唑噻吩化合物的方法。

33. 发明授权

US07462614B2 Imidazotriazine compounds 失效
标题翻译：咪唑并三嗪化合物
公开(公告)号：US07462614B2
公开(公告)日：2008-12-09
申请号：US10550434
申请日：2004-03-29
申请人： Mui Cheung , Nigel Paul King , Kevin Wayne Kuntz , Robert Anthony Mook, Jr. , Mark Andrew Pobanz , James Michael Salovich , Brian John Wilson
发明人： Mui Cheung , Nigel Paul King , Kevin Wayne Kuntz , Robert Anthony Mook, Jr. , Mark Andrew Pobanz , James Michael Salovich , Brian John Wilson
IPC分类号： C07D487/04 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译：本发明提供式（I）化合物：其中所有变量如本文所定义，含有该化合物的药物组合物，其制备方法及其作为药剂的用途。

34. 发明授权

US07456952B2 System for real-time fluorescent determination of trace elements 有权
标题翻译：用于实时荧光测定微量元素的系统
公开(公告)号：US07456952B2
公开(公告)日：2008-11-25
申请号：US11531469
申请日：2006-09-13
申请人： Dwight Sherod Walker
发明人： Dwight Sherod Walker
IPC分类号： G01J3/30
CPC分类号： G01N21/64 , G01N21/03 , G01N21/9508 , G01N23/043 , G01N2021/0339 , G01N2021/6417 , G01N2021/845
摘要： A system for use in in-situ analysis of pharmaceutical samples, said system comprising means for holding a plurality of said samples, wherein said samples are present in the form of a powder formulation; means for moving said plurality of samples along a sample path; means for generating a plurality of incident radiation pulses of different wavelength; means for illuminating at least a respective one of said samples with at least a respective one of said radiation pulses during said movement of said samples, said radiation pulse having a suitable range of radiation wavelengths capable of inducing a fluorescent response; means for detecting a first resultant fluorescence emitted from each of said samples; first control means in communication with said moving means and said incident radiation generating means for synchronizing said means for illuminating each of said samples with said moving means.
摘要翻译：一种用于药物样品的原位分析的系统，所述系统包括用于保持多个所述样品的装置，其中所述样品以粉末制剂的形式存在; 用于沿着采样路径移动所述多个样本的装置; 用于产生不同波长的多个入射辐射脉冲的装置; 用于在所述样品运动期间用至少一个所述辐射脉冲照射至少一个所述样品的装置，所述辐射脉冲具有能够诱导荧光响应的适当范围的辐射波长; 用于检测从每个所述样品发射的第一合成荧光的装置; 与所述移动装置和所述入射辐射发生装置通信的第一控制装置，用于使所述用于照亮每个所述样本的装置与所述移动装置同步。

35. 发明授权

US07442793B2 Peptide deformylase inhibitors 有权
标题翻译：肽变性酶抑制剂
公开(公告)号：US07442793B2
公开(公告)日：2008-10-28
申请号：US10538625
申请日：2003-12-11
申请人： Jinhwa Lee , Siegfried B. Christensen, IV
发明人： Jinhwa Lee , Siegfried B. Christensen, IV
IPC分类号： C07D237/26 , C07D215/38 , C07D407/00 , C07D319/14
CPC分类号： C07D471/04 , C07C259/06 , C07D215/48 , C07D307/68 , C07D307/85 , C07D317/68 , C07D319/18 , C07D321/10
摘要： Novel PDF inhibitors and novel methods for their use are provided.
摘要翻译：提供了新的PDF抑制剂及其使用的新方法。

36. 发明申请

US20080255184A1 Thienopyridine B-Raf Kinase Inhibitors 审中-公开
标题翻译：噻吩并吡啶B-Raf激酶抑制剂
公开(公告)号：US20080255184A1
公开(公告)日：2008-10-16
申请号：US12090575
申请日：2006-10-23
申请人： Jun Tang
发明人： Jun Tang
IPC分类号： A61K31/444 , C07D495/04 , A61P35/00
CPC分类号： C07D495/04
摘要： The present invention provides thienopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.
摘要翻译：本发明提供噻吩并吡啶化合物，含有它们的组合物，以及其制备方法及其作为药剂的用途。

37. 发明申请

US20080249301A1 Regioselective Process for Preparing Benzimidazole Thiophenes 审中-公开
标题翻译：用于制备苯并咪唑噻吩的区域选择性方法
公开(公告)号：US20080249301A1
公开(公告)日：2008-10-09
申请号：US12065655
申请日：2006-08-28
申请人： Keith Hornberger , Mui Cheung , Mark Andrew Pobanz , Kyle Allen Emmitte , Kevin Wayne Kuntz , Jennifer Gabriel Badiang
发明人： Keith Hornberger , Mui Cheung , Mark Andrew Pobanz , Kyle Allen Emmitte , Kevin Wayne Kuntz , Jennifer Gabriel Badiang
IPC分类号： C07D235/04 , C07D401/10 , C07D413/14 , C07D403/10 , C07D243/08
CPC分类号： C07D333/40 , C07D409/04
摘要： The present invention provides a process for preparing benzimidazole thiophene compounds of formula (I). Intermediates used in the process are also claimed.
摘要翻译：本发明提供制备式（I）的苯并咪唑噻吩化合物的方法。还要求用于该方法中的中间体。

38. 发明申请

US20080214640A1 Thrombopoietin mimetics 有权
公开(公告)号：US20080214640A1
公开(公告)日：2008-09-04
申请号：US11650651
申请日：2007-01-08
申请人： Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
发明人： Kevin J. Duffy , Connie Erickson-Miller , Daniel F. Eppley , Julian Jenkins , Juan I. Luengo , Nannan Liu , Alan T. Price , Antony N. Shaw , Sophie Visonneau , Kenneth Wiggall
IPC分类号： A61K31/4152 , C07D231/46 , A61P7/02
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

39. 发明申请

US20080214455A1 Novel Chemical Compounds 审中-公开
标题翻译：新型化合物
公开(公告)号：US20080214455A1
公开(公告)日：2008-09-04
申请号：US11912969
申请日：2006-05-03
申请人： Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Michael N. Zimmerman , Neil W. Johnson , Jiri Kasparec
发明人： Kevin Duffy , Deping Chai , Mirela Colon , Duke M. Fitch , Sarah Rae King , Antony N. Shaw , Rosanna Tedesco , Kenneth Wiggall , Michael N. Zimmerman , Neil W. Johnson , Jiri Kasparec
IPC分类号： C07D417/02 , C07D417/14 , A61K31/5377 , A61K31/498 , A61K31/496 , A61K31/4709 , A61K38/22 , A61P7/00
CPC分类号： C07D417/06
摘要： This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.
摘要翻译：本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3活性相关的疾病的方法。

40. 发明申请

US20080206189A1 METHOD OF TREATING CANCER BY ADMINISTERING CONJUGATES COMPRISING HUMAN IL-18 AND SUBSTITUTION MUTANTS THEREOF 有权
标题翻译：通过管理包含人IL-18及其替代物的宿主治疗癌症的方法
公开(公告)号：US20080206189A1
公开(公告)日：2008-08-28
申请号：US11962811
申请日：2007-12-21
申请人： Narendra BAM , Jacob Bongers , Robert B. Kirkpatrick , Cheryl A. Janson , Zdenka Jonak , Xianyang Qiu , Ping Yeh , Kyung Johanson
发明人： Narendra BAM , Jacob Bongers , Robert B. Kirkpatrick , Cheryl A. Janson , Zdenka Jonak , Xianyang Qiu , Ping Yeh , Kyung Johanson
IPC分类号： A61K45/00
CPC分类号： C07K14/54 , A61K38/00 , A61K47/60
摘要： Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjugated cytokines demonstrate enhanced and unexpected biological properties when compared to the corresponding unconjugated cytokines.
摘要翻译：将人白细胞介素-18（IL-18）多肽及其取代突变体与人IL-18蛋白的特定部位的水溶性聚合物缀合。这些共轭人IL-18及其取代突变体保留生物活性。当与相应的未结合的细胞因子相比时，这些缀合的细胞因子表现出增强的和意想不到的生物学特性。

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