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31. 发明申请

US20100065738A1 METHOD AND APPARATUS FOR ION AXIAL SPATIAL DISTRIBUTION FOCUSING 有权
标题翻译：离子空间分布聚焦的方法与装置
公开(公告)号：US20100065738A1
公开(公告)日：2010-03-18
申请号：US12506605
申请日：2009-07-21
申请人： Andrew BOWDLER
发明人： Andrew BOWDLER
IPC分类号： H01J49/28 , H01J49/26
CPC分类号： H01J49/40 , H01J49/06 , H01J49/067
摘要： The present invention provides a mass spectrometer including an ion source for generating pre-cursor ions, ion fragmentation means for generating fragment ions from the pre-cursor ions, a reflectron for focusing the kinetic energy distribution of the ions, and an ion detector wherein the mass spectrometer also includes axial spatial distribution focusing means which in use acts on the ions after the ion fragmentation means and before the reflectron, the axial spatial distribution focusing means being operable to reduce the spatial distribution of the ions in the direction of the ion optical axis of the spectrometer. Suitably the axial spatial distribution focusing means comprising a cell with two electrodes 52, 54 which may be apertures or high transmission grids. A pulsed electrostatic field is generated by applying a high voltage pulse 60 to the first electrode 52 at the time when the pre-cursor ions of interest 56, 58 have just passed into the pulser 50. The second electrode 54 is maintained at 0V during this time.
摘要翻译：本发明提供了一种质谱仪，其包括用于产生前体离子的离子源，用于从前体离子产生碎片离子的离子碎裂装置，用于聚焦离子的动能分布的反射器，以及离子检测器，其中质谱仪还包括轴向空间分布聚焦装置，其在使用中作用于离子碎片装置之后的离子并且在反射体之前，轴向空间分布聚焦装置可操作以减少离子在离子光轴方向上的空间分布的光谱仪。适当地，轴向空间分布聚焦装置包括具有两个电极52,54的单元，其可以是孔或高传输格栅。当感兴趣的前置离子56,58刚刚进入脉冲发生器50时，通过将高电压脉冲60施加到第一电极52来产生脉冲静电场。在此期间，第二电极54保持在0V 时间。

32. 发明申请

US20090309023A1 ELECTRON SPECTROSCOPY 有权
标题翻译：电子光谱
公开(公告)号：US20090309023A1
公开(公告)日：2009-12-17
申请号：US12482577
申请日：2009-06-11
申请人： Simon Page
发明人： Simon Page
IPC分类号： G01N23/00
CPC分类号： H01J37/05 , G01N23/2273 , H01J37/08 , H01J37/295 , H01J37/30 , H01J2237/05 , H01J2237/08 , H01J2237/0815
摘要： The present invention provides an electron spectroscopy apparatus (12) comprising a high energy particle source (12) for irradiating a sample, an electron detector system (16) (e.g. including a delay line detector) for detecting electrons emitted from the sample and an ion gun (8) for delivering a polycyclic aromatic hydrocarbon (PAH) ion beam to the sample, wherein the ion gun comprises a polycyclic aromatic hydrocarbon ion source, for example comprising coronene. In an embodiment, the PAH is located in a heated chamber (22) and vaporised to produce gas phase PAH. The gas phase PAH molecules are then ionised by electron impact, extracted from the ion source via an extraction field and focussed using ion optics. The PAH ion beam can be used for surface cleaning and depth analysis.
摘要翻译：本发明提供了一种包括用于照射样品的高能粒子源（12），用于检测从样品发射的电子的电子检测器系统（16）（例如包括延迟线检测器）的电子分光装置（12）用于将多环芳烃（PAH）离子束输送到样品的枪（8），其中所述离子枪包括多环芳族烃离子源，例如包含芳烃。在一个实施方案中，PAH位于加热室（22）中并蒸发以产生气相PAH。气相PAH分子然后通过电子轰击电离，通过提取场从离子源提取，并使用离子光学聚焦。 PAH离子束可用于表面清洁和深度分析。

33. 发明申请

US20090129551A1 Electrode for X-ray apparatus 审中-公开
标题翻译： X射线装置用电极
公开(公告)号：US20090129551A1
公开(公告)日：2009-05-21
申请号：US12285608
申请日：2008-10-09
申请人： Peter Robert Butler , Simon Charles Page
发明人： Peter Robert Butler , Simon Charles Page
IPC分类号： H05G2/00 , G01N23/00
CPC分类号： H01J35/12 , H01J35/186 , H01J2235/081 , H01J2235/084 , H01J2235/086 , H01J2235/1204 , H01J2235/1262 , H01J2235/1295
摘要： The present invention provides an electrode, typically an anode, for use in an x-ray generating apparatus comprising an electron source. The electrode comprises a housing, a diamond member mounted to the housing, and a target located on the diamond member, which target in use is bombarded with electrons from the electron source so as to generate x-rays. A bonding layer is located between the housing the diamond member, which bonding layer comprises an alloy having a solidus or melting point of less than 900° C. A particularly preferred alloy comprises silver, copper and indium. This arrangement assists in dissipating heat generated at the electrode surface whilst retaining the structural integrity of the electrode.
摘要翻译：本发明提供一种用于包括电子源的X射线产生装置的电极，通常为阳极。电极包括壳体，安装到壳体的金刚石构件和位于金刚石构件上的靶，其目标在使用中由来自电子源的电子轰击以产生x射线。接合层位于壳体之间的金刚石构件之间，该接合层包括具有小于900℃的固相线或熔点的合金。特别优选的合金包括银，铜和铟。这种布置有助于消散在电极表面产生的热，同时保持电极的结构完整性。

34. 发明申请

US20060060770A1 Charged particle spectrometer and detector therefor 有权
标题翻译：带电粒子光谱仪及其检测器
公开(公告)号：US20060060770A1
公开(公告)日：2006-03-23
申请号：US10533570
申请日：2003-11-04
申请人： Simon Page , Colin Park , Christopher Hopper
发明人： Simon Page , Colin Park , Christopher Hopper
IPC分类号： B01D59/44 , G01N23/00
CPC分类号： H01J49/48
摘要： A charged particle (e.g. photoelectron) spectrometer is operable in a first mode to produce an energy spectrum relating to the composition of a sample being analysed, and in a second mode to produce a charged particle image of the surface of the sample being analysed. A detector is used to detect charged particles produced in both modes of operation. A method of operation of the spectrometer includes the step of selecting which of said first and second modes to use and the detector being operated accordingly.
摘要翻译：带电粒子（例如光电子）光谱仪可在第一模式下操作以产生与所分析的样品的组成相关的能谱，并且在第二模式中产生被分析的样品的表面的带电粒子图像。检测器用于检测在两种操作模式下产生的带电粒子。光谱仪的操作方法包括以下步骤：选择要使用的所述第一和第二模式中的哪一种，并且相应地操作检测器。

35. 发明授权

US5185524A Charged particle energy analyzers 失效
标题翻译：充电颗粒能量分析仪
公开(公告)号：US5185524A
公开(公告)日：1993-02-09
申请号：US699669
申请日：1991-05-14
申请人： Simon C. Page
发明人： Simon C. Page
IPC分类号： H01J37/05 , H01J37/244 , H01J49/44 , H01J49/48
CPC分类号： H01J49/484 , H01J37/05
摘要： A charged particle energy analyzer includes two hemispherical electrodes and means for developing an inverse square electric field in the gap between the two electrodes. An afocal charged particle lens arrangement is arranged to project a charged particle image of a sample into the electric field. Two baffles are disposed in the gap between the electrodes the baffles being effective to restrict the energy and angular divergence of the particles transmitted by the analyzer, the baffles being positioned so as to reduce the dependence of the energy and the orientation of the charged particles transmitted by the baffles on the position of the particles within the image. A two-dimensional detector is arranged to detect the charged particle image transmitted by the analyzer.

36. 发明授权

US5077472A Ion mirror for a time-of-flight mass spectrometer 失效
标题翻译：飞行时间质谱仪的离子镜
公开(公告)号：US5077472A
公开(公告)日：1991-12-31
申请号：US550400
申请日：1990-07-10
申请人： Stephen C. Davis
发明人： Stephen C. Davis
IPC分类号： G01N27/62 , H01J49/40
CPC分类号： H01J49/405
摘要： An ion mirror for a time-of-flight mass spectrometer comprises a monopole electrode structure which operates at d.c. voltage. This electrode structure defines a field region in which an incident ion experiences an electrostatic reflecting force having a magnitude proportional to the separation of the ion from where it entered the field region or from where the ion exits the field region, if the latter separation is smaller. The ion occupies the field region for a time interval related to its mass but not its energy.

37. 发明授权

US10655157B2 Microbial analysis 审中-公开
公开(公告)号：US10655157B2
公开(公告)日：2020-05-19
申请号：US15028052
申请日：2014-10-09
申请人： KRATOS ANALYTICAL LIMITED
发明人： Gerald Stubiger , Omar Belgacem
IPC分类号： C12Q1/04 , G01N33/68 , G01N33/92 , H01J49/04
摘要： The present invention is concerned with a method of identifying microbial strains (e.g. from a cell culture), the method comprising; i) a lipid extraction step, comprising extraction of phospholipids from the microbe, suitably with an extraction composition comprising more than 50 vol % MeOH; ii) a sample preparation step, comprising preparation of a MALDI sample incorporating the extracted lipids; iii) a data gathering step, comprising performing MALDI-based mass spectrometry on the MALDI sample, and iv) a microbe identification step, comprising analysis of the mass spectrometry data to characterise or identify the microbial strain. Suitably the method also includes extracting proteins from the microbes and analysing the extracted proteins using MALDI-based mass spectrometry so as to obtain not only lipid m/z data but also protein m/z data.

38. 发明授权

US10340131B2 Methods and apparatuses relating to cleaning and imaging an ion source using reflected light 有权
公开(公告)号：US10340131B2
公开(公告)日：2019-07-02
申请号：US15516056
申请日：2015-09-21
申请人： KRATOS ANALYTICAL LIMITED
发明人： John Mark Allison
IPC分类号： B08B7/00 , H01J49/16
摘要： A method of cleaning an ion source. The method includes: at a first reflective surface of a mirror, reflecting light that has a wavelength in a first wavelength band onto a surface of the ion source so that contaminant material is desorbed from the surface of the ion source; at a second reflective surface of the mirror, reflecting light that has a wavelength in a second wavelength band and that comes from the surface of the ion source towards an imaging apparatus for producing an image of the surface of the ion source, wherein the light that has a wavelength in the second wavelength band passes through the first reflective surface of the mirror before being reflected at the second reflective surface of the mirror.

39. 发明授权

US08716674B2 Timing device and method 有权
标题翻译：定时装置及方法
公开(公告)号：US08716674B2
公开(公告)日：2014-05-06
申请号：US13883589
申请日：2011-11-03
申请人： Ian Sherwood
发明人： Ian Sherwood
IPC分类号： H01J49/02
CPC分类号： H01J49/022 , G06F13/4295 , H01J49/40 , H03K5/133 , H03M9/00 , H04L7/00 , H04L7/033
摘要： The present invention provides a timing device, especially a timing device for use in mass spectrometers, for example TOF mass spectrometers, for processing trigger signal data containing a trigger signal indicating the occurrence of a trigger event, the timing device having: a trigger signal deserialiser configured to receive trigger signal data containing a trigger signal indicating the occurrence of a trigger event as serial data and to output the trigger signal data as parallel data, and wherein suitably the timing device has a processing means configured to process trigger signal data outputted by the trigger signal deserialiser as parallel data.
摘要翻译：本发明提供一种定时装置，特别是在质谱仪中使用的定时装置，例如TOF质谱仪，用于处理包含指示触发事件发生的触发信号的触发信号数据，定时装置具有：触发信号解串器被配置为接收包含指示触发事件发生的触发信号的触发信号数据作为串行数据，并且将触发信号数据作为并行数据输出，并且其中适当地，定时装置具有处理装置，其被配置为处理由触发信号解串器作为并行数据。

40. 发明申请

US20130221215A1 TIMING DEVICE AND METHOD 有权
标题翻译：时序设备及方法
公开(公告)号：US20130221215A1
公开(公告)日：2013-08-29
申请号：US13883589
申请日：2011-11-03
申请人： Ian Sherwood
发明人： Ian Sherwood
IPC分类号： H01J49/02 , H03M9/00
CPC分类号： H01J49/022 , G06F13/4295 , H01J49/40 , H03K5/133 , H03M9/00 , H04L7/00 , H04L7/033
摘要： The present invention provides a timing device, especially a timing device for use in mass spectrometers, for example TOF mass spectrometers, for processing trigger signal data containing a trigger signal indicating the occurrence of a trigger event, the timing device having: a trigger signal deserialiser configured to receive trigger signal data containing a trigger signal indicating the occurrence of a trigger event as serial data and to output the trigger signal data as parallel data, and wherein suitably the timing device has a processing means configured to process trigger signal data outputted by the trigger signal deserialiser as parallel data.
摘要翻译：本发明提供一种定时装置，特别是在质谱仪中使用的定时装置，例如TOF质谱仪，用于处理包含指示触发事件发生的触发信号的触发信号数据，定时装置具有：触发信号解串器被配置为接收包含指示触发事件发生的触发信号的触发信号数据作为串行数据，并且将触发信号数据作为并行数据输出，并且其中适当地，定时装置具有处理装置，其被配置为处理由触发信号解串器作为并行数据。

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