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31. 发明申请

US20140029270A1 PROCESSING MACHINE 审中-公开
标题翻译：加工机
公开(公告)号：US20140029270A1
公开(公告)日：2014-01-30
申请号：US13816213
申请日：2012-07-26
申请人： Masami Suzuki , Satoshi Tokuoka , Satoru Maeda
发明人： Masami Suzuki , Satoshi Tokuoka , Satoru Maeda
IPC分类号： F21V8/00 , B29D11/00
CPC分类号： G02B6/0043 , B21K5/20 , B23K26/0006 , B23K26/082 , B23K26/0853 , B23K26/352 , B23K26/389 , B23K2103/50 , B29D11/00673 , G02B6/0061 , G02B6/0065 , Y10T428/24273
摘要： A processing machine is configured to include a processing device capable of applying processing for forming many holes to a processing area as a part of a region to be processed in a workpiece, a transferring device to relatively move the workpiece with respect to the processing device after the processing is applied to a certain area in the region to be processed, and to position an unprocessed area as a new area to be processed by the processing device, a processing pattern storage unit to store information defining arrangement positions of the holes formed by the processing device, and a control unit to determine a target processing position of each of the holes by adding a position correction amount of each hole on a random basis to the position of each hole defined by the information stored in the processing pattern storage unit.
摘要翻译：一种加工机构，其特征在于，包括能够对作为工件的待处理区域的一部分的处理区域进行多孔加工处理的处理装置，在所述处理装置之后相对于所述处理装置使所述工件相对移动的传送装置，处理被应用于要处理的区域中的某个区域，并且将未处理区域定位为由处理装置处理的新区域;处理模式存储单元，用于存储定义由所述处理装置形成的孔的布置位置的信息处理装置和控制单元，通过将每个孔的位置校正量随机地添加到由存储在处理模式存储单元中的信息定义的每个孔的位置来确定每个孔的目标处理位置。

32. 发明申请

US20130186871A1 LASER PROCESSING MACHINE 有权
标题翻译：激光加工机
公开(公告)号：US20130186871A1
公开(公告)日：2013-07-25
申请号：US13814227
申请日：2012-07-26
申请人： Masami Suzuki , Norio Nishi , Junichi Matsumoto , Nobutaka Yoneyama , Satoshi Tokuoka , Etsushi Kato
发明人： Masami Suzuki , Norio Nishi , Junichi Matsumoto , Nobutaka Yoneyama , Satoshi Tokuoka , Etsushi Kato
IPC分类号： B23K26/04 , B23K26/067
CPC分类号： B23K26/04 , B23K26/032 , B23K26/042 , B23K26/0643 , B23K26/0665 , B23K26/067 , B23K26/082 , B23K26/0853
摘要： A processing machine includes mirrors and to reflect a beam L oscillated from a laser oscillator to a predetermined surface on which a workpiece is arranged, optical axis operating mechanisms and to position an optical axis of the beam L at a desired target irradiation position by changing directions of the mirrors and, a camera sensor to capture an image of the target irradiation position and its periphery reflected in the mirror, and an error calibration mechanism to detect an error between the target irradiation position instructed to the optical axis operating mechanisms and an actual position of the optical axis of the beam L in the predetermined surface by referring to the image captured by the camera sensor. A correction amount to the optical axis operating mechanisms and is determined based on the error to irradiate the target irradiation position with the beam L during processing.
摘要翻译：加工机器包括反射镜并将从激光振荡器振荡的光束L反射到其上布置工件的预定表面，光轴操作机构，并且通过改变方向将光束L的光轴定位在期望的目标照射位置以及用于拍摄目标照射位置的图像及其反射镜中的周边的图像的摄像机传感器，以及用于检测指示到光轴操作机构的目标照射位置与实际位置之间的误差的误差校准机构通过参照由照相机传感器拍摄的图像，在预定表面中的光束L的光轴。对光轴操作机构的校正量，并且基于在处理期间用光束L照射目标照射位置的误差来确定。

33. 发明申请

US20080165814A1 Pulse oscillating type solid laser unit and laser process unit 失效
标题翻译：脉冲振荡型固体激光单元和激光加工单元
公开(公告)号：US20080165814A1
公开(公告)日：2008-07-10
申请号：US11785620
申请日：2007-04-19
申请人： Nobuaki Iehisa
发明人： Nobuaki Iehisa
IPC分类号： H01S3/13
CPC分类号： B23K26/24 , B23K26/064 , B23K26/0853 , B23K26/702 , H01S3/0941 , H01S3/10069 , H01S3/1312 , H01S3/1643 , H01S5/0428 , H01S5/0617 , H01S5/0683
摘要： A pulse oscillating type solid laser unit that has a laser unit body whose exciting source is a laser diode that emits light in a principal energy absorbing spectrum of a solid laser activated media, and characterized by that prior to radiating laser light outside the laser unit body as a calibrating operation of a pulse laser output value, specified several varieties of rectangle pulse current values are conducted to a laser diode inside the pulse oscillating type solid laser unit so as to pulse-oscillate the laser unit body, a mean laser output value in each rectangle pulse current value is measured by the use of a laser output measuring instrument arranged inside the laser unit body so as to obtain a mean laser output value data, and in case that the laser output light is radiated outside the laser unit body, a pulse current value linear-predicted based on an obtained mean output value data is conducted to the laser diode so as to obtain a desired pulse laser output value.
摘要翻译：一种脉冲振荡型固体激光器单元，其具有激光单元体，其激励源为激光二极管，其以固体激光活化介质的主能量吸收光谱发光，其特征在于，在激光单元体外部照射激光作为脉冲激光输出值的校准操作，将脉冲振荡型固体激光器单元内的激光二极管指定若干种矩形脉冲电流值，以脉冲振荡激光单元体，平均激光输出值通过使用布置在激光单元体内的激光输出测量仪器来测量每个矩形脉冲电流值，以获得平均激光输出值数据，并且在激光输出光照射到激光单元体外部的情况下，基于获得的平均输出值数据线性预测的脉冲电流值被传送到激光二极管，以获得期望的脉冲激光输出值。

34. 发明授权

US07088761B2 Laser apparatus 有权
标题翻译：激光设备
公开(公告)号：US07088761B2
公开(公告)日：2006-08-08
申请号：US10492049
申请日：2002-02-18
申请人： Nobuaki Iehisa
发明人： Nobuaki Iehisa
IPC分类号： H01S3/091 , H01S3/08 , B01K26/00
CPC分类号： B23K26/0613 , B23K26/0604 , B23K2103/02 , B23K2103/10 , B23K2103/12 , H01S3/005 , H01S3/2383 , H01S5/4025 , H01S5/4087
摘要： A laser system is constructed so that a solid-state laser beam emitted from an Nd:YAG laser unit and a laser diode beam emitted from a combining LD which oscillates in a wavelength range shorter than that of the solid-state laser beam are combined by a dichroic beam splitter, the resultant beam is guided to an optical fiber, and a workpiece is irradiated with the combining LD beam and the solid-state laser beam with absolute irradiation positions and irradiation shapes of the beams almost matched each other. Thus, problems of high cost and high power consumption of the laser system due to low energy conversion efficiency, which become problems in a high-output high-luminance solid-state laser unit can be solved.
摘要翻译：激光系统被构造成使得从Nd：YAG激光器单元发射的固态激光束和从组合LD发射的激光二极管束在比固态激光束的波长短的波长范围内振荡的光束通过二向色光束分离器，合成的光束被引导到光纤，并且用绝对照射位置和光束的照射形状的组合LD光束和固态激光束照射工件几乎彼此匹配。因此，可以解决在高输出高亮度固体激光器单元中成为问题的由于低能量转换效率导致的激光系统的高成本和高功耗的问题。

35. 发明授权

US12018283B2 Method for producing insulin-producing cells 有权
公开(公告)号：US12018283B2
公开(公告)日：2024-06-25
申请号：US16962190
申请日：2019-01-24
申请人： KATAOKA CORPORATION , Kyoto Prefectural Public University Corporation
发明人： Ping Dai , Yukimasa Takeda , Yoshinori Harada , Junichi Matsumoto , Ayumi Kusaka
IPC分类号： C12N5/071
CPC分类号： C12N5/0676 , C12N2501/999 , C12N2506/1307
摘要： The present invention chiefly aims to provide a process for directly inducing insulin-producing cells from somatic cells without performing artificial gene transfer. The present invention can include a process for producing an insulin-producing cell by inducing differentiation directly from a somatic cell, the process comprising a step of culturing the somatic cell in the presence of a cAMP inducer, and six members selected from the group consisting of a GSK3 inhibitor, a TGF-β inhibitor, a BMP inhibitor, a p53 inhibitor, a PI3K inhibitor, a Notch inhibitor and a RAR agonist, or all members thereof. The insulin-producing cells obtained by the present invention are useful in regenerative medicine and the like.

36. 发明公开

US20230278139A1 WELDING METHOD AND LASER DEVICE 审中-公开
公开(公告)号：US20230278139A1
公开(公告)日：2023-09-07
申请号：US18175987
申请日：2023-02-28
申请人： KATAOKA CORPORATION
发明人： Takeshi YAMAMURA , Katsutoshi NAGASAKI , Keisuke HAYASHI
IPC分类号： B23K26/24 , B23K26/082 , B23K26/12
CPC分类号： B23K26/24 , B23K26/082 , B23K26/123
摘要： A welding method includes: arranging end portions of a first member and a second member next to each other facing an end surface of the end portions towards a laser device; performing rotational irradiation to the end surface of the end portions of the first member and the second member with laser light at a predetermined rotating diameter, wherein a spot diameter of the laser light is set to be equal to or larger than the rotating diameter, and wherein an irradiation region of the laser light by the rotational irradiation is set to extend over the first member and the second member.

37. 发明公开

US20230242862A1 CELL TREATMENT DEVICE, LEARNING DEVICE, AND LEARNED MODEL PROPOSAL DEVICE 审中-公开
公开(公告)号：US20230242862A1
公开(公告)日：2023-08-03
申请号：US18011911
申请日：2021-05-21
申请人： KATAOKA CORPORATION
发明人： Junichi MATSUMOTO , Tadao MORISHITA , Chiharu TABEI
IPC分类号： C12M1/34 , G06N20/00 , G06T7/00
CPC分类号： C12M41/46 , G06N20/00 , G06T7/00
摘要： The cell treatment apparatus of the present disclosure is a cell treatment apparatus including: an observation unit; a laser emitter; and a controller. The controller includes at least one processor that is configured to detect, using image data that includes the cell captured by an observation unit and a learned model capable of detecting a target cell or a non-target cell, a target cell or a non-target cell in the image data; set a region where the target cell is present or a region where the non-target cell is not present as a laser irradiation region to be subjected to laser irradiation by the laser emitter, and apply a laser emitted from the laser emitter to the laser irradiation region in the cell culture tool to treat the target cell.

38. 发明申请

US20230092230A1 LASER PROCESSING MACHINE, LASER PROCESSING SYSTEM, ROTATOR UNIT APPARATUS, LASER PROCESSING METHOD, AND METHOD FOR PRODUCING PROBE CARD 有权
公开(公告)号：US20230092230A1
公开(公告)日：2023-03-23
申请号：US17610950
申请日：2021-06-08
申请人： KATAOKA CORPORATION
发明人： Shinichi NAKASHIBA , Osamu ENDO
IPC分类号： B23K26/06 , B23K26/062 , B23K26/082 , B23K26/08 , B23K26/384 , B23K26/388 , B23K26/70
摘要： A laser processing machine including: a laser source that emits a laser beam; a polarization rotator unit; a beam rotator unit; a lens; and a controller, which apply the laser beam to a workpiece, the polarization rotator unit includes a wave plate and first actuator that rotates the wave plate, the beam rotator unit includes an optical system that adjusts an irradiation angle of the laser beam to the workpiece by making an incident laser beam eccentric to output and making the laser beam incident on the lens at a position eccentric from a central axis, a second actuator rotates the optical system, the lens condenses the laser beam on the workpiece, the controller controls a rotational speed ratio between the first actuator and the second actuator, and adjusts a polarized state of the laser beam by controlling the rotational speed ratio.

39. 发明授权

US11504810B2 Cell processing method, laser processing machine 有权
公开(公告)号：US11504810B2
公开(公告)日：2022-11-22
申请号：US15739395
申请日：2016-04-05
申请人： KATAOKA CORPORATION
发明人： Masami Suzuki , Norio Nishi , Junichi Matsumoto
IPC分类号： C12Q1/68 , B23K26/38 , C12N5/00 , B23K26/12 , C12N1/00 , C12M1/33 , C12M1/00 , B23K26/00 , C12N5/074 , G01N1/28
摘要： In order to cut a plurality of clumps having an approximately uniform shapes and approximately uniform dimensions out of a cell aggregate which has proliferated and appropriately eliminate contamination with fragments of different shapes or dimensions, when cutting the clumps of approximately uniform shape out of the cell aggregate which has proliferated, cutting lines along which the clumps of a specific shape are cut out are set such that the area of a peripheral part of the cell aggregate which is not cut by the cutting line exceeds the surface area of one of the clumps, and the cell aggregate is cut by irradiating with laser light in such a way as to trace the cutting lines.

40. 发明申请

US20220025336A1 METHOD FOR PRODUCING INSULIN-PRODUCING CELLS, AND COMPOSITION 有权
公开(公告)号：US20220025336A1
公开(公告)日：2022-01-27
申请号：US17288636
申请日：2019-11-11
申请人： KATAOKA CORPORATION , Kyoto Prefectural Public University Corporation
发明人： Ping DAI , Yukimasa TAKEDA , Yoshinori HARADA , Junichi MATSUMOTO , Ayumi KUSAKA
IPC分类号： C12N5/071
摘要： It is a main object of the present invention to provide a new producing method capable of efficiently performing direct conversion or induction from a somatic cell to an insulin-producing cell. The present invention can include, for example, a process for producing an insulin-producing cell by direct differentiation induction from a somatic cell, comprising a step of culturing a somatic cell in a serum-free differentiation induction medium, or a step of culturing a somatic cell in a differentiation induction medium containing 5 μg/mL or more of insulin. According to the present invention, insulin-producing cells having a high insulin secretion ability can be produced directly and efficiently from a somatic cell. The insulin-producing cells obtained according to the present invention are useful in regenerative medicine and the like.

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