专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20140380522A1 SOYBEAN RESISTANT TO CYST NEMATODES 审中-公开
标题翻译：大豆抵抗CYST NEMATODES
公开(公告)号：US20140380522A1
公开(公告)日：2014-12-25
申请号：US14218669
申请日：2014-03-18
申请人： Melissa G. Mitchum , David Lightfoot , Pramod Kaitheri Kandoth , Shimming Liu , Khalid Meksem
发明人： Khalid Meksem , Shiming Liu , Pramod Kaitheri Kandoth , Melissa G. Mitchum , David Lightfoot
IPC分类号： C12N15/82
CPC分类号： C12N15/8285 , A01H1/04 , A01H5/10 , C07K14/415 , Y02A40/164
摘要： A transgenic soybean plant or parts thereof, resistant to soybean cyst nematodes, transformed to express Glyma18g02570, Glyma18g02580, or Glyma18g02590, or a variant thereof. Also provided is a method of making such a plant. Also provided is an artificial DNA construct encoding Glyma18g02570, Glyma18g02580, or Glyma18g02590, or a variant thereof.
摘要翻译：转化为表达Glyma18g02570，Glyma18g02580或Glyma18g02590或其变体的大豆孢囊线虫耐转基因大豆植物或其部分。还提供了制造这种植物的方法。还提供了编码Glyma18g02570，Glyma18g02580或Glyma18g02590或其变体的人造DNA构建体。

32. 发明申请

US20140087006A1 USE OF TRANSPLATIN TO PREVENT HEARING LOSS 有权
标题翻译：使用运输车辆防止听力损失
公开(公告)号：US20140087006A1
公开(公告)日：2014-03-27
申请号：US14094864
申请日：2013-12-03
申请人： Board of Trustees of Southern Illinois University
发明人： Vickram Ramkumar , Debashree Mukherjea , Len Rybak
IPC分类号： A61K33/24
CPC分类号： A61K33/24 , A61K9/0019 , A61K9/0046 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for treating and preventing toxic side effects of platinum-based chemotherapy agents are disclosed, in which transplatin is administered to a subject. Transplatin is shown to have protective effects against cisplatin-induced ototoxicity, nephotoxicity and neurotoxicity. Anti-inflammatory activity of transplatin is demonstrated and methods and compositions for treating and preventing inflammatory pain are described.
摘要翻译：公开了用于治疗和预防铂类化疗药物的毒副作用的方法和组合物，其中向受试者施用转铂。显示对于顺铂诱导的耳毒性，照射剂和神经毒性具有保护作用。证明了转铁蛋白的抗炎活性，描述了治疗和预防炎性疼痛的方法和组合物。

33. 发明授权

US08114606B2 ARL-1 specific antibodies 有权
标题翻译： ARL-1特异性抗体
公开(公告)号：US08114606B2
公开(公告)日：2012-02-14
申请号：US12032327
申请日：2008-02-15
申请人： Deliang Cao
发明人： Deliang Cao
IPC分类号： G01N33/53 , G01N33/573 , G01N1/30 , G01N33/48 , C12Q1/26 , C12N9/04 , C07K7/08 , C07K16/40
CPC分类号： C07K16/40 , C07K2319/60 , C12N15/113 , C12N2310/14 , Y10S435/96 , Y10S435/967 , Y10S435/975 , Y10S530/806 , Y10S530/828 , Y10S530/846 , Y10S530/866 , Y10S530/867
摘要： This invention provides antibodies immunologically specific for human ARL-1 (also referred to AKR1B10), a species of the aldo-keto reductase superfamily of proteins. The invention also provides methods of making and methods of using said antibodies.
摘要翻译：本发明提供对人ARL-1（也称为AKR1B10）免疫特异性的抗体，其是蛋白质的醛酮还原酶超家族。本发明还提供了制备方法和使用所述抗体的方法。

34. 发明申请

US20110195411A1 ARL-1 SPECIFIC ANTIBODIES AND USES THEREOF 有权
标题翻译： ARL-1特异性抗体及其用途
公开(公告)号：US20110195411A1
公开(公告)日：2011-08-11
申请号：US13017618
申请日：2011-01-31
申请人： Deliang Cao
发明人： Deliang Cao
IPC分类号： C12Q1/68 , G01N33/573
CPC分类号： C07K16/40 , C07K16/3015 , C07K16/3069 , C07K2317/34 , C07K2319/60 , C12N15/113 , C12N2310/14
摘要： This invention provides antibodies immunologically specific for human ARL-1 (also referred to AKR1B10), a species of the aldo-keto reductase superfamily of proteins. The invention also provides methods of making and methods of using said antibodies.
摘要翻译：本发明提供对人ARL-1（也称为AKR1B10）免疫学特异性的抗体，其是蛋白质的醛酮还原酶超家族。本发明还提供了制备方法和使用所述抗体的方法。

35. 发明授权

US07841805B2 Engineered composite wooden crib for use as a mine support 失效
标题翻译：工程复合木制婴儿床用作矿山支援
公开(公告)号：US07841805B2
公开(公告)日：2010-11-30
申请号：US11900486
申请日：2007-09-12
申请人： Yoginder Paul Chugh
发明人： Yoginder Paul Chugh
IPC分类号： E21D15/00
CPC分类号： E21D15/02
摘要： This invention provides improvements through 1) a composite, engineered wooden support element for construction of cribs in mines to provide support between two surfaces, 2) use of support elements to construct cribs, and 3) a wedge system to provide substantial sustained preload on a crib. The wooden support element consists of a center elongate element wherein the wood grain runs transversely to the crib element loading direction, and at least two outer plate elements wherein the wood grain runs axially with the crib element loading direction. Each outer plate element is attached to a surface of the center elongate element using fastening means and the outer plate element wood grain direction is aligned transversely to the grain direction in the center elongate element. The crib structure may be constructed by superimposing only these support elements in 2×2 layers or in conjunction with solid prismatic wooden elements. A wooden wedge system with relatively low angle surface and with wood grain running axially is utilized to apply vertical preload. Due to high stiffness of the wedge in the axial direction, a substantial vertical preload can be applied and sustained to make cribbing structure a more efficient load carrying structure. The wooden support elements are lightweight, have controllable higher stiffness and load carrying capacity than current cribs, engineered yielding characteristics and allow much lower resistance to air flow in underground mine roadways.
摘要翻译：本发明通过以下方面提供了改进：1）用于在矿井中建造婴儿床以在两个表面之间提供支撑的复合工程木质支撑元件，2）使用支撑元件构造婴儿床;以及3）楔形系统，以在婴儿床木制支撑元件由中心细长元件组成，其中木纹横向于婴儿床装载方向延伸，以及至少两个外部板元件，其中木材纹理沿着婴儿床装载方向轴向延伸。每个外板元件使用紧固装置附接到中心细长元件的表面，并且外板元件木纹方向在中心细长元件中横向于颗粒方向对准。婴儿床结构可以通过仅将这些支撑元件叠加在2×2层中或与实心棱柱形木质元件结合而构成。使用具有相对较低角度表面并且轴向运行的木纹的木制楔形系统来施加垂直预载荷。由于楔形件在轴向方向上的高刚度，可以施加和维持基本上的垂直预载荷，以使得装载结构成为更有效的承载结构。木制支撑元件重量轻，具有比目前的婴儿床更高的刚度和承载能力，设计屈服特性，并允许在地下矿井道路中气流阻力更低。

36. 发明申请

US20090163828A1 Tinnitus Testing Device and Method 审中-公开
标题翻译：耳鸣测试装置及方法
公开(公告)号：US20090163828A1
公开(公告)日：2009-06-25
申请号：US12397277
申请日：2009-03-03
申请人： Jeremy Turner , James Michael Kinder
发明人： Jeremy Turner , James Michael Kinder
IPC分类号： A61B5/00
CPC分类号： A61B5/128 , A61B5/04001 , A61B5/04845 , A61B5/121 , A61F11/00
摘要： Objectively identifying an acoustic characteristic of tinnitus of a subject. The subject is exposed to a sound pattern having a background acoustic signal preceding an audible silence. The background acoustic signal has a selected acoustic characteristic. An electrical response of the subject's central nervous system to the exposure to the sound pattern is measured. The measured electrical response has a first portion representing the electrical response of the subject's central nervous system to the background acoustic signal, and a second portion representing the electrical response of the subject's central nervous system to the audible silence in the sound pattern. The first portion of the measured electrical response is compared to the second portion of the measured electrical response and a determination is made as to whether the subject has tinnitus with an acoustic characteristic similar to the selected acoustic characteristic based on the comparison.
摘要翻译：客观地识别受试者的耳鸣的声学特征。受试者暴露于具有在可听见沉默之前的背景声信号的声音图案。背景声信号具有选定的声学特征。测量受试者的中枢神经系统对声音模式的暴露的电响应。测量的电响应具有表示受试者的中枢神经系统对背景声信号的电响应的第一部分，以及表示受试者的中枢神经系统对声音模式中的可听静音的电响应的第二部分。将测量的电响应的第一部分与测量的电响应的第二部分进行比较，并且基于该比较确定对象是否具有与所选择的声学特性相似的声学特征的耳鸣。

37. 发明授权

US07071230B2 Therapeutic use of D-methionine to reduce the toxicity of noise 失效
公开(公告)号：US07071230B2
公开(公告)日：2006-07-04
申请号：US09911195
申请日：2001-07-23
申请人： Kathleen C. M. Cambpell
发明人： Kathleen C. M. Cambpell
IPC分类号： A61K31/195
CPC分类号： A61K31/7076 , A61K31/10 , A61K31/145 , A61K31/198 , A61K31/22 , A61K31/28 , A61K31/49 , A61K31/704 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Methods of preventing or reducing hearing or balance loss and damage to ear cells in patients who have been exposed to toxic levels of noise are provided. These methods comprise administering an effective amount of a methionine protective agent, such as D-methionine, prior to, simultaneously with, or subsequently to exposure to noise. Combinations of these time periods can also be employed.

38. 发明申请

US20050266438A1 Genetic networks regulated by attenuated GH/IGF1 signaling and caloric restriction 审中-公开
标题翻译：受GH / IGF1信号衰减和热量限制的遗传网络
公开(公告)号：US20050266438A1
公开(公告)日：2005-12-01
申请号：US11083538
申请日：2005-03-16
申请人： Stephen Spindler , Tomoshi Tsuchiya , Joseph Dhahbi , Andrzej Bartke
发明人： Stephen Spindler , Tomoshi Tsuchiya , Joseph Dhahbi , Andrzej Bartke
IPC分类号： A61K49/00 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The invention is based on the discovery that the growth hormone-insulin-like growth factor-1 genetic signaling pathway and caloric restriction in conjunction extend lifespan and delay the onset of age-related diseases.
摘要翻译：本发明基于以下发现：生长激素 - 胰岛素样生长因子-1遗传信号通路和热量限制在一起延长了寿命并延迟了与年龄有关的疾病的发病。

39. 发明公开

US20240335198A1 VASCULAR ANASTOMOTIC COUPLING DEVICE 审中-公开
公开(公告)号：US20240335198A1
公开(公告)日：2024-10-10
申请号：US18616545
申请日：2024-03-26
申请人： BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY
发明人： Michael W. Neumeister , Jessie L. Koljonen , John C. Johnson
IPC分类号： A61B17/11 , A61B17/00
CPC分类号： A61B17/11 , A61B2017/00477 , A61B2017/00862 , A61B2017/1107 , A61B2017/1121 , A61B2017/1132
摘要： A vascular anastomotic coupling device includes, for each of two vessels prepared for anastomosis, an inner ring sized to slide over an outer diameter of one of the two vessels. An outer ring is configured to trap an everted portion of the one of the two vessels between itself and the inner ring. Interface features on the inner ring and outer ring are configured to trap and hold the everted portion of the one of the two vessels between them and fix a position of the inner ring and outer ring with respect to each other. A connection interface on the outer ring is configured, when mounted on the one of the two vessels, to join with the outer ring of the other of the two vessels to join the two vessels and complete anastomosis of the two vessels.

40. 发明公开

US20240229010A1 TUNING CRISPR/CAS9 ACTIVITY WITH CHEMICALLY MODIFIED NUCLEOTIDE SUBSTITUTIONS 审中-公开
公开(公告)号：US20240229010A1
公开(公告)日：2024-07-11
申请号：US17698390
申请日：2022-03-18
申请人： The Royal Institution for the Advancement of Learning/McGill University , Board of Trustees of Southern Illinois University
发明人： Keith Gagnon , Masad Damha , Elise Malek-Adamian , Maryam Habibian , Daniel O'Reilly , Zachary Kartje
IPC分类号： C12N15/10 , A61K48/00 , C12N9/22 , C12N15/11 , C12N15/113 , C12N15/90
CPC分类号： C12N15/102 , A61K48/00 , C12N9/22 , C12N15/11 , C12N15/113 , C12N15/90 , C12N15/907 , C12N2310/20 , C12N2310/315 , C12N2310/318 , C12N2310/319 , C12N2310/3231 , C12N2310/344 , C12N2310/346 , C12N2800/80
摘要： The present disclosure provides CRISPR/Cas9 ribonucicoprotein compositions comprising chemically modified CRISPR RNA (crRNA) guide and trans-acting CRISPR RNA (traerRNA) components. Methods of using the disclosed CRISPR/Cas9 ribonucleoprotein compositions are also provided.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式