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31. 外观设计

USD579178S1 Gown 有权
标题翻译：袍
公开(公告)号：USD579178S1
公开(公告)日：2008-10-28
申请号：US29266602
申请日：2006-09-25
申请人： Roberta J. Snyder , Michael Snyder
设计人： Roberta J. Snyder , Michael Snyder

32. 发明申请

US20080145364A1 Method for High Throughput Screening for Anitbodies and Proteins Inducing Apoptosis 审中-公开
标题翻译：高通量筛选诱导细胞凋亡的方法
公开(公告)号：US20080145364A1
公开(公告)日：2008-06-19
申请号：US11816074
申请日：2006-02-15
申请人： Sherman M. Weissman , Michael Snyder
发明人： Sherman M. Weissman , Michael Snyder
IPC分类号： A61K39/395 , C40B30/06 , C07K16/18 , A61P43/00 , A61K38/00 , C07K1/00
CPC分类号： G01N33/6854 , C07K2317/73 , G01N33/5011 , G01N2510/00
摘要： High throughput assays used to identify antibodies and proteins that induce cell death are described herein. It is not necessary to identify the antigens the antibodies are reactive with prior to performing the assays. Instead, libraries of antibodies and proteins, including murine, human, humanized, single chain, and synthetic antibodies, are screened using high throughput assays to identify those antibodies and proteins which cause cell death. Standard technology is then used to screen for cell viability. Antibodies and proteins which induce apoptosis preferentially or exclusively of cancer cells are then isolated, characterized, and may be cloned. A method for cloning antibodies and proteins has been developed, which provides means for rapid identification of the antibody or protein and the gene encoding the antibody or protein, based on the presence of a “bar code” or “unique sequence.” A method for high throughput production of antibodies to human proteins has also been developed.
摘要翻译：本文描述了用于鉴定诱导细胞死亡的抗体和蛋白质的高通量测定。在进行测定之前，不需要鉴定抗体与抗体反应的抗原。相反，使用高通量测定法筛选抗体和蛋白质的文库，包括鼠，人，人源化，单链和合成抗体，以鉴定导致细胞死亡的那些抗体和蛋白质。然后使用标准技术筛选细胞活力。然后分离，表征并且可以克隆诱导凋亡优先或排除癌细胞的抗体和蛋白质。已经开发了用于克隆抗体和蛋白质的方法，其基于“条形码”或“唯一序列”的存在，提供用于快速鉴定抗体或蛋白质和编码抗体或蛋白质的基因的方法。还开发了用于高通量生产人类蛋白质的抗体的方法。

33. 发明申请

US20060248281A1 Prefetching using hashed program counter 有权
公开(公告)号：US20060248281A1
公开(公告)日：2006-11-02
申请号：US11120288
申请日：2005-05-02
申请人： Hassan Al-Sukhni , James Holt , Matt Smittle , Michael Snyder , Brian Grayson
发明人： Hassan Al-Sukhni , James Holt , Matt Smittle , Michael Snyder , Brian Grayson
IPC分类号： G06F12/00
CPC分类号： G06F12/0862 , G06F9/30047 , G06F9/3455 , G06F9/383 , G06F9/3832 , G06F2212/6026
摘要： Generating a hashed value of the program counter in a data processing system. The hashed value can be used for prefetching in the data processing system. In some examples, the hashed value is used to identify whether a load instruction associated with the hashed value has an address that is part of a strided stream in an address stream. In some examples, the hashed value is a subset of bits of the bits of the program counter. In other examples, the hashed value may be derived in other ways from the program counter.

34. 发明申请

US20050216080A1 INTRAOCULAR LENS WITH IMPROVED HAPTIC AND METHOD OF IMPLANTING SAME 审中-公开
标题翻译：具有改进的习惯和内嵌方法的内窥镜
公开(公告)号：US20050216080A1
公开(公告)日：2005-09-29
申请号：US10908384
申请日：2005-05-10
申请人： Michael Snyder
发明人： Michael Snyder
IPC分类号： A61B17/04 , A61B17/06 , A61F2/16 , A61F9/013
CPC分类号： A61F2/16 , A61B17/0469 , A61B17/0482 , A61B2017/0472 , A61B2017/06057 , A61F2002/1681 , A61F2002/1683 , A61F2220/0008
摘要： Opthalomogical implant device and procedure employing improved haptic structure, improved haptic suture guide, or both.
摘要翻译： Opthalomogical植入装置和采用改进的触觉结构，改进的触觉缝线引导件或两者的方法。

35. 发明申请

US20050182242A1 Global analysis of protein activities using proteome chips 审中-公开
标题翻译：使用蛋白质组芯片的蛋白质活性的全球分析
公开(公告)号：US20050182242A1
公开(公告)日：2005-08-18
申请号：US10477329
申请日：2002-05-13
申请人： Michael Snyder , HengZhu Zhu , Paul Bertone , Scott Bidlingmaier , Metin Bilgin , Antonio Casamayor , Mark Gerstein , Ronald Jansen , Ning Lan
发明人： Michael Snyder , HengZhu Zhu , Paul Bertone , Scott Bidlingmaier , Metin Bilgin , Antonio Casamayor , Mark Gerstein , Ronald Jansen , Ning Lan
IPC分类号： G01N33/53 , C07K1/04 , C07K1/107 , C07K7/06 , C07K14/47 , C12N1/19 , C12P21/02 , C12Q1/25 , C40B30/04 , G01N33/543 , G01N33/566 , G01N33/68 , G01N33/92 , G01N37/00 , C07K1/00 , A61K38/00 , C07K17/00 , C12N1/00 , G01N33/50
CPC分类号： C40B30/04 , C07K1/047 , C07K1/1077 , C07K14/47 , G01N33/6818 , G01N33/6842 , G01N33/6845 , G01N33/92
摘要： The present invention relates to proteome chips comprising arrays having a large proportion of all proteins expressed in a single species. The invention also relates to methods for making proteome chips. The invention also relates to methods for using proteome chips to systematically assay all protein interactions in a species in a high-throughput manner. The present invention also relates to methods for making and purifying eukaryotic proteins in a high-density array format. The invention also relates to methods for making protein arrays by attaching double-tagged fusion proteins to a solid support. The invention also relates to a method for identifying whether a signal is positive.
摘要翻译：本发明涉及包含在单一物种中表达的大部分蛋白质的阵列的蛋白质组学芯片。本发明还涉及制备蛋白质组芯片的方法。本发明还涉及使用蛋白质组芯片以高通量方式系统地测定物种中所有蛋白质相互作用的方法。本发明还涉及以高密度阵列格式制备和纯化真核蛋白质的方法。本发明还涉及通过将双标记融合蛋白连接到固体支持物来制备蛋白质阵列的方法。本发明还涉及一种用于识别信号是否为正的方法。

36. 发明公开

US20240341950A1 Temporary Keratoprosthesis, Corneal Transplant Suturing Jig, Temporary Endoprosthesis, and Method of Using 审中-公开
公开(公告)号：US20240341950A1
公开(公告)日：2024-10-17
申请号：US18634470
申请日：2024-04-12
申请人： Michael Snyder
发明人： Michael Snyder
IPC分类号： A61F2/14 , A61F9/007
CPC分类号： A61F2/142 , A61F2/148 , A61F9/007
摘要： A temporary keratoprosthesis, a corneal transplant suturing jig, a temporary endoprosthesis, methods of using the same, and kits comprising the same. The temporary keratoprosthesis and corneal transplant comprise grooves into which sutures are located during ophthalmological surgery such that the sutures are prevented from migrating and/or obscuring a view into the eye during surgery. The temporary keratoprosthesis, corneal transplant suturing jig, and temporary endoprosthesis are employed alone or in unison to maintain intraocular pressure during surgery.

37. 发明公开

US20240341949A1 Temporary Keratoprosthesis, Corneal Transplant Suturing Jig, Temporary Endoprosthesis, and Method of Using 审中-公开
公开(公告)号：US20240341949A1
公开(公告)日：2024-10-17
申请号：US18134849
申请日：2023-04-14
申请人： Michael Snyder
发明人： Michael Snyder
IPC分类号： A61F2/14 , A61F9/007
CPC分类号： A61F2/142 , A61F9/00727 , A61F2002/0081 , A61F2220/0008 , A61F2250/0059
摘要： A temporary keratoprosthesis, a corneal transplant suturing jig, a temporary endoprosthesis, methods of using the same, and kits comprising the same. The temporary keratoprosthesis and corneal transplant comprise grooves into which sutures are located during ophthalmological surgery such that the sutures are prevented from migrating and/or obscuring a view into the eye during surgery. The temporary keratoprosthesis, corneal transplant suturing jig, and temporary endoprosthesis are employed alone or in unison to maintain intraocular pressure during surgery.

38. 发明授权

US10127346B2 Systems and methods for interpreting a human genome using a synthetic reference sequence 有权
公开(公告)号：US10127346B2
公开(公告)日：2018-11-13
申请号：US13445923
申请日：2012-04-13
申请人： Frederick Dewey , Euan A. Ashley , Matthew Wheeler , Michael Snyder , Carlos Bustamante
发明人： Frederick Dewey , Euan A. Ashley , Matthew Wheeler , Michael Snyder , Carlos Bustamante
IPC分类号： G06N5/02 , G06F19/12 , G06F19/18 , G06F19/22 , G06F19/24 , G06F15/00 , G11C17/00
摘要： In an embodiment of the present invention, three novel human reference genome sequences were developed based on the most common population-specific DNA sequence (“major allele”). Methods were developed for their integration into interpretation pipelines for highthroughput whole genome sequencing.

39. 发明申请

US20150370963A9 Phased Whole Genome Genetic Risk In A Family Quartet 审中-公开
标题翻译：家族四重奏的基因全基因组遗传风险
公开(公告)号：US20150370963A9
公开(公告)日：2015-12-24
申请号：US13445923
申请日：2012-04-13
申请人： Frederick Dewey , Euan Ashley , Matthew Wheeler , Michael Snyder , Carlos Bustamante
发明人： Frederick Dewey , Euan Ashley , Matthew Wheeler , Michael Snyder , Carlos Bustamante
IPC分类号： G06F19/24 , G06F19/18
CPC分类号： G06F19/12 , G06F19/18 , G06F19/22 , G06F19/24 , G06N5/02
摘要： In an embodiment of the present invention, three novel human reference genome sequences were developed based on the most common population-specific DNA sequence (“major allele”). Methods were developed for their integration into interpretation pipelines for highthroughput whole genome sequencing.
摘要翻译：在本发明的一个实施方案中，基于最常见的群体特异性DNA序列（“主要等位基因”）开发了三种新的人参照基因组序列。开发了将其整合到用于高通量全基因组测序的解释管道中的方法。

40. 发明申请

US20140235507A1 Protein Chips for High Throughput Screening of Protein Activity 审中-公开
标题翻译：蛋白质芯片高通量筛选蛋白质活性
公开(公告)号：US20140235507A1
公开(公告)日：2014-08-21
申请号：US13840960
申请日：2013-03-15
申请人： Michael Snyder , Mark Reed , Heng Zhu , James Frank Klemic
发明人： Michael Snyder , Mark Reed , Heng Zhu , James Frank Klemic
IPC分类号： C12Q1/48
CPC分类号： C12Q1/485 , B01J19/0046 , B01J2219/00274 , B01J2219/00313 , B01J2219/00317 , B01J2219/00382 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , B82Y15/00 , B82Y30/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/5008 , G01N33/5041 , G01N33/543 , G01N33/54313 , G01N2500/00
摘要： The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip. The invention also relates to methods of using the protein chips for high density and small volume chemical reactions. Also, the invention relates to polymers useful as protein chip substrates and methods of making protein chips. The invention further relates to compounds useful for the derivatization of protein chip substrates.
摘要翻译：本发明涉及可用于大规模研究蛋白质功能的蛋白质芯片，其中芯片包含密集堆积的反应孔。本发明还涉及使用蛋白质芯片同时测定存在于蛋白质样品中或在一个蛋白质芯片上的蛋白质的存在，量和/或功能的方法，或者测定每个探针的存在，相对特异性和结合亲和力在芯片上的每种蛋白质的探针的混合物中。本发明还涉及使用蛋白质芯片进行高密度和小体积化学反应的方法。此外，本发明涉及可用作蛋白质芯片底物的聚合物和制备蛋白质芯片的方法。本发明还涉及可用于蛋白质芯片底物衍生化的化合物。

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