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31. 发明授权

US4357331A 7.alpha.Methoxycephalosporin derivatives 失效
标题翻译： 7α甲氧头孢菌素衍生物
公开(公告)号：US4357331A
公开(公告)日：1982-11-02
申请号：US104220
申请日：1979-12-17
申请人： Katsuyoshi Iwamatsu , Shigeharu Inoue , Keinosuke Miyauchi , Shinichi Kondo , Shigeo Seki , Yujiro Yamada
发明人： Katsuyoshi Iwamatsu , Shigeharu Inoue , Keinosuke Miyauchi , Shinichi Kondo , Shigeo Seki , Yujiro Yamada
IPC分类号： A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/00 , C07D501/04 , C07D501/36 , C07D501/40 , C07D501/57 , C07D501/60
CPC分类号： C07D501/57
摘要： A 7.alpha.-methoxycephalosporin derivative represented by the formula (I): ##STR1## wherein R.sub.1 represents a heterocyclic ring or an --S-- heterocyclic ring; R.sub.2 represents a hydrogen atom, a carboxy group or a --COOR.sub.5 group wherein R.sub.5 represents a lower alkyl group, a dialkylamino-lower alkyl group or a ##STR2## group wherein R.sub.6 represents a lower alkyl group, a lower acyl group or a lower alkoxycarbonyl group and Y represents a hydrogen atom or a lower alkyl group; R.sub.3 represents a hydrogen atom, a carbamoyl group or a lower acyl group; R.sub.4 represents a hydrogen atom, a lower alkyl group, a dialkylamino-lower alkyl group or a ##STR3## group wherein R.sub.6 and Y are defined as above; A and B, which may be the same or different, each represents a straight chain or branched chain alkylene group having 1 to 5 carbon atoms; and x represents 0 or 1; or a pharmaceutically acceptable salt thereof and a process for producing the same.
摘要翻译：由式（I）表示的7α-甲氧头孢菌素衍生物：其中R 1表示杂环或-S-杂环; R2表示氢原子，羧基或-COOR5基团，其中R5表示低级烷基，二烷基氨基 - 低级烷基或其中R6表示低级烷基，低级酰基或低级烷氧基羰基基团，Y表示氢原子或低级烷基; R3表示氢原子，氨基甲酰基或低级酰基; R4表示氢原子，低级烷基，二烷基氨基 - 低级烷基或基团，其中R6和Y如上定义; A和B可以相同或不同，各自表示具有1至5个碳原子的直链或支链亚烷基; x表示0或1; 或其药学上可接受的盐及其制备方法。

32. 发明授权

US4160026A Antibiotics SF-1130-x.sub.1 and -x.sub.2 substances and production and use thereof 失效
标题翻译：抗生素SF-1130-x {hd 1 {b和-x {hd 2 {b物质及其生产和使用
公开(公告)号：US4160026A
公开(公告)日：1979-07-03
申请号：US826766
申请日：1977-08-22
申请人： Katsuyoshi Iwamatsu , Shoji Omoto , Takashi Shomura , Hiroshi Watanabe , Michio Kojima , Shigeharu Inoue , Taro Niida , Takashi Hisamatsu , Shingo Uchida
发明人： Katsuyoshi Iwamatsu , Shoji Omoto , Takashi Shomura , Hiroshi Watanabe , Michio Kojima , Shigeharu Inoue , Taro Niida , Takashi Hisamatsu , Shingo Uchida
IPC分类号： C12P13/00 , A61K35/74 , A61P31/04 , A61P37/04 , C07G11/00 , C07H5/06 , C12P1/06 , C12P19/04 , C12D9/14
CPC分类号： C07H5/06 , C07G11/00 , C12P1/06 , Y10S435/886
摘要： New antibiotics SF-1130-x.sub.1 substance and SF-1130-x.sub.2 substance are produced by cultivating a microorganism Streptomyces myxogenes SF-1130 now deposited under FERM-P. 676 and ATCC. 31305 in a liquid culture medium under aerobic conditions, and these antibiotics may be isolated from the fermentation broth and are useful as an activator for enhancing the host defense system in living animals. The activity of these antibiotics may be improved when used in combination with one or more of maltose, maltotriose, maltotetraose, maltopentaose, maltohexaose and maltoheptaose.
摘要翻译：新型抗生素SF-1130-x1物质和SF-1130-x2物质是通过培养现在以FERM-P沉积的微生物Streptomyces myxogenes SF-1130生产的。 676和ATCC。 31305在有氧条件下在液体培养基中，这些抗生素可以从发酵液中分离出来，可用作增强活体动物宿主防御系统的活化剂。当与麦芽糖，麦芽三糖，麦芽四糖，麦芽五糖，麦芽六糖和麦芽七糖中的一种或多种组合使用时，可以改善这些抗生素的活性。

33. 发明授权

US4017607A 9,3",4"-Triacyl ester of the antibiotic SF-837 M.sub.1 substance and the production thereof 失效
标题翻译： 9,3 {41,4 {41-抗生素SF-837M {HD 1 {B物质及其制备的三
公开(公告)号：US4017607A
公开(公告)日：1977-04-12
申请号：US597188
申请日：1975-07-18
申请人： Shigeharo Inouye , Shoji Omoto , Katsuyoshi Iwamatsu , Takashi Tsuruoka , Taro Niida , Toyoaki Kawasaki
发明人： Shigeharo Inouye , Shoji Omoto , Katsuyoshi Iwamatsu , Takashi Tsuruoka , Taro Niida , Toyoaki Kawasaki
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/08
CPC分类号： C07H17/08
摘要： As new compounds are provided 9,3",4"-trialkanoyl SF-837 M.sub.1 substances which have therapeutically useful antibacterial activity and do not show any objectionable long-lasting bitter taste upon its oral administration. These 9,3",4"-trialkanoyl SF-837 M.sub.1 substances may be prepared from SF-837 substance, 9,2',3"-tri-acetyl SF-837 M.sub.1 substance, 9,2'-di-acetyl SF-837 substance, 9-propionyl SF-837 substance or 9,2'-dipropionyl SF-837 substance by acylating the latter with an alkanoic acid anhydride at 50.degree.-120.degree. C to produce the corresponding 9,2',3",4"-tetra-alkanoyl SF-837 M.sub.1 substance and occasionally the 9,18,2',3",4"-penta-alkanoyl SF-837 M.sub.1 substance, with involving the shift of the 4"-alkanoyl group to the 3"-hydroxyl group. Partial and selective hydrolysis of the 9,2',3",4"-tetra-alkanoyl SF-837 M.sub.1 substance and/or the 9,18,2',3",4"-penta-alkanoyl SF-837 M.sub.1 substance so produced gives the desired 9,3",4"-tri-alkanoyl SF-837 M.sub.1 substance.
摘要翻译：当新化合物被提供具有治疗上有用的抗菌活性的9,3“，4” - 三烷酰基SF-837M1物质，并且在其口服给药时不显示任何令人不快的持久苦味。这些9,3“，4” - 三烷酰基SF-837 M1物质可以由SF-837物质，9,2'，3“ - 三乙酰基SF-837M1物质，9,2'-二 - 乙酰基SF-837物质，9-丙酰基SF-837物质或9,2'-二丙酰基SF-837物质，通过用烷基酸酐在50°-120℃下酰化后者，产生相应的9,2' 3“，4” - 四烷酰基SF-837 M1物质，偶尔有9,18,2'，3“，4” - 五烷酰基SF-837 M1物质，涉及4 “ - 烷酰基与3” - 羟基。 9,2'，3“，4” - 四烷酰基SF-837 M1物质和/或9,18,2'，3“，”4“ - 五烷酰基SF- 837如此生产的M1物质得到所需的9,3“，”4“ - 三烷酰基SF-837 M1物质。

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