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31. 发明申请

US20080269219A1 Neurotrophin production/secretion promoting agent 失效
标题翻译：神经营养素生产/分泌促进剂
公开(公告)号：US20080269219A1
公开(公告)日：2008-10-30
申请号：US12080461
申请日：2008-04-03
申请人： Yu Momose , Katsuhito Murase
发明人： Yu Momose , Katsuhito Murase
IPC分类号： A61K31/5377 , A61K31/421 , A61K31/426 , A61K31/4525 , A61P25/00 , A61P1/00 , A61P29/00 , A61K31/496 , A61K31/443 , A61K31/506
CPC分类号： C07D263/34 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/38 , C07D263/46 , C07D263/48 , C07D277/32 , C07D277/40 , C07D277/54 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/14
摘要： A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula: wherein R1 represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, a thiol group which may optionally be substituted, or an amino group which may optionally be substituted; A represents an acyl group which may optionally be substituted, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, or a carboxyl group which may optionally be esterified or amidated; B represents an aromatic group which may optionally be substituted; X represents oxygen atom, sulfur atom, or nitrogen atom which may optionally be substituted; and Y represents a divalent hydrocarbon group or heterocyclic group, or a salt thereof; which is useful as an agent for preventing or treating neuropathy.
摘要翻译：神经营养蛋白产生/分泌促进剂，其包含下式的唑衍生物：其中R 1表示卤素原子，可任选被取代的杂环基，可任选被取代的羟基，可以任选被取代的硫醇基，或可任意被取代的氨基; A表示可任选被取代的酰基，可任选被取代的杂环基，可任意取代的羟基或可任意被酯化或酰胺化的羧基; B表示可任选被取代的芳族基团; X表示可任选被取代的氧原子，硫原子或氮原子; Y表示二价烃基或杂环基，或其盐; 其可用作预防或治疗神经病的药剂。

32. 发明授权

US06605629B1 Neurotrophin production secretion promoting agent 有权
标题翻译：神经营养蛋白生成分泌促进剂
公开(公告)号：US06605629B1
公开(公告)日：2003-08-12
申请号：US09868304
申请日：2001-06-29
申请人： Yu Momose , Katsuhito Murase
发明人： Yu Momose , Katsuhito Murase
IPC分类号： C07D41312
CPC分类号： C07D263/34 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/38 , C07D263/46 , C07D263/48 , C07D277/32 , C07D277/40 , C07D277/54 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/14
摘要： A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula: wherein R1 represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, a thiol group which may optionally be substituted, or an amino group which may optionally be substituted; A represents an acyl group which may optionally be substituted, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, or a carboxyl group which may optionally be esterified or amidated; B represents an aromatic group which may optionally be substituted; X represents oxygen atom, sulfur atom, or nitrogen atom which may optionally be substituted; and Y represents a divalent hydrocarbon group or heterocyclic group, or a salt thereof; which is useful as an agent for preventing or treating neuropathy.
摘要翻译：一种神经营养因子产生/分泌促进剂，其包含下式的唑衍生物：其中R1表示卤素原子，可任意取代的杂环基，可任选被取代的羟基，可任选被取代的硫醇基，或可任选被取代的氨基; A表示可任选被取代的酰基，可任选被取代的杂环基，可任意取代的羟基或可任意被酯化或酰胺化的羧基; B表示可任选被取代的芳族基团; X表示可任选被取代的氧原子，硫原子或氮原子; Y表示二价烃基或杂环基，或其盐; 其可用作预防或治疗神经病的药剂。

33. 发明授权

US5972970A Oxazolidinedione derivatives, their production and use 失效
标题翻译：恶唑二酮衍生物，其生产和使用
公开(公告)号：US5972970A
公开(公告)日：1999-10-26
申请号：US832916
申请日：1997-04-04
申请人： Takashi Sohda , Hitoshi Ikeda , Yu Momose , Sachiko Imai
发明人： Takashi Sohda , Hitoshi Ikeda , Yu Momose , Sachiko Imai
IPC分类号： C07D491/048 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/435 , A61K31/44 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61K31/535 , A61K31/5377 , A61P3/06 , A61P3/08 , A61P3/10 , A61P9/12 , A61P43/00 , C07D263/44 , C07D277/22 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/052 , C07D498/04 , C07D413/06
CPC分类号： C07D263/44 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Novel 2,4-oxazolidinedione compounds of the formula: ##STR1## wherein R is a hydrocarbon residue or a heterocyclic group each of which may be substituted; Y is --CO--, --CH(OH)-- or --NR.sup.3 -- (wherein R.sup.3 is an alkyl group which may be substituted); m is 0 or 1; n is 0, 1 or 2; X is CH or N; A is bivalent straight or branched hydrocarbon chain residue having 1 to 7 carbon atoms; R.sup.1 and R.sup.2 each are hydrogen or an alkyl group, or R.sup.1 and R.sup.2 are combined with each other to form a 5- to 6-membered heterocyclic group optionally containing nitrogen; L and M each are hydrogen, or L and M are combined with each other to form a bond, or pharmaceutically acceptable salts thereof, having excellent hypoglycemic and hypolipidemic activities and are useful as anti-diabetics or hypolipidemic agents.
摘要翻译：下式的新型2,4-恶唑烷二酮化合物：其中R是可以被取代的烃残基或杂环基; Y是-CO - ， - CH（OH） - 或-NR 3 - （其中R 3是可被取代的烷基）; m为0或1; n为0,1或2; X是CH或N; A是具有1至7个碳原子的二价直链或支链烃链残基; R 1和R 2各自为氢或烷基，或者R 1和R 2彼此结合形成任选含有氮的5至6元杂环基; L和M各自为氢，或L和M彼此结合以形成具有优异的降血糖和降血脂活性的键或其药学上可接受的盐，并且可用作抗糖尿病药或降血脂药。

34. 发明授权

US5302608A Age formation inhibitors 失效
标题翻译：年龄形成抑制剂
公开(公告)号：US5302608A
公开(公告)日：1994-04-12
申请号：US71036
申请日：1993-06-02
申请人： Takashi Sohda , Hitoshi Ikeda , Yu Momose
发明人： Takashi Sohda , Hitoshi Ikeda , Yu Momose
IPC分类号： C07D277/48 , C07D417/04 , C07D417/12 , A61K31/425
CPC分类号： C07D417/04 , C07D277/48 , C07D417/12
摘要： Thiourea compounds represented by the general formula: ##STR1## wherein A is an aromatic ring group which may be substituted; R.sup.1 is a hydrogen atom or a lower alkyl or aryl group which may be substituted, or may combine with A to form a cyclic ring; and --COB is an acyl group of a carboxylic acid or an esterified carboxyl group or salts thereof are provided as agents for inhibiting the formation of AGE (Advanced Glycosidation End Product), which are employable for treating diseases caused by AGE-formation, such as diabetic complications, senile cataract, atherosclerosis etc.
摘要翻译：由以下通式表示的硫脲化合物：其中A是可被取代的芳环基团; R1是氢原子或可被取代的低级烷基或芳基，或可以与A结合形成环状环; 提供-COB为羧酸或酯化羧基的酰基或其盐作为用于抑制AGE（Advanced Glycosidation End Product）形成抑制剂的药剂，其可用于治疗由AGE形成引起的疾病，例如糖尿病并发症，老年性白内障，动脉粥样硬化等。

35. 发明授权

US5240950A Carbazate derivatives, their production and use 失效
标题翻译：碳酸盐衍生物，其生产和使用
公开(公告)号：US5240950A
公开(公告)日：1993-08-31
申请号：US403288
申请日：1989-09-07
申请人： Takashi Sohda , Hitoshi Ikeda , Yu Momose
发明人： Takashi Sohda , Hitoshi Ikeda , Yu Momose
IPC分类号： C07D237/20 , A61K31/33 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/433 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/505 , A61K31/517 , A61P3/08 , A61P3/10 , A61P9/10 , A61P13/02 , A61P15/00 , A61P27/02 , A61P27/12 , A61P43/00 , C07C281/02 , C07D213/74 , C07D215/38 , C07D217/22 , C07D231/38 , C07D235/30 , C07D239/42 , C07D239/84 , C07D261/14 , C07D263/48 , C07D277/20 , C07D277/42 , C07D285/04 , C07D285/08 , C07D285/12 , C07D285/135 , C07D521/00
CPC分类号： C07D213/74 , C07C281/02 , C07D215/38 , C07D217/22 , C07D231/38 , C07D239/42 , C07D261/14 , C07D263/48 , C07D277/42 , C07D285/08 , C07D285/135
摘要： There are provided carbazate derivatives of the formula:R.sup.1 --N.dbd.CH--NHNH--R.sup.2wherein R.sup.1 is a heterocyclic group; and R.sup.2 is an esterified carboxyl group, and their salts, which are useful as AGE-formation inhibitory agents.The derivatives or the salts can be produced by reacting compounds of the formula: R.sup.1 --N.dbd.CH--OR.sup.3 wherein R.sup.1 is a heterocyclic group; and R.sup.3 is a lower alkyl group, with a carbazic acid ester or its salt.

36. 发明授权

US08067453B2 Neurotrophin production/secretion promoting agent 失效
标题翻译：神经营养素生产/分泌促进剂
公开(公告)号：US08067453B2
公开(公告)日：2011-11-29
申请号：US12080461
申请日：2008-04-03
申请人： Yu Momose , Katsuhiro Murase
发明人： Yu Momose , Katsuhiro Murase
IPC分类号： A61K31/42
CPC分类号： C07D263/34 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/38 , C07D263/46 , C07D263/48 , C07D277/32 , C07D277/40 , C07D277/54 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/14
摘要： A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula: wherein R1 represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, a thiol group which may optionally be substituted, or an amino group which may optionally be substituted; A represents an acyl group which may optionally be substituted, a heterocyclic group which may optionally be substituted, a hydroxy group which may optionally be substituted, or a carboxyl group which may optionally be esterified or amidated; B represents an aromatic group which may optionally be substituted; X represents oxygen atom, sulfur atom, or nitrogen atom which may optionally be substituted; and Y represents a divalent hydrocarbon group or heterocyclic group, or a salt thereof; which is useful as an agent for preventing or treating neuropathy.
摘要翻译：一种神经营养因子产生/分泌促进剂，其包含下式的唑衍生物：其中R1表示卤素原子，可任意取代的杂环基，可任选被取代的羟基，可任选被取代的硫醇基，或可任选被取代的氨基; A表示可任选被取代的酰基，可任选被取代的杂环基，可任意取代的羟基或可任意被酯化或酰胺化的羧基; B表示可任选被取代的芳族基团; X表示可任选被取代的氧原子，硫原子或氮原子; Y表示二价烃基或杂环基，或其盐; 其可用作预防或治疗神经病的药剂。

37. 发明授权

US07183276B2 Azole compounds 失效
标题翻译：唑类化合物
公开(公告)号：US07183276B2
公开(公告)日：2007-02-27
申请号：US10505742
申请日：2003-02-27
申请人： Nozomu Sakai , Yu Momose , Katsuhito Murase , Masatoshi Hazama
发明人： Nozomu Sakai , Yu Momose , Katsuhito Murase , Masatoshi Hazama
IPC分类号： A61K31/5377 , A61K31/421 , A61K31/454 , A61K31/541 , C07D413/04 , C07D279/12 , C07F9/653 , C07D211/46
CPC分类号： C07D413/04 , C07D263/32 , C07D263/38 , C07D263/46 , C07D263/48 , C07D277/30 , C07D277/40 , C07D277/46 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F9/653 , C07F9/6539
摘要： The present invention provides a compound represented by the formula (I) wherein R1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group, A is an optionally substituted cyclic amino group or —NR2—W—D wherein R2 is a hydrogen atom or an alkyl group, W is a bond or a divalent acyclic hydrocarbon group, and D is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom, and Y is a bond or a divalent acyclic hydrocarbon group, or a salt thereof, which is useful for the prophylaxis or treatment of diabetic neuropathy and the like.
摘要翻译：本发明提供由式（I）表示的化合物，其中R 1为氢原子，卤素原子，任选取代的烃基，任选取代的杂环基，任选取代的羟基，任选取代的硫醇基或任选取代的氨基，A是任选取代的环氨基或-NR 2 -WD，其中R 2是氢原子或烷基基团，W是键或二价无环烃基，D是任选取代的环状基团，任选取代的氨基或任选取代的酰基，B是任选取代的烃基或任选取代的杂环基，X是氧原子，硫原子或任选取代的氮原子，Y是可用于预防或治疗糖尿病性神经病变等的键或二价无环烃基或其盐。

38. 发明授权

US06555565B2 Apoptosis inhibitor 失效
公开(公告)号：US06555565B2
公开(公告)日：2003-04-29
申请号：US10047816
申请日：2002-01-15
申请人： Junji Matsui , Naoki Tarui , Yu Momose , Ken-ichi Naruo
发明人： Junji Matsui , Naoki Tarui , Yu Momose , Ken-ichi Naruo
IPC分类号： A61K31427
CPC分类号： A61K31/427 , A61K31/422 , A61K31/425 , A61K31/4439
摘要： An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: —CO—, —CH(OH)— or —NR3— where R3 represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R1; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond; or a salt thereof, or a compound having an insulin sensitivity enhancing activity.

39. 发明授权

US06211215B1 Heterocyclic compounds, their production and use 失效
标题翻译：杂环化合物，其生产和使用
公开(公告)号：US06211215B1
公开(公告)日：2001-04-03
申请号：US09180955
申请日：1998-11-18
申请人： Yu Momose , Etsuya Matsutani
发明人： Yu Momose , Etsuya Matsutani
IPC分类号： C07D41312
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D413/12
摘要： Heterocyclic compounds represented by the general formula (I) wherein R stands for an optionally substituted aromatic heterocyclic group; X stands for oxygen atom, an optionally oxidated sulfur atom, —C(═O)— or —CH(OH)—; Y stands for CH or N; m denotes an integer of 0 to 10: n denotes an integer of 1 to 5: cyclic group stands for an optionally substituted aromatic azole group; and ring A is optionally further substituted, or salts thereof. The compound (I) possesses action of inhibiting tyrosine kinase and useful as antitumor agents.
摘要翻译：由通式（I）表示的杂环化合物，其中R表示任选取代的芳族杂环基; X表示氧原子，任选氧化的硫原子，-C（= O） - 或-CH（OH） - ; Y表示对于CH或N; m表示0至10的整数：n表示1至5的整数：环状基团表示任选取代的芳族唑基; 环A任选被进一步取代，或其盐。化合物（I）具有抑制酪氨酸激酶的作用，可用作抗肿瘤剂。

40. 发明授权

US6087384A Apoptosis inhibitor 有权
标题翻译：凋亡抑制剂
公开(公告)号：US6087384A
公开(公告)日：2000-07-11
申请号：US272747
申请日：1999-03-15
申请人： Junji Matsui , Naoki Tarui , Yu Momose , Ken-ichi Naruo
发明人： Junji Matsui , Naoki Tarui , Yu Momose , Ken-ichi Naruo
IPC分类号： A61K31/422 , A61K31/425 , A61K31/427 , A61K31/4439 , A61K31/444 , C07D413/02 , C07D413/14 , C07D417/02 , C07D417/14 , A01K31/426 , A01K31/427
CPC分类号： A61K31/427 , A61K31/422 , A61K31/425 , A61K31/4439
摘要： An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: --CO--, --CH(OH)-- or --NR.sup.3 -- where R.sup.3 represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R.sup.1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R.sup.1 ; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond; or a salt thereof, or a compound having an insulin sensitivity enhancing activity.
摘要翻译：一种凋亡抑制剂，其包含下式化合物：其中R表示可被取代的烃基或可被取代的杂环基; Y表示式-CO-，-CH（OH） - 或-NR 3 - ，其中R 3表示可被取代的烷基; m为0或1; n为0,1或2; X表示CH或N; A表示化学键或碳原子数为1〜7的二价脂肪族烃基; Q表示氧或硫; R1表示氢或烷基; 环E可以具有另外1至4个取代基，其可以与R 1组合形成环; L和M分别表示氢或可以相互结合形成化学键; 或其盐，或具有胰岛素敏感性增强活性的化合物。

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