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31. 发明授权

US4592857A 2,3-dicyano-5-substituted pyrazines 失效
标题翻译： 2,3-二氰基-5-取代的吡嗪
公开(公告)号：US4592857A
公开(公告)日：1986-06-03
申请号：US641730
申请日：1984-08-17
申请人： Shigeru Sugimori , Yasuyuki Goto
发明人： Shigeru Sugimori , Yasuyuki Goto
IPC分类号： C07D241/24 , C09K19/34 , G02F1/13
CPC分类号： C07D241/24 , C09K19/3452
摘要： Novel liquid crystal compounds having a positive dielectric anisotropy and liquid crystal compositions containing the same are provided, which liquid crystal compounds are 2,3-dicyano-5-substituted pyrazines expressed by the general formula ##STR1## wherein n represents 0 or 1; X represents R, ##STR2## in the case of n=0 and R, ##STR3## in the case of n=1; and R represents a linear chain alkyl group or an alkoxy group, each of 1 to 10 carbon atoms, and which liquid crystal compositions, when sealed in a TN cell, make it possible to operate the cell under a low threshold voltage and in a small consumption of electric power.
摘要翻译：提供具有正介电各向异性的新型液晶化合物和含有它们的液晶组合物，该液晶化合物是通式（I）表示的2,3-二氰基-5-取代的吡嗪，其中n表示0或 1; 在n = 0的情况下，X表示R，，在n = 1的情况下，R表示R， + TR R表示1〜10个碳原子的直链状烷基或烷氧基，在TN电池中密封时，液晶组成物能够在低阈值电压下操作电池，小型化消耗电力。

32. 发明授权

US4536321A Fluorobenzene derivatives and liquid crystal compositions containing the same 失效
标题翻译：含氟苯衍生物和含有它们的液晶组合物
公开(公告)号：US4536321A
公开(公告)日：1985-08-20
申请号：US580628
申请日：1984-02-16
申请人： Shigeru Sugimori , Tetsuhiko Kojima , Yasuyuki Goto , Toyoshiro Isoyama , Kazunori Nigorikawa
发明人： Shigeru Sugimori , Tetsuhiko Kojima , Yasuyuki Goto , Toyoshiro Isoyama , Kazunori Nigorikawa
IPC分类号： C07C49/813 , C07C49/84 , C07C63/72 , C09K19/30 , C09K3/34 , C07C49/807 , C07C121/64 , G02F1/13
CPC分类号： C07C255/00 , C07C49/813 , C07C49/84 , C07C63/72 , C09K19/3003
摘要： Novel liquid crystal compounds having a large positive dielectric anisotropy value and also a low viscosity and a good stability to heat, light, air and water, and liquid crystal compositions containing the same are provided, which compounds are fluorobenzene derivatives expressed by the general formula ##STR1## wherein n represents 1 or 2, X represents CN or COCH.sub.3, and R represents hydrogen atom or an alkyl group or an alkoxy group each of 1 to 15 carbon atoms.
摘要翻译：提供具有大的正介电各向异性值以及低粘度和对热，空气和水的良好稳定性的新型液晶化合物和含有它们的液晶组合物，该化合物是由通式其中n表示1或2，X表示CN或COCH 3，R表示氢原子或碳原子数1〜15的烷基或烷氧基。

33. 发明授权

US4450094A Nematic liquid crystal compositions for display apparatuses 失效
标题翻译：用于显示装置的向列型液晶组合物
公开(公告)号：US4450094A
公开(公告)日：1984-05-22
申请号：US219921
申请日：1980-12-24
申请人： Hideo Sato , Yasuyuki Goto , Hideo Saito , Shinichi Sawada , Keiichi Matsunami , Kohzo Hirata
发明人： Hideo Sato , Yasuyuki Goto , Hideo Saito , Shinichi Sawada , Keiichi Matsunami , Kohzo Hirata
IPC分类号： C09K19/34 , C09K19/42 , C09K3/34
CPC分类号： C09K19/42 , C09K19/3402 , C09K2019/3422
摘要： Liquid crystal compositions suitable for liquid crystal display elements according to multiplexing mode are provided. The compositions consist of at least one nematic liquid crystal compound having a positive dielectric anisotropy (N.sub.p) and at least one nematic liquid crystal compound having a negative dielectric anisotropy (N.sub.n), at least one compound of the group consisting of said at least one N.sub.p and said at least one N.sub.n being expressed by the general formula ##STR1## wherein R.sub.1 is 1-10 C alkyl group or alkoxy group, carboxyl group or cyano group and R.sub.2 is 1-10 C alkyl group or alkoxy group or carboxyl group.
摘要翻译：提供了适用于根据复用模式的液晶显示元件的液晶组合物。组合物由至少一种具有正介电各向异性（Np）和至少一种具有负介电各向异性（Nn）的向列型液晶化合物的至少一种向列液晶化合物，至少一种由所述至少一个Np组成的组的化合物并且所述至少一个Nn由通式“IMAGE”表示，其中R1为1-10C烷基或烷氧基，羧基或氰基，R2为1-10C烷基或烷氧基或羧基。

34. 发明授权

US4431564A Liquid-crystalline biphenyl or terphenyl derivatives 失效
标题翻译：液晶联苯或三联苯衍生物
公开(公告)号：US4431564A
公开(公告)日：1984-02-14
申请号：US369111
申请日：1982-04-16
申请人： Masahiro Fukui , Hiromichi Inoue , Yasuyuki Goto , Hideo Sato , Takashi Inukai
发明人： Masahiro Fukui , Hiromichi Inoue , Yasuyuki Goto , Hideo Sato , Takashi Inukai
IPC分类号： C07C29/09 , C07C29/20 , C07C29/62 , C07C35/17 , C07C35/48 , C07C43/164 , C07C43/174 , C07C43/176 , C07C205/42 , C07C255/53 , C09K19/00 , C09K19/12 , C09K3/34 , C07C121/75
CPC分类号： C07C255/00 , C07C205/42 , C07C29/095 , C07C29/20 , C07C35/17 , C07C35/48 , C07C43/164 , C07C43/1742 , C07C43/176 , C09K19/12 , C07C2101/14 , C09K2019/123
摘要： New liquid crystal (l. c.) compounds having a positive dielectric anisotropy, 4"-(.beta.-alkyloxyethyl)-4-cyanobiphenyls and 4'-(.beta.-alkyloxyethyl)-4-cyanoterphenyls expressed by the general formula ##STR1## wherein R represents an alkyl group of 1.about.9C and n is 2 or 3; a process for preparing the same; and l.c. compositions containing at least one of the same, are provided. When the compounds are added to a l.c. having a nearly zero or negative anisotropy, a l.c. composition having a positive dielectric anisotropy can be obtained. The compounds have a greater optical anisotropy and a superior compatibility with other l.c. compounds.
摘要翻译：具有正介电各向异性的新的液晶（lc）化合物，由通式“IMAGE”表示的4“ - （β-烷氧基乙基）-4-氰基联苯和4' - （β-烷氧基乙基）-4-氰基苯基，其中R表示 1差异9C的烷基和n是2或3; 其制备方法; 和l.c. 提供含有至少一种相同的组合物。当化合物加入到皮下具有几乎为零或负的各向异性，可以获得具有正介电各向异性的组成。这些化合物具有更大的光学各向异性，并且与其它直流相容性优异。化合物。

35. 发明授权

US08911746B2 Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis 有权
标题翻译：重组多蛋白疫苗用于治疗和诊断利什曼病
公开(公告)号：US08911746B2
公开(公告)日：2014-12-16
申请号：US13794903
申请日：2013-03-12
申请人： Yasuyuki Goto , Steven G. Reed
发明人： Yasuyuki Goto , Steven G. Reed
IPC分类号： A61K39/008 , C12N15/62 , C07K14/44 , A61K39/00
CPC分类号： A61K39/008 , A61K2039/552 , A61K2039/55572 , C07K14/44 , C12N15/62
摘要： Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise fusion polypeptides comprising multiple Leishmania antigens, in particular, KMP11, SMT, A2 and/or CBP, or immunogenic portions or variants thereof, as well as polynucleotides encoding such fusion polypeptides.
摘要翻译：公开了用于预防，治疗和检测利什曼病的组合物和方法。组合物通常包含包含多个利什曼原虫抗原，特别是KMP11，SMT，A2和/或CBP或其免疫原性部分或变体，以及编码这种融合多肽的多核苷酸的融合多肽。

36. 发明授权

US08425919B2 Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis 有权
公开(公告)号：US08425919B2
公开(公告)日：2013-04-23
申请号：US12466580
申请日：2009-05-15
申请人： Yasuyuki Goto , Steven G. Reed
发明人： Yasuyuki Goto , Steven G. Reed
IPC分类号： A61K39/008 , C07H21/04
CPC分类号： C07K14/44 , A61K39/008 , C12N15/62 , Y02A50/41
摘要： Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise fusion polypeptides comprising multiple Leishmania antigens, in particular, KMP11, SMT, A2 and/or CBP, or immunogenic portions or variants thereof, as well as polynucleotides encoding such fusion polypeptides.

37. 发明授权

US07833534B2 Compounds and methods for diagnosis and treatment of leishmaniasis 有权
标题翻译：利什曼病诊断和治疗的化合物和方法
公开(公告)号：US07833534B2
公开(公告)日：2010-11-16
申请号：US11733440
申请日：2007-04-10
申请人： Yasuyuki Goto , Steven G. Reed
发明人： Yasuyuki Goto , Steven G. Reed
IPC分类号： A61K39/02 , A61K49/00 , A61N63/00
CPC分类号： G01N33/56905 , G01N33/5008 , G01N33/5023 , G01N33/5091 , G01N33/6854 , G01N2500/00
摘要： Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.
摘要翻译：提供了用于诊断，预防，治疗和检测利什曼病感染和刺激患者免疫应答的化合物和方法。所公开的化合物包括含有一种或多种利什曼原虫抗原或其变体的至少一种免疫原性部分的多肽和融合蛋白。另外，公开了筛选具有免疫原性的串联重复蛋白的筛选文库的方法。描述了可用于预防和治疗利什曼病以及利什曼病感染检测的包含多核苷酸，多肽，融合蛋白及其变体的疫苗和药物组合物。

38. 发明授权

US07569258B2 Chlorofluorobenzene liquid crystal compound, liquid crystal composition, and liquid crystal display device 有权
标题翻译：氯氟苯液晶化合物，液晶组合物和液晶显示装置
公开(公告)号：US07569258B2
公开(公告)日：2009-08-04
申请号：US11368305
申请日：2006-03-03
申请人： Yasuyuki Goto , Teru Shimada , Teruyo Sugiura
发明人： Yasuyuki Goto , Teru Shimada , Teruyo Sugiura
IPC分类号： C09K19/30 , C09K19/12 , C07C25/13
CPC分类号： C07C25/13 , C07C43/225 , C09K19/12 , C09K19/14 , C09K19/20 , C09K19/3003 , C09K19/3028 , C09K19/3066 , C09K2019/0407 , C09K2019/0411 , C09K2019/123 , C09K2019/301 , C09K2019/3016 , Y10T428/10
摘要： Such a liquid crystal compound is provided that has stability to heat, light and so forth, has a nematic phase in a wide temperature range, has a small viscosity, a suitable optical anisotropy, and suitable elastic constants K33 and K11 (K33: bend elastic constant, K11: splay elastic constant), and has suitable negative dielectric anisotropy and excellent compatibility with other liquid crystal compounds. A liquid crystal composition containing the liquid crystal compound, and a liquid crystal display device containing the liquid crystal composition are also provided.The liquid crystal compound is represented by one of formulas (a) to (d), the liquid crystal composition contains the liquid crystal compound, and the liquid crystal display device contains the liquid crystal composition: wherein Ra and Rb are independently linear alkyl or linear alkoxy, rings A1, A2, B and C are independently trans-1,4-cyclohexylene or 1,4-phenylene, Z11, Z12, Z2 and Z3 are independently a single bond or alkylene, and one of X1 and X2 is fluorine, and the other thereof is chlorine.
摘要翻译：这种液晶化合物具有对热，光等具有稳定性，在宽温度范围内具有向列相，具有小的粘度，适当的光学各向异性和适当的弹性常数K33和K11（K33：弯曲弹性常数，K11：弹性弹性常数），具有合适的负介电各向异性，与其他液晶化合物的相容性好。还提供了含有液晶化合物的液晶组合物和含有液晶组合物的液晶显示装置。液晶化合物由式（a）〜（d）中的一种表示，液晶组成物含有液晶化合物，液晶显示装置含有液晶组成物：其中，Ra和Rb独立地为直链烷基或直链烷氧基，环A1，A2，B和C独立地为反式-1,4-亚环己基或1,4-亚苯基，Z11，Z12，Z2和Z3独立地为单键或亚烷基，X1和X2之一为氟，另一个是氯。

39. 发明申请

US20070290605A1 Organic Electroluminescent Element and Manufacturing Method Thereof, and Phosphorus-Containing Organic Compound and Manufacturing Method Thereof 审中-公开
标题翻译：有机电致发光元件及其制造方法和含磷有机化合物及其制造方法
公开(公告)号：US20070290605A1
公开(公告)日：2007-12-20
申请号：US10599334
申请日：2005-04-20
申请人： Yasuyuki Goto , Mitsuharu Noto , Tsuyoshi Hayashida , Masanao Era
发明人： Yasuyuki Goto , Mitsuharu Noto , Tsuyoshi Hayashida , Masanao Era
IPC分类号： H01J1/63 , C07F9/28 , H01J9/00
CPC分类号： H01L51/56 , C07F9/5329 , H01L51/0007 , H01L51/0037 , H01L51/0039 , H01L51/0042 , H01L51/005 , H01L51/0058 , H01L51/0085 , H01L51/5012 , H01L51/5048
摘要： An organic electroluminescent element comprising an anode, a cathode and a plurality of organic compound layers sandwiched between the anode and cathode, the organic compound layers including: a hole-transporting layer made of an organic compound insoluble in alcohols; and an electron-transporting layer formed on the hole-transporting layer by a wet method, the electron-transporting layer being made of a phosphorus-containing organic compound soluble in the alcohols.
摘要翻译：一种有机电致发光元件，包括阳极，阴极和夹在阳极和阴极之间的多个有机化合物层，有机化合物层包括：由不溶于醇的有机化合物制成的空穴传输层; 以及通过湿法在空穴传输层上形成的电子传输层，电子传输层由可溶于醇的含磷有机化合物制成。

40. 发明申请

US20060198968A1 Chlorofluorobenzene liquid crystal compound, liquid crystal composition, and liquid crystal display device 有权
标题翻译：氯氟苯液晶化合物，液晶组合物和液晶显示装置
公开(公告)号：US20060198968A1
公开(公告)日：2006-09-07
申请号：US11368305
申请日：2006-03-03
申请人： Yasuyuki Goto , Teru Shimada , Teruyo Sugiura
发明人： Yasuyuki Goto , Teru Shimada , Teruyo Sugiura
IPC分类号： C09K19/52 , C07C25/13 , C09K19/30 , C07C25/02 , C09K19/12
CPC分类号： C07C25/13 , C07C43/225 , C09K19/12 , C09K19/14 , C09K19/20 , C09K19/3003 , C09K19/3028 , C09K19/3066 , C09K2019/0407 , C09K2019/0411 , C09K2019/123 , C09K2019/301 , C09K2019/3016 , Y10T428/10
摘要： Such a liquid crystal compound is provided that has stability to heat, light and so forth, has a nematic phase in a wide temperature range, has a small viscosity, a suitable optical anisotropy, and suitable elastic constants K33 and K11 (K33: bend elastic constant, K11: splay elastic constant), and has suitable negative dielectric anisotropy and excellent compatibility with other liquid crystal compounds. A liquid crystal composition containing the liquid crystal compound, and a liquid crystal display device containing the liquid crystal composition are also provided. The liquid crystal compound is represented by one of formulas (a) to (d), the liquid crystal composition contains the liquid crystal compound, and the liquid crystal display device contains the liquid crystal composition: wherein Ra and Rb are independently linear alkyl or linear alkoxy, rings A1, A2, B and C are independently trans-1,4-cyclohexylene or 1,4-phenylene, Z11, Z12, Z2 and Z3 are independently a single bond or alkylene, and one of X1 and X2 is fluorine, and the other thereof is chlorine.
摘要翻译：这种液晶化合物具有对热，光等具有稳定性，在宽温度范围内具有向列相，具有小的粘度，适当的光学各向异性和适当的弹性常数K 33 和K 11（K 33）：弯曲弹性常数K 11伸展弹性常数），具有合适的负介电各向异性和优异的相容性与其他液晶化合物。还提供了含有液晶化合物的液晶组合物和含有液晶组合物的液晶显示装置。液晶化合物由式（a）〜（d）中的一种表示，液晶组成物含有液晶化合物，液晶显示装置含有液晶组成物：其中，Ra和Rb独立地为直链烷基或直链烷氧基，环A 1，A 2，B和C独立地是反式-1,4-亚环己基或1,4-亚苯基，Z 11， Z 12，Z 2和Z 3独立地是单键或亚烷基，X 1和X 2之一 >和X 2是氟，另一个是氯。

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