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31. 发明授权

US5312441A Method and apparatus for discrimination of ventricular tachycardia from supraventricular tachycardia and for treatment thereof 失效
标题翻译：用于区分室上性心动过速并用于治疗室性心动过速的方法和装置
公开(公告)号：US5312441A
公开(公告)日：1994-05-17
申请号：US867931
申请日：1992-04-13
申请人： Steven J. Mader , John R. Lisowski , Walter H. Olson , Kenneth P. Huberty
发明人： Steven J. Mader , John R. Lisowski , Walter H. Olson , Kenneth P. Huberty
IPC分类号： A61N1/365 , A61N1/362 , A61N1/39 , A61N1/36
CPC分类号： A61N1/3962 , A61N1/3621
摘要： An implantable cardioverter including apparatus for measuring the width of a patient's R-wave in order to determine whether or not to deliver an antitachycardia therapy. The means for measuring the width of the R-wave comprises a digitizing means for converting electrical signals from the ventricle to digital signals and means for analyzing the digitized signals to determine the end points of sensed R-waves. End points are identified in response to the occurrence of a series of sequential digitized signals which differ from proceeding signals by more than a predetermined amount, and the width of the R-wave is defined as the interval between the first such identified end point associated with a detected R-wave and the last such detected end point associated with the same detected R-wave.
摘要翻译：一种植入式心律转复器，其包括用于测量患者的R波的宽度的装置，以便确定是否递送抗心动过速疗法。用于测量R波宽度的装置包括用于将来自脑室的电信号转换为数字信号的数字化装置，以及用于分析数字化信号以确定感测到的R波的终点的装置。响应于一系列与进行信号不同的预定量的顺序数字化信号的出现来识别终点，并且将R波的宽度定义为与第一个这样识别的终点相关联的间隔检测到的R波和与相同检测到的R波相关联的最后一个这样的检测到的终点。

32. 发明授权

US5193535A Method and apparatus for discrimination of ventricular tachycardia from ventricular fibrillation and for treatment thereof 失效
标题翻译：用于从心室颤动中鉴别心室颤动的方法和装置及其治疗
公开(公告)号：US5193535A
公开(公告)日：1993-03-16
申请号：US750679
申请日：1991-08-27
申请人： Gust H. Bardy , Walter H. Olson , David K. Peterson , Robert T. Taepke
发明人： Gust H. Bardy , Walter H. Olson , David K. Peterson , Robert T. Taepke
IPC分类号： A61N1/362 , A61N1/365 , A61N1/39
CPC分类号： A61N1/3621 , A61N1/365 , A61N1/3962
摘要： An implantable cardioverter/defibrillator provided with method and apparatus for discrimination between ventricular tachycardia and ventricular fibrillation. The device is provided with two pairs of electrodes, each pair of electrodes coupled to processing circuitry for identifying a predetermined fiducal point in the electrical signal associated with a ventricular depolarization. The cumulative beat to beat variability of the intervals separating the two identified fiducal points, over a series of detected depolarizations is analyzed. The result of this analysis is used to distinguish between ventricular tachycardia and ventricular fibrillation.
摘要翻译：一种植入式心脏复律器/除颤器，其具有用于区分室性心动过速和心室颤动的方法和装置。该装置设置有两对电极，每对电极耦合到处理电路，用于识别与心室去极化相关联的电信号中的预定的基准点。分析了通过一系列检测到的去极化来分离两个识别的基准点的间隔的累积节拍差异的差异。该分析的结果用于区分室性心动过速和室颤。

33. 发明授权

US09096685B2 Genetic modification of targeted regions of the cardiac conduction system 有权
标题翻译：心脏传导系统目标区域的遗传修饰
公开(公告)号：US09096685B2
公开(公告)日：2015-08-04
申请号：US12578198
申请日：2009-10-13
申请人： Vinod Sharma , Walter H. Olson
发明人： Vinod Sharma , Walter H. Olson
IPC分类号： A61K31/70 , A61K48/00 , C12N15/00 , C07K14/705 , A61K38/17 , C07K1/00
CPC分类号： C07K14/705 , A61K38/00 , A61K38/177
摘要： Disclosed are compositions, methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of cells of targeted regions of the cardiac conduction system. In particular, a bio-pacemaker composition is delivered to cardiac cells to increase the intrinsic pacemaking rate of the cells, wherein the bio-pacemaker composition increases expression of a channel or subunit thereof that produces funny current and a T-type Ca2+ channel or subunit thereof, and expresses one or more molecules that suppresses the expression of the wild type potassium channel.
摘要翻译：公开了用于预防或治疗心脏功能障碍的组合物，方法和系统，特别是心脏起搏功能障碍，通过心脏传导系统的靶向区域的细胞的遗传修饰。特别地，将生物起搏器组合物递送到心脏细胞以增加细胞的固有起搏速率，其中生物起搏器组合物增加产生滑稽电流的通道或其亚基的表达，以及T型Ca 2+通道或亚基并表达抑制野生型钾通道表达的一种或多种分子。

34. 发明申请

US20120065253A1 GENETIC MODIFICATION OF TARGETED REGIONS OF THE CARDIAC CONDUCTION SYSTEM 有权
标题翻译：心脏导管系统目标区域的遗传修饰
公开(公告)号：US20120065253A1
公开(公告)日：2012-03-15
申请号：US13224593
申请日：2011-09-02
申请人： Vinod Sharma , Walter H. Olson
发明人： Vinod Sharma , Walter H. Olson
IPC分类号： A61K48/00 , A61P9/06
CPC分类号： C12N15/86 , A61K38/177 , A61K48/00 , A61K48/005 , C12N2750/14143
摘要： Disclosed are methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of the conduction system of the heart. In one embodiment, the invention provides a method of genetically modifying the cells by delivering to the cells one or more coding sequence in a genetic construct capable of modifying the expression of ion channels of the cells.
摘要翻译：公开了通过心脏传导系统的遗传修饰来预防或治疗心脏功能障碍，特别是心脏起搏功能障碍的方法和系统。在一个实施方案中，本发明提供了通过向细胞递送能够修饰细胞的离子通道的表达的遗传构建体中的一个或多个编码序列来遗传修饰细胞的方法。

35. 发明授权

US07787947B2 Method and apparatus for using an optical hemodynamic sensor to identify an unstable arrhythmia 有权
标题翻译：使用光学血液动力学传感器来识别不稳定心律失常的方法和装置
公开(公告)号：US07787947B2
公开(公告)日：2010-08-31
申请号：US11394477
申请日：2006-03-31
申请人： Sourav Bhunia , Walter H. Olson , Can Cinbis
发明人： Sourav Bhunia , Walter H. Olson , Can Cinbis
IPC分类号： A61N1/00
CPC分类号： A61B5/14542 , A61B5/1459 , A61N1/3621 , A61N1/36557 , A61N1/3956
摘要： A medical device identifies a hemodynamically unstable arrhythmia based upon optical hemodynamic sensor signals. The optical hemodynamic sensor includes a light source for transmitting light corresponding to first and second wavelengths through a blood perfused tissue of a patient and a light detector for generating optical signals corresponding to an intensity of the detected light at the first and second wavelengths. At a low motion period for the patient, optical signals are obtained from the optical hemodynamic sensor and are analyzed to determine a baseline motion level for the patient. Subsequent signals obtained from the optical hemodynamic sensor are compared to the baseline motion levels, with only those signals corresponding to periods where motion does not exceed the baseline level of motion being further analyzed to determine if they are consistent with a hemodynamically unstable arrhythmia.
摘要翻译：医疗设备基于光学血液动力学传感器信号识别血液动力学不稳定的心律失常。光学血液动力学传感器包括用于通过患者的血液灌注组织透射与第一和第二波长相对应的光的光源，以及用于产生与第一和第二波长的检测光的强度对应的光信号的光检测器。在患者的低运动周期中，从光学血液动力学传感器获得光学信号，并且被分析以确定患者的基线运动水平。将从光学血液动力学传感器获得的后续信号与基线运动水平进行比较，只有那些对应于运动未超过基线运动水平的周期的信号进行进一步分析，以确定它们是否与血液动力学不稳定的心律失常一致。

36. 发明授权

US07684864B2 Subcutaneous cardioverter-defibrillator 有权
标题翻译：皮下心律转复除颤器
公开(公告)号：US07684864B2
公开(公告)日：2010-03-23
申请号：US11116577
申请日：2005-04-28
申请人： Walter H. Olson , King Y. Moy , Joey G. Nakayama , Gary F. Prokop , Gary J. Stilwell
发明人： Walter H. Olson , King Y. Moy , Joey G. Nakayama , Gary F. Prokop , Gary J. Stilwell
IPC分类号： A61N1/02
CPC分类号： A61N1/3968 , A61N1/0504 , A61N1/375 , A61N1/3756
摘要： SubQ ICDs are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion-defibrillation sense and stimulation electrodes for delivery of cardioversion-defibrillation shock and pacing therapies across the heart when necessary. Configurations include one hermetically sealed housing with 1 or, optionally, 2 subcutaneous sensing and cardioversion-defibrillation therapy delivery leads or alternatively, 2 hermetically sealed housings interconnected by a power/signal cable. The housings are generally dynamically configurable to adjust to varying rib structure and associated articulation of the thoracic cavity and muscles. Further the housings may optionally be flexibly adjusted for ease of implant and patient comfort.
摘要翻译：公开了SubQ ICD，其完全可植入皮下，以最小的手术侵入患者身体，并提供分布式心脏复律除颤感和刺激电极，用于在需要时在整个心脏中递送心脏复律除颤电击和起搏治疗。配置包括一个密封的外壳，具有1个或任选地2个皮下感测和心脏复律除颤治疗输送引线，或者备选地，通过电源/信号电缆互连的2个气密密封外壳。这些外壳通常是可动态配置的，以适应胸部结构和胸腔和肌肉关联的变化。此外，为了便于植入和患者舒适，还可以灵活地调整这些外壳。

37. 发明授权

US07622303B2 Methods for identifying patients at risk for life threatening arrhythmias 有权
标题翻译：确定危及生命危险的心律失常患者的方法
公开(公告)号：US07622303B2
公开(公告)日：2009-11-24
申请号：US11050611
申请日：2005-02-03
申请人： Orhan Soykan , Timothy H. Robinson , Walter H. Olson , Vinod Sharma , Amy C. Dearking
发明人： Orhan Soykan , Timothy H. Robinson , Walter H. Olson , Vinod Sharma , Amy C. Dearking
IPC分类号： G01N33/00
CPC分类号： G01N33/6893 , G01N2800/326 , Y10T436/13
摘要： In general, the invention is directed to systems and techniques for assessing a risk of ventricular tachyarrhythmia in a patient by measuring one or more biochemical markers that reflect the health of a patient. Typically, the patient submits a sample, such as a blood sample, which is tested for one or more biomarkers. Based upon the results of the tests, the patient's risk of ventricular tachyarrhythmia may be assessed. When the patient is found to be at risk, the patient may receive an implantable medical device or drug therapy to address the risk.
摘要翻译：通常，本发明涉及通过测量反映患者健康的一种或多种生物化学标记来评估患者的心室性快速性心律失常风险的系统和技术。通常，患者提交样品，例如血液样品，其被测试用于一种或多种生物标志物。根据测试结果，可以评估患者的心室性心律失常风险。当患者被发现处于危险中时，患者可能会接受可植入的医疗设备或药物治疗来解决风险。

38. 发明授权

US07383085B2 Subcutaneous implantable cardioverter/defibrillator 有权
标题翻译：皮下植入式心律转复除颤器
公开(公告)号：US07383085B2
公开(公告)日：2008-06-03
申请号：US11419284
申请日：2006-05-19
申请人： Walter H. Olson
发明人： Walter H. Olson
IPC分类号： A61N1/39
CPC分类号： A61N1/3622 , A61N1/0563 , A61N1/375 , A61N1/3918 , A61N1/3956 , A61N1/3968 , A61N1/3981
摘要： Implantable cardioverter-defibrillators (ICDs) are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion/defibrillation and pace/sense electrodes for delivery of cardioversion/defibrillation shock and pacing therapies across the heart when necessary. At least two hermetically sealed housings forming first and second hermetically sealed housings coupled together by a cable support first, second and, optionally, third cardioversion/defibrillation electrodes. The relatively bulky high voltage battery and high voltage capacitors, and circuitry powered by a low voltage power source for detecting a tachyarrhythmia, charging the high voltage capacitor, and discharging the high voltage capacitor to provide a cardioversion/defibrillation shock are distributed between the first and second hermetically sealed housings.
摘要翻译：公开了植入式心律转复除颤器（ICD），其完全可植入皮下，以最小的手术入侵患者身体，并提供分布式心脏复律/除颤和步调/感应电极，用于在需要时在整个心脏递送心脏复律/除颤休克和起搏疗法。至少两个气密密封的壳体形成第一和第二密封壳体，其通过电缆支撑件第一，第二以及任选的第三心电复律/除颤电极耦合在一起。相对庞大的高电压电池和高压电容器以及由用于检测快速性心律失常的低压电源供电的电路，对高压电容器充电以及对高压电容器进行放电以提供心脏复律/除颤电击分布在第一和第二个密封的外壳。

39. 发明授权

US6052620A Prioritized rule based method and apparatus for diagnosis and treatment of arrhythmias 失效
标题翻译：用于诊断和治疗心律失常的优先规则方法和装置
公开(公告)号：US6052620A
公开(公告)日：2000-04-18
申请号：US47649
申请日：1998-03-25
申请人： Jeffrey M. Gillberg , Walter H. Olson
发明人： Jeffrey M. Gillberg , Walter H. Olson
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61B5/042 , A61B5/046 , A61B5/0464 , A61B5/7264
摘要： An implantable anti-tachyarrhythmia device which delivers anti-tachyarrhythmia therapies to a patient's heart in response to detection of tachyarrhythmias. The device defines first criteria indicating the presence of atrial tachycardia and second criteria indicating the presence of atrial fibrillation, and compares the time elapsed since the either the first or second criteria were initially met to a defined time duration. In response to the defined duration having passed and either of the first or second criteria being met, the device triggers delivery of an appropriate anti-tachyarrhythmia therapy. The timer is reset on detection of termination of atrial tachyarrhythmia, but not on failure of the first and second criteria to be met. The first and second criteria are defined such that they can not be concurrently met.
摘要翻译：一种可植入的抗快速性心律失常装置，其响应于快速性心律失常的检测而向患者的心脏递送抗快速性心律失常疗法。该装置定义了指示心房性心动过速存在的第一标准和指示心房颤动存在的第二标准，并且比较了从第一或第二标准开始满足到限定的持续时间之后经过的时间。响应于已经通过的限定的持续时间并满足第一或第二标准中的任一个，该装置触发适当的抗快速性心律失常治疗的递送。在检测到心房性心律失常终止时，定时器复位，但不符合第一和第二标准的失败。第一和第二个标准被定义为不能同时满足。

40. 发明授权

US5755736A Prioritized rule based method and apparatus for diagnosis and treatment of arrhythmias 失效
公开(公告)号：US5755736A
公开(公告)日：1998-05-26
申请号：US895342
申请日：1997-07-16
申请人： Jeffrey M. Gillberg , Walter H. Olson
发明人： Jeffrey M. Gillberg , Walter H. Olson
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61B5/042 , A61B5/046 , A61B5/0464 , A61B5/7264
摘要： An implantable anti-tachyarrhythmia device which delivers anti-tachyarrhythmia therapies to a patient's heart in response to detection of tachyarrhythmias. The device defines first criteria indicating the presence of atrial tachycardia and second criteria indicating the presence of atrial fibrillation, and compares the time elapsed since the either the first or second criteria were initially met to a defined time duration. In response to the defined duration having passed and either of the first or second criteria being met, the device triggers delivery of an appropriate anti-tachyarrhythmia therapy. The timer is reset on detection of termination of atrial tachyarrhythmia, but not on failure of the first and second criteria to be met. The first and second criteria are defined such that they can not be concurrently met.

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