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31. 发明申请

US20130178479A1 PHARMACEUTICAL COMBINATIONS 审中-公开
标题翻译：药物组合
公开(公告)号：US20130178479A1
公开(公告)日：2013-07-11
申请号：US13876021
申请日：2011-10-03
申请人： Yan Chen , Xizhong Huang , Leon Murphy , Beat Nyfeller
发明人： Yan Chen , Xizhong Huang , Leon Murphy , Beat Nyfeller
IPC分类号： A61K31/436 , A61K31/496 , A61K31/4745
CPC分类号： A61K31/436 , A61K31/4188 , A61K31/4745 , A61K31/496 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a pharmaceutical combination which comprises (a) an mTOR catalytic inhibitor, such as a catalytic phosphatidylinositol-3-kinase (PI3K) and mTOR inhibitor compound which is an imidazoquinoline derivative and (b) at least one allosteric mTOR inhibitor compound, and optionally, at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the treatment of an mammalian target of rapamycin (mTOR) kinase dependent proliferative diseases; and the uses of such a combination in the treatment of mTOR kinase dependent proliferative diseases; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human.
摘要翻译：本发明涉及药物组合，其包含（a）mTOR催化抑制剂，例如催化磷脂酰肌醇-3-激酶（PI3K）和作为咪唑并喹啉衍生物的mTOR抑制剂化合物和（b）至少一种变构mTOR抑制剂化合物和任选的至少一种用于同时，分别或顺序使用的药学上可接受的载体，特别是用于治疗雷帕霉素（mTOR）激酶依赖性增殖性疾病的哺乳动物靶标; 以及这种组合在治疗mTOR激酶依赖性增殖性疾病中的应用; 包含这种组合的药物组合物; 使用这种组合来制备用于治疗增殖性疾病的药物; 包括作为用于同时，分开或顺序使用的组合制剂的组合的商业包装或产品; 以及治疗温血动物，特别是人的方法。

32. 发明申请

US20130035318A1 C-17 AND C-3 MODIFIED TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY 有权
标题翻译： C-17和C-3修饰的TRAILRPENOIDS与HIV成熟抑制活性
公开(公告)号：US20130035318A1
公开(公告)日：2013-02-07
申请号：US13359727
申请日：2012-01-27
申请人： ALICIA REGUEIRO-REN , Zheng Liu , Jacob Swidorski , Ny Sin , Brian Lee Venables , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell
发明人： ALICIA REGUEIRO-REN , Zheng Liu , Jacob Swidorski , Ny Sin , Brian Lee Venables , Sing-Yuen Sit , Yan Chen , Jie Chen , Nicholas A. Meanwell
IPC分类号： C07J53/00 , A61K31/58 , A61P31/18 , A61K31/565
CPC分类号： A61K31/565 , A61K31/56 , A61K31/58 , A61K31/704 , A61K45/06 , C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.
摘要翻译：阐述了具有药物和生物影响特性的化合物，其药物组合物和使用方法。特别地，具有独特抗病毒活性的C-17和C-3修饰的三萜类化合物作为HIV成熟抑制剂提供，如式I，II和III化合物所示：这些化合物可用于治疗HIV和AIDS。

33. 发明授权

US08324362B2 Nucleic acid encoding 10FN3 polypeptide inhibitors of Type 2 vascular endothelial growth factor receptors 有权
标题翻译：编码2型血管内皮生长因子受体的10FN3多肽抑制剂的核酸
公开(公告)号：US08324362B2
公开(公告)日：2012-12-04
申请号：US12788240
申请日：2010-05-26
申请人： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
发明人： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC分类号： C07H21/04 , C12N15/63 , C12N15/09 , C12N1/21 , C12N1/15 , C12N5/10 , A61K38/39 , C07K14/78 , A61P35/00
CPC分类号： C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
摘要： The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
摘要翻译：本公开内容涉及新型血管内皮生长因子受体（VEGFR）结合多肽和使用这些多肽抑制由血管内皮生长因子（VEGF）介导的生物活性的方法。本公开还提供了与单结构域结合多肽相关的各种改进。

34. 发明申请

US20120299701A1 METHOD AND APPARATUS FOR PASSCODE ENTRY 审中-公开
标题翻译：用于进食的方法和装置
公开(公告)号：US20120299701A1
公开(公告)日：2012-11-29
申请号：US13520064
申请日：2009-12-30
申请人： Yanming Zou , Xiaohui Xie , Changsong Liu , Yan Chen
发明人： Yanming Zou , Xiaohui Xie , Changsong Liu , Yan Chen
IPC分类号： G06F7/04
CPC分类号： G06F21/31 , G06K9/50 , G06K2209/01
摘要： An apparatus and method for receiving a first user input comprising a first set of strokes; causing a representation of the first set of strokes to be displayed; whilst the representation of the first set of strokes is displayed, receiving a second user input comprising a second set of strokes; causing a representation of each of the second set of strokes to be displayed as it is received, the representation of the second set of strokes at least partially overlapping the representation of the first set of strokes; resolving the first user input into a first character; and resolving the second user input into a second character.
摘要翻译：一种用于接收包括第一组笔划的第一用户输入的装置和方法; 导致要显示的第一组笔画的表示; 同时显示第一组笔画的表示，接收包括第二组笔画的第二用户输入; 使得所述第二组笔划中的每一个的表示在其被接收时被显示，所述第二组笔划的表示至少部分地与所述第一组笔画的表示重叠; 将所述第一用户输入解析为第一字符; 并将第二用户输入解析为第二个字符。

35. 发明授权

US08306961B2 System and method for launching a resource in a network 有权
标题翻译：在网络中启动资源的系统和方法
公开(公告)号：US08306961B2
公开(公告)日：2012-11-06
申请号：US13051505
申请日：2011-03-18
申请人： Alex Bethlehem , Laura Armstrong , Yan Chen , Zhenwu Li , Paul Zhiyong Zhou
发明人： Alex Bethlehem , Laura Armstrong , Yan Chen , Zhenwu Li , Paul Zhiyong Zhou
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： H04L67/306 , H04L63/102 , H04L67/10 , H04L67/36
摘要： The disclosure provides a system and method for a client connected to a server in a computer network to access a resource, such as an application, database (either local, server, or web-based), service and/or a file, stored in the network. The system comprises: the client in the network; the server in the network; an instance of the resource stored in at least one of the server and the client; a file associated with the application stored in at least one of the server and the client; and an access module operating to provide the client with access to the server. In the system at the client, a first icon associated with a said resource is provided and if the instance of the resource is stored at the server, the application is automatically accessed when the icon at the client is activated.
摘要翻译：本公开提供了一种用于连接到计算机网络中的服务器的客户端的系统和方法，用于访问存储在计算机网络中的资源，例如应用程序，数据库（本地，服务器或基于Web），服务和/或文件网络。该系统包括：网络中的客户端; 网络中的服务器; 存储在服务器和客户端中的至少一个中的资源的实例; 与存储在服务器和客户端中的至少一个中的应用相关联的文件; 以及操作以向客户端提供对服务器的访问的访问模块。在客户机的系统中，提供与所述资源相关联的第一图标，并且如果资源的实例被存储在服务器上，则当客户端上的图标被激活时，应用程序被自动访问。

36. 发明申请

US20120154109A1 ESTABLISHING AN AUTHENTICATED WIRELESS CONNECTION BETWEEN SHORT-RANGE WIRELESS TERMINALS MORE CONVENIENTLY 审中-公开
标题翻译：在短距离无线终端之间建立认证无线连接更为方便
公开(公告)号：US20120154109A1
公开(公告)日：2012-06-21
申请号：US13405316
申请日：2012-02-26
申请人： Yan Chen , Xiao He , Kuang Hu , Guo Jun Zhang
发明人： Yan Chen , Xiao He , Kuang Hu , Guo Jun Zhang
IPC分类号： G06F7/04
CPC分类号： H04M1/7253 , G06F3/04883 , H04L63/0492 , H04L63/08 , H04M2250/22 , H04W12/06
摘要： A method for establishing a wireless connection based on a touch screen of a wireless device. The wireless device includes a slide-out processing section for determining, in response to a slide-out from an edge of the touch screen, a first slide-out parameter for determining by the other wireless device an object to be connected, and broadcasting the first slide-out parameter. The wireless device further includes a slide-in processing section for determining a slide-in parameter in response to a slide-in from the edge of the touch screen and reception of a second slide-out parameter directionally transmitted from the other wireless device. Furthermore, if the determined slide-in parameter matches the second slide-out parameter, then the slide-in processing section establishes a wireless connection between the wireless device and the other wireless device. As a result, an authenticated wireless connection between short-range wireless terminals can be established more conveniently.
摘要翻译：一种用于基于无线设备的触摸屏建立无线连接的方法。无线装置包括滑出处理部分，用于响应于从触摸屏的边缘滑出来确定用于由另一无线设备确定要连接的对象的第一滑出参数，并且广播第一个滑出参数。无线设备还包括滑入式处理部分，用于响应于从触摸屏的边缘的滑入以及从另一无线设备定向发送的第二滑出参数的接收来确定滑入参数。此外，如果所确定的滑入参数与第二滑出参数匹配，则滑入式处理部分在无线设备与另一无线设备之间建立无线连接。结果，可以更方便地建立短距离无线终端之间的认证无线连接。

37. 发明授权

US08145662B2 Methods and apparatus for generating a data dictionary 有权
标题翻译：用于生成数据字典的方法和装置
公开(公告)号：US08145662B2
公开(公告)日：2012-03-27
申请号：US12347938
申请日：2008-12-31
申请人： Yan Chen , Joe Anthony Beynon , Baruch Perlov , Sanjay Pundlkrao Ghatare , Alvaro Bolivar , Nishith Parikh , Karin Mauge , Guanglei Song
发明人： Yan Chen , Joe Anthony Beynon , Baruch Perlov , Sanjay Pundlkrao Ghatare , Alvaro Bolivar , Nishith Parikh , Karin Mauge , Guanglei Song
IPC分类号： G06F17/30 , G06F7/00
CPC分类号： G06F17/30598 , G06F17/30731
摘要： There is provided a method and system generate a data dictionary for searching data items stored in an information resource. In one embodiment, the system generates a list of synonyms for keywords entered in search queries to the system. A keyword and synonym form a token pair. Token pairs are evaluated according to a bidirectional divergence value calculated for distributions of search results, wherein the searches are based on the token pairs. Token pairs are then selected based on the divergence value. The selected token pairs are compiled into a data dictionary. In one embodiment, the data dictionary is a synonym dictionary used for user search query expansion to find matching items.
摘要翻译：提供了一种方法和系统生成用于搜索存储在信息资源中的数据项的数据字典。在一个实施例中，系统生成在系统的搜索查询中输入的关键词的同义词列表。关键字和同义词形成一个令牌对。根据针对搜索结果的分布计算的双向发散值来评估令牌对，其中搜索基于令牌对。然后基于发散值选择令牌对。所选的令牌对被编译成数据字典。在一个实施例中，数据字典是用于用户搜索查询扩展以找到匹配项的同义字典。

38. 发明授权

US08091363B2 Low residence combustor fuel nozzle 有权
标题翻译：低住宅燃烧器燃油喷嘴
公开(公告)号：US08091363B2
公开(公告)日：2012-01-10
申请号：US11998769
申请日：2007-11-29
申请人： Daniel J. Sullivan , Peter Stuttaford , Robert J. Kraft , Khalid Oumejjoud , Yan Chen
发明人： Daniel J. Sullivan , Peter Stuttaford , Robert J. Kraft , Khalid Oumejjoud , Yan Chen
IPC分类号： F02C1/00 , B05B7/10
CPC分类号： F23R3/286 , F23R3/14
摘要： Embodiments for an apparatus and associated method for reducing the residence time in a gas turbine combustor are disclosed. The embodiments of the present invention comprise a fuel nozzle that extends to a downstream plane of an end cap for a combustion liner where the axial distance of the premixer is reduced, however the swirl for mixing the fuel and air, is increased. As a result, the mixing of the fuel and air is essentially unchanged, thereby allowing higher air pressures and operating temperatures within the premixer without inducing auto-ignition.
摘要翻译：公开了用于减少在燃气轮机燃烧器中的停留时间的设备和相关方法的实施例。本发明的实施例包括燃料喷嘴，其延伸到用于燃烧衬套的端盖的下游平面，其中预混合器的轴向距离减小，然而用于混合燃料和空气的涡流增加。结果，燃料和空气的混合基本上没有变化，从而允许在预混合器内更高的空气压力和操作温度而不引起自动点火。

39. 发明申请

US20120004137A1 IDENTIFICATION OF NUCLEIC ACID DELIVERY VEHICLES USING DNA DISPLAY 审中-公开
标题翻译：使用DNA显示鉴定核酸递送车辆
公开(公告)号：US20120004137A1
公开(公告)日：2012-01-05
申请号：US13147898
申请日：2010-02-16
申请人： Richard W. Wagner , Yan Chen , Steven Mark Shamah
发明人： Richard W. Wagner , Yan Chen , Steven Mark Shamah
IPC分类号： C40B30/06 , C40B40/06
CPC分类号： C12Q1/6897 , C12N15/1068 , C12N15/1075 , C12Q2563/107 , C12Q2525/207 , C12Q2525/205 , C12Q2565/626 , C12Q2525/203 , C12Q2525/197
摘要： The present invention features methods and compositions for the identification of molecules that facilitate the intracellular delivery of a, e.g., nucleic acid molecule. The methods and compositions of the invention utilize any display methodology wherein a library (e.g., a small molecule or protein library) is coupled to a nucleic acid (e.g., RNA or DNA) that encodes each library member.
摘要翻译：本发明的特征在于用于鉴定促进例如核酸分子的细胞内递送的分子的方法和组合物。本发明的方法和组合物利用任何显示方法，其中文库（例如，小分子或蛋白质文库）与编码每个文库成员的核酸（例如RNA或DNA）偶联。

40. 发明申请

US20110311482A1 Hepatitis C Virus Inhibitors 有权
标题翻译：丙型肝炎病毒抑制剂
公开(公告)号：US20110311482A1
公开(公告)日：2011-12-22
申请号：US12966175
申请日：2010-12-13
申请人： Xiangdong Alan Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Yan Chen
发明人： Xiangdong Alan Wang , Li-Qiang Sun , Sing-Yuen Sit , Ny Sin , Paul Michael Scola , Yan Chen
IPC分类号： A61K38/21 , A61K31/437 , C07D471/04 , A61K31/4375 , A61P31/14 , C07D217/24 , A61K31/497 , C07D401/14 , A61K31/501 , C07D403/14 , A61K31/7056 , A61K31/4709
CPC分类号： A61K38/06 , A61K31/40 , A61K38/00 , A61K38/005 , A61K45/06 , C07D207/16 , C07D217/24 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , C07D491/04 , C07K5/06034 , C07K5/06052 , C07K5/0808 , C07K5/0827 , A61K2300/00
摘要： Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译：公开了具有以下通式的丙型肝炎病毒抑制剂：其中R1，R2，R3，R'，B，Y和X在说明书中描述。还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。

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