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31. 发明申请

US20090317843A1 METHOD FOR MEASURING PLASMA LEVELS OF LONG PENTRAXIN PTX3 审中-公开
标题翻译：测定长庚酸PTX3等离子体水平的方法
公开(公告)号：US20090317843A1
公开(公告)日：2009-12-24
申请号：US12520059
申请日：2006-12-22
申请人： Alberto Mantovani , Giuseppe Peri , Fabio Pasqualini
发明人： Alberto Mantovani , Giuseppe Peri , Fabio Pasqualini
IPC分类号： G01N33/00 , G01N33/53
CPC分类号： G01N33/6893 , G01N33/5002 , G01N2333/71 , G01N2800/32
摘要： The present invention relates to a method for measuring PTX3 in a biological fluid, particularly in human or animal plasma. Particularly, the present invention relates to a method for measuring PTX3 levels in a human or animal derived plasma sample, comprising a stage of the treatment of said plasma sample with a red blood cell agglutinating agent and a subsequent stage of determining the plasma levels of PTX3.
摘要翻译：本发明涉及用于测量生物流体中特别是在人或动物血浆中的PTX3的方法。特别地，本发明涉及用于测定人或动物衍生的血浆样品中PTX3水平的方法，其包括用红细胞凝集剂处理所述血浆样品的阶段，以及随后确定PTX3血浆水平的阶段。

32. 发明申请

US20080015153A1 Pharmaceutical compositions containing the long pentraxin PTX3 有权
标题翻译：含有长五倍子PTX3的药物组合物
公开(公告)号：US20080015153A1
公开(公告)日：2008-01-17
申请号：US11882180
申请日：2007-07-31
申请人： Barbara Bottazzi , Martiho Introna , Alberto Mantovani , Annunciata Vecchi
发明人： Barbara Bottazzi , Martiho Introna , Alberto Mantovani , Annunciata Vecchi
IPC分类号： A61K38/17 , A61P31/00 , A61P35/02
CPC分类号： A61K38/1709 , A61K48/00 , C07K14/47 , C07K14/71 , Y02A50/481
摘要： Pharmaceutical compositions are described containing a long pentraxin PTX3, particularly human PTX3, for the therapy of infectious and inflammatory or tumour diseases; expression vectors containing cDNA coding for PTX3; recombinant host cells transfected with such vectors; a method for producing substantial amounts of PTX3 involving the culturing of such cells, and the use of said vectors in the gene therapy of tumours.
摘要翻译：描述的药物组合物含有长的pentraxin PTX3，特别是人PTX3，用于治疗感染性和炎性或肿瘤疾病; 含有编码PTX3的cDNA的表达载体; 用这些载体转染的重组宿主细胞; 用于生产涉及培养这种细胞的大量PTX3的方法，以及所述载体在肿瘤基因治疗中的用途。

33. 发明申请

US20060148001A1 Compositions and methods for treating female fertility 审中-公开
公开(公告)号：US20060148001A1
公开(公告)日：2006-07-06
申请号：US11342851
申请日：2006-01-31
申请人： Alberto Mantovani
发明人： Alberto Mantovani
IPC分类号： G01N33/53
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K38/1709 , A61K48/00 , A61K49/0004 , C12N15/8509 , C12N2750/14111 , C12N2840/203 , G01N33/689 , G01N33/74 , G01N2333/4756 , G01N2800/367
摘要： The PTX3 gene or equivalent PTX3 activity is required for female fertility. Manipulation of PTX3 activity will regulate female fertility. The effects of female sterility may be ameliorated, reproductive ability may be increased or decreased as desired, female fertility may be enhanced, or combinations thereof. The need for therapies that affect female fertility is thereby addressed.

34. 发明授权

US07041648B2 Compositions and methods for treating female fertility 失效
标题翻译：治疗女性生育力的组成和方法
公开(公告)号：US07041648B2
公开(公告)日：2006-05-09
申请号：US10785427
申请日：2004-02-25
申请人： Alberto Mantovani
发明人： Alberto Mantovani
IPC分类号： A61K38/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K38/1709 , A61K48/00 , A61K49/0004 , C12N15/8509 , C12N2750/14111 , C12N2840/203 , G01N33/689 , G01N33/74 , G01N2333/4756 , G01N2800/367
摘要： The PTX3 gene or equivalent PTX3 activity is required for female fertility. Manipulation of PTX3 activity will regulate female fertility. The effects of female sterility may be ameliorated, reproductive ability may be increased or decreased as desired, female fertility may be enhanced, or combinations thereof. The need for therapies that affect female fertility is thereby addressed.
摘要翻译： PTX3基因或等效的PTX3活性是女性生育力所必需的。 PTX3活性的操作将调节女性的生育能力。雌性不育的作用可以被改善，生殖能力可以根据需要增加或减少，雌性生殖力可以增强，或其组合。从而解决了影响女性生育能力的治疗需求。

35. 发明授权

US06380162B1 Ice inhibiting peptides 失效
标题翻译：抑冰肽
公开(公告)号：US06380162B1
公开(公告)日：2002-04-30
申请号：US09297369
申请日：1999-07-01
申请人： Marta Muzio , Martino Introna , Alberto Mantovani
发明人： Marta Muzio , Martino Introna , Alberto Mantovani
IPC分类号： A61K3810
CPC分类号： C07K14/54 , A61K38/00
摘要： The present invention relates to a peptide capable of binding to ICE and/or to enzymes of the ICE family, which peptide consists essentially of the amino acid sequence of SEQ ID NO:1 reported in the Sequence Listing, in which Xaa is selected between Asp and Ala, optionally containing one or more amino acids at its N-terminal and/or C-terminal end. It also relates to the use of the above peptide, for the preparation of pharmaceutical compositions active in pathologies requiring ICE inhibition and/or inhibition of enzymes of the ICE family.
摘要翻译：本发明涉及能够结合ICE和/或ICE家族的酶的肽，该肽基本上由序列表中报道的SEQ ID NO：1的氨基酸序列组成，其中Xaa选自Asp 和Ala，任选在其N-末端和/或C-末端含有一个或多个氨基酸。它还涉及上述肽用于制备在需要ICE抑制和/或抑制ICE家族酶的病态中活性的药物组合物的用途。

36. 发明授权

US06332732B1 Device for rapid tool coupling and release on tool arms 失效
标题翻译：用于工具臂快速联接和释放的装置
公开(公告)号：US06332732B1
公开(公告)日：2001-12-25
申请号：US09496190
申请日：2000-02-02
申请人： Alberto Mantovani
发明人： Alberto Mantovani
IPC分类号： F16B218
CPC分类号： E02F3/3627 , E02F3/364 , E02F3/365 , E02F3/3663 , Y10T403/591 , Y10T403/593
摘要： The device for rapid tool coupling and release on tool arms comprises a first rapid-attachment organ associated to a tool arm and is provided with at least one tooth and with hollow coupling seatings destined to couple in seatings and also with at least one pivot predisposed on the tool. The rapid-attachment organ is provided with at least a portion of coupling surface destined to couple on contact with at least a portion of plane on the seatings; the coupling surface is oriented in such a way that a perpendicular thereof does not intersect an axis of the pivot coupled in a hollow seating. Each of the at least one tooth of the coupling element, which is axially mobile internally of a guide having an axis lying in a perpendicular plane to the axis of the pivot coupled in a hollow seating, has an inclined plane destined to couple with a corresponding flat surface afforded on the at least one seating; the inclined plane being inclined with respect to the axis of the guide and generating together with the axis of the guide a slight tapering of a free end of the at least one tooth destined to couple by insertion thereof in the at least one seating.
摘要翻译：用于在工具臂上快速工具联接和释放的装置包括与工具臂相关联的第一快速附接器具，并且设置有至少一个齿，并且具有中空联接座，用于在座中耦合，并且还具有至少一个预先位于工具。快速附着器具设置有至少一部分耦合表面，其目的地是与座上的至少一部分平面接触; 联接表面被定向成使得其垂直线不与联接在空心座中的枢轴的轴线相交。耦合元件的至少一个齿，其在具有位于与连接在中空座中的枢轴的垂直平面的轴线的引导件的轴向移动的内部具有旨在与相应的在至少一个座位上提供平坦表面; 所述倾斜平面相对于所述引导件的轴线倾斜并且与所述引导件的轴线一起产生，所述至少一个齿的自由端通过将所述至少一个齿的自由端插入到所述至少一个座中来连接。

37. 发明授权

US5981713A Antibodies to intereleukin-1 antagonists 失效
标题翻译：抗白细胞介素-1拮抗剂的抗体
公开(公告)号：US5981713A
公开(公告)日：1999-11-09
申请号：US910884
申请日：1997-08-13
申请人： Francesco Colotta , Marta Muzio , Alberto Mantovani
发明人： Francesco Colotta , Marta Muzio , Alberto Mantovani
IPC分类号： A61K38/00 , C07K14/54 , C12N15/12 , C07K16/18
CPC分类号： C07K14/54 , A61K38/00
摘要： A novel interleukin-1 antagonist active against both IL-1.alpha. and IL-1.beta. and DNA encoding same/re described. Antibodies specific for the novel IL-1 antagonist and prophylatic, therapeutic and diagnostic uses of the IL-1 antagonist in pathologies associated with IL-1 production are also described.
摘要翻译：一种对IL-1α和IL-1β有活性的新型白细胞介素-1拮抗剂和编码相同/重述的DNA。还描述了特异于新型IL-1拮抗剂的抗体和IL-1拮抗剂在与IL-1生成相关的病理学中的预防，治疗和诊断用途。

38. 发明授权

US09081018B2 Diagnostic test for inflammatory endothelial dysfunctions in pregnancies 有权
标题翻译：妊娠中炎性内皮功能障碍的诊断试验
公开(公告)号：US09081018B2
公开(公告)日：2015-07-14
申请号：US12159724
申请日：2006-12-18
申请人： Alberto Mantovani , Cecilia Garlanda , Andrea Doni , Irene Cetin
发明人： Alberto Mantovani , Cecilia Garlanda , Andrea Doni , Irene Cetin
IPC分类号： C07K16/24 , G01N33/543 , G01N33/68
CPC分类号： G01N33/689 , C07K16/24 , G01N33/543 , G01N2333/4715 , G01N2800/368 , G01N2800/50 , G01N2800/7095
摘要： The present invention relates to a diagnostic test for inflammatory endothelial dysfunctions in pregnant women. Particularly, the present invention relates to a method of diagnosing or evaluating the risk of contracting an inflammatory endothelial dysfunction of the maternal compartment comprising the following steps: a) detecting the plasma levels of long pentraxin PTX3 in blood samples taken from a pregnant woman; b) comparing the PTX3 plasma level data, obtained according to step a), with statistically significant PTX3 plasma level data of normal pregnant population.
摘要翻译：本发明涉及孕妇炎症性内皮功能障碍的诊断试验。特别地，本发明涉及一种诊断或评价母体隔室炎症性内皮功能障碍的风险的方法，包括以下步骤：a）检测从怀孕妇女获取的血液样品中的长五倍体PTX3的血浆水平; b）将根据步骤a）获得的PTX3血浆水平数据与正常怀孕人群的统计学显着的PTX3血浆水平数据进行比较。

39. 发明申请

US20090023166A1 Method For the in Vitro Diagnosis of Autoimmune Immune Response by Detection of Antibodies Directed Against The Pentraxin 3 Antigen 审中-公开
标题翻译：通过检测针对Pentraxin 3抗原的抗体的自身免疫免疫反应的体外诊断方法
公开(公告)号：US20090023166A1
公开(公告)日：2009-01-22
申请号：US12223004
申请日：2007-01-19
申请人： Pascale Jeannin , Yves Delneste , Alberto Mantovani
发明人： Pascale Jeannin , Yves Delneste , Alberto Mantovani
IPC分类号： G01N33/53 , C12Q1/00 , G01N33/566
CPC分类号： G01N33/564
摘要： A method for the in vitro diagnosis of an autoimmune immune response in an individual by detection, in a biological fluid from said individual, of antibodies directed against the pentraxin 3 (PTX3) antigen, characterized in that the presence of antibodies directed against the PTX3 antigen (anti-PTX3 antibodies) are determined in a biological fluid from the individual, and kits for implementing the method.
摘要翻译：一种通过在来自所述个体的生物流体中检测针对五倍体素3（PTX3）抗原的抗体体外诊断个体中自身免疫免疫应答的方法，其特征在于存在针对PTX3抗原的抗体（抗PTX3抗体）在来自个体的生物流体中测定，以及用于实施该方法的试剂盒。

40. 发明申请

US20080261251A1 Monoclonal Antibodies, Hybridomas, Improved Method for Determining the Protein Ptx3 and Kit for Said Determination 失效
标题翻译：单克隆抗体，杂交瘤，用于测定所述测定的蛋白质Ptx3和试剂盒的改进方法
公开(公告)号：US20080261251A1
公开(公告)日：2008-10-23
申请号：US11587528
申请日：2005-04-27
申请人： Alberto Mantovani , Giuseppe Peri
发明人： Alberto Mantovani , Giuseppe Peri
IPC分类号： G01N33/53 , C12N5/06 , C07K16/18
CPC分类号： G01N33/6893 , G01N2333/47
摘要： Method for determining the level of PTX3 protein in a sample of a biological fluid; hybridoma capable of producing a rat anti-PTX3 monoclonal antibody where said hybridoma is selected from the group comprising MNB10 and Pen-3; specific anti-PTX3 rat monoclonal antibody selected from the monoclonal antibodies produced by the hybridomas MNB10 and Pen-3; kit for determining the level of PTX3 protein in a biological fluid wherein the said kit includes a rat anti-PTX3 monoclonal antibody.
摘要翻译：用于测定生物流体样品中PTX3蛋白水平的方法; 能够产生大鼠抗PTX3单克隆抗体的杂交瘤，其中所述杂交瘤选自MNB10和Pen-3; 选自由杂交瘤MNB10和Pen-3产生的单克隆抗体的特异性抗PTX3大鼠单克隆抗体; 用于确定生物流体中PTX3蛋白水平的试剂盒，其中所述试剂盒包括大鼠抗PTX3单克隆抗体。

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