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31. 发明申请

US20120058175A1 Transdermal Preparation 有权
标题翻译：透皮制剂
公开(公告)号：US20120058175A1
公开(公告)日：2012-03-08
申请号：US13318370
申请日：2010-04-30
申请人： Satoshi Amano , Tomohiro Shinoda , Natsumi Kase
发明人： Satoshi Amano , Tomohiro Shinoda , Natsumi Kase
IPC分类号： A61K9/70 , A61P25/28 , A61K31/15 , A61P9/12 , A61K9/00 , A61K31/138
CPC分类号： A61K45/06 , A61K9/7084 , A61K31/138 , A61K31/15 , A61K2300/00
摘要： Provided is a transdermal preparation, which is capable of long-term (1-day to 7-day) release of a basic drug from a preparation, continuously and at a consistent concentration; shows little reduction over time in the drug content, even if multiple drugs are contained in the preparation; and is produced by a simple process. The transdermal preparation comprises a substrate, and an adhesive layer containing a basic drug and a water-soluble polymer.
摘要翻译：提供一种透皮制剂，其能够以连续和一致的浓度从制剂中长期（1至7天）释放碱性药物; 即使制剂中含有多种药物，药物含量随时间推移几乎没有减少; 并通过简单的过程生产。透皮制剂包括底物和含有碱性药物和水溶性聚合物的粘合剂层。

32. 发明申请

US20100113590A1 ADAM INHIBITOR 审中-公开
标题翻译： ADAM抑制剂
公开(公告)号：US20100113590A1
公开(公告)日：2010-05-06
申请号：US12524543
申请日：2007-12-27
申请人： Takuya Hiruma , Hirotada Fukunishi , Masaru Suetsugu , Yukiko Matsunaga , Satoshi Amano , Michio Shibata
发明人： Takuya Hiruma , Hirotada Fukunishi , Masaru Suetsugu , Yukiko Matsunaga , Satoshi Amano , Michio Shibata
IPC分类号： A61K31/341 , C07D307/62 , A61P35/00 , A61P17/00
CPC分类号： A61K31/375 , A61K8/676 , A61K2800/782 , A61Q19/00 , A61Q19/08 , C07D307/62
摘要： Disclosed is an ADAM inhibitor which enables to prevent or improve conditions caused by increase in ADAM activity. Specifically disclosed is an ascorbic acid derivative represented by the general formula (1) below or a salt thereof. [chemical formula 1] (1), wherein R represents a linear or branched alkyl group having 1 to 22 carbon atoms.
摘要翻译：公开了一种能够预防或改善由ADAM活性增加引起的病症的ADAM抑制剂。具体公开的是下述通式（1）表示的抗坏血酸衍生物或其盐。 [化学式1]（1）其中，R表示碳原子数1〜22的直链状或支链状的烷基。

33. 发明申请

US20050089516A1 Skin vitalizing composition for external use anti-aging preparation 审中-公开
标题翻译：皮肤活性成分外用抗衰老制剂
公开(公告)号：US20050089516A1
公开(公告)日：2005-04-28
申请号：US10931252
申请日：2004-09-01
申请人： Satoshi Amano , Yuki Ogura , Yukiko Matsunaga , Takanari Tsuda , Yukari Aoyama , Nobuyoshi Koga
发明人： Satoshi Amano , Yuki Ogura , Yukiko Matsunaga , Takanari Tsuda , Yukari Aoyama , Nobuyoshi Koga
IPC分类号： A61L27/00 , A61K8/55 , A61K8/64 , A61K8/97 , A61K8/98 , A61K31/661 , A61K36/18 , A61K36/53 , A61K38/00 , A61K38/22 , A61K45/00 , A61K45/06 , A61P17/00 , A61P43/00 , A61Q19/00 , A61Q19/08 , A61K38/48
CPC分类号： A61K8/64 , A61K8/553 , A61K8/97 , A61K8/985 , A61K2800/782 , A61Q1/02 , A61Q19/00 , A61Q19/08
摘要： The invention provides an epidermal basement membrane structure formation accelerating preparation and a skin external preparation comprising a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane. It also provides, as a means for producing artificial skin having an adequately formed basement membrane, an artificial skin-forming medium which comprises a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane and a matrix metalloprotease inhibitor, as well as a method for producing the same.
摘要翻译：本发明提供了一种表皮基底膜结构形成促进制剂和皮肤外用制剂，其包含丝氨酸蛋白酶抑制剂和任选的表皮基底膜细胞外基质蛋白组分产生促进剂。它还提供了用于生产具有充分形成的基底膜的人造皮肤的手段，人造皮肤形成培养基包括丝氨酸蛋白酶抑制剂和任选的表皮基底膜的细胞外基质蛋白组分的产生促进剂和基质金属蛋白酶抑制剂，以及其制备方法。

34. 发明授权

US06689936B1 Method for evaluating a compound for its effect on skin 有权
标题翻译：评价化合物对皮肤的影响的方法
公开(公告)号：US06689936B1
公开(公告)日：2004-02-10
申请号：US09393483
申请日：1999-09-10
申请人： Robert Burgeson , Satoshi Amano , Jiro Kishimoto , Toshio Nishiyama , Ritsuko Ehama
发明人： Robert Burgeson , Satoshi Amano , Jiro Kishimoto , Toshio Nishiyama , Ritsuko Ehama
IPC分类号： A01K6700
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , A61K49/0006 , A61K49/0008
摘要： The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter.
摘要翻译：本发明提供评估其对皮肤的影响的方法。本发明还提供具有与皮肤代谢启动子偶联的报告基因的非人转基因动物，例如小鼠。

35. 发明授权

US06300425B1 Thermosetting resin composition 失效
标题翻译：热固性树脂组合物
公开(公告)号：US06300425B1
公开(公告)日：2001-10-09
申请号：US09286801
申请日：1999-04-06
申请人： Satoshi Amano , Hideshi Tomita
发明人： Satoshi Amano , Hideshi Tomita
IPC分类号： C08L6300
CPC分类号： C08L79/00 , C08G18/025 , C08G59/4042 , C08L63/00 , C09D163/00 , C08L2666/04
摘要： A modified carbodiimide resin obtainable by reacting a carbodiimide resin comprising a repeating unit represented by the general formula: —(NCN—R1)— wherein R1 represents a divalent organic group, with an aromatic diamine represented by the general formula: H2N—R2—NH2 wherein R2 represents a divalent organic group having a benzene ring, and a thermosetting resin composition comprising the modified carbodiimide resin and an epoxy resin.
摘要翻译：通过使包含由以下通式表示的重复单元的碳二亚胺树脂与其中由通式H2N-R2-NH2表示的芳族二胺反应得到的改性碳化二亚胺树脂： - （NCN-R1） - 其中R 1表示二价有机基团其中R2表示具有苯环的二价有机基团，和包含改性碳二亚胺树脂和环氧树脂的热固性树脂组合物。

36. 发明授权

US6166466A Insulating material for enameled wire of motor of refrigeration compressor 失效
标题翻译：制冷压缩机电机漆包线绝缘材料
公开(公告)号：US6166466A
公开(公告)日：2000-12-26
申请号：US661874
申请日：1996-06-12
申请人： Satoshi Amano , Tomoki Nakamura , Takahiko Ito
发明人： Satoshi Amano , Tomoki Nakamura , Takahiko Ito
IPC分类号： C08G73/00 , C10M171/00 , F04B39/02 , H01B3/30 , H02K3/30 , C08G18/02 , H02K3/44
CPC分类号： C10M171/008 , C08G73/00 , H01B3/306 , Y10T428/31551
摘要： The present invention provides an insulating material for the enameled wire of a motor of a refrigeration compressor using hydrofluorocarbons as the refrigerant and, as the refrigerating machine oil, a synthetic lubricating oil having at least one ester bond in a molecule such as ester-modified polyoxyalkylene glycol type, ester-modified ether type or ester type, which insulating material contains a compound having at least one carbodiimide group.This insulating material for the enameled wire of a motor of a refrigeration compressor, which is free from the above-mentioned problems of the prior art, which can prevent the surface deterioration or peeling (blister or cracking) etc. seen in the conventional insulating material used for covering the enameled wire (e.g. magnet wire) of a refrigeration compressor, caused by a mixture of the hydrofluorocarbons and the synthetic lubricating oil both used in the compressor, which invites neither insulation breakdown nor reduction in insulation and has improved resistances to said substitute flon and said synthetic lubricating oil, and which further can impart deterioration resistance to the synthetic lubricating oil.
摘要翻译：本发明提供一种使用氢氟烃作为制冷剂的制冷压缩机的电动机的漆包线绝缘材料，作为制冷机油，在分子中具有至少一个酯键的合成润滑油如酯改性的聚氧化烯乙二醇型，酯改性醚型或酯型，该绝缘材料含有具有至少一个碳二亚胺基团的化合物。用于制冷压缩机的电动机的漆包线的绝缘材料，其不含现有技术的上述问题，其可以防止在常规绝缘材料中看到的表面变质或剥离（起泡或开裂）等用于覆盖由压缩机中使用的氢氟烃和合成润滑油的混合物引起的制冷压缩机的漆包线（例如电磁线），其既不会绝缘击穿也不会减少绝缘，并且具有改善的对所述替代物的抵抗力氟利昂和所述合成润滑油，并且还可以赋予合成润滑油耐劣化性。

37. 发明授权

US5939200A Insulating film for use in motor of refrigeration compressor 失效
标题翻译：用于制冷压缩机电机的绝缘膜
公开(公告)号：US5939200A
公开(公告)日：1999-08-17
申请号：US720450
申请日：1996-09-30
申请人： Satoshi Amano , Tomoki Nakamura , Takahiko Ito
发明人： Satoshi Amano , Tomoki Nakamura , Takahiko Ito
IPC分类号： F25B31/02 , C08J5/18 , C08J7/04 , C08K5/29 , C08L67/02 , C08L79/00 , C08L101/00 , C09D179/00 , F25B31/00 , H02K3/44 , C08G18/02
CPC分类号： H02K3/44 , C08J7/047 , C08K5/29 , C08L67/02 , C08L79/00 , C08J2479/00 , F25B31/00 , Y10T428/31551
摘要： The present invention provides an insulating film for use in the motor of a refrigeration compressor using a substitute flon and a refrigerating machine oil in particular combination, which film is obtained by adding to a base film, or coating on the surface of a base film, a compound having at least one carbodiimide group, or, which film is made essentially of a compound having at least one carbodiimide group, represented by the following formula (1): ##STR1## or the following formula (2): ##STR2## or the following formula (3): ##STR3## or the following formula (4): ##STR4## This insulating film can eliminate the problems of the prior art, has excellent resistance to hydrolysis and forms no sludge, resultantly can prevent reduction in insulating property, and further has deterioration resistance to refrigerating machine oil.
摘要翻译：本发明提供了一种用于特别组合的使用替代氟里昂和冷冻机油的制冷压缩机的电动机的绝缘膜，该膜通过添加到基膜或基膜表面上涂覆而获得，或具有至少一个碳二亚胺基团的化合物，或者该膜主要由具有至少一个碳二亚胺基团的化合物制成，由下式（1）表示：或下式（2）：或下式（3）：或下述式（4）：该绝缘膜可以消除现有技术的问题，具有优异的耐水解性，不产生污泥，从而能够防止绝缘性降低，并且还具有对制冷机油的耐劣化性。

38. 发明授权

US09707188B2 Transdermal preparation 有权
公开(公告)号：US09707188B2
公开(公告)日：2017-07-18
申请号：US13580168
申请日：2011-02-24
申请人： Arata Toshimitsu , Satoshi Amano , Kumi Morimoto
发明人： Arata Toshimitsu , Satoshi Amano , Kumi Morimoto
IPC分类号： A61F13/02 , A61K9/70 , A61K9/00
CPC分类号： A61K9/7061 , A61K9/0014 , A61K9/0021
摘要： A transdermal preparation comprising a multivalent metal chloride, a basic drug having an amino group, and an ester group-containing base material, is useful because of its excellent drug content stability.

39. 发明授权

US09101564B2 Heparanase activity inhibitor, wrinkle improving agent containing same, and pharmaceutical composition 有权
标题翻译：肝素酶活性抑制剂，含有它的皱纹改善剂和药物组合物
公开(公告)号：US09101564B2
公开(公告)日：2015-08-11
申请号：US13261236
申请日：2010-09-29
申请人： Shunsuke Iriyama , Hirotada Fukunishi , Masaru Suetsugu , Satoshi Amano
发明人： Shunsuke Iriyama , Hirotada Fukunishi , Masaru Suetsugu , Satoshi Amano
IPC分类号： A61K8/00 , A61K31/05 , A61K8/34 , A61Q19/08
CPC分类号： A61K31/05 , A61K8/347 , A61K2800/782 , A61Q19/08
摘要： A heparanase activity inhibitor containing, as an active ingredient, a 4-alkylresorcinol represented by formula (I): wherein R represents a C1-6 linear or branched alkyl group.
摘要翻译：含有由式（I）表示的4-烷基间苯二酚作为活性成分的乙酰肝素酶活性抑制剂：其中R表示C1-6直链或支链烷基。

40. 发明授权

US08702664B2 Transdermal preparation 有权
标题翻译：透皮制剂
公开(公告)号：US08702664B2
公开(公告)日：2014-04-22
申请号：US13201999
申请日：2010-02-09
申请人： Satoshi Amano , Tomohiro Shinoda , Natsumi Kase , Keita Mori
发明人： Satoshi Amano , Tomohiro Shinoda , Natsumi Kase , Keita Mori
IPC分类号： A61M35/00
CPC分类号： A61K9/7084 , A61K31/138
摘要： By providing a non-liquid drug reservoir layer 2 having first and second principal surfaces and containing a drug and a polymer that is to be a base, a drug permeation layer 4 disposed at the first principal surface side of the drug reservoir layer 2 and being lower in permeability of the drug than the drug reservoir layer 2, and a first backing 3 with a bending resistance of 10 to 80 mm that is formed so as to cover a side surface of the drug reservoir layer, skin irritation can be reduced.
摘要翻译：通过设置具有第一主表面和第二主表面并且含有药物和要成为基底的聚合物的非液体药物储存层2，设置在药物储存层2的第一主表面侧的药物渗透层4，药物的透过率低于药物贮存层2，并且形成为覆盖药物储存层的侧面的抗弯曲性为10〜80mm的第一背衬3，因此可以降低皮肤刺激性。

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