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31. 发明授权

US09303891B2 Air conditioning ventilator 有权
标题翻译：空调呼吸机
公开(公告)号：US09303891B2
公开(公告)日：2016-04-05
申请号：US12527806
申请日：2008-02-19
申请人： Takashi Takahashi , Tomohiro Yabu
发明人： Takashi Takahashi , Tomohiro Yabu
IPC分类号： F24F11/00 , F24F12/00 , F24F7/06
CPC分类号： F24F12/006 , F24F7/06 , F24F11/30 , F24F2012/007 , F24F2110/10 , F24F2110/12 , Y02B30/563
摘要： An air conditioning ventilator includes a ventilation unit, an air conditioning unit and a bypass channel. The ventilation unit has an air supply channel configured to supply air from an outdoor space to a target space, and an air supply fan configured to create a first airflow from the outdoor space to the target space within the air supply channel. The air conditioning unit has an intake channel configured to take in air from the target space, a temperature regulator configured to regulate the temperature of air that has passed through the intake channel, a discharge channel configured to discharge temperature-adjusted air that has been regulated by the temperature regulator to the target space, and an air-conditioning fan configured to create a second airflow from the intake channel to the discharge channel via the temperature regulator. The bypass channel bypassed the air supply channel and the discharge channel.
摘要翻译：空调通风机包括通风单元，空调单元和旁路通道。通风单元具有：空气供给通道，其构造成将空气从室外空间供给到目标空间;以及空气供给风扇，其构造成在空气供给通道内从室外空间向目标空间产生第一气流。空调单元具有被配置为从目标空间吸入空气的进气通道，构造成调节通过进气通路的空气的温度的温度调节器，配置为排出已调节的温度调节空气的排出通道通过所述温度调节器到所述目标空间，以及空调风扇，其构造成经由所述温度调节器从所述进气通道到所述排出通道产生第二气流。旁路通道绕过供气通道和排放通道。

32. 发明授权

US09085772B2 Method for suppressing receptor tyrosine kinase-mediated pro-survival signaling in cancer cell 有权
标题翻译：抑制癌细胞中受体酪氨酸激酶介导的原始存活信号传导的方法
公开(公告)号：US09085772B2
公开(公告)日：2015-07-21
申请号：US13976186
申请日：2011-12-26
申请人： Takashi Takahashi , Tomoya Yamaguchi
发明人： Takashi Takahashi , Tomoya Yamaguchi
IPC分类号： C12Q1/68 , C12N15/113 , A61K31/7088 , C12Q1/48 , G01N33/50 , G01N33/574 , G01N33/566 , A61K38/22 , A61K35/17 , A61K35/745
CPC分类号： C12N15/1137 , A61K31/7088 , A61K35/17 , A61K35/745 , A61K38/2271 , C12N15/1138 , C12N2310/14 , C12Q1/485 , G01N33/5011 , G01N33/566 , G01N33/57407 , G01N33/57423 , G01N2500/00
摘要： In order to provide a screening method for a compound capable of suppressing a mechanism of ROR1 by targeting ROR1 and to provide a drug comprising as an active ingredient a compound capable of suppressing the mechanism, it has been found out that suppressing a function of ROR1 makes it possible to suppress receptor tyrosine kinase-mediated pro-survival signaling in a cancer cell. Further, it has been found out that suppressing a function of ROR1 also effectively suppresses growth of cancer cell lines having acquired resistance to inhibitors of receptor tyrosine kinases such as EGFR and MET.
摘要翻译：为了提供能够通过靶向ROR1来抑制ROR1的机制的化合物的筛选方法，并且提供包含作为有效成分的能够抑制机理的化合物的药物，已经发现抑制ROR1的功能使得可能抑制癌细胞中的受体酪氨酸激酶介导的原始存活信号传导。此外，已经发现，抑制ROR1的功能还有效地抑制了具有获得性的受体酪氨酸激酶抑制剂如EGFR和MET的耐药性的癌细胞系的生长。

33. 发明授权

US08962674B2 Curcumin derivative 有权
标题翻译：姜黄素衍生物
公开(公告)号：US08962674B2
公开(公告)日：2015-02-24
申请号：US12516948
申请日：2007-11-30
申请人： Takashi Takahashi , Ichiro Hijikuro , Hachiro Sugimoto , Takeshi Kihara , Yoshiari Shimmyo , Tetsuhiro Niidome
发明人： Takashi Takahashi , Ichiro Hijikuro , Hachiro Sugimoto , Takeshi Kihara , Yoshiari Shimmyo , Tetsuhiro Niidome
IPC分类号： A61K31/404 , C07D209/12 , C07D209/08
CPC分类号： C07D209/08 , A61K31/404 , C07D209/12
摘要： The present invention provides a novel compound that is structurally similar to curcumin and has a suppressive effect on Aβ aggregation, a degradative effect on Aβ aggregates, an inhibitory effect on β-secretase, and a protective effect on neurons. The novel compound is a compound represented by the following general formula (Ia) or a salt thereof: wherein R1 represents a 4-hydroxy-3-methoxyphenyl group or the like, and R2 represents a 1H-indol-6-yl group or the like.
摘要翻译：本发明提供了结构上类似于姜黄素并对A＆Bgr具有抑制作用的新型化合物; 聚集，对A＆Bgr的降解作用; 聚集体，对分泌酶的抑制作用，以及对神经元的保护作用。新化合物是由下列通式（Ia）表示的化合物或其盐：其中R1表示4-羟基-3-甲氧基苯基等，R2表示1H-吲哚-6-基或喜欢。

34. 发明申请

US20140305608A1 BODY WASTE TREATING MATERIAL, METHOD FOR MANUFACTURING BODY WASTE TREATING MATERIAL, AND APPARATUS FOR MANUFACTURING THE SAME 审中-公开
标题翻译：身体废物处理材料，制造身体废物处理材料的方法及其制造装置
公开(公告)号：US20140305608A1
公开(公告)日：2014-10-16
申请号：US13704682
申请日：2012-09-12
申请人： Susumu Okamoto , Takashi Takahashi , Yoshikazu Horihata , Koichi Narita , Akio Takase , Shinichi Matsuo , Toru Shimizu , Hiroaki Takayanagi , Hyunjin Seo , Akihiro Sugiyama , Takashi Murakami
发明人： Susumu Okamoto , Takashi Takahashi , Yoshikazu Horihata , Koichi Narita , Akio Takase , Shinichi Matsuo , Toru Shimizu , Hiroaki Takayanagi , Hyunjin Seo , Akihiro Sugiyama , Takashi Murakami
IPC分类号： D21J3/00
CPC分类号： D21J3/00 , A01K1/0155 , D21C5/02 , D21C5/025 , Y02W30/648
摘要： An object of the present invention is in that a body waste treating material can be manufactured by using a defective fibrous material unsuitable for forming paper generated upon treating a pulpable raw material without materials for complementing a water absorptive property and a water retention property and a wasting step in manufacturing at a low cost, and resources may be efficiently used.[Solution to Problem]This invention is characterized by molding a defective fibrous material unsuitable for forming paper that is a fibrous material obtained by defiberizing and dehydrating a pulpable raw material to a certain shape. The defective fibrous material is characterized by including thin and/or short fibers.
摘要翻译：本发明的目的在于，可以通过使用不适合于形成纸浆处理原料产生的纸而不适于补充吸水性和保水性的物质和浪费的不良纤维材料来制造身体废物处理材料低成本的制造步骤，可以有效地利用资源。 [问题的解决方案]本发明的特征在于，将不适合于形成纸的有缺陷的纤维材料成型为将可打浆原料脱水并脱水得到的纤维材料成形为一定形状。缺陷纤维材料的特征在于包括薄纤维和/或短纤维。

35. 发明授权

US08703922B2 Low-viscosity liquid crystal compound 有权
标题翻译：低粘度液晶复合物
公开(公告)号：US08703922B2
公开(公告)日：2014-04-22
申请号：US13518932
申请日：2010-12-27
申请人： Yutaka Ikeda , Jun Yamashita , Ichiro Hijikuro , Satoshi Imuta , Yasuhiro Hiroki , Takashi Takahashi
发明人： Yutaka Ikeda , Jun Yamashita , Ichiro Hijikuro , Satoshi Imuta , Yasuhiro Hiroki , Takashi Takahashi
IPC分类号： C07H15/00 , C07H15/04 , A61K31/70 , A61K31/7028 , C07C57/03
CPC分类号： A61K47/14 , A61K9/0019 , A61K9/0024 , A61K47/08 , A61K47/10 , A61K47/22 , A61K47/26 , C07H15/10 , C09K19/06
摘要： The present invention relates to a liquid crystal compound that can be used as a base for injection formulations. The present invention provides an amphipathic compound having the following general formula (I): wherein X and Y each denotes a hydrogen atom or together denote an oxygen atom, n denotes an integer from 0 to 2, m denotes the integer 1 or 2, and R denotes a hydrophilic group generated by removal of one hydroxyl group from any one selected from the group consisting of glycerol, erythritol, pentaerythritol, diglycerol, triglycerol, xylose, sorbitol, ascorbic acid, glucose, galactose, mannose, dipentaerythritol, maltose, mannitol, and xylitol; as well as a base for injection formulations and depot formulation comprising the same.
摘要翻译：本发明涉及可用作注射制剂的基质的液晶化合物。本发明提供具有以下通式（I）的两亲化合物：其中X和Y各自表示氢原子或一起表示氧原子，n表示0至2的整数，m表示整数1或2，并且 R表示通过从选自甘油，赤藓糖醇，季戊四醇，双甘油，三甘油，木糖，山梨醇，抗坏血酸，葡萄糖，半乳糖，甘露糖，二季戊四醇，麦芽糖，甘露糖醇，甘露糖醇，和木糖醇; 以及用于注射制剂的基料和包含其的包含药剂的制剂。

36. 发明授权

US08686024B2 Indoline derivatives 失效
标题翻译：二氢吲哚衍生物
公开(公告)号：US08686024B2
公开(公告)日：2014-04-01
申请号：US13148011
申请日：2010-02-03
申请人： Hachiro Sugimoto , Jun Takahashi , Takashi Takahashi , Ichiro Hijikuro
发明人： Hachiro Sugimoto , Jun Takahashi , Takashi Takahashi , Ichiro Hijikuro
IPC分类号： A61K31/404 , C07D209/10
CPC分类号： C07D405/14 , C07D209/08 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12
摘要： The present invention provides a novel indoline derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or a salt thereof represented by the following formula (1) that has an excellent butyrylcholinesterase inhibitory activity. In the formula, R1 represents an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, an arylalkyl group, a heteroarylalkyl group, a cycloalkylalkyl group, a heterocycloalkylalkyl group, a dihydrofurylalkyl group, an alkenyl group, a tetrahydronaphthyl group, or an indanyl group; R2 represents a hydrogen atom, an alkyl group, an arylalkyl group, a cycloalkylalkyl group, a heteroarylalkyl group, a heterocycloalkylalkyl group, an aryl group, or an acyl group; R3 each independently represents a hydrogen atom, an alkyl group, or a dialkylaminocarbonyl group; R4 each independently represents a hydrogen atom or an alkyl group; and R5 represents a hydrogen atom or an alkyl group. Each functional group may have a substituent.
摘要翻译：本发明提供具有优异的丁酰胆碱酯酶抑制活性的新型二氢吲哚衍生物或其药理学上可接受的盐或其由下式（1）表示的衍生物或其盐的溶剂合物。在该式中，R 1表示烷基，环烷基，杂环烷基，芳基，杂芳基，芳烷基，杂芳基烷基，环烷基烷基，杂环烷基烷基，二氢呋喃基烷基，烯基，四氢萘基或茚满基; R2表示氢原子，烷基，芳基烷基，环烷基烷基，杂芳基烷基，杂环烷基烷基，芳基或酰基; R3各自独立地表示氢原子，烷基或二烷基氨基羰基; R4各自独立地表示氢原子或烷基; R 5表示氢原子或烷基。每个官能团可以具有取代基。

37. 发明申请

US20140088029A1 NOVEL PYRAZOLE DERIVATIVE 有权
标题翻译：新型吡咯衍生物
公开(公告)号：US20140088029A1
公开(公告)日：2014-03-27
申请号：US14110188
申请日：2012-04-11
申请人： Hachiro Sugimoto , Michiaki Okuda , Takashi Takahashi , Ichiro Hijikuro , Hidetaka Suzuki , Shinichi Nakayama
发明人： Hachiro Sugimoto , Michiaki Okuda , Takashi Takahashi , Ichiro Hijikuro , Hidetaka Suzuki , Shinichi Nakayama
IPC分类号： C07D401/14 , C07D403/10 , C07H15/26 , C07D405/14 , C07D403/06
CPC分类号： C07D401/14 , C07D209/12 , C07D401/12 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , C07H15/203 , C07H15/26
摘要： Provided is a novel therapeutic means for Alzheimer's disease. In particular, provided is a compound represented by the following general formula (I): [wherein Ar1 represents 2-methoxy-4-(2-pyridylmethoxy)phenyl etc. and Ar2 represents a 1H-indol-6-yl group etc.] or a salt thereof.
摘要翻译：提供了阿尔茨海默病的新型治疗方法。特别地，提供由以下通式（I）表示的化合物：[其中Ar 1表示2-甲氧基-4-（2-吡啶基甲氧基）苯基等，Ar 2表示1H-吲哚-6-基等] 或其盐。

38. 发明授权

US08244478B2 Method of classifying gene expression strength in lung cancer tissues 失效
标题翻译：肺癌组织中基因表达强度分类方法
公开(公告)号：US08244478B2
公开(公告)日：2012-08-14
申请号：US12942770
申请日：2010-11-09
申请人： Takashi Takahashi , Shuta Tomita , Tetsuya Mitsudomi , Yasushi Yatabe , Nobuhiko Ogura , Masato Some
发明人： Takashi Takahashi , Shuta Tomita , Tetsuya Mitsudomi , Yasushi Yatabe , Nobuhiko Ogura , Masato Some
IPC分类号： G06F7/00
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the method. A method useful in the decision of a survival rate of a patient with non-small cell lung cancer comprising confirming the expression strength of at least one gene in lung cancer tissues isolated from the patient.
摘要翻译：本发明提供一种确认基因表达的方法，该方法可用于决定患者肺癌的5年生存率，并在该方法中使用DNA探针试剂盒。用于决定患有非小细胞肺癌的患者存活率的方法，其包括确认从患者分离的肺癌组织中至少一种基因的表达强度。

39. 发明授权

US08239612B2 Memory controller, flash memory system with memory controller, and control method of flash memory 有权
标题翻译：内存控制器，带存储器控制器的闪存系统以及闪存的控制方法
公开(公告)号：US08239612B2
公开(公告)日：2012-08-07
申请号：US12239127
申请日：2008-09-26
申请人： Naoki Mukaida , Takashi Takahashi
发明人： Naoki Mukaida , Takashi Takahashi
IPC分类号： G06F12/00 , G06F13/00 , G06F13/28
CPC分类号： G06F12/0246 , G06F12/0292 , G06F2212/1016 , G06F2212/7211
摘要： The memory controller updates a count number based on a new assignment of a logical block to a physical block, and writes count information in the physical block to which the logical block is newly assigned. The count information is defined by the count number. The memory controller decides, based on the count number and the count information stored in each physical block, whether or not to transfer stored data in a physical block to another physical block.
摘要翻译：存储器控制器基于对物理块的逻辑块的新分配来更新计数，并将计数信息写入到新分配了逻辑块的物理块中。计数信息由计数值定义。存储器控制器基于存储在每个物理块中的计数和计数信息来确定是否将物理块中的存储数据传送到另一物理块。

40. 发明申请

US20120082986A1 CELL PROLIFERATION INHIBITOR 有权
标题翻译：细胞增殖抑制剂
公开(公告)号：US20120082986A1
公开(公告)日：2012-04-05
申请号：US13054288
申请日：2009-07-17
申请人： Takashi Takahashi , Tomoya Yamaguchi , Shuta Tomida
发明人： Takashi Takahashi , Tomoya Yamaguchi , Shuta Tomida
IPC分类号： C12Q1/68 , C12Q1/18 , G01N33/566 , C07H21/02 , C12N15/85
CPC分类号： A61K31/7088
摘要： The present inventors revealed a TTF-1-specific oncogenic process by elucidating the molecular mechanism regulated by the master regulatory factor TTF-1. The present inventors focused on the elucidation of the essence of the lineage-specific survival signal which is a novel canceration signal. Thus, the present inventors found that the expression of ROR1, which is a receptor tyrosine kinase, is induced by the master regulatory factor TTF-1, and demonstrated the presence of a characteristic canceration signal transduction system.
摘要翻译：本发明人通过阐明由主调节因子TTF-1调节的分子机制，发现了TTF-1特异性致癌过程。本发明人专注于阐明作为新型癌变信号的谱系特异性生存信号的本质。因此，本发明人发现，作为受体酪氨酸激酶的ROR1的表达由主调控因子TTF-1诱导，并且证明存在特征性癌变信号转导系统。

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