会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 38. 发明申请
    • On-Chip Disease Diagnostic Platform for Dual-Gate Ion Sensitive Field Effect Transistor
    • 双栅离子敏感场效应晶体管片上疾病诊断平台
    • US20170067890A1
    • 2017-03-09
    • US15356503
    • 2016-11-18
    • Taiwan Semiconductor Manufacturing Company, Ltd.
    • Ching-Hui LinChun-Ren ChengYi-Hsien ChangShih-Fen Huang
    • G01N33/543G01N27/414
    • G01N33/54373G01N27/4145G01N27/4148H01L51/0093H01L51/0512
    • Dual-gate ion-sensitive field effect transistor (ISFET) and methods implementing the dual-gate ISFETs for disease diagnostics are disclosed herein. An exemplary method includes providing a biological sample to a dual-gate ISFET. The dual-gate ISFET includes a fluidic gate structure and a gate structure, where the fluidic gate structure and the gate structure are disposed over opposite surfaces of a device substrate. The method further includes generating enzymatic reactions from enzyme-modified detection mechanisms. The enzyme-modified detection mechanisms release ions into an electrolyte solution of the fluidic gate structure. The method further includes biasing the fluidic gate structure and the gate structure to generate an electrical signal as a sensing layer of the fluidic gate structure reacts with the ions. The electrical signal indicates an ion concentration in the electrolyte solution that correlates with a presence or a quantity of target analytes in the biological sample.
    • 本文公开了双栅离子敏感场效应晶体管(ISFET)和实现用于疾病诊断的双栅极ISFET的方法。 一种示例性方法包括向双栅极ISFET提供生物样品。 双栅极ISFET包括流体栅极结构和栅极结构,其中流体栅极结构和栅极结构设置在器件衬底的相对表面上。 该方法还包括从酶修饰的检测机制产生酶反应。 酶修饰的检测机制将离子释放到流体门结构的电解质溶液中。 该方法还包括偏压流体栅极结构和栅极结构以在流体栅极结构的感测层与离子反应时产生电信号。 电信号表示与生物样品中目标分析物的存在或数量相关的电解质溶液中的离子浓度。