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31. 发明授权

US5792648A Human macrophage antigen 失效
公开(公告)号：US5792648A
公开(公告)日：1998-08-11
申请号：US690095
申请日：1996-07-31
申请人： Jennifer L. Hillman , Janice Au-Young , Surya K. Goli
发明人： Jennifer L. Hillman , Janice Au-Young , Surya K. Goli
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P37/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C07H21/04 , C12N15/63
CPC分类号： C07K14/7056 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human macrophage antigen (TMAH). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding TMAH. The invention also provides for the use of substantially purified TMAH and its agonists, antibodies, antagonists or inhibitors in pharmaceutical compositions for treatment of diseases associated with expression of TMAH. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the genomic sequence or transcripts encoding TMAH and anti-TMAH antibodies which specifically bind to TMAH.

32. 发明授权

US5763248A CDNA encoding a human ATP synthase Fo subunit (ASYSD) 失效
标题翻译： CDNA编码人类ATP合成酶Fo亚基（ASYSD）
公开(公告)号：US5763248A
公开(公告)日：1998-06-09
申请号：US948195
申请日：1997-10-09
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C12N9/14 , C12N15/00 , C12N15/63 , C12N15/85 , C07H71/04
CPC分类号： C12N9/14 , A61K38/00
摘要： The present invention provides a human ATP synthase d subunit (ASYSD) and polynucleotides which encode ASYSD. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing ASYSD and for treating disorders associated with expression of ASYSD.
摘要翻译：本发明提供了人ATP合成酶d亚基（ASYSD）和编码ASYSD的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。本发明还提供了用于产生ASYSD和用于治疗与ASYSD表达相关的疾病的方法。

33. 发明授权

US5763220A Human apoptosis-related calcium-binding protein 失效
公开(公告)号：US5763220A
公开(公告)日：1998-06-09
申请号：US766605
申请日：1996-12-12
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： G01N33/53 , A61K38/00 , A61K45/00 , A61P1/00 , A61P1/16 , A61P9/10 , A61P13/12 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/14 , A61P31/20 , A61P31/22 , A61P35/00 , A61P37/04 , A61P37/06 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , C12P21/02 , C12N1/00 , C12N15/63
CPC分类号： C07K14/4747 , C07K14/4702 , A61K38/00
摘要： The present invention provides a human apoptosis-related calcium-binding protein (HARC) and polynucleotides which identify and encode HARC. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HARC and a method for producing HARC. The invention also provides for agonists, antibodies, or antagonists specifically binding HARC, and their use, in the prevention and treatment of diseases associated with expression of HARC. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HARC for the treatment of diseases associated with the expression of HARC. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HARC.

34. 发明授权

US5734038A Human DBI/ACBP-like protein 失效
标题翻译：人类DBI / ACBP样蛋白
公开(公告)号：US5734038A
公开(公告)日：1998-03-31
申请号：US700626
申请日：1996-08-16
申请人： Janice Au-Young , Jennifer L. Hillman , Surya K. Goli
发明人： Janice Au-Young , Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N15/09 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K45/08 , A61K48/00 , A61P25/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12N15/00 , C07H21/04 , C12N1/20 , C12P21/06
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human Diazepam binding inhibitor/acyl-CoA binding protein (DBI/ACBP)-like protein (DBIH). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding DBIH. The invention also provides for the use of substantially purified DBIH for drug delivery as well as for the production of recombinant proteins for the treatment of diseases associated with the expression of DBIH. Additionally, the invention provides for the use of antisense molecules to DBIH in the treatment of diseases associated with the expression of DBIH. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding DBIH and antibodies which specifically bind to the protein.
摘要翻译：本发明提供鉴定并编码新的人地西泮结合抑制剂/酰基辅酶A结合蛋白（DBI / ACBP）样蛋白（DBIH）的多核苷酸。本发明提供了包含编码DBIH的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供使用基本上纯化的DBIH用于药物递送以及用于产生用于治疗与DBIH表达相关的疾病的重组蛋白质。另外，本发明提供了用于治疗与DBIH表达有关的疾病的DBIH反义分子的用途。本发明还描述了利用包含与编码DBIH的天然存在的序列和特异性结合蛋白质的抗体杂交的多核苷酸的诊断组合物的诊断测定法。

35. 发明授权

US06531575B1 ATP synthase subunits 失效
标题翻译： ATP合酶亚基
公开(公告)号：US06531575B1
公开(公告)日：2003-03-11
申请号：US09546306
申请日：2000-04-10
申请人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
发明人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
IPC分类号： C07K100
CPC分类号： C12N9/14 , A61K38/00
摘要： The present invention provides two ATP synthase subunits (designated individually as Asy-1 and Asy-2, and collectively as Asy) and polynucleotides which identify and encode Asy. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Asy and a method for producing Asy. The invention also provides for use of Asy and agonists, antibodies, or antagonists specifically binding Asy, in the prevention and treatment of diseases associated with expression of Asy. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Asy for the treatment of diseases associated with the expression of Asy. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Asy.
摘要翻译：本发明提供两个ATP合成酶亚单位（分别命名为Asy-1和Asy-2，统称为Asy）和识别和编码Asy的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码Asy的核酸序列和产生Asy的方法。本发明还提供了用于预防和治疗与Asy表达相关的疾病的Asy和特异性结合Asy的激动剂，抗体或拮抗剂。另外，本发明提供反义分子用于编码Asy的多核苷酸用于治疗与Asy表达相关的疾病。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合Asy的抗体的诊断测定法。

36. 发明授权

US06207148B1 Disease associated protein kinases 失效
标题翻译：疾病相关蛋白激酶
公开(公告)号：US06207148B1
公开(公告)日：2001-03-27
申请号：US09272796
申请日：1999-03-19
申请人： Olga Bandman , Jennifer L. Hillman , Neil C. Corley , Karl J. Guegler , Preeti Lal , Surya K. Goli , Purvi Shah
发明人： Olga Bandman , Jennifer L. Hillman , Neil C. Corley , Karl J. Guegler , Preeti Lal , Surya K. Goli , Purvi Shah
IPC分类号： A61K3843
CPC分类号： C12N9/1205 , A61K38/00
摘要： The invention provides human disease associated protein kinases and polynucleotides (collectively designated DAPK) which identify and encode them. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing and treating disorders associated with expression of human disease associated protein kinases.
摘要翻译：本发明提供了识别和编码它们的人类疾病相关蛋白激酶和多核苷酸（统称为DAPK）。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供用于诊断和治疗与人类疾病相关蛋白激酶的表达相关的疾病的方法。

37. 发明授权

US06172199B2 Human ubiquitin-conjugating enzyme 失效
标题翻译：人泛素结合酶
公开(公告)号：US06172199B2
公开(公告)日：2001-01-09
申请号：US09318317
申请日：1999-05-25
申请人： Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
发明人： Janice Au-Young , Surya K. Goli , Jennifer L. Hillman
IPC分类号： A61K39395
CPC分类号： C12N9/93 , C07K16/40
摘要： The present invention provides a polynucleotide (ubcp) which identifies and encodes a novel ubiquitin-conjugating enzyme (UBCP). The invention provides for genetically engineered expression vectors and host cells comprising the nuclei acid sequence encoding UBCP. The invention also provides for the use of substantially purified UBCP and its agonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of UBCP. Additionally, the invention provides for the use of antisense molecules to ubcp in pharmaceutical compositions for treatment of diseases associated with the expression of UBCP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of ubcp or anti-UBCP antibodies which specifically bind to UBCP.
摘要翻译：本发明提供鉴定和编码新型泛素缀合酶（UBCP）的多核苷酸（ubcp）。本发明提供了包含编码UBCP的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供在商业生产重组蛋白质和用于治疗与UBCP表达有关的疾病的药物组合物中使用基本上纯化的UBCP及其激动剂，拮抗剂或抑制剂。此外，本发明提供了用于治疗与UBCP表达相关的疾病的药物组合物中的ubcp的反义分子的用途。本发明还描述了利用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与特异性结合UBCP的ubcp或抗UBCP抗体的基因组序列或转录物杂交。

38. 发明授权

US6156523A Serine/threonine protein kinases 失效
标题翻译：丝氨酸/苏氨酸蛋白激酶
公开(公告)号：US6156523A
公开(公告)日：2000-12-05
申请号：US153939
申请日：1998-09-16
申请人： Olga Bandman , Y. Tom Tang , Surya K. Goli , Neil C. Corley , Karl J. Guegler , Gina A. Gorgone , Jennifer L. Hillman
发明人： Olga Bandman , Y. Tom Tang , Surya K. Goli , Neil C. Corley , Karl J. Guegler , Gina A. Gorgone , Jennifer L. Hillman
IPC分类号： C12N15/09 , A61K38/00 , A61K38/45 , A61K45/00 , A61P1/00 , A61P1/18 , A61P3/00 , A61P3/10 , A61P5/14 , A61P5/38 , A61P7/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/08 , A61P27/02 , A61P27/06 , A61P27/12 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/08 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12Q1/68 , A61K38/43 , C07K14/00 , C12N9/00 , C12N15/52 , G01N23/53
CPC分类号： C12N9/1205 , C12Y207/01037 , A61K38/00
摘要： The invention provides human serine/threonine protein kinases (HSTK) and polynucleotides which identify and encode HSTK. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HSTK.
摘要翻译：本发明提供人丝氨酸/苏氨酸蛋白激酶（HSTK）和识别和编码HSTK的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HSTK表达相关的病症的方法。

39. 发明授权

US6110722A F.sub.0 ATP synthase subunit 失效
标题翻译： F0 ATP合酶亚基
公开(公告)号：US6110722A
公开(公告)日：2000-08-29
申请号：US66049
申请日：1998-04-24
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N9/14 , C12N15/60 , C12N9/88 , A61K38/51
CPC分类号： C12N9/14
摘要： The present invention provides a human ATP synthase subunit (ASYS) and polynucleotides which encode ASYS. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing ASYS and for treating disorders associated with expression of ASYS.
摘要翻译：本发明提供了人ATP合酶亚基（ASYS）和编码ASYS的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。本发明还提供了用于产生ASYS和用于治疗与ASYS表达相关的疾病的方法。

40. 发明授权

US6103874A Human KDEL receptor 失效
标题翻译：人类KDEL受体
公开(公告)号：US6103874A
公开(公告)日：2000-08-15
申请号：US133735
申请日：1998-08-13
申请人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
发明人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/06 , A61P5/14 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/566 , C07K14/00 , A61K38/16 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a novel human KDEL receptor (NHKR) and polynucleotides which identify and encode NHKR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHKR and a method for producing NHKR. The invention also provides for agonists, antibodies, or antagonists specifically binding NHKR, and their use, in the prevention and treatment of diseases associated with expression of NHKR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHKR for the treatment of diseases associated with the expression of NHKR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHKR.
摘要翻译：本发明提供了一种新的人KDEL受体（NHKR）和识别并编码NHKR的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码NHKR的核酸序列和生产NHKR的方法。本发明还提供了特异性结合NHKR的激动剂，抗体或拮抗剂及其在预防和治疗与NHKR表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码NHKR的多核苷酸用于治疗与NHKR表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHKR的抗体的诊断测定法。

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