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31. 发明申请

US20170217918A1 ANTIDIABETIC BICYCLIC COMPOUNDS 审中-公开
公开(公告)号：US20170217918A1
公开(公告)日：2017-08-03
申请号：US15328735
申请日：2015-08-06
申请人： Helen CHEN , Steven L. COLLETTI , Duane MONG , Yan GUO , Michael MILLER , Anilkumar NAIR , Christopher W. PLUMMER , Dong XIAO , De-Yi YANG , Merck Sharp & Dohme Corp.
发明人： Helen Chen , Steven L. Colletti , Duane DeMong , Yan Guo , Michael Miller , Anilkumar Nair , Christopher W. Plummer , Dong Xiao , De-Yi Yang
IPC分类号： C07D311/60 , C07D405/14 , C07D471/08 , C07D487/08 , C07D487/04 , C07D491/107 , C07D413/12 , C07D491/08 , C07D405/10 , C07D491/048
CPC分类号： C07D311/60 , A61K31/366 , A61K31/397 , A61K31/4985 , A61K45/06 , C07D405/10 , C07D405/14 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/048 , C07D491/08 , C07D491/107 , A61K2300/00
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

32. 发明申请

US20160332968A1 ANTIDIABETIC COMPOUNDS 审中-公开
标题翻译：抗菌化合物
公开(公告)号：US20160332968A1
公开(公告)日：2016-11-17
申请号：US15110894
申请日：2015-02-03
申请人： Harry CHOBANIAN , Duane DEMONG , Yan Guo , Zhiyong Hu , Barbara PIO , Christopher PLUMMER , Dong XIAO , Cangming YANG , Rui ZHANG , Merck Sharp & Dohme Corp. , Michael MILLER
发明人： Harry Chobanian , Duane DeMong , Yan Guo , Zhiyong Hu , Michael Miller , Barbara Pio , Christopher W. Plummer , Dong Xiao , Michael Yang
IPC分类号： C07D211/42 , C07D211/22 , C07D205/04 , C07D209/54 , C07D209/52 , C07D207/12 , C07D205/12 , C07C217/52 , C07D401/04 , C07D265/30 , C07C59/72 , C07D213/64 , C07D213/69 , C07D239/52 , C07D231/20 , C07D307/88 , C07D491/056 , C07D307/86 , C07D213/30 , C07D213/647 , C07D207/08
CPC分类号： C07D211/42 , A61K31/366 , A61K31/397 , A61K31/40 , A61K31/44 , A61K31/4985 , A61K45/06 , C07C59/72 , C07C217/52 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D205/12 , C07D207/08 , C07D207/10 , C07D207/12 , C07D209/52 , C07D209/54 , C07D211/22 , C07D213/30 , C07D213/64 , C07D213/647 , C07D213/65 , C07D213/69 , C07D231/20 , C07D239/52 , C07D265/30 , C07D307/86 , C07D307/88 , C07D401/04 , C07D491/056 , A61K2300/00
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译：结构式（I）的新型化合物及其药学上可接受的盐是G蛋白偶联受体40（GPR40）的激动剂，可用于治疗，预防和抑制G蛋白偶联受体受体40.本发明的化合物可用于治疗2型糖尿病，以及通常与该疾病相关的病症，包括肥胖症和脂质疾病，例如混合或糖尿病性血脂异常，高脂血症，高胆固醇血症和高甘油三酯血症

33. 发明申请

US20160304515A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIM CHANNEL 有权
标题翻译：肾脏外侧药物通道的抑制剂
公开(公告)号：US20160304515A1
公开(公告)日：2016-10-20
申请号：US15101467
申请日：2014-12-16
申请人： Harry CHOBANIAN , Barbara PIO , Yan GUO , Fa-Xiang DING , Shuzhi DONG , Shawn P. WALSH , Jinlong JIANG , Dooseop KIM , MERCK SHARP & DOHME CORP.
发明人： Harry Chobanian , Barbara Pio , Yan Guo , Fa-Xiang Ding , Shuzhi Dong , Shawn P. Walsh , Jinlong Jiang , Dooseop Kim
IPC分类号： C07D471/04 , A61K45/06 , A61K31/55 , C07D487/04 , A61K31/4985 , C07D498/04 , A61K31/519 , A61K31/437
CPC分类号： C07D471/04 , A61K31/401 , A61K31/4178 , A61K31/424 , A61K31/437 , A61K31/4422 , A61K31/496 , A61K31/4965 , A61K31/4985 , A61K31/519 , A61K31/55 , A61K31/585 , A61K45/06 , C07D487/04 , C07D498/04 , A61K2300/00
摘要： The present invention provides compounds of Formula (I) (Formula (I)) including pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

34. 发明授权

US08599168B2 Touch detection method and circuit for capacitive touch panels 有权
标题翻译：电容触摸屏的触摸检测方法和电路
公开(公告)号：US08599168B2
公开(公告)日：2013-12-03
申请号：US13066183
申请日：2011-04-07
申请人： Lianghua Mo , Yan Guo
发明人： Lianghua Mo , Yan Guo
IPC分类号： G06F3/045
CPC分类号： G06F3/044
摘要： A touch detection method for capacitive touch panels includes the steps of scanning the rows and columns of the capacitive matrix of a touch panel respectively; obtaining the capacitance differential value; processing the obtained capacitance differential value; and determining whether there is a touch on the touch panel in response to the processed capacitance differential value. The capacitance differential value is obtained by one of the steps of synchronously scanning two rows at the same time; synchronously scanning two columns at the same time; scanning one row to obtain the capacitance differential value between the row and a reference capacitance; and scanning one column to obtain the capacitance differential value between the column and a reference capacitance. The present invention creates conditions for the elimination of common code interferences and greatly improves the interference resistance of a capacitive touch panel.
摘要翻译：电容触摸面板的触摸检测方法包括以下步骤：分别扫描触摸面板的电容矩阵的行和列; 获得电容差分值; 处理所获得的电容差分值; 以及响应于所处理的电容差分值来确定触摸面板上是否存在触摸。通过同步同时扫描两行的步骤之一获得电容差分值; 同时同步扫描两列; 扫描一行以获得行与参考电容之间的电容差分值; 并扫描一列以获得列与参考电容之间的电容差分值。本发明创造了消除通用代码干扰的条件，并大大提高了电容式触摸面板的抗干扰能力。

35. 发明申请

US20130279642A1 BOTTOM NOZZLE FILTERING DEVICE AND DEBRIS-PREVENTIVE BOTTOM NOZZLE USING THE SAME 审中-公开
标题翻译： BOTTOM喷嘴过滤装置和防止底漆喷嘴使用它
公开(公告)号：US20130279642A1
公开(公告)日：2013-10-24
申请号：US13978686
申请日：2011-10-14
申请人： Wenchi Yu , Weicai Li , Yuemin Zhou , Xianfeng Lv , Yan Guo , Yuli Liu
发明人： Wenchi Yu , Weicai Li , Yuemin Zhou , Xianfeng Lv , Yan Guo , Yuli Liu
IPC分类号： G21C3/32 , B01D35/02
CPC分类号： G21C3/3206 , B01D29/03 , B01D35/02 , G21C3/322 , G21C3/3305 , Y02E30/38
摘要： The present invention provides a bottom nozzle filtering device and a debris-preventive bottom nozzle that can be used for a light water reactor (LWR) nuclear fuel assembly. The bottom nozzle filtering device includes a plurality of successively spliced unit plates; a through flow channel is formed between the spliced adjacent unit plates; the flow channel includes a plurality of spaced straight-section flow inlets and straight-section flow outlets, and a flow subchannel communicating; the outlet section of each straight-section flow inlet in the middle splits respectively into two flow subchannels, and the inlet section of each straight-section flow outlet in the middle communicates respectively with the two flow subchannels. The flow direction of the coolant is controlled by the straight-section flow inlet, the straight-section flow outlet, the flow subchannel to prevent unnecessary eddies forming, making the pressure loss effectively controlled and improving the filtering effect.
摘要翻译：本发明提供了可用于轻水反应堆（LWR）核燃料组件的底部喷嘴过滤装置和防碎底部喷嘴。底部喷嘴过滤装置包括多个连续拼接的单元板; 在接合的相邻单元板之间形成通流通道; 流动通道包括多个间隔开的直线部分流入口和直流部分流出口，以及流动通道。中间的每个直段流入口的出口部分别分成两个流通道，中间的每个直段流出口的入口部分分别与两个流动通道连通。冷却液的流动方向由直流流入口，直流流出口，流动通道进行控制，防止不必要的涡流成形，有效控制压力损失，提高过滤效果。

36. 发明申请

US20130030000A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PAIN AND OTHER INDICATIONS 审中-公开
标题翻译：用于治疗疼痛和其他症状的药物组合物
公开(公告)号：US20130030000A1
公开(公告)日：2013-01-31
申请号：US13574303
申请日：2011-01-25
申请人： Harry R. Chobanian , Linus S. Lin , Ping Liu , Marc D. Chioda , Robert J. DeVita , Ravi P. Nargund , Yan Guo , Terence G. Hamill , Wenping Li , Darrell Arthur Henze
发明人： Harry R. Chobanian , Linus S. Lin , Ping Liu , Marc D. Chioda , Robert J. DeVita , Ravi P. Nargund , Yan Guo , Terence G. Hamill , Wenping Li , Darrell Arthur Henze
IPC分类号： A61K31/497 , A61K31/506 , A61K31/513 , A61K31/4439 , A61K31/421 , A61K31/4245 , A61K31/4545 , A61K31/501 , A61K31/4725 , A61K31/4709 , A61P29/00 , A61P25/22 , A61P3/04 , A61P27/02 , A61P11/06 , A61P27/06 , A61P9/00 , A61P25/24 , A61P43/00 , A61P19/02 , A61P25/28 , A61P25/18 , A61P25/30 , A61P25/16 , A61P25/08 , A61P11/00 , A61P35/00 , A61P1/00 , A61P1/04 , A61P1/12 , A61P17/04 , A61P1/16 , A61P25/06 , A61P25/02 , A61K31/444
CPC分类号： A61K31/422 , A61K31/4178
摘要： The present invention is directed to a composition useful for the treatment of a FAAH mediated disease, disorder or conditions comprising a FAAH inhibitor and a second activation, comprising a selected imidazole or oxazole FAAH inhibitor and a second active agent. The compositions will be useful in the treatment of a wide range of disease, disorder, or conditions including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer disease, and Parkinson's disease. In another aspect the invention discloses herein is directed to compositions useful in the treatment of neuropathic and nociceptive pain, said compositions comprising etoricoxib.
摘要翻译：本发明涉及可用于治疗包含选择的咪唑或恶唑FAAH抑制剂和第二活性剂的FAAH介导的疾病，病症或包含FAAH抑制剂和第二活化的病症的组合物。该组合物可用于治疗广泛的疾病，病症或病症，包括骨关节炎，类风湿性关节炎，糖尿病性神经病，带状疱疹后神经痛，肌肉痛和纤维肌痛，以及急性疼痛，偏头痛，睡眠障碍，阿尔茨海默病，和帕金森病。另一方面，本发明公开了本发明涉及用于治疗神经性疼痛和伤害性疼痛的组合物，所述组合物包含埃托考昔。

37. 发明申请

US20120077357A1 SELF REFERENCING PIN 有权
标题翻译：自引引码
公开(公告)号：US20120077357A1
公开(公告)日：2012-03-29
申请号：US12890646
申请日：2010-09-25
申请人： Bin Zou , Yan Guo , Robert L. Sankman , Jiangqi He
发明人： Bin Zou , Yan Guo , Robert L. Sankman , Jiangqi He
IPC分类号： H01R12/00 , H01R43/16 , H01R13/02
CPC分类号： H01R43/16 , H01L23/49811 , H01L2924/0002 , H01R12/57 , H01R2103/00 , H05K1/0219 , H05K1/0231 , H05K1/0242 , H05K1/0251 , H05K1/113 , H05K2201/09336 , H05K2201/09663 , H05K2201/1031 , Y02P70/611 , Y10T29/49204 , H01L2924/00
摘要： Methods and apparatus relating to self-referencing pins are described. In one embodiment, a pin electrically couples a first agent to a second agent. The pin includes two or more portions that are at least partially separated by an insulator, e.g., to improve crosstalk performance. Other embodiments are also disclosed and claimed.
摘要翻译：描述与自引用引脚相关的方法和装置。在一个实施例中，引脚将第一试剂电耦合到第二试剂。该销包括至少部分地被绝缘体隔开的两个或多个部分，例如，以提高串扰性能。还公开并要求保护其他实施例。

38. 发明申请

US20110248955A1 Touch detection method and circuit for capacitive touch panels 有权
标题翻译：电容触摸屏的触摸检测方法和电路
公开(公告)号：US20110248955A1
公开(公告)日：2011-10-13
申请号：US13066183
申请日：2011-04-07
申请人： Lianghua Mo , Yan Guo
发明人： Lianghua Mo , Yan Guo
IPC分类号： G06F3/044
CPC分类号： G06F3/044
摘要： The present invention discloses a touch detection method and circuit for capacitive touch panels. The touch detection method for capacitive touch panels comprises scanning the rows and columns of the capacitive matrix of a touch panel respectively, wherein during the scanning of the rows or columns of the capacitive matrix of the touch panel, two rows or columns are synchronously scanned at the same time to obtain the capacitance differential value between the two rows or columns, or one row or column is scanned at the same time to obtain the capacitance differential value between the row or column and a reference capacitance; and then processing the obtained capacitance differential value. The present invention creates conditions for the elimination of common code interferences and greatly improves the interference resistance of a capacitive touch panel.
摘要翻译：本发明公开了一种用于电容式触摸屏的触摸检测方法和电路。电容式触摸屏的触摸检测方法包括分别扫描触摸面板的电容矩阵的行和列，其中在扫描触摸面板的电容矩阵的行或列期间，两行或列被同步地扫描在同时获得两行或两列之间的电容差分值，或同时扫描一行或一列，以获得行或列与参考电容之间的电容差分值; 然后处理所获得的电容差分值。本发明创造了消除通用代码干扰的条件，并大大提高了电容式触摸面板的抗干扰能力。

39. 发明申请

US20110221701A1 Multi-touch detection method for capacitive touch screens 审中-公开
标题翻译：电容触摸屏多点触摸检测方法
公开(公告)号：US20110221701A1
公开(公告)日：2011-09-15
申请号：US13065024
申请日：2011-03-10
申请人： Jingkai Zhang , Yan Guo , Lianghua Mo
发明人： Jingkai Zhang , Yan Guo , Lianghua Mo
IPC分类号： G06F3/045
CPC分类号： G06F3/044 , G06F3/0418 , G06F2203/04104
摘要： This invention discloses a multi-touch detection method for capacitive touch screens, which includes the following steps: conducting scan detection of capacitance of the rows and columns of a touch screen matrix to respectively acquire the capacitance data of the rows and columns of the touch screen matrix; acquiring an initial capacitance threshold value and calculating capacitance value of each row and each column by subtracting the initial capacitance threshold value from the capacitance data of each row and each column respectively; judging whether a curved section with a capacitance value of more than zero exists in the calculated capacitance value curve of the rows and columns; if so, the gravity center point of each curved section with a calculated capacitance value of more than zero is taken as the contact point coordinate corresponding to the curved section; if not, no touch is made; and the column coordinate and the row coordinate of each contact point is sent to a processor for processing. This invention reduces the volume of data with processing necessity, decreases the load of the processor, improves the anti-interference performance of a system to a certain extent, and also lowers the probability of wrong touch.
摘要翻译：本发明公开了一种用于电容式触摸屏的多点触摸检测方法，包括以下步骤：对触摸屏矩阵的行和列的电容进行扫描检测，以分别获取触摸屏的行和列的电容数据矩阵; 通过从每行和每列的电容数据中减去初始电容阈值来获取初始电容阈值并计算每行和每列的电容值; 判断所计算的行和列的电容值曲线中是否存在电容值大于零的弯曲部分; 如果是，则将计算的电容值大于零的每个弯曲部分的重心点作为与弯曲部分相对应的接触点坐标; 如果没有，没有触摸; 并将每个接触点的列坐标和行坐标发送到处理器进行处理。本发明通过处理必要性来减少数据量，降低处理器的负担，在一定程度上提高系统的抗干扰性能，并降低错误触摸的可能性。

40. 发明授权

US07889149B2 Aperture matched polyrod antenna 有权
标题翻译：孔径匹配多孔天线
公开(公告)号：US07889149B2
公开(公告)日：2011-02-15
申请号：US12004681
申请日：2007-12-21
申请人： Rodolfo Diaz , Jeffrey Peebles , Yan Guo
发明人： Rodolfo Diaz , Jeffrey Peebles , Yan Guo
IPC分类号： H01Q13/00
CPC分类号： H01Q13/24 , B33Y80/00 , Y10T29/49016
摘要： A dielectric polyrod having at least one tapered section, where a section exposed outside of the waveguide is tapered a long a curve that depends on the dielectric constant of the material used. The invention also relates to an aperture matched polyrod antenna which includes the same and an inductive tuning element used to achieve wideband impedance match and to create a Gaussian beam in the radiating near field of the antenna, suitable to mimic a small region plane wave.
摘要翻译：具有至少一个锥形部分的介电聚合物，其中暴露在波导外部的部分根据所使用的材料的介电常数形成长的曲线。本发明还涉及一种孔径匹配的多极天线，其包括它们和用于实现宽带阻抗匹配并且在天线的辐射近场中产生适合于模拟小区域平面波的高斯波束的感应调谐元件。

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