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31. 发明申请

US20050276764A1 Topical use of bis-arylimidazo[1,2-a]thiolane derivatives 审中-公开
标题翻译：双芳基咪唑并[1,2-a]硫杂环戊烷衍生物的局部用途
公开(公告)号：US20050276764A1
公开(公告)日：2005-12-15
申请号：US11147117
申请日：2005-06-06
申请人： Ludger Kolbe , Uwe Pfannenbecker , Inge Kruse , Tobias Sokolowski , Jeannine Immeyer , Karen Dieck , Gerd Dannhardt
发明人： Ludger Kolbe , Uwe Pfannenbecker , Inge Kruse , Tobias Sokolowski , Jeannine Immeyer , Karen Dieck , Gerd Dannhardt
IPC分类号： A61K8/49 , A61K31/429 , A61P17/06 , A61Q17/04 , A61Q19/00 , A61K7/15 , A61K7/42
CPC分类号： A61Q19/002 , A61K8/49 , A61K31/429 , A61K2800/70 , A61Q17/04 , A61Q19/00 , A61Q19/004
摘要： The invention is a topical, anti-inflammatory medical, cosmetic, or dermatological preparation comprising at least one compound of the formula (DKH) wherein n is 1 or 2; and R1 and R2, independently of each other, are selected from the group consisting of phenyl, 2-toly, 3-tolyl, 4-tolyl, 2-methoxyphenyl, 3-methoxyphenyl, and 4-methoxyphenyl. The invention also includes methods for treating or preventing itchiness, hyperreactive skin conditions, sensitive skin, photostress, impure skin, the effects of UV radiation, and irritation comprising applying said preparation to the skin.
摘要翻译：本发明是包含至少一种式（DKH）化合物，其中n为1或2的局部，抗炎药物，化妆品或皮肤病学制剂; 和R 1和R 2彼此独立地选自苯基，2-甲苯基，3-甲苯基，4-甲苯基，2-甲氧基苯基，3-甲氧基苯基和4-甲氧基苯基。本发明还包括用于治疗或预防瘙痒，皮肤反应过度反应，敏感皮肤，光应激，不纯的皮肤，紫外线辐射的影响和刺激的方法，包括将所述制剂施用于皮肤。

32. 发明授权

US11497942B2 Cosmetic or dermatological preparation comprising a combination of a dye and an anti-inflammatory active ingredient 有权
公开(公告)号：US11497942B2
公开(公告)日：2022-11-15
申请号：US11004617
申请日：2004-12-03
申请人： Rainer Kröpke , Ludger Kolbe , Anette Bürger , Claudia Mundt
发明人： Rainer Kröpke , Ludger Kolbe , Anette Bürger , Claudia Mundt
IPC分类号： A61Q19/00 , A61K9/14 , A61K8/34 , A61K8/29 , A61K8/42 , A61K8/26 , A61K8/92 , A61K9/00 , A61K8/19
摘要： The present invention is a cosmetic or dermatological preparation comprising 0.01% by weight to 5% by weight of at least one red light-filtering dye and 0.0001% by weight to 10% by weight of at least one anti-inflammatory active ingredient. The preparation can be used for the prophylaxis and treatment of sun-irritated skin and to aid the body's own repair mechanisms.

33. 发明授权

US09168297B2 Regulation of skin pigmentation by neuregulin-1 (NRG-1) 有权
标题翻译：神经调节蛋白-1（NRG-1）皮肤色素沉着调控
公开(公告)号：US09168297B2
公开(公告)日：2015-10-27
申请号：US13805638
申请日：2011-06-23
申请人： Vincent J. Hearing , Wonseon Choi , Ludger Kolbe , Rainer Wolber
发明人： Vincent J. Hearing , Wonseon Choi , Ludger Kolbe , Rainer Wolber
IPC分类号： A61K38/00 , A61K38/17 , A61K38/18 , A61K39/395 , C07K14/475 , A61K31/7105 , A61K38/08 , A61K38/10
CPC分类号： A61K39/3955 , A61K31/7105 , A61K38/08 , A61K38/10 , A61K38/1883 , C07K14/4756
摘要： Disclosed herein are compositions and methods of using such compositions to modulate pigmentation and proliferation of a melanocyte, such as to prevent or treat skin disorders, including skin cancer or for use for cosmetic purposes. In one example, a method of modulating pigmentation of a melanocyte includes contacting the melanocyte (such as a human melanocyte) with an agent that modulates neuregulin-1 (NRG-1) activity, such as an agent that increases or decreases NRG-1 activity, thereby modulating pigmentation of the melanocyte. In one particular example, the method of increasing melanocyte pigmentation or proliferation can be used to reduce UV skin damage, including that associated with skin cancer. In another example, the method of decreasing melanocyte pigmentation can be used to treat a skin pigmentation disorder associated with undesired increased skin pigmentation.
摘要翻译：本文公开了使用这种组合物调节黑素细胞的色素沉着和增殖的组合物和方法，例如预防或治疗皮肤病，包括皮肤癌或用于美容目的。在一个实例中，调节黑素细胞色素沉着的方法包括将黑素细胞（例如人黑素细胞）与调节神经调节蛋白-1（NRG-1）活性的试剂接触，例如增加或减少NRG-1活性的试剂，从而调节黑素细胞的色素沉着。在一个具体实例中，增加黑素细胞色素沉着或增殖的方法可用于减少UV皮肤损伤，包括与皮肤癌相关的损伤。在另一个实例中，减少黑素细胞色素沉着的方法可用于治疗与不期望的增加的皮肤色素沉着相关的皮肤色素沉着紊乱。

34. 发明授权

US09017707B2 Cosmetic or dermatological preparations containing licochalcone A or an extract of radix glycyrrhizae inflatae, containing licochalcone A 有权
标题翻译：化妆品或皮肤病学制剂，其含有哌甲屈酮A或甘草提取物，含有苯甲酮酮A
公开(公告)号：US09017707B2
公开(公告)日：2015-04-28
申请号：US13897793
申请日：2013-05-20
申请人： Karen Tom Dieck , Ludger Kolbe , Claudia Mundt , Ursula Wensorra , Rainer Wolber
发明人： Karen Tom Dieck , Ludger Kolbe , Claudia Mundt , Ursula Wensorra , Rainer Wolber
IPC分类号： A61K31/12 , A61K8/97 , A61K8/35 , A61Q19/00 , A61K8/86 , A61K8/34
CPC分类号： A61K31/12 , A61K8/345 , A61K8/35 , A61K8/86 , A61K8/97 , A61Q19/00 , A61Q19/004
摘要： Disclosed are cosmetic or dermatological preparations for the treatment or alleviation of erythema which comprise an aqueous extract of Radix Glycyrrhizae inflatae or licochalcone A and optionally one or more ethoxylated or propoxylated raw materials and/or one or more polyols.
摘要翻译：公开了用于治疗或缓解红斑的化妆品或皮肤病学制剂，其包含甘草甘草酸或查耳酮A的含水提取物和任选的一种或多种乙氧基化或丙氧基化原料和/或一种或多种多元醇。

35. 发明授权

US08920785B2 Cosmetic or dermatological preparations with a content of one or more thiazole derivates 有权
标题翻译：含有一种或多种噻唑衍生物的化妆品或皮肤病学制剂
公开(公告)号：US08920785B2
公开(公告)日：2014-12-30
申请号：US13634586
申请日：2011-02-21
申请人： Ludger Kolbe , Cathrin Scherner
发明人： Ludger Kolbe , Cathrin Scherner
IPC分类号： A61K8/49 , A61Q19/02 , C07D471/04 , C07D417/12 , C07D277/42 , C07D277/48
CPC分类号： A61K8/49 , A61Q19/02 , C07D277/48 , C07D417/12
摘要： Cosmetic or dermatological preparations having an effective content of one or more thiazoles of the general formula.
摘要翻译：具有一种或多种通式的噻唑的有效含量的化妆品或皮肤病学制剂。

36. 发明申请

US20130095053A1 REGULATION OF SKIN PIGMENTATION BY NEUREGULIN-1 (NRG-1) 有权
标题翻译：神经细胞-1（NRG-1）皮肤色素调节
公开(公告)号：US20130095053A1
公开(公告)日：2013-04-18
申请号：US13805638
申请日：2011-06-23
申请人： Vincent J. Hearing , Wonseon Choi , Ludger Kolbe , Rainer Wolber
发明人： Vincent J. Hearing , Wonseon Choi , Ludger Kolbe , Rainer Wolber
IPC分类号： A61K39/395 , A61K38/10 , A61K38/08 , A61K31/7105
CPC分类号： A61K39/3955 , A61K31/7105 , A61K38/08 , A61K38/10 , A61K38/1883 , C07K14/4756
摘要： Disclosed herein are compositions and methods of using such compositions to modulate pigmentation and proliferation of a melanocyte, such as to prevent or treat skin disorders, including skin cancer or for use for cosmetic purposes. In one example, a method of modulating pigmentation of a melanocyte includes contacting the melanocyte (such as a human melanocyte) with an agent that modulates neuregulin-1 (NRG-1) activity, such as an agent that increases or decreases NRG-1 activity, thereby modulating pigmentation of the melanocyte. In one particular example, the method of increasing melanocyte pigmentation or proliferation can be used to reduce UV skin damage, including that associated with skin cancer. In another example, the method of decreasing melanocyte pigmentation can be used to treat a skin pigmentation disorder associated with undesired increased skin pigmentation.
摘要翻译：本文公开了使用这种组合物调节黑素细胞的色素沉着和增殖的组合物和方法，例如预防或治疗皮肤病，包括皮肤癌或用于美容目的。在一个实例中，调节黑素细胞色素沉着的方法包括将黑素细胞（例如人黑素细胞）与调节神经调节蛋白-1（NRG-1）活性的试剂接触，例如增加或减少NRG-1活性的试剂，从而调节黑素细胞的色素沉着。在一个具体实例中，增加黑素细胞色素沉着或增殖的方法可用于减少UV皮肤损伤，包括与皮肤癌相关的损伤。在另一个实例中，减少黑素细胞色素沉着的方法可用于治疗与不期望的增加的皮肤色素沉着相关的皮肤色素沉着紊乱。

37. 发明授权

US08343465B2 Cooling cosmetic or dermatological preparations comprising (1R,2S,5R)-2-isopropyl-5-methyl-N-(2-(pyridin-2-yl)ethyl)-cyclohexane carboxamide and/or (1R,2S,5R)-N-(4-cyanomethyl-phenyl)-2-isopropyl-5-methylcyclohexane carboxamide for reducing skin reddening 有权
标题翻译：包含（1R，2S，5R）-2-异丙基-5-甲基-N-（2-（吡啶-2-基）乙基） - 环己烷甲酰胺和/或（1R，2S，5R） - N-（4-氰基甲基 - 苯基）-2-异丙基-5-甲基环己烷甲酰胺，用于减少皮肤变红
公开(公告)号：US08343465B2
公开(公告)日：2013-01-01
申请号：US12402997
申请日：2009-03-12
申请人： Ludger Kolbe , Julia Eckert , Gitta Neufang , Stefanie Knaupmeier
发明人： Ludger Kolbe , Julia Eckert , Gitta Neufang , Stefanie Knaupmeier
IPC分类号： A01N43/08 , A01N37/12 , A01N37/44 , A01N43/36 , A61K31/34 , A61K31/24 , A61K8/19 , A61K9/00 , C07D307/00 , C07C205/00 , C07C229/00
CPC分类号： A61K8/4926 , A61K8/42 , A61K31/4402 , A61K2800/75 , A61Q9/02 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/002 , A61Q19/004
摘要： A topical cosmetic and dermatological preparation for reducing skin reddening which comprises (1R,2S,5R)-2-isopropyl-5-methyl-N-(2-(pyridin-2-yl)ethyl)-cyclohexane carboxamide and/or (1R,2S,5R)—N-(4-cyanomethyl-phenyl)-2-isopropyl-5-methylcyclohexane carboxamide.
摘要翻译：一种用于减少皮肤变红的局部化妆品和皮肤病学制剂，其包含（1R，2S，5R）-2-异丙基-5-甲基-N-（2-（吡啶-2-基）乙基） - 环己烷甲酰胺和/或（1R ，2S，5R）-N-（4-氰基甲基 - 苯基）-2-异丙基-5-甲基环己烷甲酰胺。

38. 发明申请

US20120259020A1 TRANSDERMAL THERAPEUTIC SYSTEMS CONTAINING 4-N-BUTYLRESORCINOL 有权
标题翻译：含有4-N-BUTYLRESORCINOL的透皮治疗系统
公开(公告)号：US20120259020A1
公开(公告)日：2012-10-11
申请号：US13499861
申请日：2010-07-14
申请人： Karl-Heinz Woeller , Ludger Kolbe , Cathrin Scherner , Rainer Wolber
发明人： Karl-Heinz Woeller , Ludger Kolbe , Cathrin Scherner , Rainer Wolber
IPC分类号： A61K31/05 , A61P17/00 , C07C39/10
CPC分类号： A61L15/44 , A61K9/7053 , A61K9/7061 , A61K9/7076 , A61L2300/216 , A61L2300/404
摘要： Transdermal therapeutic systems that contain 4-n-butylresorcinol as an active ingredient.
摘要翻译：含有4-正丁基间苯二酚作为活性成分的透皮治疗系统。

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