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31. 发明授权

US5275702A Distillation method of separating organic solvents 失效
标题翻译：分离有机溶剂的蒸馏方法
公开(公告)号：US5275702A
公开(公告)日：1994-01-04
申请号：US928298
申请日：1992-08-12
申请人： Takehiko Kataoka , Haruo Kawasaki , Harutoshi Ohura , Yoshinobu Uchida , Akihiko Yasaki , Shinichi Kishimoto
发明人： Takehiko Kataoka , Haruo Kawasaki , Harutoshi Ohura , Yoshinobu Uchida , Akihiko Yasaki , Shinichi Kishimoto
IPC分类号： B01D3/14 , B01D3/36 , C07B63/00 , C07C7/06 , C07C15/06 , C07C51/46 , C07C53/08 , C07K5/075
CPC分类号： C07K5/0613 , B01D3/36 , C07C51/46
摘要： The present invention discloses a method to separate each component from a mixed solution of organic solvents obtained during the production of .alpha.-L-aspartyl-L-phenylalanine methyl ester, which is useful as a sweetener, namely, a mixed solution of acetic acid and toluene or a mixed solution of acetic acid, toluene and formic acid, recovering each component with a high recovery ratio with as small number of operations as possible. The method rationalizes the process and is highly valuable in practical use.When each component is separated and recovered from a mixed solution containing acetic acid and toluene as the main components, acetic acid and toluene are separated by azeotropic distillation using water as an azeotropic solvent, and when each component is separated and recovered from a mixed solution containing acetic acid, toluene and formic acid as the main components, (a) the mixed solution is distilled and formic acid is recovered from the top of the column and a mixed solution of acetic acid and toluene is recovered from the bottom of the column; and (b) the mixed solution obtained from the bottom is distilled by using water as an azeotropic solvent and toluene is recovered from the top of the column and acetic acid is recovered from the bottom of the column.
摘要翻译：本发明公开了一种将（α）-L-天冬氨酰基-L-苯丙氨酸甲酯制备期间获得的有机溶剂的混合溶液中的每种成分分离的方法，其可用作甜味剂即乙酸混合溶液酸和甲苯或乙酸，甲苯和甲酸的混合溶液，以尽可能少的操作以高回收率回收每种组分。该方法使过程合理化，在实际应用中非常有价值。当从含有乙酸和甲苯作为主要组分的混合溶液中分离和回收各成分时，使用水作为共沸溶剂通过共沸蒸馏分离乙酸和甲苯，并且当将每种组分从含有乙酸，甲苯和甲酸为主要成分，（a）蒸馏出混合溶液，从塔顶回收甲酸，从塔底回收乙酸和甲苯的混合溶液; 和（b）通过使用水作为共沸溶剂蒸馏从底部获得的混合溶液，并从塔顶回收甲苯，从塔底回收乙酸。

32. 发明授权

US5248806A Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester 失效
标题翻译：制备（ALPHA）-L-阿糖基-L-苯甲酰胺甲酯的方法
公开(公告)号：US5248806A
公开(公告)日：1993-09-28
申请号：US885977
申请日：1992-05-20
申请人： Shinichi Kishimoto , So Abe , Toshihisa Kato
发明人： Shinichi Kishimoto , So Abe , Toshihisa Kato
IPC分类号： C07K1/02 , C07K1/14 , C07K5/06 , C07K5/072 , C07K5/075
CPC分类号： C07K5/0613
摘要： An acid addition salt of .alpha.-APM is dissolved or suspended in an aqueous medium at 50.degree. C. or lower at a pH of 3 or less and a concentration of the salt of 3 wt.% or more (solution A). A liquid having a pH of 3 or more and containing or not containing .alpha.-APM is prepared (solution B) and gradually mixed with solution A with stirring. The temperature of the liquid mixture is kept to be 40.degree. C. or lower and the pH value of the mixture is kept at 3 or more, optionally adding a base thereto, whereby crystals of .alpha.-APM are precipitated out.

33. 发明授权

US5097060A Process for crystallizing L-alpha-aspartyl-L-phenyl-alanine methyl ester 失效
标题翻译：用于结晶L-ALPHA-ASPARTYL-L-PHENYL-ALANINE METHYLESTER的方法
公开(公告)号：US5097060A
公开(公告)日：1992-03-17
申请号：US715711
申请日：1991-06-18
申请人： Masayoshi Naruse , Haruo Kawasaki , Shinichi Kishimoto , Harutoshi Oura , Masao Nakamura , Hideo Takeda
发明人： Masayoshi Naruse , Haruo Kawasaki , Shinichi Kishimoto , Harutoshi Oura , Masao Nakamura , Hideo Takeda
IPC分类号： A23L27/30 , A23G3/00 , A23G3/34 , A23G3/42 , A23G3/44 , A23G9/32 , A23G9/34 , C07C67/00 , C07C231/00 , C07C231/24 , C07K1/14 , C07K5/072 , C07K5/075
CPC分类号： A23G3/44 , A23G3/346 , A23G3/42 , A23G9/32 , A23G9/34 , A23L27/32 , C07K5/0613 , A23G2200/06 , A23G2200/10
摘要： A process for crystallizing L-alpha-aspartyl-L-phenylalanine methyl ester from its aqueous solution by cooling, which comprises adjusting the initial concentration of the ester so that the amount of a precipitated solid phase to be formed after cooling becomes about 10 grams or more per liter of the solvent, cooling the solution through conductive heat transfer through a cooled surface to form an apparently sherbet-like pseudosolid phase without causing forced flow by mechanical stirring or the like, and optionally further cooling the system after formation of the pseudosolid phase, is disclosed along with various apparatuses which may be used to carry out the invention.

34. 发明授权

US4876204A Method and apparatus of automatic continuous analysis using analytical implement 失效
标题翻译：使用分析工具进行自动连续分析的方法和装置
公开(公告)号：US4876204A
公开(公告)日：1989-10-24
申请号：US782356
申请日：1985-10-01
申请人： Kazushige Inoue , Hiroshi Yamamoto , Hiroshi Hyodo , Shinichi Kishimoto
发明人： Kazushige Inoue , Hiroshi Yamamoto , Hiroshi Hyodo , Shinichi Kishimoto
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： G01N35/00029 , G01N2035/00039 , G01N2035/00049 , G01N2035/00089 , G01N2035/00108 , G01N2035/00118 , G01N2035/1025 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165
摘要： An autonomous continuous analysis method and apparatus using Dip and Read type analytical implements. A series of operations of taking out analytical implements, dipping them in the sample solution, optical measurement, calculation, and disposal of the used sample solution are performed automatically.The dip stage, in particular, is automated by use of an analytical-implement automatic supply device and an analytical implement automatic handling device which, holding an analytical implement, dips it in the sample solution, and sets it ona reaction turntable. A number of analytical implements are put in a storage section comprising a bottom section provided with an analytical implement groove and at least one inside surface which is parallel with the groove, are taken out one by one by the relative movement of the groove and in normal and reverse direction and by stopping in a specified position after confirming by a detector that an implement has been caught in the groove.
摘要翻译：一种使用Dip和Read型分析仪器的自主连续分析方法和装置。自动执行一系列取出分析工具，浸渍在样品溶液中，进行光学测量，计算和处理的操作。特别地，浸渍阶段通过使用分析工具自动供应装置和分析工具自动处理装置来自动化，其分离工具自动处理装置，其保持分析工具，将其浸入样品溶液中，并将其设置在反应转台上。许多分析用具被放入存储部分中，该存储部分包括设置有分析用具槽的底部部分和与槽平行的至少一个内表面，通过槽的相对运动逐个取出并且在正常情况下并且在由检测器确认工具已经被捕获在凹槽中之后停止在指定位置。

35. 发明授权

US4810816A Process for the production of n-formyl-aspartyl-phenylalanine or its methyl ester 失效
标题翻译： N-甲酰基 - 天冬氨酰 - 苯丙氨酸或其甲酯的制备方法
公开(公告)号：US4810816A
公开(公告)日：1989-03-07
申请号：US99733
申请日：1987-09-22
申请人： Toshiaki Tsuji , Shinichi Kishimoto
发明人： Toshiaki Tsuji , Shinichi Kishimoto
IPC分类号： C07K1/02 , C04B35/64 , C07K1/113 , C07K5/06 , C07K5/075 , C07C101/02
CPC分类号： C07K5/0613
摘要： A process for producing N-formyl-aspartylphenylalanine or its methyl ester, wherein aspartic acid is reacted with formic acid and acetic anhydride in approximately stoichiometric quantities in the presence or absence of a catalyst and phenylalanine or its methyl ester is directly added to the dehydration mixture. This process has a higher yield of the desired N-formyl-dipeptide and minimizes the amount of by-products and unreacted starting materials.

36. 发明授权

US4610827A Amino acid complex and a method for optical resolution of a DL-amino acid 失效
标题翻译：氨基酸复合物和DL-氨基酸的光学拆分方法
公开(公告)号：US4610827A
公开(公告)日：1986-09-09
申请号：US629468
申请日：1984-07-10
申请人： Toshihide Yukawa , Toru Ikeda , Shinichi Kishimoto , Katsumi Sugiyama
发明人： Toshihide Yukawa , Toru Ikeda , Shinichi Kishimoto , Katsumi Sugiyama
IPC分类号： C07B57/00 , C07C67/00 , C07C227/34 , C07C229/02 , C07C229/36 , C07C239/00 , C07C271/22 , C07C301/00 , C07C323/58 , C07D209/20 , C07C103/50
CPC分类号： C07C271/22
摘要： A method for optical resolution of a DL-amino acid comprising reacting the DL-amino acid with an optically active N-acyl aspartic acid in a solvent or mixture of solvents, and separating the resulting two diasteromeric salts by way of the difference between their solubilities in the solvent or mixture of solvents. The difference in solubility may be enhanced by cooling, concentration, addition of a solubility-decreasing organic solvent, pH adjustment or salting out.
摘要翻译：一种DL-氨基酸的光学拆分方法，包括将DL-氨基酸与光学活性N-酰基天冬氨酸在溶剂或溶剂混合物中反应，并通过其溶解度之间的差异分离得到的两种非对映异构体盐在溶剂或溶剂混合物中。通过冷却，浓缩，添加溶解度降低的有机溶剂，pH调节或盐析可以提高溶解度的差异。

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