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31. 发明申请

US20090196389A1 Signal processing method and circuit to convert analog signal to digital signal 有权
标题翻译：信号处理方法和电路将模拟信号转换为数字信号
公开(公告)号：US20090196389A1
公开(公告)日：2009-08-06
申请号：US12320324
申请日：2009-01-23
申请人： Kenji Yamashita
发明人： Kenji Yamashita
IPC分类号： H04L7/04
CPC分类号： H04N5/06 , G09G5/008 , H04N5/126
摘要： A phase determination unit in a signal processing circuit generates sampling clocks with different phases in a clock generator and sequentially provides them to an analog-to-digital convertor. Then, the phase determination unit obtains differences between each adjacent two signal levels in each sampled digital signal by use of the sampling clocks, and monitors a polarity change in the differences, extracts a more inappropriate phase for use in sampling from phases of the sampling clocks on the basis of the absolute values of the differences where the polarity change is detected, and determines an antiphase of the extracted phase as a phase of the sampling clock to be provided to the analog-to-digital convertor.
摘要翻译：信号处理电路中的相位确定单元在时钟发生器中产生具有不同相位的采样时钟，并将它们顺序地提供给模数转换器。然后，相位确定单元通过使用采样时钟获得每个采样数字信号中每个相邻两个信号电平之间的差异，并且监视差异中的极性变化，从采样时钟的相位提取用于采样的更不合适的相位基于检测到极性变化的差异的绝对值，并将所提取的相位的反相确定为要提供给模数转换器的采样时钟的相位。

32. 发明申请

US20070184662A1 Double-side polishing carrier and fabrication method thereof 审中-公开
标题翻译：双面抛光载体及其制造方法
公开(公告)号：US20070184662A1
公开(公告)日：2007-08-09
申请号：US11629950
申请日：2005-06-23
申请人： Kenji Yamashita , Yukio Oono , Yuuji Sugimoto
发明人： Kenji Yamashita , Yukio Oono , Yuuji Sugimoto
IPC分类号： C03C15/00 , H01L21/306 , B44C1/22 , H01L21/302
CPC分类号： B24B37/28
摘要： The carrier (10) for double-side polishing has a base material 10a the material of which is stainless steel (SUS) , for example, as is before, and the base material 10a is coated with a coating layer 10b of a material having a hardness higher than that of the base material 10a. The coating layer 10b is desirably coated uniformly without variations in thickness and not warped easily, and the material for the coating layer 10b of the double-side polishing carrier 10 is desirably any one selected from diamond-like carbon, a nitride film, a sapphire film and a titanium nitride film. For production of the double-side polishing carrier 10, a double-side polishing carrier 10′ having been used for polishing is prepared first. The used carrier 10′ is coated with the coating layer 10b. The invention can suppress the progress of abrasion of the double-side polishing carrier, and can provide satisfactory thickness accuracy, film thickness distribution accuracy, and surface roughness.
摘要翻译：用于双面抛光的载体（10）具有基材10，其材料例如是以前的不锈钢（SUS），并且基材10a涂覆有涂层10b 硬度高于基材10a的硬度的材料。涂层10b优选地均匀地涂覆而不会发生变化，并且不易弯曲，双面抛光载体10的涂层10b的材料理想地是选自金刚石状碳，氮化物膜，蓝宝石膜和氮化钛膜。为了制造双面抛光载体10，首先制备用于抛光的双面抛光载体10'。用过的载体10'涂覆有涂层10b。本发明可以抑制双面抛光载体的磨损进程，并且可以提供令人满意的厚度精度，膜厚分布精度和表面粗糙度。

33. 发明授权

US06764688B2 Method for inducing immunosuppressive cells and a culture device to be used therefor 失效
标题翻译：诱导免疫抑制细胞的方法和用于其的培养装置
公开(公告)号：US06764688B2
公开(公告)日：2004-07-20
申请号：US09254170
申请日：1999-03-02
申请人： Kenji Yamashita , Takeshi Fukuchi , Tomoko Nishino
发明人： Kenji Yamashita , Takeshi Fukuchi , Tomoko Nishino
IPC分类号： A61K4500
CPC分类号： C12N5/0636 , A61K2035/122 , C12M25/00 , C12N2501/23 , C12N2501/515 , C12N2501/599
摘要： The present invention provides a method for inducing immunosuppressive cells by cultivating human cells with the use of a culture device having an affinity for protein and the culture device to be used therefor. According to the present invention, immunosuppressive cells can be efficiently induced by using a solid culture and can provide an efficient therapeutic system for diseases caused by hypersensitivity of the immune system with less side effect.
摘要翻译：本发明提供通过使用对蛋白质具有亲和力的培养装置和用于其的培养装置培养人细胞来诱导免疫抑制细胞的方法。根据本发明，可以通过使用固体培养物有效地诱导免疫抑制细胞，并且可以为免疫系统的超敏反应引起的疾病提供有效的治疗系统，而副作用较小。

34. 发明授权

US06620890B1 Composition for peelable coating 失效
标题翻译：可去皮涂层用组合物
公开(公告)号：US06620890B1
公开(公告)日：2003-09-16
申请号：US09668211
申请日：2000-09-22
申请人： Kenji Yamashita , Masayuki Matsuki , Noritsumi Matsuyama , Takanori Endo , Hideaki Tojo , Hisashi Kurota
发明人： Kenji Yamashita , Masayuki Matsuki , Noritsumi Matsuyama , Takanori Endo , Hideaki Tojo , Hisashi Kurota
IPC分类号： C08L9100
CPC分类号： C08L51/003 , C08F265/04 , C08F265/06 , C09D5/20 , C09D151/003 , C08L2666/02
摘要： A composition for peelable coating, which composition exhibits excellent properties such as film-formability and water resistance and can be dried at ambient temperature without any particular heating, to thereby provide excellent coating performance. The composition contains a core/shell copolymer including an acrylic copolymer portion A having a high glass transition temperature of 30° C.-70° C. and an acrylic copolymer portion B having a low glass transition temperature of 5° C. to −30° C. and being formed through multi-step polymerization. The core/shell copolymer is made up of 5-40 wt. % of the acrylic copolymer portion A and 60-95 wt. % of the acrylic copolymer portion B, on the basis of the total amount of the portion A and the portion B. The acrylic copolymer portion A and the acrylic copolymer portion B contain the same hard-polymer-providing monomer unit and soft-polymer-providing monomer unit. Each copolymer portion contains a hard-polymer-providing monomer unit and a soft-polymer-providing monomer unit in a total amount of 70 wt. % or more.
摘要翻译：用于可剥离涂层的组合物，该组合物表现出优异的性能如成膜性和耐水性，并且可以在环境温度下进行干燥而无需任何特别的加热，从而提供优异的涂布性能。该组合物含有包含具有30℃-70℃的高玻璃化转变温度的丙烯酸共聚物部分A和玻璃化转变温度低至5℃至-30℃的丙烯酸共聚物部分B的核/壳共聚物 ℃，并通过多步聚合形成。核/壳共聚物由5-40wt。丙烯酸共聚物部分A的％和60-95重量％丙烯酸类共聚物部分B的含量为基于A部分和B部分的总量。丙烯酸共聚物部分A和丙烯酸共聚物部分B含有相同的提供硬聚合物的单体单元和软聚合物 - 提供单体单元。每个共聚物部分包含总量为70重量％的提供硬聚合物的单体单元和提供软聚合物的单体单元。％或者更多。

35. 发明授权

US5556943A Cell adhesion protein, gene coding for the same, process for preparing the same and carrier onto which the same is immobilized 失效
标题翻译：细胞粘附蛋白，编码相同的基因，其制备方法和其上固定有载体的载体
公开(公告)号：US5556943A
公开(公告)日：1996-09-17
申请号：US328152
申请日：1994-10-24
申请人： Kenji Yamashita , Takaaki Ohara , Hideo Niwa , Fumio Osakada , Takeshi Fukuchi , Tadahiro Edamura , Tetsu Kakutani
发明人： Kenji Yamashita , Takaaki Ohara , Hideo Niwa , Fumio Osakada , Takeshi Fukuchi , Tadahiro Edamura , Tetsu Kakutani
IPC分类号： A61K38/00 , C07K14/705 , C12N1/21 , C12N15/12 , C07K14/47
CPC分类号： C07K14/70528 , A61K38/00
摘要： A sheep LFA-3 protein and derivertires thereof, and derivertives of a human LFA-3 protein, gene coding for the proteins, and processes for preparing the proteins. Said proteins have high affinity for human T-cells.
摘要翻译：绵羊LFA-3蛋白质及其衍生物，人LFA-3蛋白质的衍生物，编码蛋白质的基因，以及制备蛋白质的方法。所述蛋白质对人T细胞具有高亲和力。

36. 发明授权

US08284315B2 PAL signal demodulating apparatus 失效
标题翻译： PAL信号解调装置
公开(公告)号：US08284315B2
公开(公告)日：2012-10-09
申请号：US12132963
申请日：2008-06-04
申请人： Kenji Yamashita
发明人： Kenji Yamashita
IPC分类号： H04N9/66
CPC分类号： H04N9/66 , H04N9/646 , H04N9/78
摘要： A PAL signal demodulating apparatus comprises BPF filters that perform band pass filtering to pass a chroma band for frames 1 to 5, thereby producing the BPF output signals for the frames, a 3D color phase distortion correcting color signal acquiring unit that calculates correlations between frames 1 and 3 and between frames 3 and 5 and takes a weighted average of the BPF output signals for frames 2 and 4 with weights according to the two calculated correlations, thereby producing a 3D color phase distortion correcting color signal N, and a carrier chrominance signal extracting unit that takes the addition/subtraction of the BPF output signal for frame 3 and the 3D color phase distortion correcting color signal, thereby extracting carrier chrominance signals, to perform correctly U/V separation for a line different in color from its preceding and following lines in the same frame.
摘要翻译： PAL信号解调装置包括执行带通滤波以通过帧1至5的色度带的BPF滤波器，从而产生用于帧的BPF输出信号; 3D彩色相位失真校正颜色信号获取单元，其计算帧1之间的相关性 3和帧3和5之间，并且根据两个计算的相关值对具有权重的帧2和4的BPF输出信号进行加权平均，从而产生3D彩色相位失真校正颜色信号N和载波色度信号提取对帧3的BPF输出信号进行相加/减法的单元，以及3D彩色相位失真校正颜色信号，从而提取载波色度信号，以便对与之前和之后的行不同的行进行正确的U / V分离在同一帧。

37. 发明授权

US07445793B2 Support for tissue regeneration and process for producing the same 有权
标题翻译：支持组织再生和生产过程
公开(公告)号：US07445793B2
公开(公告)日：2008-11-04
申请号：US10527075
申请日：2003-09-09
申请人： Hideo Niwa , Takeshi Fukuchi , Ichiro Shimizu , Masao Sato , Akiko Nishi , Kenji Yamashita , Tadashi Kaneko , Hajime Ohgushi , Koji Hattori , Kota Uematsu
发明人： Hideo Niwa , Takeshi Fukuchi , Ichiro Shimizu , Masao Sato , Akiko Nishi , Kenji Yamashita , Tadashi Kaneko , Hajime Ohgushi , Koji Hattori , Kota Uematsu
IPC分类号： A61F2/02 , A61F2/00 , A61F2/28 , A61K9/14 , A61K48/00
CPC分类号： A61L27/3895 , A61L27/3852 , A61L27/56 , A61L2430/06 , C12N5/0068 , C12N5/0655 , C12N2533/40
摘要： The present invention provides a scaffold in which cells can be stably retained and grafted in a uniform distribution state in the culture, preferable proliferation ability and viability can be secured, and particularly in the case of cartilage, fixation treatment such as suture can be carried out in the transplantation into affected parts after the culture, and the mechanical strength is provided sustainable for (weighted) compression at the initial stage of transplantation.The present invention relates to a 3-dimensional porous scaffold for tissue regeneration which comprises a structure composed of vertically long-shaped pores having a pore diameter of not less than 10 μm to not more than 500 μm and pore length of not less than 20 μm to not more than 1 cm being juxtaposedly arranged obtained by a production process comprising rapid freeze-drying as a key technology. Further, the invention relates to the above 3-dimensional porous scaffold in which seeding properties of cells are improved by a pore enlargement treatment of one side face by a separation operation, a salt elution operation of a surface part, or a combination of these operations. It becomes possible to produce a 3-dimensional cell combination having excellent degree of tissue formation and medical treatment effect by seeding a cell or precursor cell derived from a tissue in this scaffold, and culturing them in an artificial environment and/or the living body.
摘要翻译：本发明提供了一种支架，其中细胞可以在培养物中以均匀的分布状态稳定地保持和接枝，可以确保优选的增殖能力和活力，特别是在软骨的情况下，可以进行诸如缝合的定影处理在培养后移植到受影响的部位，并且在移植的初始阶段提供可持续的（加权）压缩的机械强度。本发明涉及用于组织再生的三维多孔支架，其包括由垂直长孔形成的结构，其孔径不小于10μm至不大于500μm，孔长度不小于20μm 通过包括快速冷冻干燥作为关键技术的生产方法并排布置而不超过1cm。此外，本发明涉及上述三维多孔支架，其中通过分离操作，表面部分的盐洗脱操作或这些操作的组合，通过单侧面的孔扩大处理来提高细胞的接种性能。可以通过将来自该支架中的组织的细胞或前体细胞接种，并在人造环境和/或生物体中进行培养，来生产具有优异的组织形成程度和医疗效果的3维细胞组合。

38. 发明申请

US20060127368A1 Support for tissue regeneration and process for producing the same 有权
标题翻译：支持组织再生和生产过程
公开(公告)号：US20060127368A1
公开(公告)日：2006-06-15
申请号：US10527075
申请日：2003-09-09
申请人： Hideo Niwa , Takeshi Fukuchi , Ichiro Shimizu , Masao Sato , Akiko Nishi , Kenji Yamashita , Tadashi Kaneko , Hajime Ohgushi , Koji Hattori , Kota Uematsu
发明人： Hideo Niwa , Takeshi Fukuchi , Ichiro Shimizu , Masao Sato , Akiko Nishi , Kenji Yamashita , Tadashi Kaneko , Hajime Ohgushi , Koji Hattori , Kota Uematsu
IPC分类号： A61K35/12 , C12N5/00
CPC分类号： A61L27/3895 , A61L27/3852 , A61L27/56 , A61L2430/06 , C12N5/0068 , C12N5/0655 , C12N2533/40
摘要： The present invention provides a scaffold in which cells can be stably retained and grafted in a uniform distribution state in the culture, preferable proliferation ability and viability can be secured, and particularly in the case of cartilage, fixation treatment such as suture can be carried out in the transplantation into affected parts after the culture, and the mechanical strength is provided sustainable for (weighted) compression at the initial stage of transplantation. The present invention relates to a 3-dimensional porous scaffold for tissue regeneration which comprises a structure composed of vertically long-shaped pores having a pore diameter of not less than 10 μm to not more than 500 μm and pore length of not less than 20 μm to not more than 1 cm being juxtaposedly arranged obtained by a production process comprising rapid freeze-drying as a key technology. Further, the invention relates to the above 3-dimensional porous scaffold in which seeding properties of cells are improved by a pore enlargement treatment of one side face by a separation operation, a salt elution operation of a surface part, or a combination of these operations. It becomes possible to produce a 3-dimensional cell combination having excellent degree of tissue formation and medical treatment effect by seeding a cell or precursor cell derived from a tissue in this scaffold, and culturing them in an artificial environment and/or the living body.
摘要翻译：本发明提供了一种支架，其中细胞可以在培养物中以均匀的分布状态稳定地保持和接枝，可以确保优选的增殖能力和活力，特别是在软骨的情况下，可以进行诸如缝合的定影处理在培养后移植到受影响的部位，并且在移植的初始阶段提供可持续的（加权）压缩的机械强度。本发明涉及用于组织再生的三维多孔支架，其包括由垂直长孔形成的结构，其孔径不小于10μm至不大于500μm，孔长度不小于20μm 通过包括快速冷冻干燥作为关键技术的生产方法并排布置而不超过1cm。此外，本发明涉及上述三维多孔支架，其中通过分离操作，表面部分的盐洗脱操作或这些操作的组合，通过单侧面的孔扩大处理来提高细胞的接种性能。可以通过将来自该支架中的组织的细胞或前体细胞接种，并在人造环境和/或生物体中进行培养，来生产具有优异的组织形成程度和医疗效果的3维细胞组合。

39. 发明申请

US20060057645A1 Novel genes 审中-公开
标题翻译：新基因
公开(公告)号：US20060057645A1
公开(公告)日：2006-03-16
申请号：US10507876
申请日：2003-03-06
申请人： Hideo Niwa , Kenji Yamashita
发明人： Hideo Niwa , Kenji Yamashita
IPC分类号： G01N33/567 , C07H21/04 , C12N5/08 , C07K16/26
CPC分类号： C12Q1/6883 , C07K14/47
摘要： The object of the present invention is to detect and select insulin-producing cells capable of proliferating, and further to differentiate/proliferate insulin-producing cells and precursory thereof, or cells related thereto. The present invention was made by finding three species of novel genes by detecting genes specifically expressed in pancreases of PHHI patients which are regarded as a model of spontaneous proliferation of pancreatic β cells, and searching for base sequence data bases. According to the present invention, proliferating insulin-producing cells can be detected using these genes, gene products or gene sequences by, for example, Northern analysis or RT-PCR. Furthermore, these genes can be differentiated into insulin-producing cells by introducing these genes into appropriate cells in genetic engineering manner.
摘要翻译：本发明的目的是检测和选择能够增殖的胰岛素生成细胞，并且进一步分化/增殖胰岛素产生细胞及其前体，或与其相关的细胞。本发明是通过检测被认为是胰腺β细胞自发增殖的模型，以及寻找碱基序列数据库的PHHI患者胰腺特异性表达的基因来发现三种新型基因。根据本发明，通过例如Northern分析或RT-PCR，可以使用这些基因，基因产物或基因序列检测增殖性胰岛素生成细胞。此外，这些基因可以通过将这些基因以遗传工程方式引入合适的细胞中而分化成胰岛素生成细胞。

40. 发明授权

US4773810A Automatic transport system for green tires between forming and vulcanizing processes 失效
标题翻译：生产轮胎在成型和硫化工艺之间的自动运输系统
公开(公告)号：US4773810A
公开(公告)日：1988-09-27
申请号：US39262
申请日：1987-04-17
申请人： Seiichiro Nishimura , Toshifumi Hata , Kenji Yamashita
发明人： Seiichiro Nishimura , Toshifumi Hata , Kenji Yamashita
IPC分类号： B29C33/02 , B29C33/44 , B29D30/00 , B65G1/00 , B65G37/00 , B65G1/10
CPC分类号： B29D30/0016 , B29D30/005 , B29D2030/0022 , B29D2030/0055 , B29D2030/0651 , Y10S414/121 , Y10S414/124
摘要： An automatic transport system for green tires between a forming process and a vulcanizing process in a tire manufacturing installing in which different kinds of tires are manufactured through a forming process of making use of a plurality of forming machines and a subsequent vulcanizing process making use of a plurality of vulcanizing machines. The automatic transport system comprises pallets each adapted to be charged with four or more formed green tires and to be used for transporting them as one unit. A temporary storage is interposed between a forming machine group and a vulcanizing machine group for temporarily storing the pallets at predetermined locations. Forming side unmanned transport trucks circulate between the forming machine group and the temporary storage with the pallet loaded thereon. Vulcanizing side unmanned transport trucks circulate between the temporary storage and the vulcanizing machine group with the pallet loaded thereon. Associated with the respective forming machines, a device places green tires into the pallet and loads the pallet onto the forming side unmanned transport truck. Associated with the respective vulcanizing machines, a device unloads the pallet from the vulcanizing side unmanned transport truck and discharges green tires from the pallet. Associated with the temporary storage, a device carries a green tires from the forming side unmanned transport truck, and associated with the temporary storage another device carries green tires onto the vulcanizing side unmanned transport truck. A control system controls travel of the forming side unmanned transport truck and the vulcanizing side unmanned transport truck in response to truck demands issued form the respective forming machines and vulcanizig machines, independently of each other.
摘要翻译：一种用于轮胎制造安装中的成型工艺和硫化工序之间的生轮胎的自动运送系统，其中通过使用多个成型机的成型工艺制造不同种类的轮胎，以及随后的使用多台硫化机。自动运送系统包括各自适于装满四个或更多个成形绿色轮胎的托盘，并用于将它们作为一个单元运输。在成型机组和硫化机组之间插入临时储存器，用于在预定位置临时存放托盘。成型机无人运输卡车在成型机组和临时存放处之间循环，托盘装载在其上。硫化侧无人运输卡车在临时存储和硫化机组之间循环，托盘装载在其上。与相应的成型机相关联，设备将绿色轮胎放置到托盘中并将托盘装载到成形侧无人运输卡车上。与相应的硫化机相关联，装置从硫化侧无人运输车卸载托盘，并从托盘排出绿色轮胎。与临时储存有关的装置，从成形侧无人运输卡车携带绿色轮胎，并与临时储存器相连，另一装置将绿色轮胎装载到硫化侧无人运输车上。控制系统响应于彼此独立的相应成型机和硫化机产生的卡车需求，控制成形侧无人运输卡车和硫化侧无人运输车辆的行驶。

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