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31. 发明授权

US09868715B2 Apigenin analogs, compositions, and methods related thereto 有权
公开(公告)号：US09868715B2
公开(公告)日：2018-01-16
申请号：US15304966
申请日：2015-04-18
申请人： Jia Zhou , Mark Hellmich , Csaba Szabo
发明人： Jia Zhou , Mark Hellmich , Csaba Szabo
IPC分类号： C07D311/30 , C07D405/12 , C07D407/12
CPC分类号： C07D311/30 , C07D405/12 , C07D407/12
摘要： Certain embodiments are directed to apigenin analogues or derivatives. In certain aspects, the derivatives are developed as cystathionine-beta-synthase (CBS) inhibitors. In certain aspects, the derivatives are used as anticancer or anti-inflammatory agents. Certain embodiments are directed methods of treating or compositions used to treat fibrosis and cancers. In certain aspects one or more compounds described herein can be administered to a subject to treat pancreatic fibrosis, liver fibrosis, pancreatic cancer, colon cancer, breast cancer, brain tumors, head/neck cancer, prostate and lung cancers as well as other inflammation.

32. 发明授权

US09328125B2 Bivalent AMPA receptor positive allosteric modulators 有权
标题翻译：二价AMPA受体阳性变构调节剂
公开(公告)号：US09328125B2
公开(公告)日：2016-05-03
申请号：US14474258
申请日：2014-09-01
申请人： Jia Zhou , Haijun Chen , Kenneth M Johnson , Cheng Z Wang
发明人： Jia Zhou , Haijun Chen , Kenneth M Johnson , Cheng Z Wang
IPC分类号： C07D471/04 , C07D213/82 , C07D209/08 , C07D209/14 , C07D401/06 , C07C311/03 , C07F5/02 , C07D231/56 , C07D401/12 , C07D207/27
CPC分类号： C07F5/025 , C07C311/03 , C07D207/27 , C07D209/08 , C07D209/14 , C07D213/82 , C07D231/56 , C07D401/06 , C07D401/12 , C07D471/04
摘要： Embodiments of the invention are directed to compounds that are positive allosteric modulators of AMPA receptors.
摘要翻译：本发明的实施方案涉及作为AMPA受体的正变构调节剂的化合物。

33. 发明授权

US09183428B2 Method and device for implementing original handwriting trace, and electronic device 有权
标题翻译：用于实现原始手写痕迹的方法和装置，以及电子装置
公开(公告)号：US09183428B2
公开(公告)日：2015-11-10
申请号：US13982749
申请日：2012-01-21
申请人： Xueping Zou , Jia Zhou , Guoying Du
发明人： Xueping Zou , Jia Zhou , Guoying Du
IPC分类号： G06K9/00 , G06F3/0488 , G06T11/20
CPC分类号： G06K9/00154 , G06F3/04883 , G06K9/00416 , G06T11/203
摘要： The present invention provides a method and device for implementing original handwriting trace, and an electronic device. The method comprises: continuously sampling handwriting trace in time order, and detecting location information and the actual stroke widths at the sampling points; for every two adjacent sampling points, determining the former point as the starting sampling point, determining the latter point as the ending sampling point, using a line connecting the two points as the center line of the stroke between the two sampling points, obtaining location information of and the corresponding longitudinal stroke width at each point on the center line, and determining, according to the location information of and the corresponding longitudinal stroke width at each point on the center line, the fill gray value of each pixel in the stroke; and filling, according to the fill gray values, the corresponding pixels, and displaying the pixels. In this manner, graphic processing of the system is avoided, thereby accelerating the stylized trace processing, and bringing smooth writing experience to users.
摘要翻译：本发明提供了一种用于实现原始手写痕迹的方法和装置，以及电子装置。该方法包括：按时间顺序连续取样手写曲线，并在采样点检测位置信息和实际笔迹宽度; 对于每两个相邻采样点，将前一点确定为起始采样点，使用将两点连接作为两个采样点之间的行程的中心线的线来确定后一点作为结束采样点，获得位置信息并根据中心线各点处的位置信息和相应的纵向行程宽度确定行程中每个像素的填充灰度值; 并根据填充灰度值填充相应的像素，并显示像素。以这种方式，避免了系统的图形处理，从而加快了风格化的追踪处理，并为用户带来了流畅的写作经验。

34. 发明申请

US20070254918A1 Dopamine-, Norepinephrine- and Serotonin- Transporter-Selective Heterocyclic Compounds and Their Therapeutic Applications 失效
标题翻译：多巴胺，去甲肾上腺素和5-羟色胺转运体选择性杂环化合物及其治疗应用
公开(公告)号：US20070254918A1
公开(公告)日：2007-11-01
申请号：US10576620
申请日：2004-10-22
申请人： Alan Kozikowski , Jia Zhou
发明人： Alan Kozikowski , Jia Zhou
IPC分类号： A61K31/445 , A61P25/00 , C07D211/00
CPC分类号： C07D211/20 , C07D211/22 , C07D211/24 , C07D405/12 , C07D413/12
摘要： One aspect of the invention relates to piperidine compounds that are useful as inhibitors of monoamine transporters. The invention also relates to pharmaceutical compositions, comprising a piperidine compound of the invention. Another aspect of the present invention relates to the use of the aforementioned compounds in a method of treating a disorder of the central nervous system in a mammal.
摘要翻译：本发明的一个方面涉及可用作单胺转运蛋白抑制剂的哌啶化合物。本发明还涉及包含本发明的哌啶化合物的药物组合物。本发明的另一方面涉及上述化合物在治疗哺乳动物中的中枢神经系统病症的方法中的用途。

35. 发明授权

US10975059B2 Small molecule BRD4 modulators for HIV epigenetic regulation 有权
公开(公告)号：US10975059B2
公开(公告)日：2021-04-13
申请号：US16441748
申请日：2019-06-14
申请人： Haitao Hu , Jia Zhou , Zhiqing Liu
发明人： Haitao Hu , Jia Zhou , Zhiqing Liu
IPC分类号： C07D403/02 , C07D403/06 , A61P31/18 , C07D207/48 , C07D401/06
摘要： The invention relates generally to novel small molecule BRD4 modulators for HIV, the preparation thereof as well as the use thereof.

36. 发明申请

US20210047329A1 SUBSTITUTED 4,6-DIHYDROSPIRO[[1,2,3]TRIAZOLO[4,5-B]PYRIDINE-7,3'-INDOLINE]-2',5(3H)-DIONE ANALOGUES 有权
公开(公告)号：US20210047329A1
公开(公告)日：2021-02-18
申请号：US16938886
申请日：2020-07-24
申请人： Jia Zhou , Pei-Yong Shi , Jimin Xu , Xuping Xie
发明人： Jia Zhou , Pei-Yong Shi , Jimin Xu , Xuping Xie
IPC分类号： C07D471/20 , A61P31/14
摘要： A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3′-indoline]-2′,5(3H)-dione analogues, the use thereof and the preparation thereof.

37. 发明申请

US20140178374A1 BAX AGONIST, COMPOSITIONS, AND METHODS RELATED THERETO 有权
标题翻译： BAX AGONIST，组合物和方法相关
公开(公告)号：US20140178374A1
公开(公告)日：2014-06-26
申请号：US14239177
申请日：2012-08-17
申请人： Xingming Deng , Jia Zhou , Chunyong Ding
发明人： Xingming Deng , Jia Zhou , Chunyong Ding
IPC分类号： C07C205/35 , A61K31/44 , A61K45/06 , A61K31/085 , C07C205/25 , A61K31/05 , C07D213/64 , A61K31/4412 , C07D295/088 , A61K31/5375 , A61K31/495 , C07C217/60 , A61K31/138 , C07D211/46 , A61K31/4465 , C07D209/12 , A61K31/404 , C07D213/643
CPC分类号： A61K31/5375 , A61K31/05 , A61K31/085 , A61K31/138 , A61K31/404 , A61K31/44 , A61K31/4412 , A61K31/4465 , A61K31/495 , A61K45/06 , C07C205/11 , C07C205/25 , C07C205/35 , C07C211/52 , C07C215/88 , C07C217/20 , C07C217/26 , C07C217/60 , C07C217/94 , C07C233/18 , C07C233/25 , C07C233/80 , C07C271/16 , C07C309/65 , C07C311/21 , C07C2601/02 , C07C2603/18 , C07D209/10 , C07D209/12 , C07D211/46 , C07D213/61 , C07D213/64 , C07D213/643 , C07D213/73 , C07D213/74 , C07D295/088 , C07D295/185 , C07D295/26
摘要： The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.
摘要翻译：本公开涉及BAX活化剂和治疗用途。在某些实施方案中，本公开涉及治疗或预防癌症（例如肺癌）的方法，包括向有需要的受试者施用治疗有效量的包含本文公开的化合物或药学上可接受的盐的药物组合物。

38. 发明申请

US20130308863A1 METHOD AND DEVICE FOR IMPLEMENTING ORIGINAL HANDWRITING, AND ELECTRONIC DEVICE 有权
标题翻译：用于实施原始手写的方法和装置，以及电子装置
公开(公告)号：US20130308863A1
公开(公告)日：2013-11-21
申请号：US13982749
申请日：2012-01-21
申请人： Xueping Zou , Jia Zhou , Guoying Du
发明人： Xueping Zou , Jia Zhou , Guoying Du
IPC分类号： G06K9/00
CPC分类号： G06K9/00154 , G06F3/04883 , G06K9/00416 , G06T11/203
摘要： The present invention provides a method and device for implementing original handwriting trace, and an electronic device. The method comprises: continuously sampling handwriting trace in time order, and detecting location information and the actual stroke widths at the sampling points; for every two adjacent sampling points, determining the former point as the starting sampling point, determining the latter point as the ending sampling point, using a line connecting the two points as the center line of the stroke between the two sampling points, obtaining location information of and the corresponding longitudinal stroke width at each point on the center line, and determining, according to the location information of and the corresponding longitudinal stroke width at each point on the center line, the fill gray value of each pixel in the stroke; and filling, according to the fill gray values, the corresponding pixels, and displaying the pixels. In this manner, graphic processing of the system is avoided, thereby accelerating the stylized trace processing, and bringing smooth writing experience to users.
摘要翻译：本发明提供了一种用于实现原始手写痕迹的方法和装置，以及电子装置。该方法包括：按时间顺序连续取样手写曲线，并在采样点检测位置信息和实际笔迹宽度; 对于每两个相邻采样点，将前一点确定为起始采样点，使用将两点连接作为两个采样点之间的行程的中心线的线来确定后一点作为结束采样点，获得位置信息并根据中心线各点处的位置信息和相应的纵向行程宽度确定行程中每个像素的填充灰度值; 并根据填充灰度值填充相应的像素，并显示像素。以这种方式，避免了系统的图形处理，从而加快了风格化的追踪处理，并为用户带来了流畅的写作经验。

39. 发明申请

US20130268556A1 SYSTEM AND METHOD FOR RECORDING AND QUERYING ORIGINAL HANDWRITING AND ELECTRONIC DEVICE 审中-公开
标题翻译：用于记录和查询原始手写和电子设备的系统和方法
公开(公告)号：US20130268556A1
公开(公告)日：2013-10-10
申请号：US13994734
申请日：2011-12-15
申请人： Shuqing Han , Jia Zhou , Guoving Du
发明人： Shuqing Han , Jia Zhou , Guoving Du
IPC分类号： G06F17/30
CPC分类号： G06F16/245 , G06F16/5846
摘要： Disclosed are a system and method for recording and querying an original handwriting trace and an electronic device. The system comprises: an input module for inputting record information and query information; a matching module for obtaining title information consisting of standard characters matching with inputted title information of original handwriting trace, and storing content information of original handwriting trace corresponding to the title information consisting of standard characters; a storage module, comprising a storage area for title information consisting of standard characters and a storage area for content information of original handwriting trace; a query module for querying title information consisting of standard characters according to the inputted query information, and obtaining content information of original handwriting trace corresponding to the title information consisting of standard characters; a display module for displaying content information of original handwriting trace; and a main control module for coordinating and controlling the above modules.
摘要翻译：公开了用于记录和查询原始手写痕迹和电子设备的系统和方法。该系统包括：用于输入记录信息和查询信息的输入模块; 匹配模块，用于获得由与原始手写痕迹的输入标题信息匹配的标准字符组成的标题信息，以及存储与由标准字符组成的标题信息相对应的原始手写痕迹的内容信息; 存储模块，包括用于由标准字符组成的标题信息的存储区域和用于原始手写痕迹的内容信息的存储区域; 查询模块，用于根据输入的查询信息查询由标准字符组成的标题信息，以及获取与由标准字符组成的标题信息相对应的原始手写痕迹的内容信息; 用于显示原始手写痕迹的内容信息的显示模块; 以及用于协调和控制上述模块的主控模块。

40. 发明授权

US08153657B2 Dopamine-, norepinephrine- and serotonin-transporter-selective heterocyclic compounds and their therapeutic applications 失效
标题翻译：多巴胺，去甲肾上腺素和5-羟色胺转运体选择性杂环化合物及其治疗应用
公开(公告)号：US08153657B2
公开(公告)日：2012-04-10
申请号：US10576620
申请日：2004-10-22
申请人： Alan P. Kozikowski , Jia Zhou
发明人： Alan P. Kozikowski , Jia Zhou
IPC分类号： A61K31/445 , C07D211/54
CPC分类号： C07D211/20 , C07D211/22 , C07D211/24 , C07D405/12 , C07D413/12
摘要： One aspect of the invention relates to piperidine compounds that are useful as inhibitors of monoamine transporters. The invention also relates to pharmaceutical compositions, comprising a piperidine compound of the invention. Another aspect of the present invention relates to the use of the aforementioned compounds in a method of treating a disorder of the central nervous system in a mammal.
摘要翻译：本发明的一个方面涉及可用作单胺转运蛋白抑制剂的哌啶化合物。本发明还涉及包含本发明的哌啶化合物的药物组合物。本发明的另一方面涉及上述化合物在治疗哺乳动物中的中枢神经系统病症的方法中的用途。

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