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31. 发明申请

US20050090469A1 Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease 有权
标题翻译：类胡萝卜素类似物或衍生物用于抑制和改善肝脏疾病
公开(公告)号：US20050090469A1
公开(公告)日：2005-04-28
申请号：US10793660
申请日：2004-03-04
申请人： Samuel Lockwood , Sean O'Malley , David Watumull , Laura Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Lockwood , Sean O'Malley , David Watumull , Laura Hix , Henry Jackson , Geoff Nadolski
IPC分类号： A01N27/00 , A61K31/01 , A61K31/015 , A61K31/045 , A61K31/07 , A61K31/075 , A61K31/12 , A61K31/13 , A61K31/185 , A61K31/215 , A61K31/225 , A61K31/255 , A61K31/325 , A61K31/401 , A61K31/404 , A61K31/4172 , A61K31/535 , A61K31/537 , A61K31/66 , A61K31/665 , A61K31/70 , A61K31/704 , A61K31/715 , C07D207/16 , C07D233/60 , C07D265/30 , C07D307/58 , C07F9/02 , C07F9/117 , C07H13/04
CPC分类号： C07D207/16 , C07C403/24 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method of treating liver disease in a subject may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. In some embodiments, a cyclic ring of a carotenoid analog or derivative may include at least one substituent. The substituent may be coupled to the cyclic ring with an ester functionality.
摘要翻译：在受试者中治疗肝脏疾病的方法可包括向受试者施用有效量的药学上可接受的制剂。药学上可接受的制剂可以包括类胡萝卜素的合成类似物或衍生物。受试者可以单独给予类胡萝卜素类似物或衍生物，或与另一种类胡萝卜素类似物或衍生物或共抗氧化剂制剂一起施用。类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。共轭多烯可以包括包含至少一个取代基的环状环。在一些实施方案中，类胡萝卜素类似物或衍生物的环状环可包括至少一个取代基。取代基可以用酯官能团偶联到环上。

32. 发明申请

US20050059659A1 Carotenoid analogs or derivatives for controlling C-reactive protein levels 审中-公开
标题翻译：用于控制C反应蛋白水平的类胡萝卜素类似物或衍生物
公开(公告)号：US20050059659A1
公开(公告)日：2005-03-17
申请号：US10793685
申请日：2004-03-04
申请人： Samuel Lockwood , Sean O'Malley , David Watumull , Laura Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Lockwood , Sean O'Malley , David Watumull , Laura Hix , Henry Jackson , Geoff Nadolski
IPC分类号： A01N27/00 , A61K31/01 , A61K31/015 , A61K31/045 , A61K31/07 , A61K31/075 , A61K31/12 , A61K31/13 , A61K31/185 , A61K31/215 , A61K31/225 , A61K31/255 , A61K31/325 , A61K31/401 , A61K31/404 , A61K31/4172 , A61K31/535 , A61K31/537 , A61K31/66 , A61K31/665 , A61K31/70 , A61K31/704 , A61K31/715 , C07D207/16 , C07D233/60 , C07D265/30 , C07D307/58 , C07F9/02 , C07F9/117 , C07H13/04
CPC分类号： C07D207/16 , C07C403/24 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method of controlling (e.g., influencing or affecting) C-reactive protein levels in a subject may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include an acyclic alkene including at least one substituent and/or a cyclic ring including at least one substituent. In some embodiments, a carotenoid analog or derivative may include at least one substituent.
摘要翻译：在受试者中控制（例如影响或影响）C反应蛋白水平的方法可包括向受试者施用有效量的药学上可接受的制剂。药学上可接受的制剂可以包括类胡萝卜素的合成类似物或衍生物。受试者可以单独给予类胡萝卜素类似物或衍生物，或与另一种类胡萝卜素类似物或衍生物或共抗氧化剂制剂一起施用。类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。共轭多烯可以包括包含至少一个取代基的无环烯烃和/或包含至少一个取代基的环状环。在一些实施方案中，类胡萝卜素类似物或衍生物可包括至少一个取代基。

33. 发明申请

US20050059635A1 Carotenoid ester analogs or derivatives for controlling C-reactive protein levels 审中-公开
标题翻译：用于控制C反应蛋白水平的类胡萝卜素酯类似物或衍生物
公开(公告)号：US20050059635A1
公开(公告)日：2005-03-17
申请号：US10793691
申请日：2004-03-04
申请人： Samuel Lockwood , Sean O'Malley , David Watumull , Laura Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Lockwood , Sean O'Malley , David Watumull , Laura Hix , Henry Jackson , Geoff Nadolski
IPC分类号： A01N27/00 , A61K31/01 , A61K31/015 , A61K31/045 , A61K31/07 , A61K31/075 , A61K31/12 , A61K31/13 , A61K31/185 , A61K31/215 , A61K31/225 , A61K31/255 , A61K31/325 , A61K31/401 , A61K31/404 , A61K31/4172 , A61K31/535 , A61K31/537 , A61K31/66 , A61K31/665 , A61K31/70 , A61K31/704 , A61K31/715 , C07D207/16 , C07D233/60 , C07D265/30 , C07D307/58 , C07F9/02 , C07F9/117 , C07H13/04
CPC分类号： C07D207/16 , C07C403/24 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method of controlling (e.g., influencing or affecting) C-reactive protein levels in a subject may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. In some embodiments, a cyclic ring of a carotenoid analog or derivative may include at least one substituent. The substituent may be coupled to the cyclic ring with an ester functionality.
摘要翻译：在受试者中控制（例如影响或影响）C反应蛋白水平的方法可包括向受试者施用有效量的药学上可接受的制剂。药学上可接受的制剂可以包括类胡萝卜素的合成类似物或衍生物。受试者可以单独给予类胡萝卜素类似物或衍生物，或与另一种类胡萝卜素类似物或衍生物或共抗氧化剂制剂一起施用。类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。共轭多烯可以包括包含至少一个取代基的环状环。在一些实施方案中，类胡萝卜素类似物或衍生物的环状环可包括至少一个取代基。取代基可以用酯官能团偶联到环上。

34. 发明申请

US20060270589A1 Carotenoids, carotenoid analogs, or carotenoid derivatives for the treatment of visual disabilities 审中-公开
标题翻译：类胡萝卜素，类胡萝卜素类似物或类胡萝卜素衍生物用于治疗视力障碍
公开(公告)号：US20060270589A1
公开(公告)日：2006-11-30
申请号：US11359984
申请日：2006-02-22
申请人： Samuel Lockwood , Geoff Nadolski
发明人： Samuel Lockwood , Geoff Nadolski
IPC分类号： A61K38/16 , A61K31/7034 , A61K31/66 , A61K31/185 , A61K31/12 , A61K31/015
CPC分类号： A61K31/015 , A61K31/12 , A61K31/185 , A61K31/66 , A61K31/7034 , A61K2300/00
摘要： A method and system used for treating visual disabilities using carotenoids, carotenoid analogs, and/or carotenoid derivatives. The analog, derivative, or intermediate may be administered such that a subject's risk of experiencing diseases associated with visual disabilities may be thereby reduced. Analogs or derivatives of carotenoids may include substituents including for example co-antioxidants (e.g., Vitamin C and Vitamin C analogs). The carotenoid analog or derivative may be synthetic. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include an acyclic alkene including at least one substituent and/or a cyclic ring including at least one substituent. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.
摘要翻译：用于使用类胡萝卜素，类胡萝卜素类似物和/或类胡萝卜素衍生物治疗视觉障碍的方法和系统。可以给予类似物，衍生物或中间体，使得受试者可能因此降低与视力障碍相关的疾病的风险。类胡萝卜素的类似物或衍生物可以包括取代基，例如共抗氧化剂（例如维生素C和维生素C类似物）。类胡萝卜素类似物或衍生物可以是合成的。类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。共轭多烯可以包括包含至少一个取代基的无环烯烃和/或包含至少一个取代基的环状环。在一些实施方案中，类胡萝卜素类似物或衍生物可包括至少一个取代基。取代基可以增强类胡萝卜素类似物或衍生物的溶解度，使得类胡萝卜素类似物或衍生物至少部分地溶解在水中。

35. 发明申请

US20060270590A1 Reduction in complement activation and inflammation during tissue injury by carotenoids, carotenoid analogs, or derivatives thereof 审中-公开
公开(公告)号：US20060270590A1
公开(公告)日：2006-11-30
申请号：US11392470
申请日：2006-03-29
申请人： Samuel Lockwood , Geoff Nadolski
发明人： Samuel Lockwood , Geoff Nadolski
IPC分类号： A61K38/16 , A61K31/7034 , A61K31/573 , A61K31/192 , A61K31/185 , A61K31/195
CPC分类号： A61K31/225 , A61K31/192 , A61K31/195 , A61K31/341 , A61K31/573 , A61K31/6615 , A61K31/7034 , A61K38/16 , A61K45/06
摘要： Administering water-soluble or dispersible synthetic analogs or derivatives of astaxanthin, lutein, zeaxanthin, or lycophyll and/or other carotenoids to a subject may reduce some of the adverse effects of inflammation in a body organ or tissue. The analogs or derivatives may be incorporated into pharmaceutical, over-the-counter, or nutraceutical preparations. Administration of the analogs or derivatives described herein may reduce deposition of inflammatory mediators such as C-reactive protein, complement system proteins or the membrane attack complex (MAC) in tissues. Reduced deposition of these molecules in tissues may reduce cell damage and/or lysis in the tissues.

36. 发明申请

US20070015735A1 Water-dispersible carotenoids, including analogs and derivatives 审中-公开
标题翻译：水分散类胡萝卜素，包括类似物和衍生物
公开(公告)号：US20070015735A1
公开(公告)日：2007-01-18
申请号：US11388237
申请日：2006-03-23
申请人： Samuel Lockwood , Geoff Nadolski
发明人： Samuel Lockwood , Geoff Nadolski
IPC分类号： A61K31/665 , A61K31/12 , A61K31/07 , C07F9/655
CPC分类号： C07D295/205 , A61K31/07 , A61K31/12 , A61K31/225 , A61K31/6615 , A61K31/665 , C07C403/24 , C07D307/62 , C07F9/117 , C07F9/65515
摘要： A method used for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The analog, derivative, or intermediate may be administered such that a subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. The carotenoid analog or derivative may be synthetic. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.
摘要翻译：用于合成用于合成类胡萝卜素合成中间体，类胡萝卜素类似物和/或类胡萝卜素衍生物的中间体的方法。可以施用类似物，衍生物或中间体，使得受试者可能因此减少经历与活性氧物质，活性氮物质，自由基和/或非自由基相关的疾病的风险。类似物或模拟组合可以施用于受试者以抑制和/或改善涉及产生活性氧，活性氮物质，自由基和/或非自由基的任何疾病。在一些实施方案中，本发明可以包括合成包括类胡萝卜素类似物或衍生物的化合物的方法。类胡萝卜素类似物或衍生物可以是合成的。在一些实施方案中，类胡萝卜素类似物或衍生物可包括至少一个取代基。取代基可以增强类胡萝卜素类似物或衍生物的溶解度，使得类胡萝卜素类似物或衍生物至少部分地溶解在水中。

37. 发明授权

US07763649B2 Carotenoid analogs or derivatives for controlling connexin 43 expression 有权
标题翻译：用于控制连接蛋白43表达的类胡萝卜素类似物或衍生物
公开(公告)号：US07763649B2
公开(公告)日：2010-07-27
申请号：US10793686
申请日：2004-03-04
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： A61K31/34 , A61K31/35 , A61K31/335
CPC分类号： C07D207/16 , C07C403/24 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method of controlling (e.g., influencing or affecting) connexin 43 expression in a subject may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. In some embodiments, controlling connexin 43 expression in a subject may effectively treat cardiac arrhythmia and/or cancerous and pre-cancerous cells in a subject. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include an acyclic alkene including at least one substituent and/or a cyclic ring including at least one substituent. In some embodiments, a carotenoid analog or derivative may include at least one substituent.
摘要翻译：在受试者中控制（例如影响或影响）连接蛋白43表达的方法可包括向受试者施用有效量的药学上可接受的制剂。在一些实施方案中，控制受试者中连接蛋白43的表达可以有效地治疗受试者的心律失常和/或癌前和癌前细胞。药学上可接受的制剂可以包括类胡萝卜素的合成类似物或衍生物。受试者可以单独给予类胡萝卜素类似物或衍生物，或与另一种类胡萝卜素类似物或衍生物或共抗氧化剂制剂一起施用。类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。共轭多烯可以包括包含至少一个取代基的无环烯烃和/或包含至少一个取代基的环状环。在一些实施方案中，类胡萝卜素类似物或衍生物可包括至少一个取代基。

38. 发明授权

US07320997B2 Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease 有权
标题翻译：药物组合物，包括用于抑制和改善疾病的类胡萝卜素酯类似物或衍生物
公开(公告)号：US07320997B2
公开(公告)日：2008-01-22
申请号：US10793692
申请日：2004-03-04
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： A61K31/341
CPC分类号： C07D207/16 , C07C403/24 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The analog or derivative is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. In some embodiments, the invention may include a pharmaceutical composition including a carotenoid analog or derivative. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. The substituent may be coupled to the cyclic ring with an ester functionality. The pharmaceutical composition may be adapted to be administered to a human subject.
摘要翻译：用于抑制和/或改善与受试者相关的疾病的发生的方法，其中受试者单独或与另一种组合施用类胡萝卜素类似物或衍生物，受试者中的活性氧，活性氮物质，自由基和/或非自由基类胡萝卜素类似物或衍生物，或共抗氧化剂制剂。施用类似物或衍生物，使得受试者可能因此减少与活性氧，活性氮物质，自由基和/或非自由基相关的疾病的风险。在一些实施方案中，本发明可以包括包含类胡萝卜素类似物或衍生物的药物组合物。类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。共轭多烯可以包括包含至少一个取代基的环状环。取代基可以用酯官能团偶联到环上。药物组合物可以适于施用于人受试者。

39. 发明授权

US07145025B2 Structural carotenoid analogs for the inhibition and amelioration of disease 有权
标题翻译：结构类胡萝卜素类似物用于抑制和改善疾病
公开(公告)号：US07145025B2
公开(公告)日：2006-12-05
申请号：US10629538
申请日：2003-07-29
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： A61K31/341
CPC分类号： C07C403/24 , C07D207/16 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid structural analog, either alone or in combination with another carotenoid analog, or co-antioxidant formulation. The analog or analog combination is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of ischemia-reperfusion injury, liver disease, cancer, cardiac arrhythmia and/or sudden cardiac death, and/or any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In one embodiment, a water-soluble and/or water-dispersible astaxanthin analog is particularly effective. This invention further includes pharmaceutical compositions comprising structural carotenoid analogs either alone or in combination.
摘要翻译：用于抑制和/或改善与受试者相关的疾病的发生的方法，其中受试者单独或与另一种类胡萝卜素组合施用类胡萝卜素结构类似物，受试者中的活性氧，活性氮物质，自由基和/或非自由基类似物或辅助抗氧化剂制剂。给予类似物或模拟组合，使得受试者可能因此减少与活性氧，活性氮物质，自由基和/或非自由基相关的疾病的风险。类似物或类似物组合可以施用于受试者以抑制和/或改善缺血再灌注损伤，肝脏疾病，癌症，心律失常和/或心脏猝死，和/或涉及产生活性氧的任何疾病，活性氮物质，自由基和/或非自由基。在一个实施方案中，水溶性和/或水分散性虾青素类似物是特别有效的。本发明还包括单独或组合包含结构类胡萝卜素类似物的药物组合物。

40. 发明授权

US07723327B2 Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease 有权
标题翻译：类胡萝卜素类似物或衍生物用于抑制和改善肝脏疾病
公开(公告)号：US07723327B2
公开(公告)日：2010-05-25
申请号：US10793660
申请日：2004-03-04
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： A61K31/34 , A61K31/40 , A61K31/53
CPC分类号： C07D207/16 , C07C403/24 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method of treating liver disease in a subject may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. In some embodiments, a cyclic ring of a carotenoid analog or derivative may include at least one substituent. The substituent may be coupled to the cyclic ring with an ester functionality.
摘要翻译：在受试者中治疗肝脏疾病的方法可包括向受试者施用有效量的药学上可接受的制剂。药学上可接受的制剂可以包括类胡萝卜素的合成类似物或衍生物。受试者可以单独给予类胡萝卜素类似物或衍生物，或与另一种类胡萝卜素类似物或衍生物或共抗氧化剂制剂一起施用。类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。共轭多烯可以包括包含至少一个取代基的环状环。在一些实施方案中，类胡萝卜素类似物或衍生物的环状环可包括至少一个取代基。取代基可以用酯官能团偶联到环上。

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