专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20100066996A1 Sample analyzer 有权
标题翻译：样品分析仪
公开(公告)号：US20100066996A1
公开(公告)日：2010-03-18
申请号：US12462118
申请日：2009-07-28
申请人： Tokihiro Kosaka , Koichi Okubo
发明人： Tokihiro Kosaka , Koichi Okubo
IPC分类号： G01N1/00 , G01N33/48 , G01N21/00
CPC分类号： G01N35/00584 , G01F23/292 , G01N35/1016
摘要： The present invention is to present a sample analyzer, comprising: an imaging device for imaging a sample container which has translucency and contains a sample; a measuring device for aspirating the sample contained in the sample container and measuring the aspirated sample; a transporting device for transporting the sample container to a supply position for supplying the sample contained in the sample container to the measuring device; a sample volume obtainer for obtaining sample volume information relating to volume of the sample in the sample container, based on an image obtained by imaging the sample container by the imaging device; and a transport controller for controlling the transporting device to perform a transport operation in accordance with the sample volume information obtained by the sample volume obtainer.
摘要翻译：本发明提供一种样本分析仪，其包括：成像装置，用于对具有半透明性并包含样品的样品容器进行成像; 用于抽吸容纳在样品容器中的样品并测量抽吸样品的测量装置; 用于将样本容器运送到用于将容纳在样本容器中的样本供给到测量装置的供给位置的运送装置; 基于通过由成像装置对样本容器进行成像而获得的图像的样本体积获取器，用于获取与样本容器中的样本体积相关的样本体积信息; 以及传送控制器，用于根据由样本体积获取器获得的样本体积信息来控制传送装置执行传送操作。

32. 发明授权

US07589892B2 Specimen imaging apparatus and specimen analyzer 有权
标题翻译：标本成像仪和标本分析仪
公开(公告)号：US07589892B2
公开(公告)日：2009-09-15
申请号：US11644603
申请日：2006-12-22
申请人： Ryuichi Tohma , Tokihiro Kosaka
发明人： Ryuichi Tohma , Tokihiro Kosaka
IPC分类号： G02B21/00
CPC分类号： G02B21/365 , G02B21/244
摘要： A specimen imaging apparatus is provided that is capable of improved high-speed operation compared to conventional apparatuses. The specimen imaging apparatus is provided with a microscope for enlarging the image of a specimen, and taking the enlarged image of the specimen obtained by the microscope. The apparatus is provided with a vibration detector for detecting a relative vibration between the objective lens of the microscope and the specimen mounted in the microscope, a focuser for focusing before the vibration detected by the vibration detector has attenuated to less than a predetermined value, and a controller for determining whether or not a vibration detected by the vibration detector is less than a predetermined value. The specimen imaging apparatus is configured so as to take the enlarged image of a specimen when the controller has determined that the vibration is less than a predetermined value.
摘要翻译：提供了与常规装置相比能够改进高速操作的标本成像装置。标本成像装置设置有用于放大样本图像的显微镜，并且获取通过显微镜获得的样本的放大图像。该装置设置有用于检测显微镜的物镜与安装在显微镜中的样本之间的相对振动的振动检测器，用于在由振动检测器检测到的振动被衰减到小于预定值之前聚焦的聚焦器，以及用于确定由所述振动检测器检测到的振动是否小于预定值的控制器。试样成像装置被配置为当控制器确定振动小于预定值时，取样本的放大图像。

33. 再颁专利

USRE35868E Apparatus for imaging particles in a liquid flow 失效
标题翻译：用于在液体流中成像颗粒的装置
公开(公告)号：USRE35868E
公开(公告)日：1998-08-11
申请号：US565580
申请日：1995-11-30
申请人： Tokihiro Kosaka
发明人： Tokihiro Kosaka
IPC分类号： G01J1/44 , G01N15/14 , G01N21/17 , G01N33/49 , G01N15/06
CPC分类号： G01N15/1427 , G01N15/1459 , G01N15/1463 , G01J2001/4493 , G01N2015/1465 , G01N2015/1477
摘要： An apparatus for imaging and analyzing particle components in a sample liquid flow containing particle components such as blood and urine, or fine particles of organic high polymer in suspension or the like. A conventional particle imaging flow cytometer is combined with a light source such as a lamp with small coherence, and an image intensifier with gate function of high response, so that a clear particle image without a deflection or interference fringe is obtained. Thus, in the apparatus having the still imaging function, by using the image intensifier with a high speed gate function, even with a light source of a long luminous time such as a lamp, a clear still image of a particle flowing at high speed is obtained.
摘要翻译：用于成像和分析含有血液和尿液等微粒成分的样品液体流中的微粒成分或悬浮液等中的有机高聚物微粒的装置。常规的颗粒成像流式细胞仪与诸如具有小相干性的灯的光源和具有高响应的门功能的图像增强器组合，从而获得没有偏转或干涉条纹的清晰的颗粒图像。因此，在具有静止成像功能的装置中，通过使用具有高速门功能的图像增强器，即使使用诸如灯的长发光时间的光源，高速流动的颗粒的清晰静止图像是获得。

34. 发明授权

US5548395A Particle analyzer 失效
标题翻译：粒子分析仪
公开(公告)号：US5548395A
公开(公告)日：1996-08-20
申请号：US937340
申请日：1992-08-31
申请人： Tokihiro Kosaka
发明人： Tokihiro Kosaka
IPC分类号： G01N15/02 , G01N15/14 , G01N21/05 , G01N21/23
CPC分类号： G01N15/147 , G01N15/1475 , G01N15/1434 , G01N2015/1497 , G01N2021/058
摘要： A particle analyzer comprising a one-dimensional image sensor for producing imaging signals by scanning a particle in a flow of specimen containing particle components such as blood and urine in a flat sheath flow thin in thickness in the light emitting direction and broad in the direction orthogonal to the light emitting direction, and a signal processing device for processing the signals and operating on the basis of the imaging signals from the one-dimensional image sensor. A particle analyzer excellent in analyzing capability for obtaining morphological information of particles in the liquid specimen flowing in a flow cell in real time is presented. Besides, by emitting light to a flowing particle, the transmitted light image is focused on the one-dimensional image sensor (line sensor), and the detected image signal from the line sensor is further processed in detail in the signal processing device. The signal processing device comprises a background correction processing circuit, a binarizing processing circuit, a binary signal processing circuit, a particle region division processing circuit and an arithmetic circuit. A particle analyzer high in analyzing capability for obtaining the absorption quantity and morphological information of individual particles in the liquid specimen flowing in a flow cell in real time is presented.
摘要翻译：一种粒子分析仪，包括一维图像传感器，用于通过在包含诸如血液和尿液的颗粒组分的样品流中扫描颗粒以产生成像信号，所述样本流在发光方向上厚度薄的扁平鞘流中，并且在正交方向上宽以及用于处理信号并且基于来自一维图像传感器的成像信号进行操作的信号处理装置。提出了一种能够实时获得在流动池中流动的液体样本中的粒子的形态信息的分析能力优异的粒子分析装置。此外，通过向流动的粒子发射光，将透射光图像聚焦在一维图像传感器（线传感器）上，并且在信号处理装置中进一步处理来自线传感器的检测图像信号。信号处理装置包括背景校正处理电路，二值化处理电路，二进制信号处理电路，粒子区域分割处理电路和运算电路。提出了一种高分析能力的粒子分析仪，用于实时获取在流动池中流动的液体样品中的各个颗粒的吸收量和形态信息。

35. 发明授权

US5469251A Apparatus for detecting fluorescence of particles in a fluid and analyzing the particles 失效
标题翻译：用于检测流体中颗粒的荧光并分析颗粒的装置
公开(公告)号：US5469251A
公开(公告)日：1995-11-21
申请号：US70667
申请日：1993-06-02
申请人： Tokihiro Kosaka , Shinichi Ogino , Yasunori Maekawa
发明人： Tokihiro Kosaka , Shinichi Ogino , Yasunori Maekawa
IPC分类号： G01N15/14 , G01N21/00 , G01N33/49 , G01N21/53 , G01N21/64 , G01N33/48
CPC分类号： G01N15/1475 , G01N2015/149
摘要： An apparatus for analyzing particles at high precision capable of obtaining informations in real time such as morphological informations and fluorescence image of cells (particles) contained in a sample liquid such as blood and urine. It comprises a flow cell (18) for forming a flat sample liquid flow (20), a light source (10) for emitting light to the sample liquid flow, an image intensifier (34) for amplifying particle fluorescence image emitted from the broader side of the sample liquid flow, a line sensor (36) for scanning the fluorescence image amplified by the image intensifier and issuing imaging signal (Sf (i)) in every scanning i, and a signal processing device (42) for processing signals or operating on the basis of the imaging signal (Sf (i)) from the line sensor.
摘要翻译：用于分析高精度的粒子的装置，能够实时获取诸如血液和尿液等样本液中包含的细胞（颗粒）的形态信息和荧光图像的实时信息。它包括用于形成平坦样品液体流（20）的流动池（18），用于向样品液体流发射光的光源（10），用于放大从较宽侧发射的颗粒荧光图像的图像增强器的样本液体流的线传感器（36），用于扫描由图像增强器放大的荧光图像并在每个扫描i中发出成像信号（Sf（i））的线传感器（36），以及用于处理信号或操作的信号处理装置基于来自线传感器的成像信号（Sf（i））。

36. 发明授权

US5457526A Apparatus for analyzing particles in fluid samples 失效
标题翻译：用于分析流体样品中颗粒的装置
公开(公告)号：US5457526A
公开(公告)日：1995-10-10
申请号：US102239
申请日：1993-08-05
申请人： Tokihiro Kosaka
发明人： Tokihiro Kosaka
IPC分类号： G01N15/14 , G01N33/49 , G06K9/00 , G06T5/30 , G06K9/20
CPC分类号： G01N15/1475 , G01N15/147 , G06K9/00127
摘要： An apparatus for analyzing particles capable of obtaining the morphological information or absorption information of particles such as cells in a liquid sample or particles moving in a fluid in real time. As a photo detector, a photo sensor array comprising photo detecting elements (photo sensors) in a row is used, and detection signal groups delivered parallel from the elements (photo sensors) are processed in parallel in a signal processing device, thereby obtaining characteristic parameters of particles moving at high speed, concerning morphology, light absorption (extinction) or the like, in real time.
摘要翻译：用于分析能够实时获得液体样品中的细胞的形态信息或吸收信息的液体样品或流体中的颗粒的装置。作为光检测器，使用包括一行的光检测元件（光传感器）的光传感器阵列，并且在信号处理装置中并行处理从元件（光传感器）并行传送的检测信号组，从而获得特征参数的颗粒高速运动，关于形态学，光吸收（消光）等。

37. 发明授权

US5426499A Particle analyzing apparatus and method wherein a one dimension image sensor optically tracks a particle 失效
标题翻译：粒子分析装置和方法，其中一维图像传感器光学跟踪粒子
公开(公告)号：US5426499A
公开(公告)日：1995-06-20
申请号：US138013
申请日：1993-10-19
申请人： Tokihiro Kosaka , Yasunori Maekawa
发明人： Tokihiro Kosaka , Yasunori Maekawa
IPC分类号： G01N15/14 , G01N21/00 , G01N33/49 , G01N21/64
CPC分类号： G01N15/1459 , G01N15/1463
摘要： A particle image analyzing apparatus including, a flow cell for enclosing a solution containing a particle to be analyzed in a sheathed flow to form the solution into a sample solution flow, an irradiation optical system for emitting light to irradiate the sample solution flow, a one dimension image sensor for receiving the light transmitted through the particle to scan the particle and output an image signal, an optical deflection device, including a variable deflection angle, for deflecting the transmitted light introduced to the image sensor, a controller for controlling the deflection angle of the optical deflection device such that the image sensor optically tracks the particle, and a signal processor for processing the output image signal of the image sensor to analyze the particle.
摘要翻译：一种颗粒图像分析装置，包括：流过池，用于将包含要被分析的颗粒的溶液封装在套管中以形成溶液流入样品溶液流;照射光学系统，用于发射光以照射样品溶液流; 尺寸图像传感器，用于接收透射通过粒子的光以扫描粒子并输出图像信号，包括可变偏转角的光学偏转装置，用于偏转引入到图像传感器的透射光;控制器，用于控制偏转角使得图像传感器光学跟踪粒子，以及信号处理器，用于处理图像传感器的输出图像信号以分析粒子。

38. 发明授权

US5159398A Flow imaging cytometer 失效
标题翻译：流动成像测微仪
公开(公告)号：US5159398A
公开(公告)日：1992-10-27
申请号：US755549
申请日：1991-09-05
申请人： Yasunori Maekawa , Tokihiro Kosaka
发明人： Yasunori Maekawa , Tokihiro Kosaka
IPC分类号： G01N15/14 , G01N21/49 , G01N21/63 , G01N21/78 , G01N33/48
CPC分类号： G01N15/1427 , G01N15/1429 , G01N15/1459 , G01N2015/144 , G01N2021/1791 , G01N21/6456
摘要： A white-light image and a fluorescent image are capable of being captured by a single video camera, and a single light source for producing exciting light is used to pick up the fluorescent image and monitor arrival of particles to the image capturing area. Specifically, besides a strobe light source, a light source, the output of which normally is low, is provided for exciting fluorescence and for monitoring cell flow-through. An image intensifier is used in the light-receiving system of the fluorescent image and is supplied with a voltage the size and timing of which are controlled in such a manner that the irradiation of a cell with the strobe light when the white-light image is captured will not have an adverse effect upon the aforementioned light-receiving system. This makes it possible to pick up two images each in a different zone on the light-receiving surface of image capturing means.

39. 发明授权

US5050987A Particle analyzing apparatus and method for determining nuclear shift index 失效
标题翻译：粒子分析装置及其测定方法
公开(公告)号：US5050987A
公开(公告)日：1991-09-24
申请号：US402866
申请日：1989-09-01
申请人： Tokihiro Kosaka
发明人： Tokihiro Kosaka
IPC分类号： G01N33/49 , A61B5/145 , A61B5/1459 , G01N15/14
CPC分类号： G01N15/1456 , G01N2015/1477
摘要： A particle suspension is irradiated with a laser beam, and scattered light from a single particle irradiated in an irradiating zone is detected as a plurality of particle signals. The laser beam in the irradiating zone is formed to be narrower than the diameter of a particle nucleus in the direction of particle flow and wider than the diameter of the particle in a direction perpendicular to the particle flow. The degree of complexity of the particle nucleus is determined from high-frequency signal components contained in one type of particle signal based on side-scattered light from one particle, and the degree of symmetry of the particle nucleus is determined from the magnitude of a difference between two types of particle signals based on side-scattered light from one particle. The degrees of complexity and symmetry of the particle nucleus serve as data for particle analysis.
摘要翻译：用激光束照射颗粒悬浮液，并且将从照射区域照射的单个颗粒的散射光检测为多个颗粒信号。照射区域中的激光束形成为比颗粒流动方向上的微粒核的直径窄，并且在垂直于颗粒流动的方向上比粒子的直径更宽。粒子核的复杂程度由基于一个粒子的侧向散射光的一种粒子信号所包含的高频信号成分确定，粒子核的对称程度由差值的大小确定基于来自一个粒子的侧向散射光的两种类型的粒子信号。粒子核的复杂程度和对称性作为粒子分析的数据。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式