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31. 发明申请

US20050031694A1 Methods for promoting growth of bone, ligament, and cartilage using zvegf4 有权
公开(公告)号：US20050031694A1
公开(公告)日：2005-02-10
申请号：US10910938
申请日：2004-08-03
申请人： Debra Gilbertson , Charles Hart
发明人： Debra Gilbertson , Charles Hart
IPC分类号： A61K38/00 , A61K38/18 , A61K38/19 , C07K14/52 , A61K9/14
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of zvegf4 in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of zvegf4.

32. 发明申请

US20050020884A1 Surgical access system 审中-公开
标题翻译：手术进入系统
公开(公告)号：US20050020884A1
公开(公告)日：2005-01-27
申请号：US10927551
申请日：2004-08-25
申请人： Charles Hart , Edward Pingleton
发明人： Charles Hart , Edward Pingleton
IPC分类号： A61B1/32 , A61B17/00 , A61B17/34
CPC分类号： A61B17/0293 , A61B17/3423 , A61B17/3498 , A61B2017/00265
摘要： The invention is directed to a hand access system that provides hand access to a surgical area while maintaining pneumoperitoneum during laparoscopic surgery. The hand access system comprises a sheath retractor adapted to dilate a wound stretchable to a desired diameter, the sheath retractor includes a first ring being adapted for disposition interiorly of the wound, a second ring being adapted for disposition exteriorly of the wound, and a sheath being disposed in a generally cylindrical form between the first ring and the second ring and operable to exert a radial retraction force on the wound. The hand access system further comprises a detachable hand seal adapted to be removable from the second ring of the sheath retractor. The sheath retractor may be formed of an elastomeric material, and the hand seal may be formed of a gel material and includes a slit providing an instrument seal in the presence of an instrument or hand and a zero seal in the absence of the instrument or hand. In another aspect, there is disclosed a surgical access device adapted for disposition relative to an incision in a patient comprising a valve including a plurality of overlapping sheets defining an access channel, and a ring having an inner diameter for holding the valve by fixing each of the overlapping sheets along a portion of the perimeter, the access channel extends into communication with the incision in the patient. Each of the overlapping sheets includes a portion of the perimeter that is not fixed to the inner diameter of the ring, which provide open edges defining the access channel. The open edges slightly overlap at the center of the ring. The open edges may have different shapes including at least one of a straight edge, concave, convex and a cross-configuration. The hand access device may further comprise a septum seal formed at the proximal and distal ends of the ring.
摘要翻译：本发明涉及一种手动进入系统，其在腹腔镜手术期间提供手术进入手术区域同时保持气腹。手动进入系统包括一个适合于将可拉伸到所需直径的伤口扩张的护套牵开器，所述护套牵开器包括适于在伤口内部配置的第一环，适于在伤口外部配置的第二环，在第一环和第二环之间以大致圆柱形的形式设置并可操作以在伤口上施加径向缩回力。手动进入系统还包括适于从皮带牵开器的第二环移除的可拆卸手动密封件。护套牵开器可以由弹性体材料形成，并且手动密封件可以由凝胶材料形成，并且包括在没有仪器或手的情况下在仪器或手的存在下提供仪器密封的狭缝和零密封。另一方面，公开了一种外科进入装置，其适于相对于患者的切口进行配置，该装置包括阀，所述阀包括限定出入通道的多个重叠片，以及具有用于通过固定每个沿着周边的一部分重叠的片材，进入通道延伸成与患者的切口连通。每个重叠片材包括未固定到环的内径的周边的一部分，其提供限定接入通道的开口边缘。开口边缘在环的中心稍微重叠。开口边缘可以具有不同的形状，包括直边，凹形，凸形和交叉构型中的至少一个。手动进入装置还可以包括形成在环的近端和远端的隔膜密封件。

33. 发明申请

US20090077584A1 Methods, systems, and products for sharing presence information 审中-公开
标题翻译：用于共享状态信息的方法，系统和产品
公开(公告)号：US20090077584A1
公开(公告)日：2009-03-19
申请号：US11901319
申请日：2007-09-17
申请人： Jay Oliver Glasgow , Brett D. Johnson , Laurence Siegel , Charles Hart
发明人： Jay Oliver Glasgow , Brett D. Johnson , Laurence Siegel , Charles Hart
IPC分类号： H04N5/445
CPC分类号： H04N5/44543 , H04N7/173 , H04N21/252 , H04N21/44222 , H04N21/4532 , H04N21/6582 , H04N21/84
摘要： Methods, systems, and products are disclosed for sharing presence information. Presence notifications are received from users, and the presence notifications describe content items currently being received by the users. A popularity of one or more of the content items being received by the users is determined. An electronic programming guide is provided that includes information regarding the one or more of the content items and the determined popularity associated with the one or more of the content items.
摘要翻译：公开了用于共享存在信息的方法，系统和产品。来自用户的存在通知，存在通知描述用户当前正在接收的内容。确定由用户接收的一个或多个内容项的流行度。提供电子节目指南，其包括关于一个或多个内容项目的信息以及与一个或多个内容项目相关联的所确定的流行度。

34. 发明申请

US20070225569A1 WOUND RETRACTION APPARATUS AND METHOD 有权
标题翻译：回绕装置和方法
公开(公告)号：US20070225569A1
公开(公告)日：2007-09-27
申请号：US11755305
申请日：2007-05-30
申请人： Richard Ewers , John Brustad , Edward Pingleton , Nabil Hilal , Payam Adlparvar , Scott Taylor , Gary Dulak , Michael Dunn , Norman Morales , Charles Hart , Robert Bowes
发明人： Richard Ewers , John Brustad , Edward Pingleton , Nabil Hilal , Payam Adlparvar , Scott Taylor , Gary Dulak , Michael Dunn , Norman Morales , Charles Hart , Robert Bowes
IPC分类号： A61B1/32
CPC分类号： A61B1/32 , A61B17/0293 , A61B17/3423 , A61B17/3431 , A61B2017/3484
摘要： A surgical wound retractor is adapted to dilate a wound stretchable to a desired diameter, the retractor includes a first ring having a diameter greater than that desired for the wound and being adapted for disposition interiorly of the wound. A second ring has a diameter greater than that desired for the wound and is adapted for disposition exteriorly of the wound. A plurality of retraction elements are disposed in a generally cylindrical relationship to each other, between the first ring and the second ring. These elements extend through the wound to exert a radial retraction force on the wound which is dependent on the distance separating the first ring and the second ring Retraction elements, both distensible and non-distensible are contemplated with appropriate attachment means at the rings to provide for variations in the retraction force. With a suitable retraction sleeve, a third ring can be provided to form a circumferential retainer to vary the retraction force. Rings can also be made inflatable or self-expanding to vary the retraction force An associated method includes the step of rolling the second ring circumferentially of the third ring to form the circumferential retainer.
摘要翻译：外科伤口牵开器适于将可拉伸至期望直径的伤口扩张，牵开器包括直径大于伤口所需直径的第一环，并适于在伤口内部配置。第二环的直径大于伤口所需的直径，并且适于在伤口的外部配置。多个退回元件在第一环和第二环之间以大致圆柱形的关系设置。这些元件延伸穿过伤口以在伤口上施加径向缩回力，这取决于分离第一环和第二环的距离，缩回元件是可伸长的和不可扩张的，在环处有合适的附接装置，以提供收缩力的变化。利用合适的缩回套筒，可以提供第三环以形成圆周保持器以改变收回力。环也可以制成充气或自膨胀以改变收缩力。相关联的方法包括在第三环周向滚动第二环以形成圆周保持器的步骤。

35. 发明申请

US20070135781A1 DEVICE FOR ISOLATING AND REMOVING TISSUE FROM A BODY CAVITY 有权
标题翻译：用于从体腔分离和去除组织的装置
公开(公告)号：US20070135781A1
公开(公告)日：2007-06-14
申请号：US11549701
申请日：2006-10-16
申请人： Charles Hart
发明人： Charles Hart
IPC分类号： A61M1/00
CPC分类号： A61B17/00234 , A61B2017/00287
摘要： A tissue isolation and removal device has a containment pouch that is opened and supported by the device. The pouch has two open/close portions both able to be closed and reopened. One portion positioned away from tissue being inserted in the pouch and covering the other portion to enclose or isolate any tissue captured in the other portion.
摘要翻译：组织隔离和去除装置具有由装置打开和支撑的容纳袋。该袋具有两个打开/关闭部分，能够关闭并重新打开。位于远离组织的一部分被插入袋中并覆盖另一部分以包围或隔离在另一部分中捕获的任何组织。

36. 发明申请

US20070112365A1 Partial occlusion surgical guide clip 审中-公开
标题翻译：局部闭塞手术指南夹
公开(公告)号：US20070112365A1
公开(公告)日：2007-05-17
申请号：US11280098
申请日：2005-11-15
申请人： Nabil Hilal , John Brustad , Edward Pingleton , Ghassan Sakakine , Charles Hart
发明人： Nabil Hilal , John Brustad , Edward Pingleton , Ghassan Sakakine , Charles Hart
IPC分类号： A61B17/08
CPC分类号： A61B17/122
摘要： A surgical guide clip is provided that comprises connectors and jaws attached at each end to the connectors. The jaws being piovtable to open the jaws and having aspects of ratcheting mechanisms to provide incremental closing of the jaws together.
摘要翻译：提供了一种手术导向夹，其包括在每个端部处连接到连接器的连接器和钳口。钳口可以打开钳口，并且具有棘轮机构的方面以提供钳口在一起的增量关闭。

37. 发明申请

US20070088241A1 Hand access laparoscopic device 有权
标题翻译：手动腹腔镜手术
公开(公告)号：US20070088241A1
公开(公告)日：2007-04-19
申请号：US11548955
申请日：2006-10-12
申请人： John Brustad , Jeremy Albrecht , Nabil Hilal , Gary Johnson , Charles Hart
发明人： John Brustad , Jeremy Albrecht , Nabil Hilal , Gary Johnson , Charles Hart
IPC分类号： A61F13/00
CPC分类号： A61B17/0293 , A61B17/02 , A61B17/0218 , A61B17/3423 , A61B17/3431 , A61B17/3439 , A61B17/3462 , A61B17/3496 , A61B17/3498 , A61B90/40 , A61B2017/00477 , A61B2017/00526 , A61B2017/0225 , A61B2017/0287 , A61B2017/3419 , A61B2017/347 , A61B2050/005 , A61B2050/0051
摘要： The invention relates to a hand access laparoscopy device having a gelcap, a retainer, a sleeve and a retention ring The gelcap includes gel that is bonded to a cap. The cap includes an inner cylindrical wall to which the gel in bonded, thereby providing a sealing area between the device and the wound in a body wall. By securing the gel to the inner cylindrical wall, the thickness of the gel and corresponding cap is minimized along with the overall footprint of the device. With the gel thickness reduced and able to be substantially flush, the “doming” phenomenon produced by insufflation of a patient's abdomen is reduced
摘要翻译：本发明涉及具有凝胶帽，保持器，套筒和保持环的手动腹腔镜装置。凝胶帽包括结合到帽的凝胶。该盖包括内部圆柱形壁，凝胶粘合到该内壁上，由此在该体壁中在该装置和该伤口之间提供密封区域。通过将凝胶固定到内圆柱形壁上，凝胶和相应的盖的厚度与装置的总体占地面积最小化。随着凝胶厚度降低并且能够基本上齐平，通过吹入患者腹部产生的“穹隆”现象减少

38. 发明申请

US20070088202A1 Circular surgical retractor 有权
标题翻译：圆形手术牵开器
公开(公告)号：US20070088202A1
公开(公告)日：2007-04-19
申请号：US11548767
申请日：2006-10-12
申请人： Jeremy Albrecht , Charles Hart , John Brustad
发明人： Jeremy Albrecht , Charles Hart , John Brustad
IPC分类号： A61B1/32
CPC分类号： A61B17/0293 , A61B17/02 , A61B17/0218 , A61B17/3423 , A61B17/3431 , A61B17/3439 , A61B17/3462 , A61B17/3496 , A61B17/3498 , A61B90/40 , A61B2017/00477 , A61B2017/00526 , A61B2017/0225 , A61B2017/0287 , A61B2017/3419 , A61B2017/347 , A61B2050/005 , A61B2050/0051
摘要： A wound retractor for retracting a surgical incision includes an inner ring, an outer ring and a distensible sleeve coupled to the inner and outer rings. The outer ring includes at least a pair of circular tubes coupled to each other. At least one of the circular tubes includes a lumen and a split that forms open ends. A noncompliant tubular hoop having a split therein is positioned in the lumen. The tubular hoop is oriented with its open ends positioned away from the split of the circular tubes. A core is positioned in the lumen of the tubular hoop. The core has a first end and a second end and is oriented with the ends positioned away from the split in the tubular hoop. The circular tubes may be parallel or may form a helical pattern similar to a Mobius strip
摘要翻译：用于缩回手术切口的缠绕牵开器包括联接到内环和外环的内环，外环和可扩张套管。外环包括彼此耦合的至少一对圆形管。圆形管中的至少一个包括形成开放端的管腔和裂口。其中分开的不合适的管状环位于内腔中。管状环被定向成其开口端定位成远离圆形管的分割。核心位于管状箍的内腔中。芯具有第一端和第二端，并且其端部定位成远离管状箍中的裂缝。圆形管可以是平行的或可以形成类似于Mobius条的螺旋形图案

39. 发明申请

US20070073314A1 MANUALLY ACTUATED SURGICAL CLIP APPLIER 有权
标题翻译：手动启动手术夹具
公开(公告)号：US20070073314A1
公开(公告)日：2007-03-29
申请号：US11536467
申请日：2006-09-28
申请人： Donald Gadberry , Frans Vandenbroek , Gary Johnson , Charles Hart , David Hearn
发明人： Donald Gadberry , Frans Vandenbroek , Gary Johnson , Charles Hart , David Hearn
IPC分类号： A61B17/10
CPC分类号： A61B17/128 , A61B17/1285 , A61B2017/0046 , A61B2017/0488
摘要： A surgical clip applier is provided having a cartridge carrying multiple surgical clips with a manual graspable actuator configured to sequentially deliver clips to the jaws of the clip applier. Both the cartridge and the jaws are connectable to a scissors-like actuator arranged to translate motion from finger loops to the jaws to open and close the jaws and thus close or crimp a delivered clip between the jaws.
摘要翻译：提供了一种手术夹具，其具有带有多个外科夹具的药筒，手动夹持致动器构造成将夹子顺序地递送到施夹器的钳口。盒和夹爪都可连接到剪刀式致动器，其被布置成将手指环的运动转移到钳口，以打开和关闭钳口，并且因此封闭或压紧夹爪之间的传送夹子。

40. 发明申请

US20070060507A1 GROWTH FACTOR HOMOLOG ZVEGF3 有权
标题翻译：生长因子HOMOLOG ZVEGF3
公开(公告)号：US20070060507A1
公开(公告)日：2007-03-15
申请号：US11552378
申请日：2006-10-24
申请人： Zeren Gao , Charles Hart , Christopher Piddington , Paul Sheppard , Kimberly Shoemaker
发明人： Zeren Gao , Charles Hart , Christopher Piddington , Paul Sheppard , Kimberly Shoemaker
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译：公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。还公开了多肽的多聚体。多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。

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