专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20060140919A1 Methods for selectively stimulating proliferation of T cells 有权
公开(公告)号：US20060140919A1
公开(公告)日：2006-06-29
申请号：US11366331
申请日：2006-03-02
申请人： Carl June , Craig Thompson , Gary Nabel , Gary Gray , Paul Rennert
发明人： Carl June , Craig Thompson , Gary Nabel , Gary Gray , Paul Rennert
IPC分类号： A61K39/395 , A61K35/14
CPC分类号： C07K14/705 , A61K2039/5158 , C07K16/2806 , C07K16/2809 , C07K16/2818 , C07K16/2896 , C07K2317/34 , C12N5/0636 , C12N2501/51 , C12N2501/515 , C12N2501/599
摘要： Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

32. 发明申请

US20060099177A1 Methods for treating HIV infected subjects 失效
公开(公告)号：US20060099177A1
公开(公告)日：2006-05-11
申请号：US11326148
申请日：2006-01-05
申请人： Carl June , Craig Thompson , Gary Nabel , Gary Gray , Paul Rennert
发明人： Carl June , Craig Thompson , Gary Nabel , Gary Gray , Paul Rennert
IPC分类号： A61K35/14 , C12N5/08
CPC分类号： C07K16/2809 , A61K35/17 , A61K2039/507 , C07K16/2806 , C07K16/2818 , C07K2317/34 , C07K2317/55 , C07K2317/74 , C07K2319/30 , C12N2740/16011
摘要： Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

33. 发明申请

US20050208042A1 Humanized immunoglobulin reactive with B7 molecules and methods of treatment therewith 失效
标题翻译：与B7分子反应的人源化免疫球蛋白及其治疗方法
公开(公告)号：US20050208042A1
公开(公告)日：2005-09-22
申请号：US10986089
申请日：2004-11-12
申请人： Man Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Celniker , Mary Collins , Samuel Goldman , Gary Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida Veldman
发明人： Man Co , Maximiliano Vasquez , Beatriz Carreno , Abbie Celniker , Mary Collins , Samuel Goldman , Gary Gray , Andrea Knight , Denise O'Hara , Bonita Rup , Geertruida Veldman
IPC分类号： G01N33/53 , A61K31/436 , A61K31/519 , A61K31/573 , A61K35/14 , A61K35/28 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/18 , A61P3/00 , A61P3/10 , A61P7/00 , A61P7/06 , A61P11/06 , A61P17/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , A61P37/06 , C07K16/00 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , G01N33/533 , G01N33/534 , G01N33/535 , C07K16/44
CPC分类号： C07K16/2827 , A61K39/395 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The invention relates to humanized anti-B7-2 and anti-B7-1 antibodies, wherein each comprise a variable region of non-human origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant rejection, inflammatory disorders and infectious diseases by administering humanized anti-B7-2 and/or anti-B7-1 antibodies.
摘要翻译：本发明涉及人源化抗B7-2和抗B7-1抗体，其中每个包含非人源可变区和至少一部分人源免疫球蛋白。本发明还涉及通过施用人源化抗B7-2和/或抗B7-1抗体治疗各种自身免疫疾病，移植排斥，炎症性疾病和感染性疾病的方法。

34. 发明申请

US20050196402A1 CTLA4-Cy4 fusion proteins 审中-公开
标题翻译： CTLA4-Cy4融合蛋白
公开(公告)号：US20050196402A1
公开(公告)日：2005-09-08
申请号：US10985832
申请日：2004-11-08
申请人： Gary Gray , Jerry Carson , Kashi Javaherian , Paul Rennert , Sandra Silver
发明人： Gary Gray , Jerry Carson , Kashi Javaherian , Paul Rennert , Sandra Silver
IPC分类号： A61K38/00 , C07K14/705 , C12N1/21 , A61K39/395 , C07K16/46
CPC分类号： C07K14/70503 , A61K38/00 , A61K2039/5154 , C07K2319/00
摘要： CTLA4-immunoglobulin fusion proteins having modified immunoglobulin constant region-mediated effector functions, and nucleic acids encoding the fusion proteins, are described. The CTLA4-immunoglobulin fusion proteins comprise two components: a first peptide having a CTLA4 activity and a second peptide comprising an immunoglobulin constant region which is modified to reduce at least one constant region-mediated biological effector function relative to a CTLA4-IgG1 fusion protein. The nucleic acids of the invention can be integrated into various expression vectors, which in turn can direct the synthesis of the corresponding proteins in a variety of hosts, particularly eukaryotic cells. The CTLA4-immunoglobulin fusion proteins described herein can be administered to a subject to inhibit an interaction between a CTLA4 ligand (e.g., B7-1 and/or B7-2) on an antigen presenting cell and a receptor for the CTLA4 ligand (e.g., CD28 and/or CTLA4) on the surface of T cells to thereby suppress an immune response in the subject, for example to inhibit transplantation rejection, graft versus host disease or autoimmune responses.
摘要翻译：描述了具有修饰的免疫球蛋白恒定区介导的效应子功能的CTLA4-免疫球蛋白融合蛋白，以及编码融合蛋白的核酸。 CTLA4免疫球蛋白融合蛋白包含两个组分：具有CTLA4活性的第一肽和包含免疫球蛋白恒定区的第二个肽，其被修饰以相对于CTLA4-IgG1融合蛋白减少至少一个恒定区介导的生物效应子功能。本发明的核酸可以整合到各种表达载体中，这又可以指导各种宿主，特别是真核细胞中相应的蛋白质的合成。本文所述的CTLA4-免疫球蛋白融合蛋白可以施用于受试者以抑制抗原呈递细胞上的CTLA4配体（例如B7-1和/或B7-2）与CTLA4配体的受体（例如， CD28和/或CTLA4），从而抑制受试者的免疫应答，例如抑制移植排斥反应，移植物抗宿主病或自身免疫应答。

35. 发明授权

US5072999A Voting booth 失效
标题翻译：投票亭
公开(公告)号：US5072999A
公开(公告)日：1991-12-17
申请号：US427612
申请日：1989-10-27
申请人： Frank Trotta , Gary Gray
发明人： Frank Trotta , Gary Gray
IPC分类号： G07C13/02
CPC分类号： G07C13/02 , A47B2200/0068
摘要： A movable heavy duty voting booth with a structural frame and lightweight panels to accommodate electronic voting mechanisms.
摘要翻译：一个可移动的重型投票亭，结构框架和轻质面板，以适应电子投票机制。

36. 发明授权

US07923532B2 Methods for diagnosing celiac sprue and reagents useful therein 有权
标题翻译：用于诊断腹腔注射液和其中有用的试剂的方法
公开(公告)号：US07923532B2
公开(公告)日：2011-04-12
申请号：US11927527
申请日：2007-10-29
申请人： Felix Hausch , Gary Gray , Lu Shan , Chaitan Khosla
发明人： Felix Hausch , Gary Gray , Lu Shan , Chaitan Khosla
IPC分类号： A61K38/00
CPC分类号： A61K38/482 , A23L29/06 , A23L33/10 , A23V2002/00 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K9/2866 , A61K9/4825 , A61K9/485 , A61K9/4891 , A61K31/42 , A61K38/4813 , C07D261/04 , C07D413/12 , C07K14/415 , C07K16/16 , C07K2317/34 , C12Y304/14005 , C12Y304/15001 , C12Y304/21026 , G01N33/564 , G01N33/6854 , G01N2800/06 , G01N2800/202 , Y02A50/473
摘要： Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
摘要翻译：将有效剂量的谷蛋白酶施用于腹腔炎或疱疹样皮炎患者可降低毒性麸质寡肽的含量，从而减弱或消除麸质的破坏作用。

37. 发明申请

US20080277939A1 Linear Generator and System to Capture Energy from Irregular Linear Movement 审中-公开
标题翻译：线性发生器和系统从不规则线性运动捕获能量
公开(公告)号：US20080277939A1
公开(公告)日：2008-11-13
申请号：US10592902
申请日：2005-03-15
申请人： Grover Richardson , Gary Gray , Charles M. Stancil
发明人： Grover Richardson , Gary Gray , Charles M. Stancil
IPC分类号： H02J7/14
CPC分类号： H02K35/02 , B60G9/003 , B60G2300/60 , F41A5/32 , F41A25/00 , H02K7/1876
摘要： A system for capturing and storing electrical energy from irregular limited reciprocal linear movement along a cylinder, such as a shock absorber of a vehicle. A linear generator with electrical coils is wound around the cylinder parallel to the movement of the cylinder or along the cylinder. The electrical current generated by the linear generator can be stored in a battery. The energy from the recoil of a large military gun can also be captured by a linear generator along the barrel of the gun and stored in the battery. A processing device can be included to control the flow of electric energy from the linear generator to the battery. The electrical current can pass through a filter and may be processed by a conditioner to limit the range of voltage generated by the linear generator.
摘要翻译：一种用于从诸如车辆的减震器的气缸的不规则有限的往复线性运动中捕获和存储电能的系统。具有电线圈的线性发生器绕圆柱体平行于气缸或气缸的运动而缠绕在气缸周围。由线性发电机产生的电流可以存储在电池中。来自大型军用枪的反冲的能量也可以沿着枪的枪管被线性发电机捕获并存储在电池中。可以包括处理装置以控制从线性发电机到电池的电能的流动。电流可以通过滤波器，并且可以由调节器处理以限制线性发生器产生的电压范围。

38. 发明授权

US07303871B2 Enzyme treatment of foodstuffs for Celiac Sprue 有权
标题翻译：芹菜汁食品酶处理
公开(公告)号：US07303871B2
公开(公告)日：2007-12-04
申请号：US10367405
申请日：2003-02-14
申请人： Felix Hausch , Gary Gray , Lu Shan , Chaitan Khosla
发明人： Felix Hausch , Gary Gray , Lu Shan , Chaitan Khosla
IPC分类号： A61K38/00
CPC分类号： A61K38/482 , A23L29/06 , A23L33/10 , A23V2002/00 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K9/2866 , A61K9/4825 , A61K9/485 , A61K9/4891 , A61K31/42 , A61K38/4813 , C07D261/04 , C07D413/12 , C07K14/415 , C07K16/16 , C07K2317/34 , C12Y304/14005 , C12Y304/15001 , C12Y304/21026 , G01N33/564 , G01N33/6854 , G01N2800/06 , G01N2800/202 , Y02A50/473
摘要： Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
摘要翻译：将有效剂量的谷蛋白酶施用于腹腔炎或疱疹样皮炎患者可降低毒性麸质寡肽的含量，从而减弱或消除麸质的破坏作用。

39. 发明申请

US20060013832A1 Methods for treating HIV infected subjects 有权
标题翻译：治疗艾滋病毒感染者的方法
公开(公告)号：US20060013832A1
公开(公告)日：2006-01-19
申请号：US11029188
申请日：2005-01-04
申请人： Carl June , Craig Thompson , Gary Nabel , Gary Gray , Paul Rennert
发明人： Carl June , Craig Thompson , Gary Nabel , Gary Gray , Paul Rennert
IPC分类号： A61K39/21 , C12N15/86
CPC分类号： C12N5/0636 , A61K35/17 , A61K38/00 , A61K39/02 , A61K39/12 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/5158 , C07K14/705 , C07K14/70521 , C07K14/70532 , C07K16/00 , C07K16/2806 , C07K16/2809 , C07K16/2812 , C07K16/2815 , C07K16/2818 , C07K16/2833 , C07K16/2866 , C07K16/289 , C07K16/2896 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/73 , C07K2317/74 , C07K2319/00 , C07K2319/30 , C12N2501/51 , C12N2501/515 , C12N2501/599 , C12N2710/00088 , C12N2740/16011
摘要： Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
摘要翻译：描述了通过激活T细胞群并用结合附属分子的配体刺激T细胞表面上的辅助分子来诱导T细胞群体增殖的方法。 T细胞增殖发生在没有外源生长因子或附属细胞的情况下。通过刺激T细胞受体（TCR）/ CD3复合物或CD2表面蛋白来完成T细胞活化。为了诱导活化的群体T细胞的增殖，T细胞表面上的辅助分子如CD28被与配合分子结合的配体刺激。通过本发明的方法扩增的T细胞群体可以被遗传转导并用于免疫治疗，或可用于诊断方法。

40. 发明申请

US20060002917A1 Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo 有权
标题翻译：脯氨酰内肽酶对体内消化性胶质肽的影响
公开(公告)号：US20060002917A1
公开(公告)日：2006-01-05
申请号：US11107539
申请日：2005-04-15
申请人： Justin Piper , Gary Gray , Chaitan Khosla
发明人： Justin Piper , Gary Gray , Chaitan Khosla
IPC分类号： A61K38/48
CPC分类号： A61K38/4873 , A61K38/482
摘要： Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
摘要翻译：将有效剂量的谷蛋白酶施用于腹腔炎或疱疹样皮炎患者可降低毒性麸质寡肽的含量，从而减弱或消除麸质的破坏作用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式